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Disparity of human immunodeficiency virus incidence and drug resistance in college student,non-student youth and older men who have sex with men:a cross-sectional study from seven major cities of China

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Chinese Medical Journal 2020年第23期133卷 2778-2786页

作者： Jing Zhang Jun-Jie Xu zhen-xing chu Qing-Hai Hu Xiao-Xu Han Bin Zhao Yong-Jun Jiang Wen-Qing Geng Hong Shang NHC Key Laboratory of AIDS Immunology(China Medical University) National Clinical Research Center for Laboratory MedicineThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of AIDS Immunology Chinese Academy of Medical SciencesShenyangLiaoning 110001China Key Laboratory of AIDS Immunology of Liaoning Province ShenyangLiaoning 110001China

Background:Human immunodeficiency virus(HIV)prevalence among student men who have sex with men(MSM)in college is more than 5.0%and keeps on increasing in *** study aims to clarify the proportion of HIV recent infection,its propeller and the source among college student ***:We conducted a multicenter cross-sectional study in seven major Chinese cities during *** recent infections(≤168 days)and incidence was measured and estimated by BED HIV-1 capture enzyme immunoassay(BED-CEIA)testing ***-related behaviors and transmitted drug resistance(TDR)were investigated and compared between the college student MSM,<25-year-old non-student youth MSM(NSYM),and≥25-year-old non-student non-youth MSM(NSNYM),using structured survey,and analyses of drug ***:Overall,4496(4496/4526,99.3%)were eligible for enrollment,comprising 565 college student MSM,1094 NSYM,and 2837 *** proportion of HIV recent infection were 70.3%(26/37),50.8%(65/128)and 35.1%(95/271),the HIV incidence rate were 10.0(95%CI:6.2-13.9)/100 person-year(PY),12.9(95%CI:9.8-16.1)/100PY,6.8(95%CI:5.4-8.2)/100 PY,and TDR prevalences were 7.4%(2/27),2.0%,(2/98)and 4.9%(11/226),among student MSM,NSYM,and NSNYM,*** HIV positive student MSM with age<21 years,the proportion of HIV recent infection is 90.9%(10/11).Factors independently associated with HIV recent infection in student MSM was usage of recreational drug in the past 6 months(adjusted odds ratio[aOR]:2.5;95%CI:1.0-5.8).Conclusions:College student MSM had higher proportion of HIV recent infection and TDR than the youth and older MSM in China during *** HIV infections were more likely to happen during the early year of college life among student MSM.

关键词： HIV incidence Drug resistance Men who have sex with men Male Students Cross-sectional studies Sexual behavior

Electrocatalytic nitrite reduction to ammonia on isolated bismuth alloyed ruthenium

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Journal of Energy Chemistry 2025年第1期100卷 369-376页

作者： Shiyao Shang Fuzhou Wang Zeyi Sun Chaofan Qiang Ke chu School of Materials Science and Engineering Lanzhou Jiaotong University

Electrochemical reduction of NO2-to NH3（NO2-RR） is recognized as an appealing approach for achieving renewable NH3synthesis and waste ***,we report isolated Bi alloyed Ru （Bi1Ru） as an efficient NO2-RR *** calculations and in situ electrochemical measurements reveal the creation of Bi1-Ru dual sites which can remarkably promote NO2-activation and suppress proton adsorption,while accelerating the NO2-RR protonation energetics to render a high NO2--to-NH3conversion ***,Bi1Ru assembled in a flow cell delivers an NH3yield rate of 1901.4μmol h-1cm-2and an NH3-Faradaic efficiency of 94.3%at an industrial-level current density of 324.3 mA *** study offers new perspectives for designing and constructing p-block single-atom alloys as robust and high-current-density NO2-RR catalysts toward the ammonia electrosynthesis.

关键词： Ammonia

Prevention and control of HIV/AIDS in China:lessons from the past three decades

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Chinese Medical Journal 2021年第23期134卷 2799-2809页

作者： Jun-Jie Xu Meng-Jie Han Yong-Jun Jiang Hai-Bo Ding Xi Li Xiao-Xu Han Fan Lv Qing-Feng Chen Zi-Ning Zhang Hua-Lu Cui Wen-Qing Geng Jing Zhang Qi Wang Jing Kang Xiao-Lin Li Hong Sun Ya-Jing Fu Ming-Hui An Qing-Hai Hu zhen-xing chu Ying-Jie Liu Hong Shang NHC Key Laboratory of AIDS Immunology(China Medical University) National Clinical Research Center for Laboratory MedicineThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of AIDS Immunology of Liaoning Province The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of AIDS Immunology Chinese Academy of Medical SciencesShenyangLiaoning 110001China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouZhejiang 310003China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseasesFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China.

In the past 37 years,human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)has undergone various major transmission routes in China,with the world most complex co-circulating HIV-1 subtypes,even the prevalence is still *** response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection,China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing,which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related *** has been providing free antiretroviral therapy(ART)since 2003,which covered>80%of the identified patients and achieved a viral suppression rate of 91%.To bend the curve of increasing the disease burden of HIV and finally end the epidemic,China should consider constraining HIV spread through sexual transmission,narrowing the gaps in identifying HIV cases,and the long-term effectiveness and safety of ART in the future.

关键词： Human immunodeficiency virus Acquired immunodeficiency syndrome Antiretroviral therapy Transmission route HIV-1 subtype

Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期68卷 152-156页

作者： Lihua Zhang Lingjing Chen Huatian Shi Yue Wei Gui Chen Tai-chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

关键词： photocatalysis noble metal-free CO2 reduction formate cobalt hydride

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang Ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng Xi Yanling Lou Liucheng Meng Chao Deng Youlu chu Zhaoyang Xu Huining Xiao Weibing Wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： Lei Zhang Lingfeng Kuang Lianke Zhang Wen chu Haiying Qin Jing Zhang Junjing He Hualiang Ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental Engineering Hangzhou Dianzi University School of Materials Science and Engineering Zhejiang University Key Laboratory of MEMS of Ministry of Education School of Integrated Circuits Southeast University

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides（HEOs/C）,specifically （PtFeCoNiCu）O/C,using a carbothermal shock （CTS） method for application as a cathode catalyst in direct borohydride fuel cells （DBFCs）.The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared （PtFeCoNiCu）O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H2O2yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).Furthermore,after 40,000 cycles of cyclic voltammetry（CV） testing,the half-wave potential of （PtFeCoNiCu）O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** （PtFeCoNiCu）O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm-2at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that HEO/C is a promising cathode catalyst for DBFCs.

关键词： Direct borohydride fuel cells (DBFC)

Effect of Temperature on the Dynamic Recrystallization of AZ31 Alloy with Pulse Current

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1281-1286页

作者： Shu-Xia Lin xing-Rong chu zhen-Ming Yue Jun Gao School of Mechanical Electrical and Information Engineering Shandong University

The tensile tests of AZ31 magnesium alloy were carried out under room temperature, 100, 150 and 200 ℃ with andwithout pulse current. The effect of temperature on dynamic recrystallization （DRX） of AZ31 alloy was studied at differentconditions. One-parameter approach was used to analyze the critical conditions of DRX, the critical stress was obtainedunder different temperatures, and the related results were validated by metallography observation. The results showed thatDRX of AZ31 alloy occurred at 200 ℃ without pulse current. When pulse current with 150 Hz/50 V parameter wasapplied at room temperature, DRX occurred, while DRX was not completed until temperature over 150 ~C. With theanalysis result of critical conditions of DRX based on one-parameter approach, the relationship between critical stress andpeak stress obtained in this present study is σc = （0.746-0.773）σp.

关键词： AZ31 alloy Electroplasticity Dynamic recrystallization One-parameter approach

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang chu Zhicheng Lin Tianyuan Fang Yuyu Zhou chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites