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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu xian.eng li Mi li xian.Wu Xiaohui Huang Ajing Xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli li Lemei Zhu lingfeng Zeng zhen.Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexian. liu Tingting li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong li zhen.Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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基于BIM的智慧农业温室大棚建模分析

农机化研究 2025年第3期47卷 217-221页

作者：李祯庄卓河南工业职业技术学院河南南阳473000

智慧农业是当前农业发展的趋势,而温室大棚作为重要的农业生产设施,对其进行建模分析具有重要意义。为此,基于BIM技术,对Venlo智慧农业温室大棚进行了建模分析。首先,对温室大棚的设计流程进行分析;然后,对BIM工作流做介绍和分析,并对... 详细信息

智慧农业是当前农业发展的趋势,而温室大棚作为重要的农业生产设施,对其进行建模分析具有重要意义。为此,基于BIM技术,对Venlo智慧农业温室大棚进行了建模分析。首先,对温室大棚的设计流程进行分析;然后,对BIM工作流做介绍和分析,并对建筑结构和节点进行深化分析;最后,设计了一栋智慧农业温室大棚,并利用BIM软件对其进行三维建模和分析。实例设计表明:基于BIM技术的智慧农业温室大棚建模分析具有较高的准确性和可操作性,可为农业生产提供重要支持。

关键词：智慧农业 Venlo温室大棚 BIM技术建筑结构三维建模

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Chemical components and protective effects of Atractylodes japonica *** Kitam against acetic acid-induced gastric ulcer in rats

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World Journal of Gastroenterology 2023年第43期29卷 5848-5864页

作者： Bi-xian.zhen.Qian Cai Feng li Department of Medicine Liaoning University of Traditional Chinese MedicineDalian 116600Liaoning ProvinceChina

BACKGROUND Atractylodes japonica *** Kitam.(***,Chinese name:Guan-Cangzhu,Japanese name:Byaku-jutsu),a perennial herb,which is mainly distributed in northeast area of China,it’s often used to treat digestive system diseases such as gastric ulcer(GU).However,the mechanism of its potential protective effects against GU remains *** To investigate the protective effects of *** on acetic acid-induced GU *** The chemical constituents of *** were determined by ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS)*** rat model of GU was simulated by acetic acid *** pathological changes of gastric tissues were evaluated by hematoxylin-eosin stain,the levels of epidermal growth factor(EGF),EGF receptor(EGFR),nuclear factor kappa-B(NF-κB),interleukin-1β(IL-1β),IL-10,Na^(+)-K^(+)-ATPase(NKA)in serum and gastric tissues were determined by enzyme-linked immunosorbent assay,and the mRNA expressions of EGFR,NF-κBp65,IkappaBalpha(IκBα)and Zonula Occludens-1(ZO-1)in gastric tissues were determined by real-time reverse transcription polymerase chain reaction,and the efficacy was ***,plasma metabolomic analysis was performed by UPLC-MS/MS to screen the specific potential biomarkers,metabolic pathways and to explore the possible *** 48 chemical constituents were *** of them have strong pharmacological activity,the results also revealed that *** significantly improved the pathological damage of gastric tissues,increased the expression levels of IL-10,IκBαrelated to anti-inflammatory factors,decreased the expression levels of IL-1β,NF-κB,NF-κBp65,related to proinflammatory factors,restored the levels of factors about EGF,EGFR,ZO-1 associated with ulcer healing and the levels of factors about NKA associated with energy *** analysis identified 10 potential differential metabolites and enriched 7 related metabolic *** These findings

关键词： Atractylodes japonica Koidz.ex Kitam. Ulcer Acetic acid Digestive system diseases Metabolomics Rats

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大型体育场馆免低开放政策绩效研究

湖北科技学院学报 2025年第1期45卷 1-9页

作者：李震湖北科技学院体育学院湖北咸宁437100

采用投入产出模型(DEA)分析扩大内需战略下大型体育场馆免低开放政策绩效,包括财政补助资金、场地资源的投入产出效率等;其次,以史密斯政策(Smith)执行理论为基础,围绕政策本身、执行机构、目标群体、政策环境等分析场馆免低开放政策绩... 详细信息

采用投入产出模型(DEA)分析扩大内需战略下大型体育场馆免低开放政策绩效,包括财政补助资金、场地资源的投入产出效率等;其次,以史密斯政策(Smith)执行理论为基础,围绕政策本身、执行机构、目标群体、政策环境等分析场馆免低开放政策绩效的制约因素;最后,提出场馆免低开放政策优化路径:完善场馆免低开放补贴指标体系;探索发放体育场馆健身券;优化绩效考核指标体系;加强场馆免低开放绩效评价,加快信息化建设步伐等等。

关键词：大型体育场馆免费低收费开放政策绩效制约因素

Existence and Nonexistence of Global Positive Solutions for a Weakly Coupled P-Laplacian System

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Acta Mathematicae Applicatae Sinica 2013年第3期29卷 541-554页

作者： xian.zhong ZENG zhen.hai li Yong-geng GU School of Mathematics and Computing Science Hunan University of Science and Technology College of Science Guangxi University for Nationalities Department of Mathematics Hunan Normal University

In this paper, we deal with a weakly coupled evolution P-Laplacian system with inhomogeneous terms. We obtain a critical criterion concerning existence and nonexistence of its global positive solutions. Such a criterion is different from that of the weakly coupled evolution P-Laplacian system with homogeneous terms. Further, we demonstrate existence and nonexistence of its global positive solutions.

关键词： the evolution P-Laplacian system inhomogeneous terms blow-up global existence

Anisotropic phononic crystal structure with low-frequency bandgap and heat flux manipulation

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 93-103页

作者： Ting Guo XiongWei Yang Qian Geng zhen.li YueMing li xian.Wang Hu Zhang State Key Laboratory for Strength and Vibration of Mechanical Structures Shaanxi Key Laboratory of Environment and Control for Flight Vehicle School of Aerospace Xi’an Jiaotong University

This study presents a two-dimensional phononic crystal with heat flux manipulation and wide bandgaps of out-of-plane modes within the low-frequency range. The anisotropic matrix made of spiral-multilayered materials with different thermal conductivities, and the coating layer inserted with metal are designed for heat flux manipulation. Rubber-coated metal cylinders are periodically embedded in the anisotropic matrix to obtain the low-frequency bandgaps of out-of-plane modes. Numerical simulation is carried out to validate the heat and elastic characteristics of the spiral-multilayered anisotropic structure and reveal the effects of the laying angle and temperature on the bandgaps. Subsequently, a spiral-multilayered plate with periodic structures is studied, which shows an obvious vibration attenuation in the frequency ranges of the bandgaps and a deflected heat flux from the initial propagation direction. In the experimental investigation, the multi-phase spiral-multilayered anisotropic plate is simplified to a single-phase anisotropic plate made of aluminum. The characteristics of this type of anisotropic phononic crystal structure may pave the way for the design of a new kind of thermo-acoustic metamaterial serving in combined thermal and acoustic environments.

关键词： heat flux manipulation bandgap anisotropic structure thermal stress spiral-multilayered structure

Weekly inter-technique combination of SLR,VLBI,GPS and DORIS at the solution level

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Research in Astronomy and Astrophysics 2018年第10期18卷 5-18页

作者： li-zhen.lian Jie-xian.Wang Cheng-li Huang Ming-Hui Xu College of Surveying and Geo-informatics Tongji UniversityShanghai 200092China CAS Key Laboratory of Planetary Sciences Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Constructing and maintaining a stable terrestrial reference frame （TRF） is one of the key objectives of fundamental astronomy and geodesy. The datum realization for all the global TRF versions, such as ITRF2014 and its predecessor ITRF2008, assumes linear time evolution for transformation parameters and then imposes some conditions on these Helmert transformation parameters. In this paper, we investigate a new approach, which is based on weekly estimation of station positions and Helmert transformation parameters from a combination of the solutions of four space-geodetic techniques, i.e., Satellite Laser Ranging （SLR）, Very Long Baseline Interferometry （VLBI）, Global Positioning System （GPS） and Doppler Orbitography and Radiopositioning Integrated by Satellite （DORIS）. For this study, an interval of one week is chosen because the arc length of the SLR solutions is seven days. The major advantage of this weekly estimated reference frame is that both the non-linear station motions and the non-linear origin motion are implicitly taken into account. In order to study the non-linear behavior of station motions and physical parameters, ITRF2008 is used as a reference. As for datum definition of weekly reference frame, on one hand SLR is the unique technique to realize the origin and determine the scale together with VLBI, and on the other hand the orientation is realized via no net rotation with respect to ITRF2005 on a subset of core stations. Given the fact that without enough collocations an inter-technique combined TRF could not exist, the selection and relative weight of local ties surveyed at co-location sites are critical issues. To get stable results, we first assume that, if there were no events such as equipment changes between the measurement epoch of the local tie and that of the space- geodetic solution, the relative position between the two co-located stations should be invariant and this local tie could be used for computing the inter-technique combined ref

关键词： reference systems - astrometry - methods data analysis - Earth