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Progress in the basic and clinical research on the Schlemm’s canal

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 816-821页

作者： Le-Ying Wang Guan-yu Su zhen-yu wei Zi-Jun Zhang Qing-Feng Liang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100005China

Glaucoma is a leading cause of irreversible blindness in the *** pressure(IOP)plays a key role in glaucoma development and ***’s canal(SC),an important structure of the anterior chamber angle,regulates the flow of aqueous humor and maintains *** of its special function of aqueous outflow,the SC has been intensive investigated *** characteristics of SC in anatomy,physiology and pathophysiology have been *** to normal,glaucomatous SC cells are more sensitive to substrate stiffness,have higher stiffness and and lower porosity leading to higher outflow *** SC collapse caused by acute IOP increase is partially or totally *** advanced inspection techniques,high-quality images of the SC can be obtained in vivo,which facilitates SC quantitative measurements clinically and allows us to investigate a new therapy paradigm for *** this review,we summarize the basic and clinical research that focused on mechanisms of aqueous outflow resistance and SC changes in physiological,pathological,and posttreatment states.

关键词： Schlemm's canal physiology pathophysiology glaucoma progress

Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2748-2760页

作者： Hua-yang Fan Ming-da Zhao Hong-jie Jiang zhen-wei yu yu-jiang Fan Xin-hua Liang Ya-ling Tang Yong Sun State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Pathology West China Hospital of StomatologySichuan UniversityChengdu 610041China

Circular RNAs(circRNAs)are ideal biomarkers of oral squamous cell carcinoma(OSCC)because of their highly stable closed-loop structure,and they can act as microRNA(miRNA)sponges to regulate OSCC *** analyzing clinical samples,we identified circCPNE1,a dysregulated circRNA in OSCC,and its expression level was negatively correlated with the clinical stage of OSCC ***-of-function assays revealed the tumor-suppressive effect of circCPNE1,which was then identified as a miR-330-3p ***-330-3p was recognized as a tumor promoter in multiple studies,consistent with our finding that it could promote the proliferation,migration,and invasion of OSCC *** results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC ***,we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p(a miRNA inhibitory analog)via electrostatic interactions to form PP@miR nanoparticles(NPs).Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination(2/5),which confirmed the critical role of miR-330-3p in OSCC *** findings provide a new perspective for the development of OSCC treatments.

关键词： Oral squamous cell carcinoma CircRNA MiRNA sponge Antagomir MiRNA delivery Cisplatin-based nanoparticles Drug delivery systems Tumor elimination

Dyeing bacterial cellulose pellicles for energetic heteroatom doped carbon nanofiber aerogels

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Nano Research 2014年第12期7卷 1861-1872页

作者： zhen-yu Wu Hai-wei Liang Chao Li Bi-Cheng Hu Xing-Xing Xu Qing Wang Jia-Fu Chen Shu-Hong yu Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at Microscale Collaborative InnovationCenter of Suzhou Nano Science and Technology Department of Chemistry University of Science and Technology of China HefeiAnhui 230026 China

The energy crisis and environmental pollution are serious challenges that humanity will face for the long-term. Despite tremendous efforts, the development of environmentally friendly methods to fabricate new energy materials is still challenging. Here we report, for the first time, a new strategy to fabricate various doped carbon nanofiber （CNF） aerogels by pyrolysis of bacterial cellulose （BC） pellicles which had adsorbed or were dyed with different toxic organic dyes. The proposed strategy makes it possible to remove the toxic dyes from waste-water and then synthesize doped CNF aerogels using the dyed BC pellicles as precursors. Compared with other reported processes for preparing heteroatom doped carbon （HDC） nanomaterials, the present synthetic method has some significant advantages, such as being green, general, low-cost and easily scalable. Moreover, the as-prepared doped CNF aerogels exhibit great potential as electrocatalysts for the oxygen reduction reaction （ORR） and as electrode materials for supercapacitors.

关键词： doped carbon nanofiberaerogels electrocatalysts oxygen reduction reaction supercapacitors organic dyes bacterial cellulose

移动Ad Hoc网络的一种自适应权值分簇算法

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西安电子科技大学学报 2008年第3期35卷 572-576页

作者：张丽余镇危张扬中国矿业大学机电学院空军第一航空学院航空电子工程系河南信阳464000

为有效解决移动Ad Hoc网络簇结构的稳定性问题,提出了一种分簇算法.在流量均衡的基础上,综合考虑节点所处的网络环境和本身状态,根据适应性权值选择簇首,实现对随机分布的移动节点自适应动态分簇,并通过可用度来优化簇内的节点数.仿真... 详细信息

为有效解决移动Ad Hoc网络簇结构的稳定性问题,提出了一种分簇算法.在流量均衡的基础上,综合考虑节点所处的网络环境和本身状态,根据适应性权值选择簇首,实现对随机分布的移动节点自适应动态分簇,并通过可用度来优化簇内的节点数.仿真测试表明,该算法在不增加开销的情况下,能适应性均衡簇首负载,有效防止簇首成为瓶颈.

关键词： Ad Hoe网络体系结构分簇算法流量均衡动态自适应

Effects of quantum noise on teleportation of arbitrary two-qubit state via five-particle Brown state

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Chinese Physics B 2024年第8期33卷 204-211页

作者：汪澳魏玉震姜敏李泳成陈虹黄旭 School of Electronics&Information Engineering Soochow UniversitySuzhou 215006China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai 200240China School of Information Engineering Huzhou UniversityHuzhou 313000China

We propose a new protocol for quantum teleportation(QT)which adopts the Brown state as the quantum *** work focuses on the teleportation of a single unknown two-qubit state via a Brown state channel in an ideal *** validate the effectiveness of our proposed scheme,we conduct experiments by using the quantum circuit simulator ***,we investigate the effects of four noisy channels,namely,the phase damping noise,the bit-flip noise,the amplitude damping noise,and the phase-flip ***,we employ Monte Carlo simulation to elucidate the fidelity density under various noise *** analysis demonstrates that the fidelity of the protocol in a noisy environment is influenced significantly by the amplitude of the initial state and the noise factor.

关键词： quantum communication Brown state fidelity

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中国农村金融脆弱性评价与预测

技术经济与管理研究 2023年第3期 71-76页

作者：余臻蔚无锡职业技术学院江苏无锡214000

文章基于Dagum基尼系数、Kernel核密度与Markov链模型,对中国农村金融脆弱性进行研究。结果显示:中国省域农村金融脆弱性呈稳步降低态势,但仍存在明显区域差异。整体看,各区域农村金融脆弱性差异在考察期内存在收敛现象,全域内部差异是... 详细信息

文章基于Dagum基尼系数、Kernel核密度与Markov链模型,对中国农村金融脆弱性进行研究。结果显示:中国省域农村金融脆弱性呈稳步降低态势,但仍存在明显区域差异。整体看,各区域农村金融脆弱性差异在考察期内存在收敛现象,全域内部差异是总差异的源头。Kernel密度估计结果显示,中国农村金融脆弱性逐年降低,但各地区存在非均衡特征。莫兰指数分析显示,中国农村金融脆弱性在地理距离上表现出空间正自相关,呈一定空间集聚现象。Markov链结果指出,中国农村金融脆弱性各状态间流动性较高,但整体趋于向好态势,不存在跨越式转移可能。

关键词：金融机构脆弱性区域异质性演变趋势农村金融

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基于复杂网络理论的计算机网络拓扑研究

计算机工程与应用 2007年第6期43卷 132-135,180页

作者：雷霆余镇危中国矿业大学计算机系北京林业大学理学院北京100083

复杂网络理论是一门新兴学科。随着计算机网络的快速发展,网络结构日益复杂,使得传统的随机网络模型已很难对其拓扑特性作出客观的描述,因此,复杂网络理论为计算机网络拓扑的研究提供了一个新的视野和思路。文章对复杂网络理论作了介绍... 详细信息

复杂网络理论是一门新兴学科。随着计算机网络的快速发展,网络结构日益复杂,使得传统的随机网络模型已很难对其拓扑特性作出客观的描述,因此,复杂网络理论为计算机网络拓扑的研究提供了一个新的视野和思路。文章对复杂网络理论作了介绍,综述了当前基于复杂网络理论计算机网络拓扑研究的状况并指出了其中存在的问题;强调将复杂网络理论应用到计算机网络拓扑研究当中的必要性。最后对复杂网络理论在未来计算机网络拓扑研究中的可能应用方向作了总结。

关键词：计算机网络复杂网络网络拓扑

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基于关联度网络流量预测的加权局域线性模型

计算机工程与应用 2007年第32期43卷 135-137,155页

作者：雷霆余镇危中国矿业大学机电与信息工程学院

用来预测混沌时间序列的传统加权局域模型一般用空间距离来定义邻近点的权重,当重构相空间嵌入维数增大时预测效果不是很理想。考虑了关联度对预测中心动力学行为的影响,提出用关联度来定义权重的方法,建立了一个用来预测网络流量新型... 详细信息

用来预测混沌时间序列的传统加权局域模型一般用空间距离来定义邻近点的权重,当重构相空间嵌入维数增大时预测效果不是很理想。考虑了关联度对预测中心动力学行为的影响,提出用关联度来定义权重的方法,建立了一个用来预测网络流量新型的加权局域线性模型。模拟试验结果表明,和传统加权模型相比,当嵌入维数较高的时候,该模型能在较大程度上提高网络流量的预测精度。

关键词：混沌关联度加权局域线性模型

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无线传感器执行器网络关键技术综述

传感器与微系统 2014年第2期33卷 4-8页

作者：孔鹏余镇危中国矿业大学(北京)机电学院北京100083

无线传感器执行器网络最近应用的越来越广泛。传感器节点和执行器节点间的协作与纯粹传感器网络相比,有着显著的优势。从网络体系结构、路由算法、协作机制和网络容错4个方面介绍了无线传感器执行器网络关键技术的最新进展,并讨论了未... 详细信息

无线传感器执行器网络最近应用的越来越广泛。传感器节点和执行器节点间的协作与纯粹传感器网络相比,有着显著的优势。从网络体系结构、路由算法、协作机制和网络容错4个方面介绍了无线传感器执行器网络关键技术的最新进展,并讨论了未来的发展趋势。

关键词：无线传感器执行器网络网络体系结构路由算法协作机制网络容错