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Intraocular pressure fluctuation and the risk of glaucomatous damage deterioration: a Meta-analysis

International Journal of Ophthalmology(English edition) 2019年第1期12卷 123-128页

作者： zhen-zhen guo Karen Chang Xin Wei Department of Ophthalmology West China Hospital Sichuan University Department of Ophthalmology First Hospital of Xi’an Graduate Institute of Clinical Dentistry School of Dentistry Taiwan University Schepens Eye Research Institute MEEIHarvard Medical School

AIM: To systematically review whether the increased fluctuation of intraocular pressure(IOP) is a risk factor for open angle glaucoma(OAG) progression. METHODS: Scientific studies relevant to IOP fluctuation and glaucoma progression were retrieved from MEDLINE,EMBASE and CENTRAL databases, and were listed as references in this paper. The hazard ratio(HR) was calculated by using fixed or random-effects models according to the heterogeneity of included studies. RESULTS: Individual data for 2211 eyes of 2637 OAG patients in fourteen prospective studies were included in this Meta-analysis. All studies were longitudinal clinical studies with follow-up period ranging from 3 to 8.5 y. The combined HR was 1.23(95%CI 1.04-1.46, P=0.02) for the association between IOP fluctuation and glaucoma onset or progression with the evidence of heterogeneity(P<0.1).Subgroup analyses with different types of IOP fluctuation were also evaluated. Results indicated that the summary HR was 0.98(95%CI 0.78-1.24) in short-term IOP fluctuation group, which showed no statistical significance with heterogeneity, whereas, the combined HR was 1.43(95%CI1.13-1.82, P=0.003) in long-term IOP fluctuation group without homogeneity. Sensitivity analysis further showed that the pooled HR was 1.10(95%CI 1.03-1.18, P=0.004) for long-term IOP fluctuation and visual function progression with homogeneity among studies(P=0.3). CONCLUSION: Long-term IOP fluctuation can be a risk factor for glaucoma progression based on the presentedevidence. Thus, controlling the swing of IOP is crucial for glaucoma or glaucoma suspecting patients.

关键词： intraocular pressure fluctuation glaucoma visual field progression

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Development of NiTiNb in-situ composite with high damping capacity and high yield strength

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Progress in Natural Science:Materials International 2011年第4期21卷 293-300页

作者： zhen-zhen BAO,Shun guo,Fu XIAO,Xin-qing ZHAO School of Materials Science and Engineering,Beihang University,Beijing 100191,China School of Materials Science and Engineering Beihang University Beijing 100191 China

The shape memory alloys are well known to exhibit high damping capacity in martensite state,but possess low yield strength because of the reorientation or de-twining of the martensite *** high damping mechanism of shape memory alloys was *** NiTiNb alloys with high yield strength and high damping capacity were designed and *** microstructure evolution,martensitic transformation behavior,damping capacity and mechanical properties of series NiTiNb alloys were *** view of the microstructure characteristics of the NiTiNb in-situ composites,the mechanism associated with high damping capacity and high yield strength was *** results show that NiTiNb alloys feature in in-situ composite,composed of primary NiTi(Nb) phase and fine lamellar eutectics of NiTi(Nb) andβ-Nb.

关键词： NiTiNb shape memory alloy mechanical properties damping capacity

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ipRGCs: possible causation accounts for the higher prevalence of sleep disorders in glaucoma patients

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1163-1167页

作者： zhen-zhen guo Shan-Ming Jiang Li-Ping Zeng Li Tang Ni Li Zhu-Ping Xu Xin Wei Department of Ophthalmology West China HospitalSichuan University

Sleep accounts for a third of one＇s lifetime, partial or complete deprivation of sleep could elicit sever disorders of body function. Previous studies have reported the higher prevalence of sleep disorders in glaucoma patients, but the definite mechanism for this phenomenon is unknown. On the other hand, it is well known by us that the intrinsically photosensitive retinal ganglion cells（ip RGCs） serve additional ocular functions, called non-image-forming（NIF） functions, in the regulation of circadian rhythm, melatonin secretion, sleep, mood and others. Specifically, ip RGCs can directly or indirectly innervate the central areas such as suprachiasmatic nucleus（SCN）, downstream pineal gland（the origin of melatonin）, sleep and wake-inducing centers and mood regulation areas, making NIF functions of ip RGCs relate to sleep. The more interesting thing is that previous research showed glaucoma not only affected visual functions such as the degeneration of classical retinal ganglion cells（RGCs）, but also affected ip RGCs. Therefore, we hypothesize that higher prevalence of sleep disorders in glaucoma patients maybe result from the underlying glaucomatous injuries of ip RGCs leading to the abnormalities of diverse NIF functions corresponding to sleep.

关键词： glaucoma intrinsically photosensitive retinal ganglion cells sleep disorders

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Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure

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World Journal of Gastroenterology 2010年第5期16卷 625-630页

作者： Tao Han,Ying Liu,Huan Liu,zheng-Yan Zhu,Yan Li,Shi-Xiang Xiao,zhen guo,zhen-Gang Zhao,Department of Hepatology,Tianjin Institute of Hepatobiliary Disease,Tianjin Key Laboratory of Artificial Cells,Tianjin Third Central Hospital,Tianjin Medical University,83 Jintang Road,Tianjin 300170, China Department of Hepatology Tianjin Institute of Hepatobiliary Disease Tianjin Key Laboratory of Artificial Cells Tianjin Third Central Hospital Tianjin Medical University 83 Jintang Road Tianjin 300170 China. hantaomd@***

AIM:To investigate whether serum thymosinβ4 can provide diagnostic or prognostic information in liver failure patients caused by chronic hepatitis B virus(HBV) infection. METHODS:Serum thymosinβ4 levels were measured in 30 patients with acute-on-chronic liver failure(ACLF), 31 patients with chronic liver failure(CLF),30 patients with compensated liver cirrhosis(CR)and 32 patients with chronic hepatitis B and 30 healthy *** thymosinβ4 levels were measured by enzyme-linked immunosorbent assay and Child-Pugh and model for end-stage liver disease(MELD)scores were calculated for each patient on ***:Compared with healthy controls,serum thymosinβ4 levels in ACLF,CLF,CR and chronic hepatitis B patients were significantly lower,6.5047 (4.7879-10.5314)μg/mL vs 0.4632(0.2759-0.8768) μg/mL,0.6981(0.5209-1.2008)μg/mL,1.8053 (0.8110-2.3397)μg/mL,3.7803(1.8570-6.4722)μg/mL, respectively(P<0.001).The levels of thymosinβ4 in liver failure(ACLF or CLF)patients were markedly lower than that in CR(P<0.001),and a difference was also found between CLF and ACLF patients(P=0.038).In patients with chronic liver disease,there was a positive relationship between thymosinβ4 levels and albumin, choline esterase,and platelet(P<0.001),and negative relationship with alanine aminotransferase(P=0.020), aspartate aminotransferase,total bilirubin,international normalized ratio of prothrombin time,and Child-Pugh and MELD scores(P<0.001).Of the 61 liver failure patients,the thymosinβ4 levels of non-survivors were significantly lower than that of survivors(P=0.007). Receiver operating characteristics analysis identified a thymosinβ4 cutoff level of 0.5708μg/mL for predicting poor prognosis in all liver failure *** serial thymosinβ4 values were observed in 13 liver failure *** initial values were observed in the *** greater improvement in thymosinβ4 value was found in those who recovered from the disease. CONCLUSION:Serum thymosinβ4 can be used as an

关键词： Thymosinβ4 Liver failure Serum Hepatitis B virus Biochemistry

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Altered surfactant protein A gene expression and protein homeostasis in rats with emphysematous changes

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Chinese Medical Journal 2008年第13期121卷 1177-1182页

作者： HU Qiong-jie XIONG Sheng-dao ZHANG Hui-lan SHI Xue-mei XU Yong-jian ZHANG zhen-xiang zhen guo-hua ZHAO Jian-ping Department of Respiratory Medicine Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background The decrease of surfactant protein （SP） secreted by the alveolar type Ⅱ cell is one of the important causes of limiting air of pulmonary emphysema. However, the SP-A gene and protein changes in this disease are rarely studied. This study was undertaken to investigate alterations in SP-A gene activity and protein, and to explore their roles in the pathogenesis of emphysematous changes. Methods Twenty Wistar rats were divided randomly into a normal control group （n=10） and a cigarette smoking （CS）＋ lipopolysaccharide （LPS） group （n=10）. Ultra-structural changes were observed under an electron microscope. The number of cells positive for SP-A was measured by immunohistochemistry. The mRNA expression and protein level of SP-A in the lung tissues were determined by quantitative polymerase chain reaction （qPCR） and Western blot separately. The protein level of SP-A in lavage fluid was determined by Western blot. Results The number of cells positive for SP-A of the CS＋LPS group （0.35±0.03） was lower than that of the blank control group （0.72±0.06, P 〈0.05）. The level of SP-A in the lung tissues of rats in the CS＋LPS group （0.2765±0.0890） was lower than that in the blank control group （0.6875±0.1578, P 〈0.05）. The level of SP-A in the lavage fluid of rats in the CS＋LPS group （0.8567±0.1458） was lower than that in the blank control group （1.3541±0.2475, P 〈0.05）. The lung tissues of rats in the CS＋LPS group showed an approximate increase （0.4-fold） in SP-A mRNA levels relative to β-actin mRNA （P 〈0.05）. Conclusions The changes of SP-A may be related to emphysematous changes in the lung. And cigarette smoke and LPS alter lung SP-A gene activity and protein homeostasis.

关键词： emphysema alveolar type Ⅱ cells surfactant protein A gene homeostasis

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Boosting cationic and anionic redox activity of Li-rich layered oxide cathodes via Li/Ni disordered regulation

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Journal of Energy Chemistry 2025年第1期100卷 533-543页

作者： Zewen Liu zhen Wu Hao Wang Xudong Zhang Yuanzhen Chen Yongning Liu Shengwu guo Shenghua Chen Yanli Nan Yan Liu State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University School of Materials Science and Engineering Xi'an University of Architecture and Technology Hefei Advanced Computing Center Operation Management Corp Ltd Network Information Center Xi'an Jiaotong University

Lithium-rich layered oxides （LLOs） are increasingly recognized as promising cathode materials for nextgeneration high-energy-density lithium-ion batteries （LIBs）.However,they suffer from voltage decay and low initial Coulombic efficiency （ICE） due to severe structural degradation caused by irreversible O ***,we introduce a three-in-one strategy of increasing Ni and Mn content,along with Li/Ni disordering and TM–O covalency regulation to boost cationic and anionic redox activity simultaneously and thus enhance the electrochemical activity of *** target material,Li1.2Ni0.168Mn0.558Co0.074O2（L1）,exhibits an improved ICE of 87.2%and specific capacity of 293.2 mA h g-1and minimal voltage decay of less than 0.53 m V cycle-1over 300 cycles at 1C,compared to Li1.2Ni0.13Mn0.54Co0.13O2（Ls）(274.4 mA h g-1for initial capacity,73.8%for ICE and voltage decay of 0.84 mV/cycle over 300 cycles at 1C).Theoretical calculations reveal that the density of states （DOS） area near the Fermi energy level for L1 is larger than that of Ls,indicating higher anionic and cationic redox reactivity than ***,L1 exhibits increased O-vacancy formation energy due to higher Li/Ni disordering of 4.76%（quantified by X-ray diffraction Rietveld refinement） and enhanced TM–O covalency,making lattice O release more difficult and thus improving electrochemical *** increased Li/Ni disordering also leads to more Ni2+presence in the Li layer,which acts as a pillar during Li+de-embedding,improving structural *** research not only presents a viable approach to designing low-Co LLOs with enhanced capacity and ICE but also contributes significantly to the fundamental understanding of structural regulation in high-performance LIB cathodes.

关键词： Ice

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荧光碳量子点的制备与生物医学应用研究进展

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中国光学 2018年第3期11卷 431-443页

作者：郭振振唐玉国孟凡渝李力杨大威中国科学院苏州生物医学工程技术研究所生物医学检验技术重点实验室江苏苏州215163

碳量子点是一类具有优异的荧光性能和高生物相容性的纳米材料,在很多领域有广泛的应用,是目前研究的热点材料。本文介绍了碳量子点不同的合成方法,以及碳量子点的荧光、化学发光、电化学发光、类过氧化物酶的活性及毒性等性能的最新研... 详细信息

碳量子点是一类具有优异的荧光性能和高生物相容性的纳米材料,在很多领域有广泛的应用,是目前研究的热点材料。本文介绍了碳量子点不同的合成方法,以及碳量子点的荧光、化学发光、电化学发光、类过氧化物酶的活性及毒性等性能的最新研究进展。此外,还对碳量子点在生物传感、生物成像及药物传递等生物医学应用进行了概述。

关键词：碳量子点荧光生物传感生物成像药物传递

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矩型风管弯头数值模拟及设计优化

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化肥设计 2017年第2期55卷 21-23,45页

作者：陈猛江珍珍郭勇中国五环工程有限公司湖北武汉430223

目前低阶煤提质项目中应用了很多大型风管,其设计的主要依据为设计规程。为提高矩形弯头管道的综合性能,利用计算流体力学软件Fluent对其进行数值模拟。在分析讨论3种结构弯头管道的流场分布、压力分布、进出口压力损失、出口速度均匀... 详细信息

目前低阶煤提质项目中应用了很多大型风管,其设计的主要依据为设计规程。为提高矩形弯头管道的综合性能,利用计算流体力学软件Fluent对其进行数值模拟。在分析讨论3种结构弯头管道的流场分布、压力分布、进出口压力损失、出口速度均匀度的基础上,指出优化弯头的总体优势及其在工程实践中的应用潜力。

关键词：矩形弯头数值模拟压力损失出口速度均匀度

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罗格列酮对百草枯中毒大鼠致急性肾损伤的保护作用

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中国急救医学 2017年第10期37卷 962-965页

作者：桑珍珍郭晋平贾春梅李勇沧州市中心医院急诊科河北沧州061000

目的探讨罗格列酮对百草枯（PQ）中毒大鼠致急性肾损伤（AKI）的保护作用。方法90只雄性SD大鼠随机分为三组，对照组（n=10）：腹腔注射0．9％氯化钠溶液1mL；模型组（n=40）：腹腔注射PQ20mg／kg；罗格列酮组（n=40）：腹腔注射PQ后立... 详细信息

目的探讨罗格列酮对百草枯（PQ）中毒大鼠致急性肾损伤（AKI）的保护作用。方法90只雄性SD大鼠随机分为三组，对照组（n=10）：腹腔注射0．9％氯化钠溶液1mL；模型组（n=40）：腹腔注射PQ20mg／kg；罗格列酮组（n=40）：腹腔注射PQ后立即腹腔注射罗格列酮20mg／kg，1次／d。注射PQ后4、24、48、72h收集各组大鼠血清和肾组织标本，采用酶联免疫法（ELISA）分析测定血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、诱导型一氧化氮和酶（iNOS）、高迁移率族蛋白B-1（HMGB-1）的含量；同时检测血清肌酐（Cr）、尿素氮（BUN）的含量；采用透射电镜观察肾组织的病理改变。结果与模型组比较，罗格列酮组大鼠各时间点血清Cr、BUN、TNF-α、IL-1β、iNOS和HMGB-1含量明显降低（P〈0．05），肾脏病理改变明显好转。结论罗格列酮能够降低血清TNF-α、IL-1β、iNOS及HMGB-1的含量，进而调节炎症反应及改善肾功能，对PQ中毒所致大鼠AKI具有一定的保护作用。

关键词：罗格列酮百草枯(PQ) 中毒急性肾损伤(AKI)

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