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Development and validation of a score predicting mortality for older patients with mitral regurgitation

Journal of Geriatric Cardiology 2023年第8期20卷 577-585页

作者： De-Jing FENG Yun-Qing YE Zhe LI Bin ZHANG Qing-Rong LIU Wei-Wei WANG zhen-yan ZHAO zheng ZHOU Qing-Hao ZHAO Zi-Kai YU Hai-Tong ZHANG zhen-ya duan Bin-Cheng WANG Jun-Xing LV Shuai GUO Run-Lin GAO Hai-yan XU Yong-Jian WU on behalf of the China-DVD and China-VHD study investigators Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

OBJECTIVE To develop and validate a user-friendly risk score for older mitral regurgitation(MR)patients,referred to as the Elder-MR *** The China Senile Valvular Heart Disease(China-DVD)Cohort Study functioned as the development cohort,while the China Valvular Heart Disease(China-VHD)Study was employed for external *** included patients aged 60 years and above receiving medical treatment for moderate or severe MR(2274 patients in the development cohort and 1929 patients in the validation cohort).Candidate predictors were chosen using Cox’s proportional hazards model and stepwise selection with Akaike’s information *** Eight predictors were identified:age≥75 years,body mass index<20 kg/m^(2),NYHA class Ⅲ/Ⅳ,secondary MR,anemia,estimated glomerular filtration rate<60 mL/min per 1.73 m^(2),albumin<35 g/L,and left ventricular ejection fraction<60%.The model displayed satisfactory performance in predicting one-year mortality in both the development cohort(C-statistic=0.73,95%CI:0.69-0.77,Brier score=0.06)and the validation cohort(C-statistic=0.73,95%CI:0.68-0.78,Brier score=0.06).The Elder-MR score ranges from 0 to 15 *** a one-year follow-up,each point increase in the Elder-MR score represents a 1.27-fold risk of death(HR=1.27,95%CI:1.21-1.34,P<0.001)in the development cohort and a 1.24-fold risk of death(HR=1.24,95%CI:1.17-1.30,P<0.001)in the validation *** to EuroSCORE II,the Elder-MR score demonstrated superior predictive accuracy for one-year mortality in the validation cohort(C-statistic=0.71 vs.0.70,net reclassification improvement=0.320,P<0.01;integrated discrimination improvement=0.029,P<0.01).CONCLUSIONS The Elder-MR score may serve as an effective risk stratification tool to assist clinical decision-making in older MR patients.

关键词： patients mitral score

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Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-ya Cheng duan-Rui Qiao Yi-Ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

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人工基质在对虾养殖中的应用

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海洋科学 2016年第9期40卷 135-139页

作者：张家松陈亮亮冯震华段亚飞董宏标李华刘青松中国水产科学研究院南海水产研究所农业部南海渔业资源开发利用重点实验室广东广州510300 上海海洋大学水产与生命学院上海201306

目前中国对虾养殖业快速发展,同时也伴随近海养殖水体日益恶化、抗生素和化学药物被滥用和水产品食品安全等一系列问题。这些问题严重制约着对虾集约化养殖的可持续发展,因此选择一种更加健康、绿色和安全的养殖模式显得尤为重要。作者... 详细信息

目前中国对虾养殖业快速发展,同时也伴随近海养殖水体日益恶化、抗生素和化学药物被滥用和水产品食品安全等一系列问题。这些问题严重制约着对虾集约化养殖的可持续发展,因此选择一种更加健康、绿色和安全的养殖模式显得尤为重要。作者通过介绍人工基质这种新型水处理技术表面生物膜的结构和形成过程,探讨了其功能性(水质调节、饲料补充和病害防治)机理,对其在对虾养殖业中的实际应用做了展望。

关键词：对虾人工基质生物膜机理

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Analysis of finite-time practical stability for time-varying polytopic systems

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Journal of Systems Engineering and Electronics 2009年第1期20卷 112-119页

作者： Zhong zhen duan Guangren Harbin Inst. of Technology Harbin 150001 P. R. China

The problem of finite-time practical stability （FTPS） for time-varying polytopic systems is discussed. Three equivalent conditions for FTPS are first proposed. To facilitate the system analysis, a sufficient linear matrix inequality （LMI） criterion on the FTPS is further provided. The definition of finite-time practical boundedness and a sufficient LMI criterion are also provided to overcome the exogenous disturbance. A numerical example is used to illustrate the effect of the proposed approach.

关键词： polytopic systems linear matrix inequality finite-time control practical stability.

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A chitosan/amido-graphene oxide-based self-powered humidity sensor enabled by triboelectric effect

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Rare Metals 2021年第8期40卷 1995-2003页

作者： Bo-Hao Liu Guang-Zhong Xie Cheng-zhen Li Si Wang zhen Yuan Zai-Hua duan ya-Dong Jiang Hui-Ling Tai State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu610054China

In this work,amido-graphene oxide(GO-NH_(2))loaded chitosan(CTS)composite material(CTS/GO-NH_(2))that acts as both the triboelectric and sensing film was prepared on rotary fan-shaped triboelectric nanogenerator for humidity *** with the pristine CTSbased triboelectric humidity sensor(CTS-THS)and GONH_(2)-THS,the CTS/GO-NH_(2)-based humidity sensor exhibited higher humidity response and better linearity in the relative humidity(RH)range of 18.7%RH-91.5%*** above results can be explained by the massive exposed and less concealed hydrophilic functional groups of CTS with the help of the wrinkle structure of GO-NH_(2).Meanwhile,the CTS/GO-NH_(2)-THS possessed good repeatability and acceptable hysteresis(~6.2%RH).Finally,a humidity sensing mechanism coupling triboelectric contact charging effect with electrons transfer principle under moisture environment was established to interpret the enhanced humidity sensing performance of the composite film-based *** work demonstrates that CTS/GONH_(2) composite film can be utilized to fabricate humidity sensors based on the triboelectric effect.

关键词： Chitosan Amido-graphene oxide Triboelectric nanogenerator Humidity sensors Hydrogen bonding interaction

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Design Optimization and Operating Performance of S-CO_(2) Brayton Cycle under Fluctuating Ambient Temperature and Diverse Power Demand Scenarios

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Journal of Thermal Science 2024年第1期33卷 190-206页

作者： yaNG Jingze yaNG zhen duan Yuanyuan Key Laboratory for Thermal Science and Power Engineering of MOE Beijing Key Laboratory for CO_(2) Utilization and Reduction TechnologyTsinghua UniversityBeijing 100084China

The supercritical CO_(2)(S-CO_(2)) Brayton cycle is expected to replace steam cycle in the application of solar power tower system due to the attractive potential to improve efficiency and reduce *** the concentrated solar power plant with thermal energy storage is usually located in drought area and used to provide a dispatchable power output,the S-CO_(2) Brayton cycle has to operate under fluctuating ambient temperature and diverse power demand *** addition,the cycle design condition will directly affect the off-design *** this work,the combined effects of design condition,and distributions of ambient temperature and power demand on the cycle operating performance are analyzed,and the off-design performance maps are proposed for the first time.A cycle design method with feedback mechanism of operating performance under varied ambient temperature and power demand is introduced *** show that the low design value of compressor inlet temperature is not conductive to efficient operation under low loads and sufficient output under high ambient *** average yearly efficiency is most affected by the average power demand,while the load cover factor is significantly influenced by the average ambient *** multi-objective optimization,the optimal solution of designed compressor inlet temperature is close to the minimum value of35℃ in Delingha with low ambient temperature,while reaches 44.15℃ in Daggett under the scenario of high ambient temperature,low average power demand,long duration and large value of peak load during the peak temperature *** the cycle designed with compressor inlet temperature of 35℃ instead of 44.15℃ in Daggett under light industry power demand,the reduction of load cover factor will reach 0.027,but the average yearly efficiency can barely be improved.

关键词： supercritical CO_(2)Brayton cycle ambient temperature fluctuating power demand scenarios design optimization off-design performance

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The impact of government incentives and penalties on willingness to recycle plastic waste: An evolutionary game theory perspective

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Frontiers of Environmental Science & Engineering 2020年第2期14卷 173-184页

作者： zhen Wang Jiazhen Huo Yongrui duan School of Economics and Management Tongji UniversityShanghai 200092China Bosch-Tongji University Chair of Global Supply Chain Management Shanghai 200092China

Because governments have introduced policies involving incentives and penalties to promote the recycling of plastic waste,it is important to understand the impact of such incentives and penalties on the willingness of stakeholders to *** this study,government is included as a player,alongside waste collectors and recyclers,in a tripartite evolutionary game model of plastic waste *** study explores the evolutionary equilibrium and performs a simulation analysis to elucidate the effect of government incentives and penalties on the willingness of other players to participate in *** conclusions are drawn from this ***,an increase in incentives or in penalties increases the probability that collectors and recyclers will participate in the recycling ***,policy support incentives encourage collectors and recyclers to participate in plastic waste recycling earlier than subsidy incentives ***,recyclers are more sensitive than collectors to government-imposed penalties.

关键词： Plastic waste Recycle Reuse Government incentives Government penalties Evolutionary game

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Enhanced positive humidity sensitive behavior of p-reduced graphene oxide decorated with n-WS_(2) nanoparticles

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Rare Metals 2021年第7期40卷 1762-1767页

作者： Zai-Hua duan Qiu-Ni Zhao Cheng-zhen Li Si Wang ya-Dong Jiang ya-Jie Zhang Bo-Hao Liu Hui-Ling Tai State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China

Most resistance-type humidity sensors exhibit negative humidity sensitivity,i.e.,their resistance decreases with a corresponding increase in *** is primarily attributed to the dominant role of ionic conduction in adsorbed *** this work,a humidity sensor based on a p-type reduced graphene oxide(p-rGO)with positive humidity sensitivity is ***,its positive humidity sensing response is further enhanced by n-type WS_(2) nanoparticles *** results show that both rGO and r GO/WS_(2) humidity sensors have good linear response in the relative humidity(RH)range of0%-91.5%.The sensitivity of the rGO/WS_(2) humidity sensor is 1.87 times that of rGO humidity sensor,which is mainly attributed to p-n heterojunction between rGO and WS_(2).Besides,the r GO/WS_(2) humidity sensor has small humidity hysteresis(-3%RH)and good *** work demonstrates a humidity sensor based on rGO/WS_(2) composite film and provides a facile route for fabricating humidity sensor with positive humidity sensing properties.

关键词： Reduced graphene oxide WS2 nanoparticles Heterojunction Humidity sensor Humidity sensing mechanism

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Thermoelectric properties of Bi0.5Sb1.4-xNaxIn0.1Te3 alloys

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Rare Metals 2019年第12期38卷 1187-1192页

作者： Yue-zhen Jiang Xing-Kai duan School of Electronic Engineering Jiujiang UniversityJiujiang 332005China School of Mechanical and Materials Engineering Jiujiang UniversityJiujiang 332005China

The Bi(0.5)Sb(1.4-x)NaxIn(0.1)Te3(x=0.02-0.20)alloys were fabricated by high vacuum melting and hotpressing *** phase structures and morphology of the bulk samples were characterized by X-ray diffraction(XRD) and scanning electron microscope(SEM),*** of In and Na co-doping on the electrical and thermal transport properties were studied from room temperature to 500 *** coefficient of the Bi(0.5)Sb(1.5)Te3 can be enhanced by substituting Sb with In and Na at near room *** electrical conductivity of the In and Na co-doped samples is lower than that of the Bi(0.5)Sb(1.5)Te3 alloy from room temperature to 500 *** and Na co-doping of appropriate percentage optimizes the thermal conductivity of the Bi(0.5)Sb(1.5)Te3 *** minimum value of thermal conductivity of Bi(0.5)Sb(1.36)Na(0.04)In(0.1)Te3 alloy is 0.45 W·m^(-1) K^(-1) at 323 *** leads to a great improvement in the thermoelectric figure of merit(zT).The maximum zT value reaches 1.42 at 323 K.

关键词： Microstructure Co-doping Thermal conductivity Electrical properties

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