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Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer

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World Journal of Gastroenterology 2014年第14期20卷 4085-4092页

作者： Yun-Feng Wang Fei-Ling Feng Xu-Hong Zhao zhen-xiong ye He-Ping Zeng zhen Li Xiao-Qing Jiang Zhi-Hai Peng Department of Hepatobiliary Surgery Qianfoshan HospitalShandong University Department of General Surgery Yangpu HospitalTongji University School of Medicine The First Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University Central Experiment Laboratory Yangpu HospitalTongji University School of Medicine

AIM: To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis. METHODS: Serum cancer antigens (CA) 199, CA242, carcinoembryonic antigen (CEA), and CA125 levels were measured in 78 patients with gallbladder cancer (GBC), 78 patients with benign gallbladder diseases, and 78 healthy controls using electrochemiluminescence. CA199, CA242, CEA, and CA125 levels and positive rates were analyzed and evaluated pre-and post-operatively. Receiver operator characteristic curves were used to determine diagnostic sensitivity and specificity of GBC. Survival time analysis, including survival curves, and multivariate survival analysis of a Cox proportional hazards model was performed to evaluate independent prognostic factors. RESULTS: Serum CA242, CA125, and CA199 levels in the GBC group were significantly higher when compared with those in the benign gallbladder disease and healthy control groups (P < 0.01). With a single tumor marker for GBC diagnosis, the sensitivity of CA199 was the highest (71.7%), with the highest specificity being in CA242 (98.7%). Diagnostic accuracy was highest with a combination of CA199, CA242, and CA125 (69.2%). CA242 could be regarded as a tumor marker of GBC infiltration in the early stage. The sensitivity of CA199 and CA242 increased with progression of GBC and advanced lymph node metastasis (P < 0.05). The 78 GBC patients were followed up for 6-12 mo (mean: 8 mo), during which time serum CA199, CA125, and CA242 levels in the recurrence group were significantly higher than in patients without recurrence (P < 0.01). The post-operative serum CA199, CA125, and CA242 levels in the non- recurrence group were significantly lower than those in the GBC group (P < 0.01). Multivariate survival analysis using a Cox proportional hazards model showed that cancer of the gallbladder neck and CA199 expression level were independent prognostic factors. CONCLUSION: CA242 is a marker of GBC infiltration in

关键词： Gallbladder cancer Tumor marker Combined detection Diagnosis Prognosis

Three-dimensional fracture of UO_(2)ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 165-176页

作者： Wei xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Fracture is the primary failure type for the UO_(2)ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional(3D)UO_(2)ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

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Science China Chemistry 2025年第2期68卷 492-498页

作者： Hailong xiong Chunyu Qi Lantian Xue Ling Zhang Hanyu Liu zhen-An Qiao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Mesoporous metals with large surface area,high pore volume,and uniform pore structure hold excellent advantages for various ***,the state-of-the-art synthesis methods are still limited to wet chemistry,which requires excessive solvents and a time-consuming drying ***,we report a facile and general mechanochemical coordination self-assembly strategy to prepare mesoporous metals(e.g.,Rh,Ru,Ir,Pt,Pd,Ag,Co,and Ni)with remarkable porous properties by using metal chlorides and cationic polymer *** with the wet chemistry process,this method proceeds without solvents and does not need complicated experimental conditions and long synthetic periods,which not only greatly reduces the consumption of cost and energy and environmental pollution,but also improves the synthesis efficiency and yield of target *** believe the developed approach will provide a general pathway for the scalable preparation of advanced porous materials.

关键词： mechanochemistry self-assembly mesoporous materials mesoporous metals electrocatalysis

Laparoscopic transcystic common bile duct exploration and laparoscopic transductal common bile duct exploration in elderly patients with cholecystolithiasis combined with choledocholithiasis

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Chinese Medical Journal 2019年第14期132卷 1745-1746页

作者： Yun-Feng Wang Ai-Li Wang zhen Li He-Ping Zeng Min Tang zhen-xiong ye Hui Wang Yong-Bing Wang Xiao-Qing Jiang Department of General Surgery Pudong New Area People's HospitalShanghai University of Medicine & Health SciencesShanghai 201200China Department of General Surgery Yangpu HospitalTongji University School of MedicineShanghai 200090China The First Department of Biliary Surgery Eastern Hepatobiliary Surgery Hospital of the Second Military Medical UniversityShanghai 200433China

To the Editor:With the development of minimally invasive surgical technology,laparoscopic transcystic common bile duct exploration plus laparoscopic cholecystectomy (LTCBDE + LC) has become the first choice of treatment for cholecystolithiasis combined with biliary *** addition,there is little prospective *** compared 150 patients who underwent LTCBDE + LC with 150 patients who underwent laparoscopic transductal common bile duct exploration (LTDBDE)+ *** patients and participants were informed of the study and voluntarily provided informed consent.

关键词： LTCBDE LC choledocholithiasis

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Exploring Mechanism of Electroacupuncture in Modulating Neuroinflammation Based on Intestinal Flora and Its Metabolites

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Chinese Journal of Integrative Medicine 2025年第2期31卷 183-192页

作者： ye Hai-min LI Zhuo-yan ZHANG Peng KANG zhen ZHOU De-sheng School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha(410208)China Neurology Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Acupuncture and Moxibustion Massage Rehabilitation Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Neurology Department The First Hospital of Hunan University of Chinese MedicineChangsha(410011)China

Neuroinflammatory responses play an important role in the pathogenesis of various diseases,particularly those affecting the central nervous *** of neuroinflammation is a crucial therapeutic strategy for the management of central nervous system *** intestinal microbial-gut-brain axis serves as a key regulatory pathway that modulates neuroinflammatory *** flora metabolites such as short-chain fatty acids,indoles and their derivatives,lipopolysaccharides,trimethylamine oxide,and secondary bile acids exert direct or indirect effects on *** have shown that electroacupuncture(EA)modulates the composition of the intestinal microbiota and its metabolites,while also suppressing neuroinflammation by targeting the TLR4/NF-κB,NLRP3/caspase-1,and microglial cell M2-type transformation *** review discusses the mechanisms by which EA regulates neuroinflammation via intestinal microbiota and its metabolites,providing information and a foundation for further investigation of the precise therapeutic mechanisms of EA in neurological disorders.

关键词： electroacupuncture intestinal flora metabolites of intestinal flora neuroinflammation nervous system disease review

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Microplastics enhance the adsorption capacity of zinc oxide nanoparticles:Interactive mechanisms and influence factors

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Journal of Environmental Sciences 2025年第1期147卷 665-676页

作者： Weiping xiong Min Hu Siying He Yuhang ye Yinping Xiang Haihao Peng Zhaomeng Chen zhengyong Xu Honglin Zhang Weixiang Li Shudian Peng College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China Hunan Boke Environmental Engineering Co.Ltd. Hengyang 421099China College of Environmental Protection and Safety Engineering University of South ChinaHengyang 421001China Hunan Modern Environmental Technology Co.Ltd. Changsha 410004China

Microplastics(MPs)are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous *** on the interaction and joint toxicity of MPs on engineered nanoparticles(ENPs)are exhaustive,but limited research on the effect of MPs on the properties of ENPs in multisolute ***,the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first *** results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on *** polyamide prevented aggregation of ZnONPs by introducing negative charges,whereas virgin polyamide affected ZnONPs with the help of electrostatic ***-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and *** results showed no chemical interaction and electrostatic interactionwas the dominant force between ***,the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic *** study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs,which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on *** also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.

关键词： Microplastics Engineered nanoparticles Adsorption Tetracycline

Interface engineering of Pt/CeO2-{100} catalysts for enhancing catalytic activity in auto-exhaust carbon particles oxidation

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Chinese Chemical Letters 2025年第2期36卷 195-200页

作者： Peng Zhang Yitao Yang Tian Qin Xueqiu Wu Yuechang Wei Jing xiong Xi Liu Yu Wang zhen Zhao Jinqing Jiao Liwei Chen State Key Laboratory of Heavy Oil Processing Key Laboratory of Optical Detection Technology for Oil and GasCollege of ScienceChina University of Petroleum School of Chemistry and Chemical In-situ Center for Physical SciencesFrontiers Science Center for Transformative MoleculesShanghai Jiao Tong University School of Chemistry and Chemical Engineering Ningxia University School of Environmental Science and Engineering Yancheng Institute of Technology State Key Laboratory of Chemical Safety SINOPEC Research Institute of Safety Engineering Co.Ltd.

Herein,we fabricate an embedding structure at the interface between Pt nanoparticles （NPs） and CeO2-{100}nanocubes with surface defect sites （CeO2-SDS） through quenching and gas bubbling-assisted membrane reduction *** in-situ substitution of Pt NPs for atomic-layer Ce lattice significantly increases the amount of reactive oxygen species from 133.68μmol/g to 199.44μmol/*** a result,the distinctive geometric structure of Pt/CeO2-SDS catalyst substantially improves the catalytic activity and stability for soot oxidation compared with the catalyst with no quenching process,i.e.,its T50and TOF values are 332°C and 2.915 h-1,*** with the results of experimental investigations and density functional theory calculations,it is unveiled that the unique embedding structure of Pt/CeO2-SDS catalyst can facilitate significantly electron transfer from Pt to the CeO2-{100}support,and induce the formation of interfacial[Ce-Ox-Pt2]bond chains,which plays a crucial role in enhancing the key step of soot oxidation through the dual activation of surface lattice oxygen and molecular *** a fundamental revelation of the interfacial electronic transmission and corresponding modification strategy contributes a novel opportunity to develop high-efficient and stable noble metal catalysts at the atomic level.

关键词： Catalytic oxidation Defective ceria Nanocube Pt NPs Soot particles

Incidence of hematological toxicity with use of immunotherapy and chemotherapy in advanced non-small cell lung cancer

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中华医学杂志(英文版) 2025年第2期138卷 2024 Sep 19页

作者： Fu Wenhai Jiang Yu ye Wenjun Zhong Ran xiong Shan Li Jianfu Li Caichen He Jianxing Liang Wenhua Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China State Key Laboratory of Respiratory Disease Guangzhou Guangdong China National Clinical Research Center for Respiratory Disease Guangzhou Guangdong China Guangzhou Institute of Respiratory Health Guangzhou Guangdong China

Gold-catalyzed intermolecular amination of allyl azides with ynamides: Efficient construction of 3-azabicyclo[3.1.0] scaffold

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Chinese Chemical Letters 2025年第2期36卷 384-388页

作者： Chong-Yang Shi Jian-Xing Gong zhen Li Chao Shu Long-Wu ye Qing Sun Bo Zhou Xin-Qi Zhu College of Chemistry and Chemical Engineering Yunnan Normal University Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfacesand College of Chemistry and Chemical EngineeringXiamen University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong University

Gold-catalyzed amination reactions based on azides via α-imino gold carbene intermediates have attracted extensive attention in the past decades because this methodology leads to the facile and efficient construction of synthetically useful N-containing molecules, especially valuable N-heterocycles. However,successful examples of intermolecular generation of α-imino gold carbenes by using azides as amination reagents are rarely explored probably due to the weak nucleophilicity of azides. Herein, we disclose an efficient gold-catalyzed intermolecular aminative cyclopropanation of ynamides with the allyl azides, enabling flexible synthesis of a wide range of valuable 3-azabicyclo[3.1.0]hex–2-ene derivatives in good to excellent yields with excellent diastereoselectivities. Importantly, this protocol represents the first use of allyl azide as an efficient amination reagent in gold-catalyzed alkyne amination reactions.

关键词： Alkynes Amination Azides Gold Heterocycles