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Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation

Chinese Chemical Letters 2024年第10期35卷 39-52页

作者： Keyang Li Yanan Wang Yatao Xu Guohua shi Sixian Wei xue Zhang Baomei Zhang Qiang Jia Huanhua Xu Liangmin Yu Jun Wu Zhiyu He Frontiers Science Center for Deep Ocean Multispheres and Earth Systems Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of Education/Sanya Oceanographic InstitutionOcean University of ChinaQingdao/Sanya 266100/572024China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266003China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Guangzhou City Polytechnic Guangzhou 510520China National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine Jiangxi University of Chinese MedicineNanchang330004China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SAR 999077China

The application of nanotechnologies in formulation has significantly promoted the development of modern medical and pharmacological science, especially for nanoparticle-based drug delivery, bioimaging, and theranostics. The advancement of engineering particle design and fabrication is largely supported by a better understanding of how their apparent characteristics(e.g., size and size distribution, surface morphology, colloidal stability, chemical composition) influence their in vivo biological performance, which raises an urgent need for practical nanoformulation methods. Based on turbulent flow mixing and the self-assembly of molecules in fluids, flash technologies emerged as effective bottom-up fabrication strategies for effective nanoformulation. Among the flash technology family, flash nanocomplexation(FNC) is considered a novel and promising candidate that can promote and optimize formulation processes in a precise spatiotemporal manner, thus obtaining excellent fabrication efficiency, reproducibility and expandability. This review presents an overview of recent advances in fabricating drug-delivery nanoparticles using FNC platforms. Firstly, brief introductions to the basic principles of FNC technology were carried out, followed by descriptions of turbulent microvolume mixers that have significantly promoted the efficiency of FNC-based fabrications. Applications of real formulation cases were then categorized according to the self-assembly-driven interactions(including electrostatic interaction, coordination interaction,hydrogen bonding and hydrophobic interaction) and discussed to reveal the progressiveness of fabricating nanoparticles and discuss how its flexibility will provide advances and replenish the philosophy of nanomedicine formulation. In the end, the commercial potential, current limitations, and prospects of FNC technology for nanoformulation will be summarized and discussed.

关键词： Nanoformulation Nanoparticles Self-assembly Flash nanocomplexation Kinetic control Drug delivery

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Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li Danielle Karakas Feng xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland Haibo Zhang John W.Semple John Freedman Qizhen shi Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's Hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Pharmacology University of TorontoTorontoONCanada. Division of Hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

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Research progress in assessment and strategies for sustainable food system within planetary boundaries

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Science China Earth Sciences 2024年第2期67卷 375-386页

作者： Minglei WANG Wenjiao shi Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China

Meeting the increasing food demand in a manner that ensures both resources and environmental sustainability poses a global *** conceptual framework of planetary boundaries(PBs)has emerged as a crucial reference in the study of sustainable food system,with specific focuses on key dimensions such as land use change,freshwater use,nitrogen(N)and phosphorus(P)cycles,and greenhouse gas(GHG)*** this study,we summarized the threshold applications of PBs in sustainable food system research at both the global and national(China)*** on these thresholds,we evaluated the sustainability conditions of the food system,considering resources such as cropland,freshwater,N and P applications,as well as environmental impacts including N and P losses,and GHG *** addition,we explored the impacts of single or combined management strategies on sustainable food *** strategies included dietary changes,improvements in technologies and management,reductions in food loss and waste,and optimization in agricultural production ***,we outlined future research directions in sustainable food system,including enhancing research on the interaction mechanisms among PBs elements within food systems,conducting downscaling studies of PBs elements at national and regional levels,and ensuring the rationality of policy-making for sustainable food systems in *** study can provide a theoretical foundation and strategies guidance for sustainable food system and agricultural land use management in the future both globally and in China.

关键词： Food system Resource use Environmental impacts Sustainable strategy Planetary boundaries

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Recent progress in all-inorganic tin-based perovskite solar cells:a review

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Science China Chemistry 2024年第4期67卷 1117-1136页

作者： Minghao Wang Yu shi School of Electronics and Information Engineering Wuxi UniversityWuxi 214105China Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China

Recently,power conversion efficiency(PCE)of organic-inorganic hybrid perovskite solar cells(PSCs)has been improved to26.1%.However,the toxicity issue of lead still hinders the large-scale commercial production and application of lead(Pb)-based halide ***,environmentally friendly tin(Sn)-based perovskites have recently shown excellent *** them,the all-inorganic Sn-based perovskites,including CsSnX_(3) and Cs_(2)SnX_(6),have better stability,more suitable bandgap,and higher charge mobility,which have attracted more attention from researchers than organic-inorganic Sn-based hybrid ***,we review recent research progress on all-inorganic Sn-based perovskite materials and corresponding solar cell ***,we also summarize the current challenges and future research directions for this type of PSCs.

关键词： solar cells perovskite all-inorganic CsSnX_(3) Cs_(2)SnX_(6)

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Optical colorimetric LiTaO_(3)wafers for highprecision lithography on frequency control of SAW devices

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Photonics Research 2024年第2期12卷 341-349页

作者： MING HUI FANG YINONG XIE FANGQI xue ZHILIN WU JUN shi SHENG YU YANG YILIN LIU ZHIHUANG LIU HSIN CHI WANG FAJUN LI QING HUO LIU JINFENG ZHU School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Quanzhou San’an Integrated Circuit Co. Ltd.Quanzhou 362300China Eastern Institute of Technology Ningbo 315200China

Surface acoustic wave(SAW)resonators based on lithium tantalate(LT,LiTaO_(3))wafers are crucial elements of mobile communication *** use of intrinsic LT wafers typically brings about low fabrication accuracy of SAW resonators due to strong UV reflection in the lithography *** hinders their resonance frequency control seriously in industrial *** doping and chemical reduction could be applied to decrease the UV reflection of LT wafers for high lithographic ***,conventional methods fail to provide a fast and nondestructive approach to identify the UV performance of standard single-side polished LT wafers for highprecision frequency ***,we propose a convenient on-line sensing scheme based on the colorimetry of reduced Fe-doped LT wafers and build up an automatic testing system for industrial *** levels of Fe doping and chemical reduction are evaluated by the lightness and color difference of LT-based *** correlation between the wafer visible colorimetry and UV reflection is established to refine the lithography process and specifically manipulate the frequency performance of SAW *** study provides a powerful tool for the fabrication control of SAW resonators and will inspire more applications on sophisticated devices of mobile communication.

关键词： lithography doping wafer

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Spin order and dynamics in the topological rare-earth germanide semimetals

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 113-127页

作者： Yuhao Wang Zhixuan zhen Jing Meng Igor Plokhikh Delong Wu Dariusz J.Gawryluk Yang Xu Qingfeng Zhan Ming shi Ekaterina Pomjakushina Toni shiroka Tian Shang Key Laboratory of Polar Materials and Devices(MOE) School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Laboratory for Multiscale Materials and Experiments Paul Scherrer InstitutVilligen PSI CH-5232Switzerland Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Laboratory for Muon-Spin Spectroscopy Paul Scherrer InstitutVilligen PSI CH-5232Switzerland Laboratorium für Festkörperphysik ETH ZürichZürich CH-8093Switzerland

The REAl(Si,Ge)(RE=rare earth)family,known to break both the inversion-and time-reversal symmetries,represents one of the most suitable platforms for investigating the interplay between correlated-electron phenomena and topologically nontrivial ***,we report on systematic magnetic,transport,and muon-spin rotation and relaxation(μSR)measurements on(Nd,Sm)AlGe single crystals,which exhibit antiferromagnetic(AFM)transitions at T_(N)=6.1 and 5.9 K,*** addition,NdAlGe undergoes also an incommensurate-to-commensurate ferrimagnetic transition at 4.5 *** transverse-fieldμSR measurements confirm the AFM transitions,featuring a~90%magnetic volume ***-field(ZF)μSR measurements reveal a more disordered internal field distribution in NdAlGe than in SmAlGe,reflected in a larger transverse muon-spin relaxation rateλTat T<

关键词： magneticWeyl semimetals topological Hall effect spin fluctuations μSR

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The metabolic profiling of Chinese yam fermented by Saccharomyces boulardii and the biological activities of its ethanol extract in vitro

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Food Science and Human Wellness 2024年第5期13卷 2718-2726页

作者： xue Li Yiwen Shao Limin Hao Qiaozhen Kang Xiaolong Wang Jiaqing Zhu Changcheng Zhao Yanling shi Jike Lu Juanjuan Yi School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Food Laboratory of Zhongyuan Zhengzhou UniversityLuohe 462300China Systems Engineering Institute Academy of Military Sciences(AMS)Beijing 100010China Henan Yinfeng Biological Engineering Technology Co. Ltd.Zhengzhou 450000China

Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional *** this study,Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic *** then,the main bioactive components and biological activities of fermented Chinese yam ethanol extract(FCYE)were *** showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese ***,corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcoholsoluble small molecular ***,the total polyphenol content and the total flavonoid content in FCYE were significantly increased,and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly *** study provided a new reference for the comprehensive utilization of Chinese yam and laid a theoretical foundation for the development and application of natural probiotic-fermented products.

关键词： Chinese yam Saccharomyces boulardii Metabolites Antioxidant Immunomodulation

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Matrix orthogonal polynomials,non-abelian Toda lattices,and Bäcklund transformations

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Science China Mathematics 2024年第9期67卷 2071-2090页

作者： shi-Hao Li Department of Mathematics Sichuan UniversityChengdu 610064China

A connection between matrix orthogonal polynomials and non-abelian integrable lattices is investigated in this *** normalization factors of matrix orthogonal polynomials expressed using quasideterminants are shown to be the solutions to the non-abelian Toda lattice in semi-discrete and full-discrete ***,with a moment modification method,we demonstrate that the B¨acklund transformation of the non-abelian Toda lattice given by Popowicz(1983)is equivalent to the non-abelian Volterra lattice,whose solutions can be expressed using quasi-determinants as well.

关键词： matrix orthogonal polynomial non-abelian Toda lattice Backlund transformation quasideterminant technique

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Weakly Compact Sets and Riesz Representation Theorem in Musielak Sequence Spaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 467-484页

作者： Wan Zhong GONG Si Yu shi Zhong Rui shi Department of Mathematics Anhui Normal UniversityWuhu 241000P.R.China Smeal College of Business Pennsylvania State UniversityUniversity ParkPennsylwania 16802USA Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

In this work,we give some criteria of the weakly compact sets and a representation theorem of Riesz's type in Musielak sequence spaces using the ideas and techniques of sequence spaces and Musielak ***,as an immediate consequence of the criteria considered in this paper,the criteria of the weakly compact sets of Orlicz sequence spaces are deduced.

关键词： Compact set weak topology Banach space dual space Musielak sequence spaces

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Using laparoscope to remove an ectopic intrauterine device in the anterior wall of urinary bladder:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3221-3225页

作者： shi-xue Liu Xing-You Dong Department of Urology Shapingba Hospital Affiliated to Chongqing UniversityChongqing 400030China

BACKGROUND An intrauterine device(IUD)is a contraceptive device placed in the uterine cavity and is a common contraceptive method for Chinese ***,an IUD may cause complications due to placement time,intrauterine pressure and other *** IUDs are among the most serious *** IUDs are common in the myometrium and periuterine organs,and there are few reports of ectopic IUDs in the urinary bladder,especially in the anterior *** SUMMARY A 52-year-old woman was hospitalized due to a urinary bladder foreign body found via abdominal ultrasound and computed tomography(CT)*** patient had a 2-year history of recurrent abdominal distension and lower abdominal pain,accompanied by frequent urination,urgency,dysuria and other *** examination revealed foreign bodies in the bladder cavity,with calculus on the surface of the foreign *** revealed a circular foreign body on the anterior wall of the urinary bladder,suggesting the possibility of an ectopic *** laparoscopic exploration,an annular IUD was found in the anterior wall of urinary bladder,and an oval calculus with a diameter of approximately 2 cm was attached to the surface of the bladder *** IUD and calculus were successfully and completely *** patient recovered well after *** Abdominal ultrasound and CT are effective methods for detecting ectopic *** IUD is located in the urinary bladder and requires early surgical *** choice of surgical method is determined by comprehensively considering the depth of the IUD in the bladder muscle layer,the situation of complicated calculus,the situation of intravesical inflammation and medical technology and equipment.

关键词： Intrauterine device Ectopic Anterior wall of the urinary bladder Calculus Laparoscope Case report

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