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Nano Research 2022年第6期15卷 4916-4924页

作者： Yu Zhang Ming-Ke xu zhenguo Wang Tianyu Zhao Liu-Xin Liu Hao-Bin Zhang zhong-zhen Yu State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029China

Lightweight,flexible,and electrically conductive porous films are promising for efficient electromagnetic interference(EMI)***,the mechanical and electrical properties of porous films are far from ***,we fabricate mechanically flexible and electrically conductive reduced graphene oxide(rGO)-Ti_(3)C_(2)T_(x)MXene(rG-M)porous films with optimized continuous cellular morphology by a controlled hydrazine foaming *** presence of MXene prevents excessive expansion of the rG-M film,improves the electron conduction paths,and enhances the mechanical *** resultant rG-M porous film has superior mechanical and electric performances compared to its rGO counterpart,giving one of the highest tensile strengths(24.5 MPa)among the porous films,a high electrical conductivity of 74.4 S·cm^(−1),and an excellent broadband EMI shielding from 8 to 26.5 GHz.A high EMI shielding effectiveness of 52.6 dB is achieved for the porous film by adjusting its thickness and treatment procedure,providing a feasible fabrication route for lightweight and high-performance EMI shielding materials.

关键词： graphene MXene electromagnetic interference shielding porous films electrical conductivity

Oxidative Stress and Role of Natural Plant Derived Antioxidants in Animal Reproduction

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Journal of Integrative Agriculture 2013年第10期12卷 1826-1838页

作者： zhong Rong-zhen ZHOU Dao-wei Northeast Institute of Geography and Agroecology Chinese Academy of Sciences

The experimental knowledge on the role of oxidative stress,and beneficial and detrimental effects of plant derived antioxidants in male and female animal reproduction are reviewed in this *** radical-induced oxidative stress in animal reproduction causes great loss to livestock *** therapy has been implicated to be effective in preventing diseases resulted from oxidative *** the advantages of lower side effects of natural antioxidants than those of synthetic antioxidants,plants or their extracts have been extensively utilized in *** many advances have been gained on application of plant derived antioxidants in alleviating oxidative stress,debatable issues still *** many opposite effects were observed even using plant extracts containing similar bioactive substances in the same animal ***,plant derived antioxidants,like free radicals,are ＂double-edged swords＂ in animal reproduction,representing that they may exhibit beneficial or detrimental effects in animal reproduction,including spermatogenesis,semen functions,estrous cycles,ovulation,ovary functions,endometrium,embryo development,and *** dose-dependent manner as an explanation of plant extracts＇ dual function,future studies are needed to investigate the mechanism of double-edged actions of plant derived antioxidants in different animal reproduction systems.

关键词： oxidative stress plant extract antioxidant double-edged effect animal reproduction

Upper Minus Total Domination Number of Regular Graphs

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Acta Mathematicae Applicatae Sinica 2017年第1期33卷 69-74页

作者： zhen-lin LI Xin-zhong LV Department of Mathematics Zhejiang Normal University Jinhua 321004 China

Let Гt-（G） be upper minus total domination number of G. In this paper, We establish an upper bound of the upper minus total domination number of a regular graph G and characterize the extremal graphs attaining the ... 详细信息

关键词： upper minus total domination regular graph

Ruin Probabilities in the Risk Process with Random Income

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Acta Mathematicae Applicatae Sinica 2008年第2期24卷 195-202页

作者： zhen-hua Bao zhong-xing Ye School of Mathematics Liaoning Normal University Dalian 116029 China Department of mathematics Shanghai Jiaotong University Shanghai 200240 China

We extend the classical risk model to the case in which the premium income process, modelled as a Poisson process, is no longer a linear function. We derive an analog of the Beekman convolution formula for the ultimate ruin probability when the inter-claim times are exponentially distributed. A defective renewal equation satisfied by the ultimate ruin probability is then given. For the general inter-claim times with zero-truncated geometrically distributed claim sizes, the explicit expression for the ultimate ruin probability is derived.

关键词： Beekman convolution formula Defective renewal equation Ruin probability Zero-truncated geo-metric distribution

Rotary unmanned aerial vehicles path planning in rough terrain based on multi-objective particle swarm optimization

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Journal of Systems Engineering and Electronics 2020年第1期31卷 130-141页

作者： xu zhen ZHANG Enze CHEN Qingwei School of Automation Nanjing University of Science and TechnologyNanjing 210094China College of Information Engineering Yangzhou UniversityYangzhou 225009China

This paper presents a path planning approach for rotary unmanned aerial vehicles(R-UAVs)in a known static rough terrain *** approach aims to find collision-free and feasible paths with minimum altitude,length and angle variable ***,a three-dimensional(3D)modeling method is proposed to reduce the computation burden of the dynamic models of *** the length,height and tuning angle of a path,the path planning of R-UAVs is described as a tri-objective optimization ***,an improved multi-objective particle swarm optimization algorithm is *** render the algorithm more effective in dealing with this problem,a vibration function is introduced into the collided solutions to improve the algorithm ***,the selection of the global best position is taken into account by the reference point ***,the experimental environment is built with the help of the Google map and the 3D terrain generator World *** results under two different rough terrains from Guilin and Lanzhou of China demonstrate the capabilities of the proposed algorithm in finding Pareto optimal paths.

关键词： unmanned aerial vehicle(UAV) path planning multiobjective optimization particle swarm optimization

Promising natural lysine specific demethylase 1 inhibitors for cancer treatment:advances and outlooks

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Chinese Journal of Natural Medicines 2022年第4期20卷 241-257页

作者： LI zhong-Rui GU Meng-zhen xu Xiao ZHANG Jing-Han ZHANG Hai-Li HAN Chao Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Lysine specific demethylase 1(LSD1),a transcriptional corepressor or coactivator that serves as a demethylase of histone 3 lysine 4 and 9,has become a potential therapeutic target for cancer ***1 mediates many cellular signaling pathways and regulates cancer cell proliferation,invasion,migration,and *** research has focused on the exploration of its pharmacological *** products are a major source of compounds with abundant scaffold diversity and structural complexity,which have made a major contribution to drug discovery,particularly anticancer *** this review,we briefly highlight recent advances in natural LSD1 inhibitors over the past *** present a comprehensive review on their discovery and identification process,natural plant sources,chemical structures,anticancer effects,and structure-activity relationships,and finally provide our perspective on the development of novel natural LSD1 inhibitors for cancer therapy.

关键词： Histone lysine demethylase LSD1 inhibitor Natural product Anticancer

Two Novel Saponins from Lysimachia capillipes

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Chinese Chemical Letters 2005年第12期16卷 1607-1610页

作者： Jing Kui TIAN Chen XIE zhong Mei ZOU Li zhen xu Shi Lin YANG Deptment of Chinese Medicine Science ＆ Engineering Zhejiang University Hangzhou 310028 Institute of Medicinal Plants Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100094

Two new saponins named capilliposide C 1 and capilliposide D 2 were isolated from the whole plants of Lysimachia capillipes, their structures were deternuned by 1D and 2D NMR, ESIMS techniques, and chemical *** C show... 详细信息

关键词： Lysimachia capillipes triterpene saponin capilliposide C and D

Deep Learning and Network Analysis:Classifying and Visualizing Geologic Hazard Reports

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Journal of Earth Science 2024年第4期35卷 1289-1303页

作者： Wenjia Li Liang Wu Xinde xu zhong Xie Qinjun Qiu Hao Liu zhen Huang Jianguo Chen School of Geography and Information Engineering China University of GeosciencesWuhan430078China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan430078China School of Computer Science China University of GeosciencesWuhan430078China Key Laboratory of Urban Land Resources Monitoring and Simulation Ministry of Natural ResourcesShenzhen518034China Hubei Key Laboratory of Intelligent Vision Based Monitoring for Hydroelectric Engineering China Three Gorges UniversityYichang443002China Wuhan Geomatics Institute Wuhan430074China Faculty of Earth Resources China University of GeosciencesWuhan430074China

If progress is to be made toward improving geohazard management and emergency decision-making,then lessons need to be learned from past geohazard information.A geologic hazard report provides a useful and reliable source of information about the occurrence of an event,along with detailed information about the condition or factors of the *** such reports,however,can be a challenging process because these texts are often presented in unstructured long text formats,and contain rich specialized and detailed *** text classification is commonly used to mine disaster text data in open domains(e.g.,news and microblogs).But it has limitations to performing contextual long-distance dependencies and is insensitive to discourse *** deficiencies are most obviously exposed in long text ***,this paper uses the bidirectional encoder representations from Transformers(BERT),to model long ***,utilizing a softmax layer to automatically extract text features and classify geohazards without manual *** latent Dirichlet allocation(LDA)model is used to examine the interdependencies that exist between causal variables to visualize *** proposed method is useful in enabling the machine-assisted interpretation of text-based ***,it can help users visualize causes,processes,and other geohazards and assist decision-makers in emergency responses.

关键词： geologic hazard network analysis latent dirichlet allocation text classification deep learning

Climatic warming in Shanghai during 1873-2019 based on homogenised temperature records

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Advances in Climate Change Research 2022年第4期13卷 496-506页

作者： Ping LIANG zhong-Wei YAN zhen LI Key Laboratory of Cities'Mitigation and Adaptation to Climate Change in Shanghai Shanghai Regional Climate CenterShanghai 200030China Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

xujahui(XJH)station in downtown Shanghai holds the longest continuous daily temperature series in China,which is unique for assessing modern climate change and impacts but must be *** present work established a set of homogenised monthly and daily surface air temperature(SAT)series during 1873-2019 at *** major inhomogeneous break points(around 1954 and 1993)were identified in the original SAT series,which had been overlooked in previous *** inhomogeneous biases were adjusted via the inter-station deviation *** adjusted SAT series shows a warming trend of 1.9℃ per century compared with 1.7℃ per century in the original *** multi-decadal variations of quasi-32-year and quasi-64-year periods are weaker in the adjusted series than in the original series,suggesting overestimated multi-decadal variability in the original data due to inhomogeneous *** to the early period 1873-1900,the recent decade(the 2010s)is warmer by 2.2℃.Urbanisation has been responsible for approximately 19.3%of the rapid warming since the *** high and low SAT extremes exhibit significant warming,especially after the *** trend in the low SAT extremes in the adjusted series is substantially larger than that in the original series,implying that previous studies might underestimate the warming in cold extremes.

关键词： Homogenised temperature series Long-term climate warming Effect of urbanisation Muli-decadal variability

Identification of 2-aminothiazoyl piperidine derivatives as a new class of adjuvants potentiating the activity of colistin against Acinetobacter baumannii

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Chinese Chemical Letters 2023年第2期34卷 468-474页

作者： Yuce Chen zhen Li Yu Yin Ping Yang Yijin Kong zhong Li Daijie Chen Xiaoyong xu Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Pharmacy Shanghai JiaoTong UniversityShanghai 200240China

The rapid prevalence of antibiotic resistance has led to a significant global health problem. Although colistin is the last resort antibiotic, it is limited by dose dependent toxicity. A critical approach to solve this problem is to use an antibiotic adjuvant, which is able to potentiate the activity of antibiotic and reduce the dosage of antibiotic. Herein, we reported a novel 2-aminothiazoyl piperidine adjuvant, which enhanced the activity of colistin against Acinetobacter baumannii(A. baumannii). Two pilot libraries of 40compounds were prepared and their adjuvant activities were evaluated. The most potential compound11j enabled to cause16-fold reduction in the minimum inhibitory concentration(MIC) of colistin at 8μg/m L. Besides, time-kill curves exhibited that compound 11j had significant adjuvant activity to kill the bacteria. The predicted ADMET analysis showed that 2-aminothiazoyl piperidine derivatives had good drug-likeness and acceptable physicochemical properties. Furthermore, membrane permeability experiments demonstrated that compound 11j was beneficial for colistin to destroy the outer membrane of bacteria. Also, the comparative molecular similarity indices analysis(Co MSIA) and the density functional theory(DFT) calculations were conducted. The results drawn from these analyses indicated that the novel scaffold provided helpful information for the finding of new adjuvant lead.

关键词： 2-Aminothiazole piperidine Antibiotic adjuvant Acinetobacter baumannii Colistin