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Deciphering the population structure and genetic basis of growth traits from whole-genome resequencing of the leopard coral grouper(Plectropomus leopardus)

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Zoological Research 2024年第2期45卷 329-340页

作者： Shao-Xuan Wu Qi-Fan Zeng Wen-tao Han Meng-Ya Wang Hui Ding Ming-Xuan Teng Ming-Yi Wang Pei-Yu Li Xin Gao zhen-Min Bao Bo Wang Jing-Jie Hu MOE Key Laboratory of Marine Genetics and Breeding College of Marine Life Sciences/Key Laboratory of Tropical Aquatic Germplasm of Hainan ProvinceSanya Oceanographic InstitutionOcean University of ChinaQingdaoShandong/SanyaHainan 266100/572025China Hainan Seed Industry Laboratory SanyaHainan 572025China Southern Marine Science and Engineer Guangdong Laboratory GuangzhouGuangdong 511458China

The leopard coral grouper(Plectropomus leopardus)is a species of significant economic *** artificial cultivation of *** has thrived in recent decades,the advancement of selective breeding has been hindered by the lack of comprehensive population genomic *** this study,we identified over 8.73 million single nucleotide polymorphisms(SNPs)through whole-genome resequencing of 326 individuals spanning six distinct ***,we categorized 226 individuals with high-coverage sequencing depth(≥14×)into eight clusters based on their genetic profiles and phylogenetic ***,four of these clusters exhibited pronounced genetic differentiation compared with the other *** identify potentially advantageous loci for ***,we examined genomic regions exhibiting selective sweeps by analyzing the nucleotide diversity(θπ)and fixation index(FST)in these four *** these high-coverage resequencing data,we successfully constructed the first haplotype reference panel specific to *** achievement holds promise for enabling high-quality,***,we combined low-coverage sequencing data with imputation techniques for a genome-wide association study,aiming to identify candidate SNP loci and genes associated with growth traits.A significant concentration of these genes was observed on chromosome 17,which is primarily involved in skeletal muscle and embryonic development and cell ***,our detailed investigation of growth-related SNPs across the eight clusters revealed that cluster 5 harbored the most promising candidate SNPs,showing potential for genetic selective breeding *** findings provide a robust toolkit and valuable insights into the management of germplasm resources and genome-driven breeding initiatives targeting ***.

关键词： Plectropomus leopardus Whole-genome resequencing Growth Haplotype reference panel Single nucleotide polymorphisms

Magnetic-biased chiral molecules enabling highly oriented photovoltaic perovskites

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National Science Review 2024年第2期11卷 221-230页

作者： Jing Chen Caner Deger zhen-Huang Su Kai-Li Wang Guang-Peng Zhu Jun-Jie Wu Bing-Chen He Chun-Hao Chen tao Wang Xing-Yu Gao Ilhan Yavuz Yan-Hui Lou Zhao-Kui Wang Liang-Sheng Liao Institute of Functional Nano&Soft Materials(FUNSOM) Laboratory of Advanced Negative Carbon TechnologiesSoochow University Department of Physics Marmara University Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of Sciences College of Energy Soochow Institute for Energy and Materials Innovations Soochow University Macao Institute of Materials Science and Engineering Macau University of Science and Technology

The interaction between sites A, B and X with passivation molecules is restricted when the conventional passivation strategy is applied in perovskite（ABX3） photovoltaics. Fortunately, the revolving A-site presents an opportunity to strengthen this interaction by utilizing an external field. Herein, we propose a novel approach to achieving an ordered magnetic dipole moment, which is regulated by a magnetic field via the coupling effect between the chiral passivation molecule and the A-site（formamidine ion） in *** strategy can increase the molecular interaction energy by approximately four times and ensure a well-ordered molecular arrangement. The quality of the deposited perovskite film is significantly optimized with inhibited nonradiative recombination. It manages to reduce the open-circuit voltage loss of photovoltaic devices to 360 mV and increase the power conversion efficiency to 25.22%. This finding provides a new insight into the exploration of A-sites in perovskites and offers a novel route to improving the device performance of perovskite photovoltaics.

关键词： perovskite photovoltaics magnetic moment A-site regulation chiral molecules

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第04期 307-317页

作者： tao Lei DOU Renjie CHEN Xueming CAO Yu DAI zhen HU Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University

Ulcerative colitis（UC）, a prevalent form of inflammatory bowel disease（IBD）, may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species（ROS） and subsequent cellular oxidative stress *** studies have identified both peroxisome proliferator-activated receptor-γ（PPARγ） and endoplasmic reticulum（ER） stress as critical targets for the treatment of IBD. Oroxyloside(C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium（DSS）-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis,including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662(1 mg·kg-1, i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages（BMDM） and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

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记谱教训

中国音乐 2024年第4期 91-96,117页

作者：张振涛南京艺术学院音乐学院

研究笙管乐,就要研究大曲;研究大曲,就要讲究谱本;讲究谱本,就要找到标本。这个标本,在河北省雄县。雄县谱本,一是存目完好,二是记年明确,三是抄列目录。三项指标,缺一不可。大曲研究,宫调定位,莫相统摄,不胜困弊,盖因未能找到坐标。拥... 详细信息

研究笙管乐,就要研究大曲;研究大曲,就要讲究谱本;讲究谱本,就要找到标本。这个标本,在河北省雄县。雄县谱本,一是存目完好,二是记年明确,三是抄列目录。三项指标,缺一不可。大曲研究,宫调定位,莫相统摄,不胜困弊,盖因未能找到坐标。拥有大量工尺谱的传统音乐,仅仅记录单行谱,难以阐释何以产生了旋律支脉的原因。当代排版技术解决了线谱、简谱、工尺谱对照的困境,让今人可以充分利用这份遗产。中西同框,古今叠加,图谱双映,简便有效。

关键词：记谱工尺谱对照谱笙管乐曲调考证

黄河口西南侧小岛河河口天然牡蛎礁的牡蛎种群结构

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生态学报 2024年第7期44卷 3086-3097页

作者：左涛张贝叶王俊左明王安东中国水产科学研究院黄海水产研究所青岛266071 青岛市海洋科学与技术试点国家实验室海洋生态与环境科学功能实验室青岛266237 上海海洋大学水产与生命学院上海201306 东营市海洋发展研究院东营257091 山东黄河三角洲国家级自然保护区管理委员会东营257091

牡蛎礁是生态系统服务价值高、但退化最严重及受关注度最高的海洋生境之一,牡蛎礁修复亦成为国际海洋生态修复的热点。掌握牡蛎自然种群状况及动态变化是评估牡蛎礁修复效果的基础。目前,我国天然牡蛎礁的牡蛎种群状况相关的背景资料较... 详细信息

牡蛎礁是生态系统服务价值高、但退化最严重及受关注度最高的海洋生境之一,牡蛎礁修复亦成为国际海洋生态修复的热点。掌握牡蛎自然种群状况及动态变化是评估牡蛎礁修复效果的基础。目前,我国天然牡蛎礁的牡蛎种群状况相关的背景资料较为缺乏。在黄河口西南侧的小岛河河口新发现天然活体牡蛎礁,但该牡蛎礁曾被大规模的商业采捕,亟需推进针对性的保护和修复研究工作。基于2021年11月对该牡蛎礁开展的牡蛎种群生态调查,分析其种类组成、年龄结构及生长特征。结果显示:该牡蛎礁分布有近江牡蛎(Crassostrea ariakensis)和长牡蛎(Crassostrea gigas)。牡蛎礁上以活体牡蛎为主,死亡牡蛎壳体数仅占6.1%—6.7%。活体牡蛎的密度和生物量分别为(2811±778)个/m^(2)和(21.97±30.43)kg/m^(2),近江牡蛎较多,其密度和生物量分别占比55.7%和76.4%。近江牡蛎和长牡蛎的年龄分别介于0+—4+龄和0+—2+龄,它们都以壳高介于30—40 mm及壳质量80%)。近江牡蛎的壳体形态参数均值都高于同龄组长牡蛎的相应值。两种牡蛎壳体均呈负异速增长,不同龄级的壳体延展方向不同。拟合von Bertalanffy生长方程得到,近江牡蛎和长牡蛎的渐近壳高分别为286 mm和173 mm,估算的拐点年龄分别为5.47龄和2.56龄,两种牡蛎的生长曲线分布存在极显著差异(P3年的原位保护、修复和连续监测计划。

关键词：近江牡蛎长牡蛎种群结构牡蛎礁黄河口

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铝卟啉折叠催化剂催化二氧化碳/环氧化物共聚反应

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高分子学报 2024年第4期55卷 396-406页

作者：周振震刘顺杰郎涛涛高凤翔王献红中国科学院长春应用化学研究所生态环境高分子材料重点实验室长春130022 中国科学技术大学应用化学与工程学院合肥230026

折叠催化剂因具有“类酶”的二级结构,被广泛应用于小分子化合物合成,然而其在高分子合成中的应用却鲜有报道.基于双氨基功能化的铝卟啉与2,5-吡啶二甲酰氯的缩聚反应,本文报道了一种铝卟啉芳香酰胺折叠体催化剂,有效(300~1250 h^(-1))... 详细信息

折叠催化剂因具有“类酶”的二级结构,被广泛应用于小分子化合物合成,然而其在高分子合成中的应用却鲜有报道.基于双氨基功能化的铝卟啉与2,5-吡啶二甲酰氯的缩聚反应,本文报道了一种铝卟啉芳香酰胺折叠体催化剂,有效(300~1250 h^(-1))、高选择性(99%)地催化了二氧化碳(CO_(2))与环氧化物的共聚反应.值得一提的是,该催化剂可以实现无助催化剂条件下CO_(2)和环氧丙烷的共聚,催化活性可达525 h^(-1),同时聚合物选择性在95%以上,并且在80℃下表现出“类酶”的最佳温度特性.在催化CO_(2)与环氧环己烷共聚时,催化活性与二氧化碳压力(1~7 MPa)呈线性正相关关系,催化活性最高可达1250 h^(-1),聚合物选择性和碳酸酯单元含量保持在99%以上.本文报道的铝卟啉折叠体催化剂为芳香酰胺折叠体在催化领域的发展提供了借鉴,同时也进一步拓展了折叠催化在高分子合成中的应用.

关键词：铝卟啉芳香酰胺折叠体二氧化碳环氧化物协同催化

基于可逆固体氧化物电池的气电双向耦合统一调度优化

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中国电机工程学报 2024年第5期44卷 1860-1871,I0016页

作者：黄祯媛高赐威陈涛左娟吴心弘东南大学电气工程学院江苏省南京市210018 国网上海能源互联网研究院有限公司上海市浦东新区200120 国网浙江综合能源服务有限公司浙江省杭州市310014

传统多能市场模型一般将异质能源转换装置视作市场主体,例如燃气电厂等。能源互联网理念下,异质能源的综合利用要求打破种类壁垒,形成统一能源传输系统。计量的能源形式不统一,能源转换方向单一,限制了能源互联网的应用场景。基于实验... 详细信息

传统多能市场模型一般将异质能源转换装置视作市场主体,例如燃气电厂等。能源互联网理念下,异质能源的综合利用要求打破种类壁垒,形成统一能源传输系统。计量的能源形式不统一,能源转换方向单一,限制了能源互联网的应用场景。基于实验数据推导可逆固体氧化物电池(reversal solid oxide cells,r SOC)等效物理模型,提出一种rSOC双向能源传输管道的电力-天然气统一市场模型,并将节点边际价格(locational marginal price,LMP)推广到异质能源的统一能价机制,验证rSOC异质能价双向传递作用。研究表明应用rSOC双向传输管道有助于节省供能成本,提高综合能源市场经济效益和调度效率。所提异质能源市场统一价格理论,以及气电统一市场模型为综合能源联合交易提供理论基础和模型参考。

关键词：综合能源系统能源互联网可逆固体氧化物电池电力市场

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2023年甘肃积石山6.2级地震序列精定位

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地震 2024年第1期44卷 204-208页

作者：左可桢赵翠萍中国地震局地震预测研究所北京100036

本文使用结合波形互相关技术的双差定位方法,对2023年甘肃积石山6.2级地震序列(截至2023年12月22日24时)进行了重定位。结果显示,主震震中位于临夏州积石山县(35.745°N, 102.827°E),震源深度约为12.5 km。余震序列呈现出NW和NNW两个... 详细信息

本文使用结合波形互相关技术的双差定位方法,对2023年甘肃积石山6.2级地震序列(截至2023年12月22日24时)进行了重定位。结果显示,主震震中位于临夏州积石山县(35.745°N, 102.827°E),震源深度约为12.5 km。余震序列呈现出NW和NNW两个展布方向。其中主震西侧的余震条带呈NW向展布,深度方向上向NE方向倾斜。重定位结果显示了该地区具有复杂的构造背景和发震机制。

关键词：积石山地震地震精定位余震空间分布发震构造

Screening of colorectal cancer: Methods and strategies

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World Journal of Clinical Oncology 2024年第7期15卷 799-805页

作者： zhen Liao Jin-tao Guo Fan Yang Shu-Peng Wang Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Colorectal cancer(CRC)has high incidence and mortality rates,and the em-ergence and application of CRC screening have helped us effectively control the occurrence and development of ***,common international screening methods include tests based on feces and blood,and examination methods that allow for visualization,such as sigmoidoscopy and *** methods have been widely used,whereas others such as multi-target stool RNA test are still being explored and developed,and are expected to become front-line screening methods for CRC in the *** choice of screening method is affected by external conditions and the patients'situation,and the clinician must choose an appropriate strategy according to the actual situation and the patient's *** article introduces various CRC screening methods and analyzes the factors relevant to the screening strategy.

关键词： Colorectal cancer Screening Stool-based test Endoscopic examination Computed tomography colonography Blood-based test