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步行方式下的城市居住建筑蓝绿空间可达性分析

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湖南城市学院学报（自然科学版） 2024年第5期33卷 44-50页

作者：王振报田琰王雨春刘方舟孙力高明阳河北工程大学建筑与艺术学院河北邯郸056038 河北工程大学管理工程与商学院河北邯郸056038 河北工程大学临床医学院河北邯郸056038 首都师范大学马克思主义学院北京100089

蓝绿空间作为城市建成环境的重要组成部分,对改善人居环境、提高城市生态建设水平具有重要意义。为了精细化地衡量城市蓝绿空间可达性,以河北省邯郸市主城区为例,通过高德地图API路径规划接口获取每一栋住宅小区建筑至最邻近水体及公园... 详细信息

蓝绿空间作为城市建成环境的重要组成部分,对改善人居环境、提高城市生态建设水平具有重要意义。为了精细化地衡量城市蓝绿空间可达性,以河北省邯郸市主城区为例,通过高德地图API路径规划接口获取每一栋住宅小区建筑至最邻近水体及公园绿地的步行时间,并在此基础上分别计算水体可达性及公园绿地可达性,最后对2类指标进行加权得到蓝绿空间可达性。研究结果表明:1)水体可达性相对较低的住宅小区建筑集中分布于丛台区、邯山区及复兴区的北部。2)公园绿地可达性相对较低的住宅小区建筑集中分布于丛台区北部、邯山区西部及复兴区的西北部。3)蓝绿空间可达性分布呈现出极其不均衡的状态,从整体来看,丛台区的蓝绿空间可达性最高,邯山区次之,复兴区最低,其中,低值区域主要分布在丛台区北部、邯山区及复兴区的西北部;丛台区蓝绿空间可达性高的住宅小区建筑数量最多;复兴区蓝绿空间可达性越高,其对应的住宅小区建筑数量越少。最后,为提升蓝绿空间的可达性,提出了优化存量、增加供给、完善交通网络、合理设置公园出入口等策略。

关键词：步行方式蓝绿空间高德地图API 水体可达性公园绿地可达性

Planning of Urban Cycling Routes Aiming at Improving Cycling Quality

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Journal of Landscape Research 2021年第4期13卷 80-83,88页

作者： wang zhenbao GONG Xin wang Fang School of Architecture and Art Hebei University of EngineeringHandanHebei 056038China

Urban cycling environment is an important part of urban slow-moving system,and reasonable route planning is beneficial to the health of *** order to improve residents’ cycling quality and enrich travel experience,the evaluation system of cycling quality in the main urban area of Handan City was established from the four aspects of convenience,safety,comfort and *** to different travel needs,the cycling evaluation index of road sections was calculated and modified to obtain the cycling time of road *** shortest route algorithm was used to generate the best riding route for convenience,the best riding route for safety,the best riding route for comfort,and the best riding route for *** evaluation indicators were combined with travel route planning to provide residents with a variety of humanized route options,and effectively improve the cycling quality and travel health of residents,which is of great significance to promoting green travel and improving residents’ health.

关键词： Urban planning Street space Evaluation of cycling quality Planning of cycling routes

Conserved peptides enhance immune efficiency of inactive vaccines against emerging avian influenza viruses in chicken

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Science China(Life Sciences) 2017年第12期60卷 1340-1347页

作者： Jin Xiao Lei Zhang zhenbao wang wangzhen Xiang Ping Lu Yingze Zhao Min Han Airong Ma Peng Qi Ming wang George F.Gao William J.Liu College of Veterinary Medicine China Agricultural UniversityBeijing 100193China Key Laboratory of Veterinary Bioproduction and Chemical Medicine of the Ministry of Agriculture Engineering and Technology ResearchCenter for Beijing Veterinary Peptide Vaccine Design and PreparationZhongmu Institutes of China Animal Husbandry Industry Co.LtdBeijing 100095China China Animal Health and Epidemiology Center Qingdao 266032China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100052China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Avian influenza viruses(AIVs) such as H5N1 and H7N9 are a great threat to poultry economics and public health. Vaccination can effectively inhibit the spread of AIV in poultry, which is also a viable strategy for controlling virus transmission from poultry to human. Adjuvants that are commonly used in current inactivated vaccines to provide stronger anti-AIV immune responses are often limited in their capacity to quantitatively induce both humoral and cellular immune responses. Herein, we assessed the levels of immune responses generated by a vaccine formulation comprising inactivated H5N1 antigen and synthetic peptides covering conserved CD4^+, CD8^+ T cell, and B cell epitopes. We found that the synthetic peptides enhanced the antibody responses against conserved influenza virus antigen M2 e. Notably, the hemagglutination inhibition test results indicated that the peptides significantly augmented the antibody responses of inactivated H5N1 antigen even in the 1/10 or 1/5 dose group, in the identical antibody level as antigen alone used at the full dose. This indicates that the peptide can significantly reduce the use of inactivated virus, lowering the cost of the vaccine. Moreover, the peptides increased the transcript levels of interleukin-4 and interferon-γcytokines in chicken peripheral blood mononuclear cells, which may facilitate both humoral and cellular immune responses. Our data suggest that this peptide combined with inactivated H5N1 antigen enhances both the humoral and cellular immune responses,which may benefit the prediction and design of synthetic peptide-based adjuvants for vaccines in chicken.

关键词： H5N1 H7N9 Avian influenza virus peptides adjuvant vaccine

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基于GMR生物传感器的病原体检测研究进展

微纳电子技术 2024年第2期61卷 13-24页

作者：杨真柳梦雨孙逊孙学成王振宝李丹青徐军广西师范大学电子与信息工程学院广西桂林541004 广西师范大学集成电路学院广西桂林541004 广西师范大学广西高校集成电路与微系统重点实验室广西桂林541004 广西师范大学类脑计算与智能芯片重点实验室广西桂林541004 贵州航天计量测试技术研究所贵阳550009 上海大学机电工程与自动化学院微电子研究与开发中心上海200444 贵州医科大学附属医院贵阳550004

对当前病原体检测方法和磁性生物传感器的优势进行了简单阐述,分别介绍了巨磁阻(GMR)传感器在生物医学检测领域的应用优势、GMR效应的来源及常见的GMR传感器的结构类型,重点关注了GMR生物传感的基本原理,包括传感器在免疫分析领域的应... 详细信息

对当前病原体检测方法和磁性生物传感器的优势进行了简单阐述,分别介绍了巨磁阻(GMR)传感器在生物医学检测领域的应用优势、GMR效应的来源及常见的GMR传感器的结构类型,重点关注了GMR生物传感的基本原理,包括传感器在免疫分析领域的应用策略和传感器表面功能化的方法。总结了GMR生物传感器在病原体检测中的发展现状,重点阐述了GMR生物传感器在靶向标签、致病菌和病毒检测方面的实际应用。最后对当前GMR生物传感器在病原体检测领域面临的问题进行简要分析,对GMR生物传感器未来的应用前景进行了展望,为新一代可用于临床检测的GMR生物检测系统的开发奠定坚实的基础。

关键词：巨磁阻(GMR)生物传感器磁性生物传感器生物医学检测病原体检测靶向标签免疫分析

The Best Walking Recommendation Path by Considering the Quality of Street Space

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Journal of Landscape Research 2021年第4期13卷 42-46页

作者： wang zhenbao SONG Jiarui LI Yongjin School of Architecture and Art Hebei University of EngineeringHandanHebei 056038China

Walking is a healthy and green way of travel,and seeking the best recommended route is the first choice for residents to *** this paper,according to actual demand of pedestrians,convenience,safety,comfort and appreciation are taken as different walking needs,to construct the evaluation system of urban street space *** the shortest path algorithm,the modified walking time cost of road section and intersection delay are used as impedance,obtaining the best walking recommendation paths of convenience,safety,comfort and appreciation between the beginning and the ***,the form of questionnaire survey is used for experimental verification of final recommended *** paper could provide residents with walking path planning scheme under different *** guaranteeing travel efficiency,it could effectively improve walking quality of residents,with important significance for improving the attraction of green travel mode,providing diverse selectivity,and improving residents’ health.

关键词： Walking Street space Evaluation system Recommended path

Polymorphism analysis and supertype definition of swine leukocyte antigen class I molecules in three-way crossbred(Landrace,Duroc,and Yorkshire)pigs:implications for the vaccine development of African swine fever virus

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Science China(Life Sciences) 2020年第10期63卷 1604-1607页

作者： Limin Ba zhenbao wang William J Liu Dongxun Wu wangzhen Xiang Peng Qi Chunna Dong Yanxin Hu Ping Lu Jin Xiao Changyuan Yu College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Zhongmu Research Institute China Animal Husbandry Industry Co.LTDBeijing 100095China China Animal Husbandry Industry Co. LTDBeijing 100095China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100052China Key Laboratory of Zoonosis of Ministry of Agriculture College of Veterinary MedicineChina Agricultural UniversityBeijing 100094China China Animal Health and Epidemiology Center Qingdao 266032China

Dear Editor,Swine major histocompatibility complex(MHC)is a highly polymorphic gene in pigs and is also called swine leukocyte antigen(SLA)(Fan et al.,2018).SLA is divided into three major categories,SLA I(SLA-1,-2,-3),SLA II,and SLA III(Smith et al.,2005).SLA I plays an important role in cellular immunity which can eliminate viruses and other foreign antigens in pigs(Macdonald et al.,2010).SLA-1,SLA-2 and SLA-3 are important SLA I alleles and are highly *** causes extreme difficulties in screening broadly protective cytotoxic lymphocyte(CTL)epitope *** supertype which is built based on peptide-binding specificity of each SLA I can overcome this difficulty to some extent(Thomsen et al.,2013).

关键词： swine Swine protective

Spatial Heterogeneity and Scale Effect of Influencing Factors of Crime Rate Based on MGWR

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Journal of Landscape Research 2022年第6期14卷 53-56,60页

作者： wang zhenbao LIU Shuyue GONG Xin School of Architecture and Art Hebei University of EngineeringHandanHebei 056038China

It is of great significance to analyze the factors influencing crime rate and their effect scale for reducing crime rate and improving the quality of living environment. By using MGWR model, combined with the data of crime rate in Chicago, the spatial scale differences of crime rate in Chicago were studied,and the causes of spatial scale differences were analyzed. By comparing R2 and AICC in the regression results of MGWR, GWR and OLS models, it is found that the fitting effect of MGWR model was *** results show that among the influencing factors ofcrime rate in Chicago, disadvantaged group factor had a small scale and strong sensitivity to crime rate, and had a great influence on local crime rate. Latino immigrant factor and employment convenience factor had a large impact scale and weak sensitivity, and had a small impact on local crime rate. It is suggested that Chicago government should take targeted measures to influence factors in different regions and scales.

关键词： GWR MGWR Murder rate Chicago Spatial heterogeneity

Convenience Analysis of Public Service Facilities in the Walking Circle of Urban Housing Estates

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Journal of Landscape Research 2021年第4期13卷 1-4,8页

作者： wang zhenbao LI Huiqing SHANG Haichao School of Architecture and Art Hebei University of EngineeringHandanHebei 056038China

A walkable urban built environment with convenient facilities is the key to improve the living quality of urban residents and build a livable city in the new *** each urban housing estate as the center and based on walking accessibility,the walking circle of housing estates was *** the six functional systems of convenient shopping,catering service,fi nancial service,scientifi c research and education,leisure and entertainment,and medical service as evaluation factors,and considering the actual frequency of residents’use of various public service facilities and the reduction of walking,the convenience evaluation system of public service facilities was *** the urban built environment within the Second Ring Road of Shijiazhuang City,Hebei Province as an example,it is found that the convenience of public service facilities in the walking circle of housing estates within the Second Ring Road presented a circular layer distribution of“low outside and high inside”.This study will provide the reference for urban renewal and renovation and improvement of facilities.

关键词： Urban housing estate Walking accessibility Public service facilities Convenience

Molecular Identification of D. nuttalli and ***

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Animal Husbandry and Feed Science 2014年第4期6卷 159-164,215页

作者： Lv Jizhou wang zhenbao Yuan Xiangfen Wu Shaoqiang Institute of Animal Quarantine Chinese Academy of Inspection and Quarantine Yili Entry-exit Inspection and Quarantine Bureau

This study was to establish a molecular identification method to distinguish Dermacentor nuttalli(D. nuttalli) and Dermacentor marginatus(D. marginatus),and to study their phylogenetic relationship. The ticks were collected from domestic animals in Xinjiang Uygur Autonomous Region for morphological identification,then their genomic DNAs were isolated for amplifying mitochondrial 16 S rRNA and cytochrome oxidase subunit I gene(COI). The phylogenetic tree was constructed based on the sequencing results of PCR products by employing Mega 5. 0 and Mrbayes 3. 2 for homology analysis. Clustering analysis PCR product for 16 S rRNA from both D. marginatus and D. nuttalli was clustered together with their respective 16 S rRNA sequences previously accessed in GenBank,and that for COI gene as well. These are basically identical with morphological identification results. Our results indicate that morphological identification,combined with molecular markers,would be a simple and accurate method for distinguishing D. nuttalli and D. marginatus.

关键词： Mitochondrial cytochrome oxidase(COI) 16S rRNA Dermacentor nuttalli Dermacentor marginatus Molecular identification