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Novel strategy of multidimensional information encryption via multi-color carbon dots aggregation-induced emission

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Nano Research 2024年第6期17卷 5680-5687页

作者： Liu Ding Xilang Jin Yuchong Gao Shouwang Kang Haiyan Bai Xuehao Ma Taotao Ai Hongwei Zhou Weixing chen Shaanxi Key Laboratory of Photoelectric Functional Materials and Devices Engineering Research Center of Light Stabilizers for Polymer Materials Universities of Shaanxi Province School of Materials and Chemical EngineeringXi’an Technological UniversityXi’an 710021China School of Material Science and Engineering Shaanxi University of TechnologyHanzhong 723000China Department of Materials Science and Engineering University of PennsylvaniaPhiladelphia 19104USA

Carbon dots(CDs)with aggregation-induced emission(AIE)have sparked significant interest in multidimensional anti-counterfeiting due to their exceptional fluorescence ***,the preparation of AIE CDs with multicolor solid-state fluorescence remains a formidable challenge due to its complicated *** the present work,a novel class of multicolor AIE CDs(M-CDs)were fabricated using selected precursor(salicylic acid,thiosalicylic acid,and 2,2'-dithiodibenzoic acid),with an eco-friendly,low-cost one-pot solvothermal *** the dilute organic solution,M-CDs manifested blue emission,but upon aggregation in the presence of water,the red,yellow,green,and blue emissions were displayed due to the AIE *** analysis,coupled with theoretical calculations,revealed that the increase in the size of sp2 domains would lower the Eg and cause a red-shift emission ***,the continuous emission of M-CDs from blue to red can be utilized as ink for multimode printing,enabling the creation of a variety of school badges and quick response *** findings hold promising implications for multi-information encryption applications.

关键词： aggregation-induced emission(AIE) luminescence mechanism multi-color emission information encryption.

Production induced fracture closure of deep shale gas well under thermo-hydro-mechanical conditions

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Petroleum Science 2024年第3期21卷 1796-1813页

作者： Shi-Ming Wei Yang Xia Yan Jin Xu-Yang Guo Jing-Yu Zi Kai-Xuan Qiu Si-Yuan chen College of Science China University of Petroleum(Beijing)Beijing102249China CNOOC Research Institute Ltd Beijing100028China The University of Hong Kong Hong Kong999077China

Deep shale gas reservoirs have geological characteristics of high temperature,high pressure,high stress,and inferior ability to pass through *** multi-stage fractured horizontal well is the key to exploiting the deep shale gas ***,during the production process,the effectiveness of the hydraulic fracture network decreases with the closure of fractures,which accelerates the decline of shale gas *** this paper,we addressed the problems of unclear fracture closure mechanisms and low accuracy of shale gas production prediction during deep shale gas *** we established the fluid—solid—heat coupled model coupling the deformation and fluid flow among the fracture surface,proppant and the shale *** the fluid—solid—heat coupled model was applied to the fracture network,it was well solved by our numerical method named discontinuous discrete fracture *** with the conventional discrete fracture method,the discontinuous discrete fracture method can describe the three-dimensional morphology of the fracture while considering the effect of the change of fracture surface permeation coefficient on the coupled fracture—matrix flow and describing the displacement discontinuity across the *** simulations revealed that the degree of fracture closure increases as the production time proceeds,and the degree of closure of the secondary fractures is higher than that of the primary *** creep and proppant embedment both increase the degree of fracture *** reduction in fracture surface permeability due to proppant embedment reduces the rate of fluid transfer between matrix and fracture,which has often been overlooked in the ***,it significantly impacts shale gas production,with calculations showing a 24.7%cumulative three-year yield *** study is helpful to understand the mechanism of hydraulic fracture ***,it provides the theoretical guidance for maintaining the long

关键词： Shalegas Fracture closure Fluid-solid-heat coupling Discontinuous discrete fracture

What can we learn from quality assurance badges in open-source software?

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Science China(Information Sciences) 2024年第4期67卷 146-163页

作者： Feng LI Yiling LOU Xin TAN zhenpeng chen Jinhao DONG Yang LI Xuanzhi WANG Dan HAO Lu ZHANG MoE Key Lab of HCST School of Computer SciencePeking University Department of Computer Science Purdue University School of Computer Science & Engineering Beihang University(BUAA) Department of Computer Science University College London(UCL)

In the development of open-source software(OSS), many developers use badges to give an overview of the software and share some key features/metrics conveniently. Among various badges, quality assurance(QA) badges make up a large proportion and are the most prevalent because QA is of vital importance in software development, and ineffective QA may lead to anomalies or defects. In this paper, we focus on QA badges in open-source projects, which present quality assurance information directly and instantly,and aim to produce some interesting findings and provide practical implications. We collect and analyze 100000 projects written in popular programming languages from GitHub and conduct a comprehensive empirical study both inside and outside QA badges. Inside QA badges, we build a category classification for all QA badges based on the properties they focus on, which shows the types of QA badges developers use. Then,we analyze the frequency of the properties that QA badges focus on, and property combinations, too, which present their use status. We find that QA badges focus on various properties while developers give different preferences to different properties. The use status also differs between different programming languages. For example, projects written in C focus on Security to a great extent. Our findings also provide implications for developers and badge providers. Outside QA badges, we conduct a correlation analysis between QA badges and some software metrics that have potential relationships with code quality, contribution quality, and popularity. We find that QA badges have statistically significant correlations with various software metrics.

关键词： quality assurance badge open-source software code quality empirical study

华蟾素通过调控HIF1α的SUMO修饰促进胃癌细胞铁死亡

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中国药理学通报 2024年第7期40卷 1342-1349页

作者：郑梓莹张燕陈文林玉婷叶磊福建医科大学附属第二医院中医科福建泉州362000

目的本研究旨在探讨华蟾素(cinobufotalin,CB)调控缺氧诱导因子1α(hypoxia inducible factor 1 alpha,HIF1α)的小泛素样修饰相关蛋白(small ubiquitin-like modifier,SUMO)修饰对胃癌细胞铁死亡的影响。方法使用不同浓度CB处理人正常胃黏膜上皮细胞(GES-1)和人胃癌细胞(MGC803)。MTT检测细胞活力并计算CB在胃癌细胞中的IC_(50)值,Transwell检测侵袭。铁死亡激动剂(erastin)或抑制剂(ferrostatin-1)处理癌细胞并评估胃癌细胞脂质活性氧(reactive oxygen species,ROS)水平、MDA水平和细胞凋亡、细胞内总铁水平和Fe^(2+)的水平。Western blot检测SUMO1和HIF1α的表达,免疫沉淀(immunoprecipitation,IP)检测SUMO1和HIF1α的相互作用。建立异种移植瘤模型,使用CB或erastin治疗,评估CB在体内对肿瘤生长和胃癌细胞铁死亡的影响。结果2μmol·L^(-1)以下CB未对GES-1细胞活力产生影响。与Con组相比,CB处理剂量依赖性地抑制MGC803细胞活力和侵袭。与Con组比较,CB处理提高胃癌细胞脂质ROS、MDA、总铁和Fe^(2+)水平,并促进细胞凋亡(均P<0.05)。CB联合erastin增强铁死亡,而ferrostatin-1处理则抑制CB诱导的胃癌细胞铁死亡。机制上,CB抑制SUMO1表达,减少HIF1α的SUMO化修饰,进而抑制其表达。CB诱导的胃癌细胞铁死亡能够被SUMO1过表达载体逆转。体内实验证实,CB能够抑制肿瘤生长并诱导胃癌细胞铁死亡。结论CB通过抑制HIF1α的SUMO化修饰进而诱导胃癌细胞铁死亡。

关键词：华蟾素胃癌缺氧诱导因子1α 小泛素样修饰蛋白铁死亡细胞凋亡

枸杞糖肽可减轻放射治疗后人牙龈成纤维细胞来源的外泌体导致的成骨抑制

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南方医科大学学报 2024年第9期44卷 1752-1759页

作者：何思齐文楠陈勋王跃张艇牟雁东成飞医院四川成都610073 宜宾市第一人民医院四川宜宾644000 四川省人民医院口腔科四川成都610072 卷烟减害降焦四川省重点实验室四川成都610100

目的研究枸杞糖肽(LbGP)对放射后人牙龈成纤维细胞(HGFs)来源的外泌体对成骨抑制的保护作用。方法将HGFs分为对照组、放射组及枸杞糖肽组,通过RT-qPCR、Western blotting及β-半乳糖苷酶染色检测细胞的凋亡、衰老水平以及α-平滑肌肌动... 详细信息

目的研究枸杞糖肽(LbGP)对放射后人牙龈成纤维细胞(HGFs)来源的外泌体对成骨抑制的保护作用。方法将HGFs分为对照组、放射组及枸杞糖肽组,通过RT-qPCR、Western blotting及β-半乳糖苷酶染色检测细胞的凋亡、衰老水平以及α-平滑肌肌动蛋白(α-SMA)的差异表达。提取各组细胞分泌的外泌体,通过电镜观察、粒径分析以及Western blotting鉴定外泌体,并分别将各组牙龈成纤维细胞产生的外泌体作用于破骨前体细胞及骨髓间充质干细胞(BMSCs)中,通过Trap染色、茜素红染色、ALP染色、RT-qPCR以及Western blotting检测细胞的破骨及成骨情况。结果衰老细胞在放射组较对照组增多,而在枸杞糖肽组较放射组减少;与对照组相比,放射组Bcl-2/Bax降低(P<0.0001),α-SMA表达水平增加(P<0.05);与放射组相比,枸杞糖肽组Bcl-2/Bax增多(P<0.05),α-SMA表达水平降低(P<0.01);与对照组相比,放射组破骨细胞增多,枸杞糖肽组破骨细胞减少;钙结节、碱性磷酸酶表达水平在放射组低于对照组,在枸杞糖肽组高于放射组;成骨相关基因(BMP2、ALP、RUNX2)及成骨相关蛋白(ALP、RUNX2)的表达水平在枸杞糖肽组高于放射组(P均<0.01)。结论枸杞糖肽可通过作用于放射后的牙龈成纤维细胞的外泌体,有效抑制破骨、促进成骨和预防放射性颌骨骨髓炎的发展,这可能为放射性颌骨骨髓炎的治疗提供一种新策略。

关键词：枸杞糖肽外泌体放射性颌骨骨坏死成骨分化

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GeV重离子束辐照LiF引起的晶体内部结构改变

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物理学报 2024年第15期73卷 147-153页

作者：陈宇鹏史路林王瑜玉程锐杨杰陈良文范伟丽董俊煜河北大学物理与科学技术学院保定071002 中国科学院近代物理研究所兰州730000 西北师范大学物理与电子工程学院兰州730070 先进能源科学与技术广东省实验室惠州516000

高能强流重离子束入射到固体物质中,沿飞行路径的离子能量沉积密度将改变宏观靶物质的温度和压强等,并可能在高压高密条件下产生新的材料缺陷.本文利用兰州重离子加速器装置HIRFL-CSR引出的能量为264 MeV/u的Xe^(36+)离子束,入射到LiF... 详细信息

高能强流重离子束入射到固体物质中,沿飞行路径的离子能量沉积密度将改变宏观靶物质的温度和压强等,并可能在高压高密条件下产生新的材料缺陷.本文利用兰州重离子加速器装置HIRFL-CSR引出的能量为264 MeV/u的Xe^(36+)离子束,入射到LiF晶体靶物质中,在线测量了LiF的发射光谱,观测到沿离子路径的晶体颜色变化.通过解离方法取得了不同位置处的X射线衍射(X-ray Diffraction)与X射线光电子能谱结果,显示在Xe离子的布拉格峰区域出现了LiF_(3)(LiF+F_(2))结构相,讨论了新的结构缺陷的产生与重离子束能量沉积密度间可能的相关性.这为离子束驱动的高能量密度物理的能量沉积过程提供了一定参考.

关键词： LiF 晶体重离子束能量密度色心

Hemostatic mechanism of Jianpi Yiqi Shexue decoction(健脾益气摄血方) in treatment of immune thrombocytopenia

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Journal of Traditional Chinese Medicine 2024年第3期44卷 537-544页

作者： LI Ruibai chen Ke MA Wei ZHANG Yayue HOU Li chen Xinyi Department of Oncology and Hemotology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100091China Department of Hemotology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

OBJECTIVE: To explore the early hemostatic mechanism of Jianpi Yiqi Shexue decoction(健脾益气摄血方, JYSD) in treating immune thrombocytopathy(ITP), based on the functional homeostasis of brain-intestine axis and blood neurotransmitter METHODS: Non-drug treatment cases: Healthy volunteers were selected as normal control group and compared with patients with dysfunctional uterine bleeding, gastrointestinal tumors with bleeding and ITP, to detect the changes of blood 5-hydroxytryptamine(5-HT), β-endorphin(β-EP), vasoactive intestinal peptide(VIP) and compare the changes of blood neurotransmitters in patients with different disease symptoms. Drug treatment cases: According to the randomized controlled multicenter clinical trial, 272 ITP patients were randomly divided into three groups: treatment group(JYSD) combined group(JYSD + Prednisone) control group(Prednisone). The changes of blood neurotransmitter(5-HT, β-EP, VIP) before and after treatment were detected on the basis of peripheral blood platelet(PLT) and grade score. RESULTS: Non-drug treatment cases: compared with the normal control group, the 5-HT level was higher, and the VIP and β-EP levels were both lower in the ITP group(P < 0.001), and the 5-HT, VIP and β-EP levels in the Gastrointestinal tumors with bleeding group were also lower compared with the normal control group(P < 0.05, 0.001). Drug treatment cases: The PLT grading scores of the combination group and the control group after treatment were lower than that before treatment(P < 0.05, 0.001). The PLT grading score of the 3 groups were compared in pairs after treatment: the combination group was the lowest among the 3 groups, which was better than the treatment group, but no better than the control group(vs the treatment group, P = 0.005, vs the control group, P = 0.709). The statistical results of full analysis set(FAS) and per protocol set(PPS) were consistent. The bleeding symptom scores of the treatment and combination groups began to drop 7 d after trea

关键词： immune thrombocytopenic purpura brain-gut axis vasoactive intestinal peptide beta-endorphin serotonin

Photonic crystal-connected bidirectional micro-ring resonator array for duplex mode and wavelength channel(de)multiplexing

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Photonics Research 2024年第8期12卷 1802-1812页

作者： ZHIWEI GUAN CHAOFENG WANG CHUANGXIN XIE HAISHENG WU JUNMIN LIU HUAPENG YE DIANYUAN FAN JIANGNAN XIAO SHUQING chen International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Physics and Engineering Technology Minzu Normal University of XingyiXingyi 562400China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Terahertz Technology Innovation Research Institute Shanghai Key Laboratory of Modern Optical SystemTerahertz Science Cooperative Innovation CenterSchool of Optical-Electrical Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China

The progress of on-chip optical communication relies on integrated multi-dimensional mode(de)multiplexers to enhance communication capacity and establish comprehensive ***,existing multi-dimensional(de)multiplexers,involving modes and wavelengths,face limitations due to their reliance on single-directional total internal reflection and multi-level mode conversion based on directional coupling *** constraints restrict their potential for full-duplex functionality and highly integrated *** solve these problems by introducing a photonic-like crystal-connected bidirectional micro-ring resonator array(PBMRA)and apply it to duplex mode-wavelength multiplexing *** directional independence of total internal reflection and the cumulative effect of the subwavelength-scale pillar within the single-level photonic crystal enable bidirectional mode and wavelength multiplexed signals to transmit among multi-pair nodes without interference,improving on-chip integration in single-level mode *** a proof of concept,we fabricated a nine-channel bidirectional multi-dimensional(de)multiplexer,featuring three wavelengths and three TE modes,compactly housed within a footprint of 80μm×80μm,which efficiently transmits QPSK-OFDM signals at a rate of 216 Gbit/s,achieving a bit error rate lower than 10^(-4).Leveraging the co-ring transmission characteristic and the orthogonality of the mode-wavelength channel,this(de)multiplexer also enables a doubling of communication capacity using two physical transmission channels.

关键词： resonator channel mode

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中小学教师职业发展空间面临的困境及其突破

教学与管理 2024年第30期 64-67页

作者：陈文娇张明瑞湖北大学师范学院武汉430062 华东师范大学教育学部上海200062

学校环境是学校教和学所发生的教学、社会、发展环境。教师作为学校环境的主体,其职业发展环境和发展空间理应得到关注,然而现实中却存在一定的困境:多重挤占的专业自主空间、体验不佳的人际交往空间、发展受限的晋升成长空间。教师职... 详细信息

学校环境是学校教和学所发生的教学、社会、发展环境。教师作为学校环境的主体,其职业发展环境和发展空间理应得到关注,然而现实中却存在一定的困境:多重挤占的专业自主空间、体验不佳的人际交往空间、发展受限的晋升成长空间。教师职业发展不仅需要坚实的物质基础和充分的环境支持作为保障,还需要良好的人际互动和交往体验,以及畅通的专业晋升路径作为激励,教师方能获得职业的满足感和幸福感。

关键词：中小学教师职业发展空间职业环境