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Alterations of sleep deprivation on brain function:A coordinatebased resting-state functional magnetic resonance imaging metaanalysis

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World Journal of Psychiatry 2024年第2期14卷 315-329页

作者： Qin Zhang Yong-Zhe Hou Hui Ding Yan-Ping Shu Jing Li Xi-zhao Chen Jia-Lin Li Qin lou Dai-Xing Wang Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Department of Psychiatry of Women and Children The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Sleep deprivation is a prevalent issue that impacts cognitive *** numerous neuroimaging studies have explored the neural correlates of sleep loss,inconsistencies persist in the reported results,necessitating an investigation into the consistent brain functional changes resulting from sleep *** To establish the consistency of brain functional alterations associated with sleep deprivation through systematic searches of neuroimaging *** metaanalytic methods,signed differential mapping(SDM)and activation likelihood estimation(ALE),were employed to analyze functional magnetic resonance imaging(fMRI)*** A systematic search performed according to PRISMA guidelines was conducted across multiple databases through July 29,*** that met specific inclusion criteria,focused on healthy subjects with acute sleep deprivation and reported whole-brain functional data in English were considered.A total of 21 studies were selected for SDM and ALE *** Twenty-one studies,including 23 experiments and 498 subjects,were *** to pre-sleep deprivation,post-sleep deprivation brain function was associated with increased gray matter in the right corpus callosum and decreased activity in the left medial frontal gyrus and left inferior parietal *** revealed increased brain functional activity in the left striatum and right central posterior gyrus and decreased activity in the right cerebellar gyrus,left middle frontal gyrus,corpus callosum,and right *** This meta-analysis consistently identified brain regions affected by sleep deprivation,notably the left medial frontal gyrus and corpus callosum,shedding light on the neuropathology of sleep deprivation and offering insights into its neurological impact.

关键词： Sleep deprivation Resting-state-functional magnetic resonance imaging Activation likelihood estimation-meta Signed differential mapping-meta

Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder

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China Foundry 2024年第2期21卷 197-204页

作者： Chun-jie Xu Yuan-ying Jin Dong Ma zhen.zhao Jia-wei Qi Shang Sui Xiang-quan Wu Can Guo Zhong-ming Zhang Yong-hui Liu Dan Shechtman School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048China Xi'an Shechtman Nobel Prize New Materials Institute Xi'an 710048China Tongchuan Huazhu Precision Technology Co. Ltd.Tongchuan 727100ShaanxiChina Faculty of Materials Science and Engineering Technion-Israel Insititue of TechnologyHaifa 3200003Israel

It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial *** this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 *** microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were *** results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and *** the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are *** the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the *** the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification ***,the microstructure in the lower part of the section solidifies relatively *** left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,*** tensile fracture belongs to the ductile-brittle hybrid *** comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder.

关键词： horizontal continuous casting(HCC) nodular cast iron ductile iron bars microstructure mechanical properties

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Properties and microstructure of copper–titanium alloys with magnesium additions

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Rare Metals 2024年第5期43卷 2290-2299页

作者： Lue Huang Li-Jun Peng Jiang Li Xu-Jun Mi Gang zhao Guo-Jie Huang Hao-Feng Xie Yi-Cheng Cao Wen-Jing Zhang zhen Yang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. LtdBejing 101407China School of Materials Science and Engineering Northeastern UniversityShenyang110000China General Research Institute for Nonferrous Metals Beijing 100088China China Academy of Space Technology Beijing 100094China China Nonferrous Metals Mining Group(Tianjin)Co.Ltd Tianjin 3001llChina

The volume fractions and morphology of precipitates in precipitation-strengthened Cu-Ti alloys,which precipitate mainly as continuous and discontinuous precipitates,are important for the application of the *** study employed hardness and electrical conductivity tests transmission electron microscopy(TEM),atom probe tomography(APT),and first-principles calculations to demonstrate that the addition of Mg is effective for accelerating nanosized continuousβ'-Cu_(4)Ti precipitation as well as for suppressing the precipitation of coarse lamellar discontinuousβ-Cu_(4)Ti precipitates along the grain boundaries,resulting in Cu-Ti alloys with high yield strength and good electrical *** results showed that the continuous precipitation ofβ'-Cu_(4)Ti was accelerated by the Mg additions,which reduced the supersaturation of the matrix,thereby reducing the chemical driving force for the discontinuous *** the other hand,Mg additions increased the mismatch between the discontinuousβ-Cu_(4)Ti precipitates and matrix decreased the nucleation rate of the discontinuous precipitates,and increased the spacing of the discontinuous precipitation layer,resulting in a lower growth rate of the discontinuous ***,the addition of Mg to Cu-Ti alloys enhances the strength and improves the resistance to over-ageing.

关键词： Cu-Ti-Mg alloy Precipitation hardening Discontinuous precipitation Continuous precipitation Microstructure formation mechanism

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正交面齿轮传动的两类界线

哈尔滨工程大学学报 2024年第4期45卷 764-770页

作者：赵亚平娄海青东北大学机械工程与自动化学院辽宁沈阳110004

为了建立系统的正交面齿轮传动啮合界线与曲率干涉界线理论,本文通过求解非线方程组获得了两类界线的数值解。证明了啮合界线在小轮齿面上是渐开线;其共轭线也是渐开线。发现干涉界线一般有2条,近齿面干涉界线存在于面齿轮内端附近,大... 详细信息

为了建立系统的正交面齿轮传动啮合界线与曲率干涉界线理论,本文通过求解非线方程组获得了两类界线的数值解。证明了啮合界线在小轮齿面上是渐开线;其共轭线也是渐开线。发现干涉界线一般有2条,近齿面干涉界线存在于面齿轮内端附近,大致沿齿高走向。近齿面干涉界点存在平凡解,是干涉界线和啮合界线共轭线的交点,位于传动副瞬时相对转动轴上。基于近齿面干涉界线,建立了面齿轮无根切内径公式,通过数值迭代可以获得内径准确值;还导出了无根切内径估算公式,便于设计中应用。

关键词：面齿轮曲率干涉啮合界线渐开线直齿轮根切非线性内径

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Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang Sun Mei zhao Ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng zhao Feifei Lv Jie Sun Hongjun Li zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Unlocking the potential:advancements and future horizons in ROR1-targeted cancer therapies

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Science China Life Sciences 2024年

作者： Lin Li Weixue Huang Xiaomei Ren zhen Wang Ke Ding Linxiang zhao Jinwei Zhang State Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical University State Key Laboratory of Chemical Biology Research Center of Chemical KinomicsShanghai Institute of Organic ChemistryChinese Academy of Sciences

While receptor tyrosine kinase-like orphan receptor 1 (ROR1) is typically expressed at low levels or absent in normal tissues,its expression is notably elevated in various malignant tumors and conditions,including chronic lymphocytic leukemia (CLL),breast cancer,ovarian cancer,melanoma,and lung *** distinctive feature positions ROR1 as an attractive target for tumor-specific ***,several targeted drugs directed at ROR1 are undergoing clinical development,including monoclonal antibodies,antibody-drug conjugates (ADCs),and chimeric antigen receptor T-cell therapy (CAR-T).Additionally,there are four small molecule inhibitors designed to bind to ROR1,presenting promising avenues for the development of PROTAC degraders targeting *** review offers updated insights into ROR1’s structural and functional characteristics,embryonic development implications,cell survival signaling pathways,and evolutionary targeting strategies,all of which have the potential to advance the treatment of malignant tumors.

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Geology and mineralization of the Dongping supergiant alkalic-hosted Au-Te deposit(>100 t Au)in Northern Hebei Province,China:A review

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China Geology 2024年第3期7卷 533-550页

作者： Shi-min zhen Da-zhao Wang Zhong-jian Zha Hai-jun Bai Jiang Wang Development and Research Center of China Geological Survey Ministry of Natural ResourcesBeijing 100037China Technical Guidance Center for Mineral Resources Exploration Ministry of Natural ResourcesBeijing 100037China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Institute of Geological Surveying and Mapping Technology of Anhui Province Hefei 230022China Third Geological Brigade of Hebei Bureau of Geology and Mineral Resources Zhangjiakou 075000China Ulanqab Real Estate Registration Center Ulanqab 012099China

The Dongping deposit is the largest alkalic-hosted gold deposit in China containing>100 t of *** paper presents a new understanding for Dongping ore system,based on the previous *** mineralization originally occurred at 400-380 Ma,simultaneous with emplacement of the Shuiquangou alkaline complex,and was overprinted by the hydrothermal activity in the *** compositions of ores indicate metals of the deposit are mainly provided by the Shuiquangou ***-forming fluids are characterized by increasing oxygen fugacity and decreasing sulfur fugacity,while tellurium fugacity increased in the Stage II-2 and decreased in Stage *** systematic changes are closely related to the processes of mineral precipitation and fluid *** precipitation from Stage Ⅰ to Stage Ⅱ was triggered by fluid boiling,which leads to the precipitation of Pb-Bi-Te,due to decrement of sulfur *** of gas phase containing high concentration of H_2Te leads to precipitation of Te-Au-Ag minerals and native *** on these hypotheses,this paper present a polyphase metallogenic model as *** the Devonian,fluids were released from alkaline magmas,which carried ore-forming materials form the surrounding rocks and precipitate the early *** the Jurassic-Cretaceous,fluorine-rich fluids exsolved from highly factionated Shangshuiquan granite,which extracted and concentrated Au from the Shuiquangou complex and the Sanggan Group metamorphic rocks,and finally formed the Dongping gold deposit.

关键词： Mineralization and alteration Alkaline intrusion Au deposit Physicochemical conditions Metallogenic model Oxygen fugacity Sulfur fugacity Mechanisms of mineral precipitation Fluid boiling Fluorine-enriched fluid Dongping gold deposit North China Craton Mineral exploration engineering

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Recent advances and trends of single-atom catalysts for proton exchange membrane fuel cell cathodes

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ChemPhysMater

ChemPhysMater 2024年第2期3卷 143-156页

作者： Zihao Wan Feng Liu Hongfei Xu Shuaili zhao zhen An Zizai Ma Zhonghua Zhang Yun Wu Xiaoguang Wang Laboratory of Advanced Materials and Energy Electrochemistry Institute of New Carbon MaterialsCollege of Material Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Datong Innoreagen Power Technology Co. LtdDatong 037000China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan250061China Department of Materials Science and Engineering Guangdong University of Petrochemical TechnologyMaoming 525000China

Proton exchange membrane fuel cells(PEMFCs),which have the advantages of high-power density,zero emission,and low noise,are considered ideal electrochemical conversion systems for converting hydrogen(H2)and oxy-gen(O_(2))/air into ***,the oxygen reduction reaction(ORR),which is accompanied by multiple electrons,results in voltage loss and low conversion efficiency of ***,PEMFCs mainly use high-load precious platinum(Pt)to promote the ORR process;however,the high cost of Pt hinders the widespread commercialization of *** the past few years,metal-nitrogen-carbon single-atom catalysts(M-N-C SACs)have attracted considerable attention and have been recognized as potential Pt-based catalysts owing to their outstanding ORR *** review briefly introduces the components of ***,we discuss the catalytic mechanisms of the M-N-C SACs for the ***,the latest advances in noble,non-noble,and heteroatom-doped M-N-C SACs used as ORR and PEMFCs cathode catalysts are systematically *** sum-mary,we have outlined the current challenges and proposed a future perspective of M-N-C SACs for PEMFCs cathodes.

关键词： Proton exchange membrane fuel cells Oxygen reductionreaction Cathode Platinum-based catalysts Metal-nitrogen-carbon single-atom catalysts