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芥子酰基蔗糖酯在大鼠胃肠道菌液中的代谢研究

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中成药 2024年第8期46卷 2531-2536页

作者：徐嘉欢许瀚洋褚建波施菁施琦渊杭州医学院浙江杭州311399

目的考察芥子酰基蔗糖酯在大鼠胃肠道菌液中的代谢情况。方法采用体外孵育方法,研究3个远志来源芥子酰基蔗糖酯(3′,6-二芥子酰基蔗糖、sibiricose A6、tenuifoliside C)在大鼠胃肠道菌液中的代谢。结果大鼠大肠菌液对芥子酰基蔗糖酯的... 详细信息

目的考察芥子酰基蔗糖酯在大鼠胃肠道菌液中的代谢情况。方法采用体外孵育方法,研究3个远志来源芥子酰基蔗糖酯(3′,6-二芥子酰基蔗糖、sibiricose A6、tenuifoliside C)在大鼠胃肠道菌液中的代谢。结果大鼠大肠菌液对芥子酰基蔗糖酯的降解具有区域选择性,其中sibiricose A6在胃、小肠、大肠菌液中较稳定;3′,6-二芥子酰基蔗糖和tenuifoliside C在胃、小肠菌液中较稳定,但在大肠菌液中迅速发生6位酯键水解,生成3′-单酰基蔗糖(sibiricose A6、球腺糖A)和芥子酸。随着孵育时间延长,蔗糖双酯3′,6-二芥子酰基蔗糖、tenuifoliside C浓度不断降低(4 h时检测不到),3′-单酰基蔗糖浓度不断升高(4 h后趋于稳定),芥子酸则呈先升高(4 h时达到峰值)后降低的趋势。芥子酸可被进一步缓慢代谢为氢化芥子酸。结论有一部分芥子酰基蔗糖酯可选择性地在大鼠大肠菌液中发生酯键水解,释放出游离态的芥子酸,具有成为后者结肠靶向前药的潜质。

关键词：芥子酰基蔗糖酯胃肠道菌液代谢

Effects of anisodamine on the expressions of vascular endothelial growth factor and intercellular adhesion molecule 1 in experimental infusion phlebitis

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Chinese Medical Journal 2012年第2期000卷 300-305页

作者： Zhang zhen-xiang Wang Peng Zhang Qiu-shi Pan xue Zhao Qing-xia Wang Xiao-kai zhengzhou Univ Coll Nursing Zhengzhou 450052 Henan Peoples R China

Background Infusion phlebitis is the most common side effect of clinical intravenous drug therapy and several clinical studies have demonstrated that anisodamine can effectively prevent the occurrence of infusion *** study was designed to investigate effects of anisodamine on the expressions of vascular endothelial growth factor （VEGF） and intercellular adhesion molecule 1 （ICAM-1） in a rabbit model of infusion phlebitis and to analyze the mechanisms of anisodamine effect on the prevention and treatment of experimental infusion *** Twenty-four specific pathogen-free male Japanese white rabbits were randomly assigned to the control group,the model group,the magnesium sulfate group and the anisodamine *** rabbit model of infusion phlebitis,induced by intravenous administration,was established and expressions of VEGF and ICAM-1 were determined and contrasted with the control group treated with normal *** evaluated expression by histopathology,immunohistochemistry,reverse transcription-polymerase chain reaction,and Western blotting *** Pathohistological changes of the model group were observed,such as loss of venous endothelial cells,inflammatory cell infiltration,edema and *** magnesium sulfate group and the anisodamine group showed significant protective effects on vascular congestion,inflammatory cell infiltration,proliferation,swelling of endothelium and perivascular *** model group showed the highest expressions of VEGF and ICAM-1 of the four groups （P〈0.01）.On the contrary,anisodamine alleviated the inflammatory damage by significantly reducing the expressions of VEGF and ICAM-1 compared with the model group （P 〈0.01）.There was no significant difference in the expressions of VEGF and ICAM-1 between the magnesium sulfate group and the anisodamine group （P 〉0.05）.Conclusion Anisodamine alleviates inflammatory damage by significantly reducing the expressions of VEGF and ICAM-1,and shows significant pr

关键词： anisodamine infusion phlebitis vascular endothelial growth factor intercellular adhesion molecule 1

深化以审判为中心的刑事诉讼制度改革——以《刑事诉讼法》再修改为中心

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西南政法大学学报 2024年第5期26卷 31-40页

作者：陈实中南财经政法大学武汉430073

以审判为中心的刑事诉讼制度改革是党中央部署的推动刑事司法现代化的重大举措。改革实施以来,在诉讼理念、司法制度和庭审程序等方面取得了一定成效。但在2018年《刑事诉讼法》修改后,推进维度单一、制度集成不足、立法未能充分吸收等... 详细信息

以审判为中心的刑事诉讼制度改革是党中央部署的推动刑事司法现代化的重大举措。改革实施以来,在诉讼理念、司法制度和庭审程序等方面取得了一定成效。但在2018年《刑事诉讼法》修改后,推进维度单一、制度集成不足、立法未能充分吸收等改革困境集中凸显。《刑事诉讼法》再修改是突破困境、深化改革的重要契机,应巩固改革成果,引领深化改革。本次修法可考虑通过总则确立原则、分则重设体例和公诉增添章节实现审判程序中心化;通过一审体例调整、配套制度调整、二审功能调整推动一审程序重心化;通过改革人民陪审员制度、优化庭前会议制度和规范庭审审理程序落实庭审程序实质化。

关键词：以审判为中心刑事诉讼法修改庭审实质化人民陪审员

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UiO-66 type metal-organic framework as a multifunctional additive to enhance the interfacial stability of Ni-rich layered cathode material

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Journal of Energy Chemistry 2020年第11期29卷 378-386页

作者： Ruixue xue Na Liu Liying Bao Lai Chen Yuefeng Su Yun Lu Jinyang Dong shi Chen Feng Wu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

To effectively alleviate the surface structure degradation caused by electrolyte corrosion and transition metal(TM) dissolution for Ni-rich(Ni content > 0.6) cathode materials, porous Zirconium based metalorganic frameworks(Zr-MOFs, UiO-66) material is utilized herein as a positive electrode additive. UiO-66 owns tunable attachment sites and strong binding affinity, making itself an efficient defluorination agent to suppress the undesirable reactions caused by fluorine species. Besides, it can also relieve TMs dissolution and block the migration of TMs toward anode side since it’s a multifarious metal ions adsorbent,realizing both cathode and anode interface protection. Benefiting from these advantages, the UiO-66 assistant Ni-rich cathode achieves superior cycling stability. Particularly in full cell, the positive effects of this multifunctional additive are more pronounced than in the half-cell, that is after 400 cycles at 2 C,the capacity retention has doubled with the addition of UiO-66. More broadly, this unique application of functional additive provides new insight into the degradation mechanism of layered cathode materials and offers a new avenue to develop high-energy density batteries.

关键词： Ni-rich layered cathode Metal-organic framework additive Electrolyte corrosion Transition metal dissolution Interfacial stability

Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis

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Chinese Journal of Cancer 2016年第3期35卷 100-108页

作者： Ying shi Song‑Ling Peng Li‑Fang Yang xue Chen Yong‑Guang Tao Ya Cao Cancer Research Institute Central South UniversityChangsha 410078HunanP.R.China Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of EducationChangsha 410078HunanP.R.China Key Laboratory of Carcinogenesis National Health and Family Planning CommissionChangsha 410078HunanP.R.China

Viral infections contribute to approximately 12%of cancers worldwide,with the vast majority occurring in developing countries and *** DNA viruses,Epstein-Barr virus(EBV) and human papillomavirus(HPV),are associated with38%of all virus-associated *** probability of one patient infected with these two distinct types of viruses is ***,we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.

关键词： Epstein-Barr virus, Human papillomavirus, Co-infection, Nasopharyngeal carcinoma, Cervical cancer,Breast cancer, Prostate cancer

我国知识产权证券化中的基础资产组合策略研究--基于投资组合框架的多案例比较分析

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北京联合大学学报（人文社会科学版） 2024年第1期22卷 55-65页

作者：刘澄史燚王丽北京科技大学经济管理学院北京100083 北京联合大学管理学院北京100101

知识产权证券化是缓解我国科技型中小企业融资困境、推动科技创新发展的重要融资方式,然而,知识产权证券化项目面临诸多风险。将多个企业的知识产权组合构成基础资产池,一定程度上能够分散风险,但需明确两个研究问题:一是入池资产的选择... 详细信息

知识产权证券化是缓解我国科技型中小企业融资困境、推动科技创新发展的重要融资方式,然而,知识产权证券化项目面临诸多风险。将多个企业的知识产权组合构成基础资产池,一定程度上能够分散风险,但需明确两个研究问题:一是入池资产的选择,二是入池资产的配置。基于我国知识产权证券化的4种模式,结合典型性、全面性和数据可获性的标准,本文选取了4个典型案例,以投资组合理论为框架,比较分析其基础资产组合方式。研究发现:我国知识产权证券化产品基础资产池呈现知识产权多元化、行业区域集中化、债权合同长期化的特征。基础资产池的底层资产标的物以纯专利权为主,同时包含著作权、商标权等其他类型知识产权;此外,当前发行的知识产权证券化产品具有明显的行业和地域倾向,基础资产池集中度较高;由于知识产权证券化项目持续时间较长,因此入池资产一般是长期债权的组合。研究结论有助于丰富知识产权证券化基础资产组合的相关研究,提供基础资产组合思路,助力我国知识产权证券化的发展。

关键词：知识产权证券化底层资产案例分析基础资产池投资组合理论

嗜酸性粒细胞在肺癌免疫治疗中作用的研究进展

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中国肿瘤生物治疗杂志 2024年第5期31卷 501-506页

作者：高原(综述) 石荟白冲(审阅) 海军军医大学第一附属医院呼吸与危重症医学科上海200433

嗜酸性粒细胞(Eos)是一种多功能免疫细胞,在外周血循环和组织中均有分布,主要受IL-5和IL-33所诱导产生。Eos与肺癌在内的多种肿瘤存在相互作用,能够通过直接杀伤、免疫调节、促进肿瘤血管正常化等方式发挥抗肿瘤作用,其功能受诱导的细... 详细信息

嗜酸性粒细胞(Eos)是一种多功能免疫细胞,在外周血循环和组织中均有分布,主要受IL-5和IL-33所诱导产生。Eos与肺癌在内的多种肿瘤存在相互作用,能够通过直接杀伤、免疫调节、促进肿瘤血管正常化等方式发挥抗肿瘤作用,其功能受诱导的细胞因子、所处的肿瘤微环境(TME)、肿瘤的病理类型、作用的时间不同而具有较强的可塑性。免疫检测点抑制剂(ICI)作为一种新兴免疫疗法极大改变了肺癌的治疗模式,然而,目前在临床实践中,仍然缺乏能够较为稳定且有效地预测其疗效和免疫相关不良反应的生物标志物。相较于PD-L1表达水平、肿瘤突变负荷等生物标志物,Eos作为一种常见的循环血细胞具有检测成本低、易获取等优点。有多项研究发现,Eos在肺癌免疫治疗中的特殊改变,且与患者预后和不良反应有一定的相关性。进一步深入开展相关的机制和临床研究后,Eos将具有成为肺癌免疫治疗中有效生物标志物的能力。

关键词：嗜酸性粒细胞非小细胞肺癌免疫治疗生物标志物

PEGylation of Double-Walled Carbon Nanotubes for Increasing Their Solubility in Water

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Nano Research 2010年第2期3卷 103-109页

作者： Haiyu Nie Wei Guo Yuan Yuan Zengpei Dou Zujin shi zhen Liu Haifang Wang Yuanfang Liu Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Institute of Nanochemistry and Nanobiology Shanghai UniversityShanghai 200444China

Polyethylene glycol(PEG)functionalized double-walled carbon nanotubes(DWNTs)have been synthesized by a[2+1]cycloaddition reaction and characterized by transmission electron microscopy,atomic force microscopy,Raman spectroscopy,thermal gravimetric analysis,and UV-visible *** affords a large increase in the aqueous solubility of *** saturated concentrations of DWNTs functionalized with diazido-terminated PEG800(with a molecular weight of 800)and azido-terminated PEG750 monomethylether(with a molecular weight of 750)are very similar-0.36 and 0.37 mg/mL(DWNTs equivalent concentration),respectively.

关键词： Double-walled carbon nanotubes(DWNTs) functionalization polyethylene glycol(PEG) water soluble

An in-situ generated Bi-based sodiophilic substrate with high structural stability for high-performance sodium metal batteries

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Journal of Energy Chemistry 2022年第8期31卷 595-603,I0016页

作者： Lulu Li Ming Zhu Guanyao Wang Fangfang Yu Liaoyong Wen Hua-Kun Liu shi-xue Dou Chao Wu School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Institute for Superconducting&Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongNSW2522Australia Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024ZhejiangChina

Sodium(Na)metal anode exhibits a potential candidate in next-generation rechargeable batteries owing to its advantages of high earth abundance and low ***,the practical development of sodium metal batteries is inherently plagued by challenges such as the side reactions and the growth of Na *** we report a highly stable Bi-based“sodiophilic”substrate to stabilize Na anode,which is created by in-situ electrochemical reactions of 3D hierarchical porous Bi_(2)MoO_(6)(BMO)*** is initially transformed into the Bi“nanoseeds”embedded in the Na-Mo-O ***,the Bi nanoseeds working as preferential nucleation sites through the formation of BiNa alloy enable the non-dendritic Na *** asymmetric cells based on such BMO-based substrate can deliver a long-term cycling for 600 cycles at a large capacity of 4 m Ah cm^(-2) and for 800 cycles at a high current density of 10 m A cm^(-2).Even at a high depth of discharge(66.67%),the Na-predeposited BMO(Na@BMO)electrodes can cycle for more than 1600 *** limited Na@BMO anodes coupled with the Na_(3)V_(2)(PO_(4))_(3) cathodes(N/P ratio of 3)in full cells also show excellent electrochemical performance with a capacity retention of about 97.4%after 1100 cycles at 2 C.

关键词： Sodium metal anode Bi_(2)MoO_(6)microspheres Sodiophilic substrate Conversion and alloying reaction Uniform sodium deposition