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Theoretical and numerical study of hydraulic characteristics of orifice energy dissipator

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Water Science and Engineering 2010年第2期3卷 190-199页

作者： Ning HE zhen-xing zhao Institute of High Energy Physics CAS Beijing 100049 R R. China College of Mechanics and Materials Hohai University Nanjing 210098 P. R. China

Different factors affecting the efficiency of the orifice energy dissipator were investigated based on a series of theoretical analyses and numerical simulations. The main factors investigated by dimension analysis were identified, including the Reynolds number （Re）, the ratio of the orifice diameter to the inner diameter of the pipe （ did ）, and the ratio of distances between orifices to the inner diameter of the pipe （ LID ）. Then, numerical simulations were conducted with a k-ε two-equation turbulence model. The calculation results show the following： Hydraulic characteristics change dramatically as flow passes through the orifice, with abruptly increasing velocity and turbulent energy, and decreasing pressure. The turbulent energy appears to be low in the middle and high near the pipe wall. For the energy dissipation setup with only one orifice, when Re is smaller than 105, the orifice energy dissipation coefficient K increases rapidly with the increase of Re. When Re is larger than l05, K gradually stabilizes. As diD increases, K and the length of the recirculation region L1 show similar variation patterns, which inversely vary with diD. The function curves can be approximated as straight lines. For the energy dissipation model with two orifices, because of different incoming flows at different orifices, the energy dissipation coefficient of the second orifice （K2） is smaller than that of the first. If LID is less than 5, the K value of the LID model, depending on the variation of/（2, increases with the spacing between two orifices L, and an orifice cannot fulfill its energy dissipation function. If LID is greater than 5, K2 tends to be steady; thus, the K value of the LID model gradually stabilizes. Then, the flow fully develops, and L has almost no impact on the value of K.

关键词： orifice energy dissipator theoretical analysis numerical simulation k-ε two-equation turbulent model hydraulic characteristics

Study of the s → dv■ rare hyperon decays in the Standard Model and new physics

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Chinese Physics C 2019年第9期43卷 26-32页

作者： Xiao-Hui Hu zhen-xing zhao INPAC Shanghai Key Laboratory for Particle Physics and Cosmology MOE Key Laboratory for Particle Physics Astrophysics and CosmologySchool of Physics and Astronomy Shanghai Jiao-Tong University

FCNC processes offer important tools to test the Standard Model（SM）and to search for possible new *** this work,we investigate the s→dvv rare hyperon decays in SM and *** find that in SM the branching ratios for these rare hyperon decays range from 10-14 to *** all the errors in the form factors are included,we find that the final branching ratios for most decay modes have an uncertainty of about 5% to 10%.After taking into account the contribution from new physics,the generalized SUSY extension of SM and the minimal 331 model,the decay widths for these channels can be enhanced by a factor of 2～7.

关键词： branching ratios rare hyperon decays form factors light-front approach new physics

Weak decays of doubly heavy baryons:"decay constants"

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Chinese Physics C 2018年第12期42卷 9-18页

作者： Xiao-Hui nu Yue-Long Shen Wei Wang zhen-xing zhao INPAC Shanghai Key Laboratory for Particle Physics and CosmologyMOE Key Laboratory for Particle PhysicsAstrophysics and CosmologySchool of Physics and AstronomyShanghai Jiao-Tong UniversityShanghai 200240China College of Information Science and Engineering Ocean University of ChinaQingdao 266100China

Inspired by the recent observation of the ∑c^＋c^＋ by the LHCb Collaboration, we explore the ＂decay constants＂ of doubly heavy baryons in the framework of QCD sum rules. With the ∑cc,∑bb, and Ωcc,Ωbc,Ωbb baryons interpolated by three-quark operators, we calculate the correlation functions using the operator product expansion and include the contributions from operators up to dimension six. On the hadron side, we consider both contributions from the lowest-lying states with J^P 1/2^＋ and from negative parity baryons with JP=1/2^-. We find that the results are stable and the contaminations from negative parity baryons are not severe. These results are ingredients for the QCD study of weak decays and other properties of doubly-heavy baryons.

关键词： doubly heavy baryons decay constant QCD sum rules

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang xingping Quan Xiaorui Geng Yujing Huang Yonghua zhao Lei Xi zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan Song Yahong Cheng Tong Li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu Xiao-Yu Chen Jie zhao Pin Li zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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基于响应面分析下中草药移栽机的优化设计

农机化研究 2025年第1期47卷 135-141页

作者：赵厚睿刘臻湖北中医药大学武汉430065 湖北轻工职业技术学院武汉430070

通过响应面分析法对中草药移栽机进行优化设计,以提高中草药种植效率和质量。首先,选取移栽速度、移栽深度和移栽器械倾角3个因素作为设计变量,选取移栽成功率和移栽损伤率作为评价指标;在此基础上,设计了一个采用多种传感器组合的控制... 详细信息

通过响应面分析法对中草药移栽机进行优化设计,以提高中草药种植效率和质量。首先,选取移栽速度、移栽深度和移栽器械倾角3个因素作为设计变量,选取移栽成功率和移栽损伤率作为评价指标;在此基础上,设计了一个采用多种传感器组合的控制系统,采用模糊控制算法进行控制,并通过试验得到的数据进行响应面分析,得出了最优设计方案。研究结果表明:最优移栽速度为0.2 m/s,最优移栽深度为15 cm,最优移栽器械倾角为25°;通过优化设计,中草药移栽机的移栽成功率提高了11.8%,移栽损伤率降低了9.6%,取得了较好的效果。

关键词：移裁机响应面分析参数优化多传感器中草药

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis