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Role of epigenetics in transformation of inflammation into colorectal cancer

World Journal of Gastroenterology 2019年第23期25卷 2863-2877页

作者： zhen-hua yang Yan-Qi Dang Guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Digestive Endoscopy Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Molecular mechanisms associated with inflammation-promoted tumorigenesis have become an important topic in cancer research. Various abnormal epigenetic changes, including DNA methylation, histone modification, chromatin remodeling, and noncoding RNA regulation, occur during the transformation of chronic inflammation into colorectal cancer(CRC). These changes not only accelerate transformation but also lead to cancer progression and metastasis by activating carcinogenic signaling pathways. The NF-κB and STAT3 signaling pathways play a particularly important role in the transformation of inflammation into CRC, and both are critical to cellular signal transduction and constantly activated in cancer by various abnormal changes including epigenetics. The NF-κB and STAT3 signals contribute to the microenvironment for tumorigenesis through secretion of a large number of pro-inflammatory cytokines and their crosstalk in the nucleus makes it even more difficult to treat CRC. Compared with gene mutation that is irreversible, epigenetic inheritance is reversible or can be altered by the intervention. Therefore, understanding the role of epigenetic inheritance in the inflammation-cancer transformation may elucidate the pathogenesis of CRC and promote the development of innovative drugs targeting transformation to prevent and treat this malignancy. This review summarizes the literature on the roles of epigenetic mechanisms in the occurrence and development of inflammation-induced CRC. Exploring the role of epigenetics in the transformation of inflammation into CRC may help stimulate futures studies on the role of molecular therapy in CRC.

关键词： Colorectal cancer Inflammation DNA methylation Histone modification LncRNA MicroRNAs Epigenetics

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Development of Multiple ELISAs for the Detection of Antibodies against Classical Swine Fever Virus in Pig Sera

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Virologica Sinica 2012年第1期27卷 48-56页

作者： zhen-hua yang Ling Li Zi-shu Pan State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China

The major immunogenic proteins （Ems, E2 and NS3） of classical swine fever virus （CSFV）（Shimen strain） were expressed in E. coli and purified by affinity chromatography. The recombinant antigens were applied to develop multiple enzyme-linked immunosorbent assays （ELISAs） for the detection of specific antibodies in pig sera. Optimum cut-off values were determined by receiver operating characteristic （ROC） analysis after testing 201 sera of vaccinated pigs and 64 negative sera of unvaccinated piglets. The multiple ELISAs were validated with 265 pig sera yielding high sensitivity and specificity in comparison with the virus neutralization results. The results demonstrated that multiple ELISAs can be a valuable tool for the detection of CSFV infection and serological surveys in CSFV-free countries or for the evaluation of the antibody responses in pigs induced by a live attenuated C-strain vaccination

关键词： Classical swine fever virus Recombinant antigens ELISA

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Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts

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Chinese Chemical Letters 2015年第1期26卷 157-159页

作者： Yue-Xia Zhang zhen-hua yang Quan-Xi Zhang Rui-Jin Li Hong Geng Chuan Dong Institute of Environmental Science Shanxi University

The aim of this study was to investigate the chemical compositions of chalk dust and examine the adverse effects of fine chalk particle matters（PM（2.5）） on rat alveolar macrophages（AMs） in *** and element concentrations of chalk particles were analyzed using quantitative energydispersive electron probe X-ray microanalysis（ED-EPMA）.The oxidative response of AMs exposed to chalk PM（2.5） was measured by luminol-dependent chemiluminescence（CL）.The results showed that（1）Chalk dust was mainly composed of gypsum（CaSO4）,calcite（CaCO3）/dolomite（CaMg（CO3）2）,and organic adhesives;（2） Fine chalk particles induced the AM production of CL,which was inhibited by about 90%by diphenyleneiodonium chloride（DPI）.Based on these results,we showed that cytotoxicity of chalk PM（2.5） may be related to the reactive oxygen species（ROS） generation.

关键词： Chemiluminescence Chalk PM2.5 Alveolar macrophages Reactive oxygen species

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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Pemetrexed-associated Ischemic Colitis in Nonsmall Cell Lung Cancer

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Chinese Medical Journal 2017年第14期130卷 1757-1758页

作者： Liang Ye zhen-hua yang Su-Rong Fang Wei Gu Department of Respiration Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China

To the Editor：The most frequently reported adverse event of pemetrexed was ***,we reported a patient with advanced lung adenocarcinoma showing pemetrexed-associated ischemic colitis.

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A comparative study of different interventional therapies for primary liver cancer

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World Journal of Gastroenterology 1997年第4期3卷 33-35页

作者： LIU Qi, JIA YuChen, TIAN JianMing, WANG zhenTang, YE hua, yang JiJin and SUN Fei

IM To compare the therapeutic effect of three types of interventional management for pimary liver cancer.METHODS 468 patients with primary liver cancer were randomly allocated to three groups: 138 cases with chemotherapy alone using mitomycin C, adriamycin and 5FU (group A); 158 with chemoembolization using lipiodol (group B); and 172 with chemoembolization using lipiodol and gelfoam (group C). All patients were angiographically and sonographically followed up.RESULTS ① 675% patients in group C had the AFP value decreased by more than 50%, which was much higher than 433% ingroup B and 322% in group A; ② The tumor size reduced by ≥50% in 203% of group A, 412% of group B and 448% of group C. There was obvious difference between groups A and group B or C (P<001); ③ The oneyear and threeyear survival rates were 205%±36% and 19%±24% for group A, 513%±44% and 101%±49% for group B, and 630%±24% and 139%±50% for group C respectively. There was obvious difference among the three groups (P<005); ④ The mean survival time for patients in groups A, B and C were 96 months, 161 months and 179 months, respectively.CONCLUSION Chemoembolization with lipiodol and gelfoam is the most effective therapy for primary liver cancer in this study. The position of the embolization should be the far and middle sections of the hepatic artery, and the proximal section should be reserved as the route of the next intraarterial chemoembolization.

关键词： liver neoplasms/therapy chemoembolization therapeutic mitomycine adriamycin lipidol 5fluouracil gelfoam

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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空挂任务不确定情形下的甩挂运输调度优化

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交通运输工程学报 2016年第5期16卷 103-111页

作者：杨珍花杨光敏徐奇郭姝娟靳志宏大连海事大学交通运输管理学院辽宁大连116026 云南省交通科学研究院云南昆明650011

在实际路网下建立了空挂任务不确定情形下的甩挂运输调度优化模型,设计两阶段启发式算法进行求解,第1阶段分别按照空挂调运距离最小和重挂任务起终(OD)点总顺差最低2种策略确定空挂调运方案,第2阶段结合任务节点顺差和贪婪思想确定所有... 详细信息

在实际路网下建立了空挂任务不确定情形下的甩挂运输调度优化模型,设计两阶段启发式算法进行求解,第1阶段分别按照空挂调运距离最小和重挂任务起终(OD)点总顺差最低2种策略确定空挂调运方案,第2阶段结合任务节点顺差和贪婪思想确定所有任务的执行序列,采用算例分析算法的性能。分析结果表明:空挂运输成本与总成本分别为325.5、1 010.5元,比原有方案分别节约10.44%、3.62%,且使用的牵引车更少;基于辽宁省内城市间甩挂运输算例所得空挂调运距离最小和重挂任务OD点总顺差最低2种策略的最优值分别为2 561.3、2 464.6元,平均求解时间分别为21.5、27.3s,第2种策略各结果的稳定性较好;模拟退火算法所得总成本均在3 100元以上,求解时间均在80s以上。可见,本文算法的精度和效率较高,重挂任务OD点总顺差最低策略在求解空挂任务不确定情形下的甩挂运输调度问题方面有着明显的优势。

关键词：甩挂运输启发式算法调度优化空挂供需任务切换距离节点任务顺差

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基于HMI和PLC的食品包装箱码垛机控制系统设计

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食品与机械 2016年第10期32卷 105-107,171页

作者：钱振华王荣扬左希庆湖州职业技术学院机电与汽车工程学院浙江湖州313000

介绍一种专门用于食品包装箱的码垛机控制系统。该系统采用PLC对升降电机和行走电机分别进行伺服和变频控制,实现了抓箱机械手升降运动的精确位置控制和平移运动的速度控制,有效地提高了码垛的可靠性和效率。HMI的使用使得操作码垛机更... 详细信息

介绍一种专门用于食品包装箱的码垛机控制系统。该系统采用PLC对升降电机和行走电机分别进行伺服和变频控制,实现了抓箱机械手升降运动的精确位置控制和平移运动的速度控制,有效地提高了码垛的可靠性和效率。HMI的使用使得操作码垛机更为直观和便捷,同时也有利于码垛机工作状态的监控及系统的维护。

关键词： HMI PLC 码垛控制

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The role of NMDA receptor 2B subunits on metaplasticity in hippocampal CA1 neurons

The role of NMDA receptor 2B subunits on metaplasticity in h...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： zhen-hua LIAO,Qian yang,Yi-Xin XIAO,Yue ZHANG,Sheng-Tian LI Institute of Nueroscinces,Shanghai Jiao Tong University,Shanghai 200240,China

＜正＞Long-term potentiation（LTP）,one of the major forms of synaptic plasticity,is thought to be an important cellular model for learning and *** has been shown from many experiments that an activation of N-methyl-D-aspartate subtype of glutamate receptors（NMDARs） plays an important role in an induction of LTP at hippocampal CA1 synapse. NMDARs are assembled from NMDAR subunit 1（NR1） and at least one type of ***1 is an essential and basic functional ***2,as contrast,serves as an assistant subunit to lead to the diversity of NMDA *** different subtypes of NR2 subunit,including NR2A,NR2B,NR2C and NR2D,NMDARs vary in their *** adult mice hippocampus,NR2A and NR2B are the predominant NR2 *** once reported by Yu Tian Wang’s group, NR2A is required for an induction of LTP and NR2B for LTD,but many other reports are also available to contradict this *** these results have suggested that the role of NR2A and NR2B on synaptic plasticity is *** 1996, Wickliffe *** and Mark *** brought us a concept of metaplasticity,*** plasticity of *** is shown from the experiments at the hippocampal CAl area that a "Priming" stimulus prior to tetanic stimulus shall change the amplitude of *** duration of "Priming" stimulus may stay for one *** this study we investigated the role of NR2A and NR2B in the induction of metaplasticity in mice hippocampal CA1 *** evidences are provided here that NR2B is involved in the regulation of *** have made further study of its functional mechanism.

关键词： synapse metaplasticity NMDA receptor NR2B LTP

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