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Acupoint application therapies for essential hypertension:a systematic review and Meta-analysis

Journal of Traditional Chinese Medicine 2022年第2期42卷 159-166页

作者： LIU Wei XIONG xingjiang QIAO Lumin CHEN Yuyi LI Yixuan SU xing chu Fuyong LIU Hongxu Department of Cardiology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Department of Cardiology Guang′anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Emergency Yinchuan Chinese Medicine HospitalNingxia 750001China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Community Healthcare Center of Shangzhuang Town Beijing 100053China Department of Medical Administration Division Beijing Mentougou Hospital of Traditional Chinese MedicineBeijing 102300China

OBJECTIVE:To evaluate the efficacy and safety of acupoint application therapies(AA)for ***:We searched Pub Med,EMBASE,the Cochrane Center Controlled Trials Register,Chinese National Knowledge Infrastructure,Chinese Scientific Journal Database,and Wanfang Med Online Database from their inceptions to October 7,*** language restriction was *** included randomized clinical trials testing AA against Western Medicine,AA versus placebo,AA combined with Western Medicine versus Western *** selection,data extraction,quality assessment,and data analyses were conducted according to the Cochrane ***:Totally 41 trials with 3772 participants were *** methodological quality of the included trials was evaluated as generally *** plus Western Medicine significantly lowered systolic blood pressure(BP)[weighted mean difference(WMD):-10.36,95%confidence intervals(CI):-12.62,-8.10;P<0.00001],diastolic BP(WMD:-5.71,95%CI:-7.30,-4.13;P<0.00001),and total effect[risk ratio(RR):1.23,95%CI:1.15,1.32;P<0.00001].The BP-lowering effect of AA was significantly higher than that of placebo[systolic BP(SBP):-8.05,95%CI:-8.67,-7.43;P<0.00001;diastolic BP(DBP):-6.66,95%CI:-7.31,-6.01,P<0.00001].The total effect also improved significantly from baseline with AA than placebo(RR:10.85,95%CI:4.71,24.98;P<0.00001).Traditional Chinese Medicine symptoms score were significantly reduced by AA compared with Western Medicine(WMD:-1.75,95%CI:-2.52,-0.99;P<0.00001),10 trials reported adverse events,indicating that the safety of SSYX Capsule is still ***:Application therapies may be considered a safe and beneficial for the treatment of hypertension and can reduce BP and improve the total *** well-designed trials are needed to support our conclusions.

关键词： hypertension systematic review acupoint application

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High-resolution gene mapping using admixture linkage disequilibrium

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Chinese Science Bulletin 2002年第20期47卷 1717-1719页

作者： TAO Shiheng chu Jianhua LIU Xiaoming ZHANG Rongmei ZHANG zhen LUO Zewei College of Life Science Northwest Sci.&Tech.University of Agriculture and ForestryYangling 712100China Laboratory of Population and Quantitative Genetics Institute of GeneticsSchool of Life ScienceFudan UniversityShanghai 200433China

This note reports simulation study on the rate of decay in linkage disequilibrium (LD) in mixed populations over multiple discrete generations and explores the usefulness of the LD analysis in high-resolution gene mapping. The results indicate that the smaller the recombination fraction and the fewer generations since admixture event, the higher power of the approach in gene mapping. The expected estimate of recombination fraction would give an estimate that is slightly biased upwards, if relevant genes are in tight linkage. The estimated recombination fraction is usually larger than the true value within 2-5 generations. From generations 10-20, the mean estimates are in good agreement with the true value. The method presented here enables estimation of means and corresponding confidence intervals of the recombination fraction at any number of generations.

关键词： gene mapping computer simulation model admixture finite populations.

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hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation

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Protein & Cell 2015年第10期6卷 767-770页

作者： Yingying xing Qiaoyun chu Run Feng Wei Wang Lixin Liu Zhongbing Lu College of Life Sciences University of Chinese Academy of Science Beijing 100049 China Key Laboratory for Polymeric Composite and Functional Materialsof Ministry of Education School of Chemistry and ChemicalEngineering Sun Yat-Sen University Guangzhou 510275 China School of Medical Science Edith Cowan University Joondalup WA 6027 Australia Department of Biochemistry and Molecular Biology Capital Medical University Beijing 10069 China

hCLP46 （human CAP10-1ike protein 46 kDa） was initially isolated and identified from human acute myeloid leukemia transformed from myelodysplastic syndrome （MDS-AML） CD34＋ cells （Teng et al., 2006） and we demons... 详细信息

关键词： inhibiting ubiquitin-proteasomal degradation

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Si-Miao-Yong-An Decoction alleviates thromboangiitis obliterans by regulating miR-548j-5p/IL-17A signaling pathway

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Chinese Journal of Natural Medicines 2024年第6期22卷 541-553页

作者： chu chu SUN Shangwen ZHANG zhen WU Qi LI Haoyang LIANG Gang MIAO Xiuming JIANG Haiqiang GAO Yan ZHANG Yunhong WANG Bin LI Xia Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remod-eling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan 250012China School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJinan 271016China Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014China International Business School Tianjin Foreign Studies UniversityTianjin 300204China Institute of Pharmaceutical Research Shandong University of Traditional Chinese MedicineJinan 250355China

Thromboangiitis obliterans(TAO)is a rare,chronic,progressive,and segmental inflammatory disease characterized by a high rate of amputation,significantly compromising the quality of life of ***-Miao-Yong-An decoction(SMYA),a tradition-al prescription,exhibits anti-inflammatory,anti-thrombotic,and various other pharmacological ***,it was fully proved to be effective for TAO therapy,but the specific therapeutic effect of SMYA on TAO has been ***,deep unveiling the mechanism of SMYA in TAO for identifying clinical therapeutic targets is extremely *** this study,we observed elev-ated levels of IL-17A in the peripheral blood mononuclear cells(PBMCs)of TAO patients,whereas the expression of miR-548j-5p was significantly decreased.A negative correlation between the levels of miR-548j-5p and IL-17A was also *** vitro ex-periments showed that overexpression of miR-548j-5p led to a decrease in IL-17A levels,whereas downregulation of miR-548j-5p showed the opposite *** a dual luciferase assay,we confirmed that miR-548j-5p directly targets ***,serum containing SMYA effectively decreased IL-17A levels by increasing the expression of *** importantly,the results of in vivo tests indicated that SMYA mitigated the development of TAO by inhibiting IL-17A through the upregulation of miR-548j-5p in vascular *** conclusion,SMYA significantly enhances the expression of miR-548j-5p,thereby reducing the levels of the target gene IL-17A and alleviating *** research not only identifies novel targets and pathways for the clinical diagnosis and treatment of TAO but also advances the innovation in traditional Chinese medicine through the elucidation of the SMYA/miR-548j-5p/IL-17A regulatory axis in the pathogenesis of TAO.

关键词： Thromboangiitis obliterans IL-17A Inflammation miR-548j-5p Si-Miao-Yong-An Decoction

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Small-molecule inhibitor of smoothend suppress neuroinflammation through hedgehog signaling independent mechanisms

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中国药理学与毒理学杂志 2018年第9期32卷 706-707页

作者： CAO Zhong-qiang zhen Xue-chu zhenG Long-tai Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow University Suzhou 215123 China

OBJECTIVE Microglial activation mediated neuroinflammation plays an important role in the progression of neurodegerative *** purpose of this study was to investigate the effect of small-molecule inhibitors of smoothend(Smo) on microglial activation mediate *** To search for the novel anti-neuroinflammatory agents,the BV-2 cel-based nitric oxide(NO) assay was used to screen a series of small-molecule inhibitors of *** production of NO and cell viability were detected by Griess and MTT assay *** expression of inflammatory factors were evaluated by Real-time quantitative PCR or Western blotting or ELISA assay,and activation of signal molecules were detected by Western *** dopaminergic neuronal cell apoptosis were measured by flow *** stereotaxic injection of LPS into the mice Substantia Nigra(SN) were employed to establish animal model of neuroinflammation and immunofluorescence staining on brain slices sections were used to verify microglial activation and dopaminergic cell *** To search for the compounds that inhibit microglial activation,we have screened a series of Smo inhibitors(0.01-40 μmol·L^(-1)) for the activity to inhibit NO production in BV-2 microglia *** the Smo inhibitors tested,Hh-079 strongly inhibited LPS-induced microglial NO production without affecting the cell ***-079 significantly inhibited the expression of proinflammatory factors in LPSstimulated BV-2 microglial ***-079 inhibited phosphorylation of IKKα/β,phosphorylation and degradation of IκBα,phosphorylation of P65 subunit of NF-κB and NF-κB transcriptional activity in LPS-stimulated BV-2 microglial ***-079 reduced cytotoxicity of conditioned media of activated microglia toward HT-22 neuroblastoma cells in a co-culture *** studies demonstrated that among the Shh-Ptch-Gli pathway,microglia cells did not express detectable levels of Shh,Smo and ***,neither Smo inhibit

关键词： smoothend inhibitor Hh-079 neuroinflammation microglia

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Self-assembled TiO_(2)hole-blocking layers for efficient perovskite solar cells

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1280-1285页

作者： Zhongbao Que Liang chu Shuaibo Zhai Yifei Feng Chen Chen Wei Liu Ruiyuan Hu Jing Hu xing’ao Li New Energy Technology Engineering Laboratory of Jiangsu Province&School of Science&School of Materials Science and Engineering&School of Electronic and Optic Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China

The self-assembly process for compatible functional layers of devices is a simple,feasible,and energy-saving *** mesoporous perovskite solar cells(PSCs),compact and scaffold TiO_(2) films generally function as the hole-blocking and electron-transporting layers,***,both of these layers are usually generated through a high-temperature annealing ***,we deposited TiO_(2) compact films through a room-temperature self-assembly process as effective hole-blocking layers for *** thickness of TiO_(2) compact films can be easily controlled by the deposition *** the optimization of TiO_(2) compact films(80 nm),the power conversion efficiency(PCE)of mesoporous PSCs without and with hole conductor layers increases up to 10.66%and 17.95%,***,an all-low-temperature planar PSC with the self-assembled TiO_(2) layer exhibits a PCE of 16.41%.

关键词： perovskite solar cells titanium dioxide self-assembly power conversion efficiency

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Highly conductive dodecaborate/MXene composites for high performance supercapacitors

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Nano Research 2020年第1期13卷 196-202页

作者： zhenxing Li Chang Ma Yangyang Wen Zhiting Wei Xiaofei xing Junmei chu Chengcheng Yu Kaili Wang Zhao-Kui Wang Key Laboratory of Heavy Oil Processing Institute of New EnergyChina University of Petroleum(Beijing)Beijing102249China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou215123China

With the increasingly prominent energy and environmental issues,the supercapacitors,as a highly efficient and clean energy conversion and storage devices,meet the requirements ***,it is still a challenge to enhance the capacitance and energy density of supercapacitors.A novel and highly conductive dodecaborate/MXene composites have been designed for high performance *** surface charge property of MXene was modified by a simple ultrasonic treatment with ammonium ion,and the dodecaborate ion can be inserted into the inner surface of MXene by electrostatic *** to the unique icosahedral cage conjugate structure formed by the B-B bond and the highly delocalized three-dimensionalπbond structure of the electrons,the negative charge is delocalied on the whole dodecaborate ion,which reduces the ability to bind to ***,the cations can move easily,and the dodecaborate can act as a“lubricant”for ion diffusion between the MXene layers,which significantly improves the ion transfer rate of *** dodecaborate/MXene composites can achieve an extremely high specific capacitance of 366 F.g^-1 at a scan rate of 2 mV.s^-1,which is more than eight times higher than that of MXene(43 F1-)at the same scan *** finding provides a novel route on the fabrication of the high performance supercapacitors.

关键词： dodecaborate MXene supercapacitors electrostatic adsorption

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Total decay width of H → gg using the infinite-order scale-setting approach based on intrinsic conformality

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Chinese Physics C 2022年第12期46卷 172-178页

作者： chu-Tian Gao xing-Gang Wu Xu-Dong Huang Jun Zeng Department of Physics Chongqing Key Laboratory for Strongly Coupled PhysicsChongqing UniversityChongqing 401331China Institute of High Energy Physics CASBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China INPAC Key Laboratory for Particle Astrophysics and Cosmology(MOE)Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China

We conducted a detailed study on the properties of the total decay width of the Higgs decay channel H→gg up toα_(s)^(6)-order QCD corrections by using the newly suggested infinite-order scale-setting approach,which is based on both the principle of maximum conformality and intrinsic *** approach is called PMC_(∞) By using the PMC_(∞)approach,we observed that the conventional renormalization scale ambiguity in perturbative QCD calculation is eliminated,and the residual scale dependence due to unknown higher-order terms can also be highly *** then obtained an accurate perturbative QCD prediction on the total decay width,e.g.,Г(H→gg)|PMC_(∞)=336.42_(-6.92)^(+7.01)keV,where the errors are squared averages of those from all the mentioned error sources.

关键词： pQCD renormalization Higgs decay

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Memristive Artificial Synapses for Neuromorphic Computing

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Nano-Micro Letters 2021年第5期13卷 218-245页

作者： Wen Huang Xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang Liang chu xing’ao Li New Energy Technology Engineering Laboratory of Jiangsu Province and School of Science Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced MaterialsSchool of Materials Science and EngineeringNanjing University of Posts and Telecommunications(NUPT)9 Wenyuan RoadNanjing 210023People’s Republic of China College of Electronic and Optical Engineering and College of Microelectronics Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195‑2120USA

Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann *** computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary *** synaptic functions with these devices is critical in neuromorphic *** the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic *** this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical *** working mechanisms of the devices are analyzed in *** is followed by a discussion of the progress in mimicking synaptic *** addition,existing application scenarios of various synaptic devices are ***,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected.

关键词： Synaptic devices Neuromorphic computing Electrical pulses Optical pulses Photoelectric synergetic effects

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肌电生物反馈疗法与脊髓损伤患者运动功能的恢复

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中国组织工程研究 2025年第14期29卷 3002-3010页

作者：梁佳佳孙姣姣刘文洁邢政李奇李庆雯褚晓蕾天津体育学院运动健康学院天津市301617 天津市天津医院天津市300211

背景:肌电生物反馈技术具有非侵入性、实时反馈、个性化治疗和促进神经可塑性等独特优势,加速了脊髓损伤患者的功能恢复。目的:综述肌电生物反馈联合运动疗法、外骨骼机器人以及虚拟现实技术在脊髓损伤运动功能恢复中的应用现状及治疗... 详细信息

背景:肌电生物反馈技术具有非侵入性、实时反馈、个性化治疗和促进神经可塑性等独特优势,加速了脊髓损伤患者的功能恢复。目的:综述肌电生物反馈联合运动疗法、外骨骼机器人以及虚拟现实技术在脊髓损伤运动功能恢复中的应用现状及治疗效果。方法:应用计算机检索中国知网、PubMed数据库建库至2024年5月期间的相关文献,英文检索词为“Spinal cord injury,EMG biofeedback,physical therapy,robotic exoskeleton,VR,motor function,exercise”,中文检索词为“脊髓损伤,肌电生物反馈,运动疗法,外骨骼机器人,虚拟现实,运动功能,运动”,最终纳入71篇文献进行综述。结果与结论:肌电生物反馈疗法促进脊髓损伤康复的机制包括促进神经可塑性变化、增强神经肌肉连接和改善运动模式。肌电生物反馈作为新兴的技术手段,通常与运动疗法、外骨骼机器人以及虚拟现实联合用于脊髓损伤后运动功能的恢复,综合治疗效果得到明显提升。然而目前仍存在一些问题和挑战,例如缺乏机制的详细解析、缺少为结合疗效提供有力证据的大规模试验、技术适应性有限等。未来的研究可以集中在这些方面:提高肌电生物反馈的个性化和精准性;可以探索将肌电生物反馈与更先进的技术或工学设备相结合开发新型康复设备,扩大应用领域;将肌电生物反馈应用到步态训练系统、呼吸训练系统以及四肢联动康复系统中,提高反馈的准确性和个性化治疗方案的效果,同时提高设备的易用性和舒适性。

关键词：脊髓损伤肌电生物反馈运动疗法外骨骼机器人联合治疗运动康复

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