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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan Tan Ying-Shi Zou Ying-Lin Yu Le-Yi Hu Ting Zhang Hui Chen Ling Jin Duo-Ru Lin Yi-Zhi liu Hao-Tian Lin zhen-zhen liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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Ab initio study of the reaction path of the reaction HNCO+CN

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Science China Chemistry 2005年第4期48卷 279-285页

作者： ZHANG Xinzhuang zhen zhen liu Xinhou Technical Institute of Physics and Chemistry of Chinese Academy of Sciences Beijing 100101China Technical Institute of Physics and Chemistry of Chinese Academy of SciencesBeijing 100101China Technical Institute of Physics and Chemistry of Chinese Academy of SciencesBeijing 100101China

We report ab initio UMP2 calculations of the reaction of CN with HNCO using 6-311G(d,p) basis *** obtained results show that the reaction has two product channels:HNCO+CN→HCN+NCO (1) and HNCO+CN→HNCN+CO (2).Channel (1) is a hydrogen abstraction reaction,which is a concerted *** calculated potential energy barrier is 20.80 kJ/mol at UMP2(full)/6-311G(d,p) *** the range of reaction temperature (1000―2100 K),the conventional transition theory rate constant for channel (1) ranges from 0.32×10?11 to 6.9×10?11cm3?mol?1·s?1,which is close to the experimental *** (2) is a stepwise re-action involving an intermediate during the process of *** UMP2(full)/6-311G(d,p) po-tential energy barrier is 83.42 kJ/mol for the rate-controlling step,which is much higher than that of channel (1).

关键词： isocyanic acid, radical reaction, ab initio method, intermediate.

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Recovery of vanadium and molybdenum from spent petrochemical catalyst by microwave-assisted leaching

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 33-40页

作者： Zhi-yuan Ma Yong liu Ji-kui Zhou Mu-dan liu zhen-zhen liu Guangdong Institute of Resources Comprehensive Utilization Guangdong Academy of Sciences State Key Laboratory of Separation and Comprehensive Utilization of Rare Metals Guangdong Provincial Key Laboratory of Development and Comprehensive Utilization of Mineral Resources

The study of the leaching of vanadium(V) and molybdenum(Mo) from spent petrochemical catalysts in sodium hydroxide(NaO H) medium was performed using two approaches, namely, conventional leaching and microwave-assisted leaching methods. The influence of microwave power, leaching time, leaching temperature, and NaOH concentration on the leaching efficiency of spent petrochemical catalyst was investigated. Under microwave-assisted conditions(600 W, 10 min, 90°C, 2.0 mol·L^(-1) NaOH, and 0.20 g·mL^(-1) solid–liquid ratio), the leaching efficiencies of V and Mo reached 94.35% and 96.23%, respectively. It has been confirmed that microwave energy has considerable potential to enhance the efficiency of the leaching process and reduce the leaching time. It is suggested that the enhancement of the leaching efficiencies of V and Mo can be attributed to the existence of a thermal gradient between solid and liquid and the generation of cracks on the mineral surface.

关键词： microwave spent petrochemical catalyst vanadium molybdenum

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Study on the strength of cold-bonded high-phosphorus oolitic hematite-coal composite briquettes

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International Journal of Minerals,Metallurgy and Materials 2014年第5期21卷 423-430页

作者： Wen Yu Ti-chang Sun zhen-zhen liu Jue Kou Cheng-yan Xu The Key Laboratory of the Ministry of Education of China for High-Efficient Mining and Safety of Metal Mines University of Science and Technology Beijing School of Civil and Environmental Engineering University of Science and Technology Beijing

Composite briquettes containing high-phosphorus oolitic hematite and coal were produced with a twin-roller briquette machine using sodium carboxymethyl cellulose, molasses, starch, sodium silicate, and bentonite as binders. The effect of these binders on the strength of the composite briquettes, including cold strength and high-temperature strength, was investigated by drop testing and compression testing. It was found the addition of Ca（OH）2 and Na2CO3 not only improved the reduction of iron oxides and promoted dephosphorization during the reduction-separation process but also provided strength to the composite briquettes during the briquetting process; a compressive strength of 152.8 N per briquette was obtained when no binders were used. On this basis, the addition of molasses, sodium silicate, starch, and ben- tonite improved the cold strength of the composite briquettes, and a maximum compressive strength of 404.6 N per briquette was obtained by using starch. When subjected to a thermal treatment at 1200~C, all of the composite briquettes suffered from a sharp decrease in compressive strength during the initial reduction process. This decrease in strength was related to an increase in porosity of the composite briquettes. X-ray diffraction （XRD） and scanning electron microscopy （SEM） analyses showed that the decrease in strength of the composite briquettes could be caused by four factors： decomposition of bonding materials, gasification of coal, transportation of byproduct gases in the composite briquettes, and thermal stress.

关键词： hematite briquetting binders compressive strength porosity direct reduction process-

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Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer

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Asian Journal of Andrology 2010年第3期12卷 336-343,I0008,I0009页

作者： Si-Yi Hu Tao liu zhen-zhen liu Elisa Ledet Cruz Velasco-Gonzalez Diptasri M Mandal Shahriar Koochekpour Stanley S Scott Cancer Center Louisiana State University Health Sciences Center New Orleans LA 70112 USA Department of Genetics Louisiana State University Health Sciences Center New Orleans LA 70112 USA School of Public Health Louisiana State University Health Sciences Center New Orleans LA 70112 USA 4Department of Microbiology and Immunology Department of Urology Department of Biochemistry and Molecular Biology Louisiana State University Healt Sciences Center New Orleans LA 70112 USA

Race, family history and age are the unequivocally accepted risk factors for prostate cancer （PCa）. Androgen receptor （AR）-dependent signaling is an important element in prostate carcinogenesis and its progression to metastatic disease. We examined the possibility of genomic changes in the AR in association with familial PCa in African Americans who have a higher incidence and mortality rate and a clinically more aggressive disease presentation than Caucasians. Genomic DNAs of 60 patients from 30 high-risk African American and Caucasian families participating in the Louisiana State University Health Sciences Center genetic linkage study of PCa were studied. Exon-specific polymerase-chain reaction, bi-directional automated sequencing and restriction enzyme genotyping were used to analyze for mutations in the coding region of the AR gene. We identified a germline AR （A1675T）（T559S） substitution mutation in the DNA-binding domain in three PCa-affected members of an African- American family with a history of early-onset disease. The present study describes the first AR germline mutation in an African-American family with a history of familial PCa. The AR （T559S） mutation may contribute to the disease by altering AR DNA-binding affinity and/or its response to androgens, non-androgenic steroids or anti-androgens. Additional studies will be required to define the frequency and contribution of the AR （A 1675T） allele to early-onset and/or familial PCa in African Americans.

关键词： African Americans androgen receptor familial prostate cancer germline mutation

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Uphill anomalous transport in a deterministic system with speed-dependent friction coefficient

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Chinese Physics B 2017年第1期26卷 139-144页

作者： Wei Guo Lu-Chun Du zhen-zhen liu Hai Yang Dong-Cheng Mei Department of Physics Kunming University Kunming 650214 China Department of Physics Yunnan University Kunming 650091 China

We investigate the transport of a deterministic Brownian particle theoretically, which moves in simple onedimensional, symmetric periodic potentials under the influence of both a time periodic and a static biasing force. The physical system employed contains a friction coefficient that is speed-dependent. Within the tailored parameter regime, the absolute negative mobility, in which a particle can travel in the direction opposite to a constant applied force, is *** behavior is robust and can be maximized at two regimes upon variation of the characteristic factor of friction coefficient. Further analysis reveals that this uphill motion is subdiffusion in terms of localization（diffusion coefficient with the form D（t） -t-（-1） at long times）. We also have observed the non-trivially anomalous subdiffusion which is significantly deviated from the localization; whereas most of the downhill motion evolves chaotically, with the normal diffusion.

关键词： speed-dependent friction coefficient anomalous transport anomalous diffusion

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Neural network study of the nuclear ground-state spin distribution within a random interaction ensemble

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Nuclear Science and Techniques 2024年第3期35卷 216-227页

作者： Deng liu Alam Noor A zhen-zhen Qin Yang Lei School of Mathematics and Physics Southwest University of Science and TechnologyMianyang 621010China School of Nuclear Science and Technology Southwest University of Science and TechnologyMianyang 621010China

The distribution of the nuclear ground-state spin in a two-body random ensemble(TBRE)was studied using a general classification neural network(NN)model with two-body interaction matrix elements as input features and the corresponding ground-state spins as labels or output *** quantum many-body system problem exceeds the capability of our optimized NNs in terms of accurately predicting the ground-state spin of each sample within the ***,our NN model effectively captured the statistical properties of the ground-state spin because it learned the empirical regularity of the ground-state spin distribution in TBRE,as discovered by physicists.

关键词： Neural network Two-body random ensemble Spin distribution of nuclear ground state

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A MODEL FOR LIQUID SLUG LENGTH DISTRIBUTION IN VERTICAL GAS-LIQUID SLUG FLOW

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Journal of Hydrodynamics 2009年第4期21卷 491-498页

作者： XIA Guo-dong CUI zhen-zhen liu Qing ZHOU Fang-de HU Ming-sheng College of Environmental and Energy Engineering Beijing University of Technology Beijing 100124 China State Key Laboratory of Multiphase Flow in Power Engineering Xi＇an Jiaotong University Xi＇an 710049 China

The slug length and the trailing Taylor bubble velocity in an upward vertical slug flow were measured by using the optical probes and the EKTAPRO 1000 high speed motion analyzer. The correlation between the trailing bubble velocity and the length of liquid slug ahead of that bubble is derived from the experimental data. Based on this correlation as well as the bubble overtaking mechanism, a model for the slug length distribution at any designated locations along the pipe is proposed. The predicted results are in agreement with the experimental data.

关键词： gas-liquid two-phase flow slug flow Taylor bubble liquid slug

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Polynomial-Time Key-Recovery Attacks Against NTRURe Encrypt from ASIACCS'15

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Journal of Systems Science & Complexity 2024年第3期37卷 1308-1325页

作者： liu zhen PAN Yanbin zhenG Jinwei School of Cyber Science and Technology Hubei Key Laboratory of Applied MathematicsHubei UniversityWuhan 430062China Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

In ASIACCS 2015, Nu nez, et al. proposed a proxy re-encryption scheme, named NTRURe Encrypt, based on NTRU, which allows a proxy to translate ciphertext under the delegator’s public key into a re-encrypted ciphertext that can be decrypted correctly by delegatee’s private key. Because of the potential resistance to quantum algorithm, high efficiency and various applications in real life,NTRURe Encrypt has drawn lots of attention and its security has been widely discussed and *** PQCrypto2019, liu, et al. proposed two key recovery attacks against it. However, their first attack heavily relies on a weaken decryption oracle, and the second attack needs to collect about 260ciphertexts from the same message by theoretical analysis, which makes both of the attacks unrealistic. In this paper, inspired by the broadcast attack against NTRU, the authors find out that for NTRURe Encrypt the delegator and the delegatee can efficiently recover each other’s private key in polynomial time without any unrealistic assumptions. In addition, the authors also show how to fix NTRURe Encrypt to resist the proposed attacks. As a by-product, the authors also show how to commit broadcast attacks against NTRU 2001 with even dg, which was thought infeasible before.

关键词： Broadcast attack key recovery NTRU NTRUReEncrypt

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Design and Gait Planning of a Worm-inspired Metameric Robot for Pipe Crawling

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Journal of Bionic Engineering 2024年第3期21卷 1265-1277页

作者： Yu liu Qingbiao Shi zhen Chen Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen361102China

The earthworm has been attracted much attention in the research and development of biomimetic robots due to their unique locomotion mechanism,compact structure,and small motion *** paper presents a new design and prototype of a worm-inspired metameric robot with a movement pattern similar to that of *** robot consists of multiple telescopic modules connected in series through joint *** telescopic module mimics the contraction and elongation motion modes of the earthworm segments.A kinematic and dynamic analysis is conducted on the telescopic module,and an input torque calculation method is provided to ensure sufficient friction between the robot and the pipe *** gait modes of the prototype robot for straight and turning locomotion are introduced,and these modes are extended to robots constructed by different numbers of telescopic *** addition,a method is proposed to increase the friction between the robot and the pipe wall in the aforementioned gait modes without changing the robot structure,thereby improving the robot’s motion ability in *** theoretical model of gait modes has also been validated through gait *** findings of this paper would provide a useful basis for the design,modeling,and control of future worm inspired robots.

关键词： Bio-inspired robot Spatial linkage mechanism Kinematics model Peristaltic locomotion

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