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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1345-1350页

作者： Juan Wu zhen-ya gao Dong-Mei Cui Hong-Hui Li Jun-Wen Zeng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Xuchang University School of MedicineXuchang 461000Henan ProvinceChina Chengdu Aier Eye Hospital Chengdu 610000Sichuan ProvinceChina

AIM:To explore the apoptosis of ARPE-19 cells after the treatment with different doses of all-trans-retinoic acid(ATRA).METHODS:ARPE-19 cells were used in the in-vitro *** cytometry assay was employed to evaluate the level of reactive oxygen species(ROS)and *** effects of ATRA(concentrations from 2.5 to 20μmol/L)on the expression of endoplasmic reticulum stress(ERS)markers in vitro were evaluated by Western blot and realtime quantitative polymerase chain reaction(qRT-PCR)*** contribution of ROS and ERS-induced apoptosis in vitro was determined by using N-acetyl-L-cysteine(NAC)and Salubrinal,an antagonist of NAC and ERS,***:Flow cytometry showed that ATRA significantly increased ARPE-19 cell apoptosis and ROS levels in each group(F=86.39,P<0.001;F=116.839.P<0.001).Western blot and qRT-PCR revealed that levels of CHOP and BIP were elevated in a concentration-dependent pattern after the cells were incubated with ATRA(2.5-20μmol/L).The upregulation of VEGF-A and CHOP induced by ATRA could be inhibited by NAC(antioxidant)and Salubrinal(ERS inhibitor)in ***:ATRA induces the apoptosis of ARPE-19 cells via activated ROS and ERS signaling pathways.

关键词： all-trans-retinoic acid retinal pigment epithelium apoptosis reactive oxygen species endoplasmic reticulum stress

Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 152-156页

作者： Hong-Hui Li Li-Jun Huo zhen-ya gao Feng Zhao Jun-Wen Zeng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen University

Bone morphogenesis proteins(BMPs) are multi-functional growth factors. They are expressed in retina,retinal pigment epithelium(RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera,biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.

关键词： bone morphogenetic protein-2 sclera myopia

Distribution of bone morphogenetic protein receptors in human scleral fibroblasts cultured in vitro and human sclera

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 661-666页

作者： zhen-ya gao Li-Jun Huo Dong-Mei Cui Xiao yang Wen-Juan Wan Jun-WenZeng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University The First Affiliated Hospital Sun Yat-sen University

AIM: To investigate the distribution of bone morphogenetic protein receptors (BMPRs) in human scleral fibroblsasts (HSFs) and in human sclera. METHODS: Primary HSFs were cultured in vitro. The mRNA levels of BMP-2 and BMPRs in HSFs were assayed by reverse transcription-polymerase chain reaction (RT-PCR). The protein distributions of BMP-2 and BMPRs in HSFs were further detected by immunocytofluorescence and western blot. Their protein expression was also detected in frozen human posterior scleral sections by immunohistofluorescence. RESULTS: BMP-2 and BMPRs were expressed in both HSFs and human sclera not only at mRNA level but also at protein level. The expressions of BMPRIA and BMPRII were higher than that of BMPRIB in the cytoplasm and cell membrane of HSFs in vitra Western blot further verified the results of immunocytofluorescence. In human sclera, BMP2, BMPR IB and BMPR II were found to be expressed in the cytomatrix of HSF, and weak signal was detected about BMPRIA. CONCLUSION: BMP-2 and all three subtypes of BMPRs were found in HSFs and may play a role in scleral remodeling.

关键词： human scleral fibroblasts BMP-2 BMPRs

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 188-197页

作者： Shuai Li zhen Ma Jin-Hua gao School of Science Hebei University of Science and TechnologyShijiazhuang 050018China School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002China School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China

We theoretically investigate the spin resolved Friedel oscillation(FO)and quasiparticle interference(QPI)in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r^(-2) in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as r^(-3).Such spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment(***ález-Herrero et al.,Science 352,437(2016)).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states(FT-LDOS).Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Recent advancements in noble-metal electrocatalysts for alkaline hydrogen evolution reaction

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Chinese Chemical Letters 2025年第1期36卷 176-200页

作者： Guoliang gao Guangzhen Zhao Guang Zhu Bowen Sun Zixu Sun Shunli Li ya-Qian Lan Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhou 234000China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China School of Chemistry South China Normal UniversityGuangzhou 510006China

Available online Alkaline water electrolysis(AWE)is a prominent technique for obtaining a sustainable hydrogen source and effectively managing the energy *** metal-based electrocatalysts,owing to their exceptional hydrogen binding energy,exhibit remarkable catalytic activity and long-term stability in the hydrogen evolution reaction(HER).However,the restricted accessibility and exorbitant cost of noble-metal materials pose obstacles to their extensive adoption in industrial *** review investigates strategies aimed at reducing the dependence on noble-metal electrocatalysts and developing a cost-effective alkaline HER catalyst,while considering the principles of sustainable *** initial discussion covers the fundamental principle of HER,followed by an overview of prevalent techniques for synthesizing catalysts based on noble metals,along with a thorough examination of recent *** subsequent discussion focuses on the strategies employed to improve noble metalbased catalysts,including enhancing the intrinsic activity at active sites and increasing the quantity of active ***,this investigation concludes by examining the present state and future direction of research in the field of electrocatalysis for the HER.

关键词： Hydrogen evolution reaction Alkaline water electrolysis Electrocatalysts Noble metal-based Synthesis method Modification strategy

Robust free-base and metalated corrole radicals with reduction-induced emission

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Chinese Chemical Letters 2025年第2期36卷 426-431页

作者： Pengfei Li Chulin Qu Fan Wu Hu gao Chengyan Zhao Yue Zhao zhen Shen State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing University School of Chemistry and Materials Science Nanjing Normal University College of Materials Science and Engineering Nanjing Forestry University

Preparing free-base porphyrinoid radicals that can function as coordination ligands is a challenging task. Here we report the synthesis of a stable, free-base benzocorrole(BC) radical containing only two inner NH protons via a retro-Diels-Alder conversion. The radical character of BC was fully supported by crystallographic analysis, spectroscopic evidence, and theoretical calculations. This neutral radical ligand allowed easy insertion of Zn(Ⅱ), Ga(Ⅲ), and Pd(Ⅱ) ions to produce radical complexes. All these radicals exhibited luminescence-on responses under weak reducing atmosphere, corresponding to the conversion to their aromatic anions. The red fluorescence was observed for BC and its Zn(Ⅱ) and Ga(Ⅲ) complexes,and the near-infrared phosphorescence(>900 nm) was detected for Pd(Ⅱ) complex at room ***, Ga(Ⅲ) corrole exhibited a variation in fluorescence in response to axial coordination. Our findings provide a promising radical platform for coordination and developing novel functional materials with switchable spin and emission.

关键词： Luminescence Macrocyclic ligands Porphyrinoids Radicals Redox chemistry

Decoupling the roles of grain boundary strength and grain size hidden in grain-level electro-chemo-mechanical failure of solid-state electrolyte

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Journal of Energy Chemistry 2025年第2期101卷 685-691页

作者： Ming Xu Xuyang Wang zhengqian Jin Xingxing Jiao ya gao Zhongxiao Song Xieyu Xu Kai Xi yangyang Liu School of Chemistry Engineering Research Center of Energy Storage Materials and Devices Ministry of Education Xi'an Jiaotong University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Research Institute of Frontier Science Southwest Jiaotong University School of Instrument Science and Technology Xi'an Jiaotong University

Garnet lithium lanthanum zirconium oxide(Li7La3Zr2O12,LLZO) is a benchmark solid-state electrolyte（SSE） material receiving considerable attention owing to its high conductivity and chemical stability against Li *** its electro-chemo-mechanical failure mechanisms have been much investigated,the equivocal roles of grain boundary strength and grain size of LLZO remain under-explored,hindering further performance *** we decoupled the effects of grain size and grain boundary strength of polycrystalline LLZO via the combination of electrochemical kinetics and the cohesive zone *** discovered that the disintegration of LLZO is initiated by the accumulation of local displacements,which strongly relates to the changes in both grain size and grain boundary ***,variations in grain boundary strength affect the diffusion and propagation pathways of damage,while the failure of LLZO is determined by the grain *** LLZO grains facilitate transgranular damage under low grain boundary strength,which can alter local chemo-mechanics within the bulk of LLZO,leading to more extensive damage *** results showcase the structure optimization pathways by preferentially controlling the growth of lithium dendrites at grain boundaries and their penetration in garnet-type SSE.

关键词： Electro-chemo-mechanics Grain boundary Growth of lithium metal Solid-state electrolyte

Unraveling the role of long non‑coding RNAs in chronic heat stress‑induced muscle injury in broilers

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Journal of Animal Science and Biotechnology 2025年第1期16卷 206-217页

作者： zhen Liu Yingsen Liu Tong Xing Jiaolong Li Lin Zhang Liang Zhao Yun Jiang Feng gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNanjing 210095People’s Republic of China Anhui Key Laboratory of Livestock and Poultry Product Safety Engineering Institute of Animal Husbandry and Veterinary MedicineAnhui Academy of Agricultural SciencesHefei 230031China Institute of Agro‑Products Processing Jiangsu Academy of Agricultural SciencesNanjing 210014People’s Republic of China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023People’s Republic of China

Background Chronic heat stress(CHS)is a detrimental environmental stressor with a negative impact on the meat quality of ***,the underlying mechanisms are not fully *** study investigates the effects of CHS on long non-coding RNA(lncRNA)expression and muscle injury in broilers,with a focus on its implications for meat *** The results showed that CHS diminished breast muscle yield,elevated abdominal fat deposition,induced cellular apoptosis(P<0.05),and caused *** analysis revealed 151 differentially expressed(DE)lncRNAs when comparing the normal control(NC)and HS groups,214 DE lncRNAs when comparing the HS and PF groups,and 79 DE lncRNAs when comparing the NC and pair-fed(PF)*** eliminating the confounding effect of feed intake,68 lncRNAs were identified,primarily associated with cellular growth and death,signal transduc-tion,and metabolic ***,the apoptosis-related pathway P53,lysosomes,and the fibrosis-related gene TGF-β2 were significantly upregulated by *** These findings indicate that chronic heat stress induces cellular apoptosis and muscle injury through lncRNA,leading to connective tissue accumulation,which likely contributes to reduced breast muscle yield and meat quality in broilers.

关键词： Apoptosis Broiler Chronic heat stress LncRNA Muscle

Evaluation of a user-friendly CSDS cage apparatus for studying depressive-like behaviors in rodents

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Animal Models and Experimental Medicine 2025年第1期8卷 179-186页

作者： Hao Zhang Dongmei gao Minghu Hu Wanqing Zhou Muxuan Han ya Sun yang Zhang Jieqiong Wang Mingzhou gao High-Level Key Disciplines of Traditional Chinese Medicine:Basic Theory of Traditional Chinese Medicine National Administration of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Key Laboratory of Traditional Chinese Medicine Classical Theory Ministry of EducationShandong University of Traditional Chinese MedicineJinanChina Experimental Center Shandong University of Traditional Chinese MedicineJinanShandongChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinanShandongChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanShandongChina Social Cooperation and Achievement Transformation Department Shandong University of Traditional Chinese MedicineJinanShandongChina

Background:Previously,a chronic social defeat stress(CSDS)model has been widely-adopted for assessing depressive-like behaviors in ***,there is still room for improvement in the CSDS model to safeguard study accuracy and the wel-fare of lab *** study team developed a novel,standardized apparatus to induce CSDS in rodents and assessed the model's practical ***:An innovative CSDS cage apparatus and water bottle was *** evaluate the effectiveness of the newly developed tools,a variety of animal models,including the tail suspension test(TST),sucrose preference test,forced swimming test(FST),novelty-suppressed feeding test,female urine sniffing test,and open field test(OFT),were adopted to assess depressive-like behaviors in *** treat-ment was also administered to observe the reversal effect,as part of the ***:The CSDS cage apparatus resulted in the manifestation of depressive-like behaviors in the model *** reductions in sucrose preference and urine sniffing time were observed,while the OFT revealed decreased central zone total distance,residence time,and frequency of ***,increased immobility was found in the FST and *** treatment was found to successfully reverse the modeling ***:The CSDS cage apparatus was validated for enhanced usability and ad-dressed the previous challenges of water bottle leakage and lab rodent welfare *** consistent results from multiple behavioral tests also supported real-world application of the apparatus,offering researchers a promising alternative to conven-tional rodent cages.

关键词： CSDS depression experimental cage leak-proof water bottle methodology

The Supply and Demand of Agricultural Products in China Based on Balanced Diet

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Asian Agricultural Research 2012年第8期4卷 5-10页

作者： ZHOU zhen-ya,ZHANG Qing,gao Ming-jie,LI Jian-ping Institute of Agricultural Resources and Regional Planning,Chinese Academy of Agricultural Sciences,Beijing 100081,China

Promoting agricultural production and ensuring the supply of agricultural products has always been the main task of agricultural development in China,but the agricultural production in China has not yet been combined with the Chinese residents' dietary needs to formulate reasonable development goals,with a certain blindness in production. According to the dietary standards in The Dietary Guidelines for Chinese Residents developed by the Chinese Nutrition Society,we calculate the demand of various types of agricultural products in China under the conditions of balanced diet. In comparison with the output of various types of agricultural products in China at present,we find that the output of most of agricultural products in China has exceeded the reasonable demand of the Chinese residents under the conditions of balanced diet. Therefore,adjusting the agricultural production structure in China and advocating balanced diet has become an important way to solve the problem of balance between supply and demand of agricultural products.

关键词： Balanced diet Agricultural products Supply and dem