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Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients

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Military Medical Research 2019年第3期6卷 189-200页

作者： Gang Lv Guo-Qiang Wang zhen-xi xia Hai-xia Wang Nan Liu Wei Wei Yong-Hua Huang Wei-Wei Zhang Department of General Surgery 309 Hospital of Chinese People’s Liberation ArmyBeijing 100091China Department of Neurology Chinese PLA Army General HospitalBeijing 100700China.

Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor ***: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 4

关键词： Acute cerebral infarction Hemorrhagic transformation Total cholesterol Low-density lipoprotein Intensive lipid-lowering statins Anti-platelet Atrial fibrillation modified Rankin scale

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei xi zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao xia Jianing LIANG Yuhao JIANG Zhiyang PENG Jiaxu LI Chen xiaO Renyou XU Wenwen WANG xiantao SHANG Shiyang LU Dapeng ZHU Hong-xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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Electro-generation of TGA by Ni-mSA-mCS bipolar membrane

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Chinese Chemical Letters 2007年第11期18卷 1411-1415页

作者： zhen xia Huang xi zheng Ri Yao Chen xiao Chen zhen Chen Experiment Center College of Chemistry and Materials Science Fujian Normal University Fuzhou 350007 China

Ni-mSA-mCS bipolar membrane （BM） was prepared by sodium alginate （SA） and chitosan （CS）, which were modified by Ca^2＋ and glutaraldehyde as linking reagents, respectively, mSA-mCS membrane was characterized by FTIR, SEM, TG and used as a separator in the electrolysis cell to produce thioglycolic acid （TGA）. The experiment results show that TGAwas prepared effectively by electro-reduction of dithiodiglycolic acid （DTDGA） with the mixture of TGA and DTDGA in the cathodic chamber. The current efficiency was up to 66.7% at the room temperature （25 ℃） during the current density of 10 mA/cm^2. Compared with the traditional metal reduction method, the electro-reduction technology saves the zinc powder and eliminates the pollution to environment.

关键词： Bipolar membrane Modified sodium alginate Modified chitosan Thioglycolic acid Dithiodiglycolic acid

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Ratiometric mode with dyads: a breakthrough in dynamic trapping and quantification for redox regulation in living cells

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Science China Chemistry 2015年第3期58卷 434-435页

作者： zhen xi College of Chemistry Nankai University

Redox-based post-translational modification of protein thiols has become an attractive strategy in cellular homeostasis and cell signaling. Due to the reductive end of the redox buffer network, the vicinal dithiol-containing proteins （VDPs） maintains an appropriate oxidation-reduction state of proteins through the reversible transformation from vicinal dithiols to disulfide, which is responsible for a variety of diseases, such as cancer, diabetes and neuro-degeneration.

关键词：氧化还原状态活细胞调控诱捕比例蛋白质二硫醇细胞信号

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A Study on the Technique of Observing Interplanetary Scintillation with Simultaneous Dual-Frequency Measurements

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Chinese Journal of Astronomy and Astrophysics 2007年第5期7卷 712-720页

作者： xi-zhen Zhang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

Ground-based observation of Interplanetary Scintillation （IPS） is an important approach of monitoring solar wind speed. We describe both the principle and method of observing the solar wind speed by using the normalized cross-spectrum of simultaneous dualfrequency IPS measurement. The effects of the solar wind properties and the angular size of the scintillation source on the measurement of solar wind speed are investigated by numerical analysis. We carry out a comparison of this method with the traditional single station-single frequency method. We outline a new IPS observation system using this method now under construction at the National Astronomical Observatories, CAS （NAOC）.

关键词： interplanetary scintillation -- method -- instrument -- telescope

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Analytic prediction for planar turbulent boundary layers

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Science China(Physics,Mechanics & Astronomy) 2016年第11期59卷 51-57页

作者： xi Chen zhen-Su She State Key Laboratory for Turbulence and Complex Systems and Department of Mechanics College of EngineeringPeking University

Analytic predictions of mean velocity profile(MVP) and streamwise(x) development of related integral quantities are presented for flows in channel and turbulent boundary layer(TBL), based on a symmetry analysis of eddy length and total stress. Specific predictions include the relations for momentum Reynolds number(Reθ) with friction Reτ and streamwise Re_x: Re_θ≈ 3.27Re_τ,and Re_x/Re_θ = 4.94(lnRe_θ + 1.88)~2 + 1; the streamwise development of the friction velocity u_τ: U_e/u_τ≈ 2.22 lnRe_x + 2.86. 3.83ln(lnRe_x), and of the boundary layer thickness δ_e: x/δ_e ≈ 7.27 lnRe_x.5.***.12.52ln(lnRe_x), which are fully validated by recent reliable data.

关键词： turbulent boundary layer symmetry analysis eddy length log law

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THE INVERSE PROBLEM OF CENTROSYMMETRICMATRICES WITH A SUBMATRIX CONSTRAINT

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Journal of Computational Mathematics 2004年第4期22卷 535-544页

作者： zhen-yunPeng xi-yanHu LeiZhang DepartmentofMathematics HunanUniversityofScienceandTechnologyXiangtan411201China (CollegeofMathematicsandEconometrics HunanUniversityChangsha410082China

By using Moore-Penrose generalized inverse and the general singular value decomposition of matrices, this paper establishes the necessary and sufficient conditions for the existence of and the expressions for the centrosymmetric solutions with a submatrix constraint of matrix inverse problem AX = B. In addition, in the solution set of corresponding problem, the expression of the optimal approximation solution to a given matrix is derived.

关键词： Centrosymmetric matrix Inverse problem Matrix norm Optimal approximation

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Performance of hybrid constructed wetland systems for treating septic tank effluent

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Journal of Environmental Sciences 2006年第4期18卷 665-669页

作者： CUI Li-hua LIU Wen ZHUxi-zhen MA Mei HUANG xi-hua xia Yan-yang Department of Environmental Science and Engineering South China Agricultural University Guangzhou 510642 China Coast to Coast Analytical Specialists Garland TX 75081 USA

The integrated wetland systems were constructed by combining horizontal-flow and vertical-flow bed, and their purification efficiencies for septic tank effluent were detected when the hydraulic retention time （HRT） was 1 d, 3 d, 5 d under different seasons. The results showed that the removal efficiencies of the organics, phosphorus were steady in the hybrid systems, but the removal efficiency of total nitrogen was not steady due to high total nitrogen concentration in the septic tank effluent. The average removal rates of COD （chemical oxygen demand） were 89%, 87%, 83%, and 86% in summer, autumn, winter and spring, respectively, and it was up to 88%, 85%, 73%, and 74% for BOD5 （5 d biochemical oxygen demand） removal rate in four seasons. The average removal rates of TP （total phosphorous） could reach up to 97%, 98%, 95%, 98% in four seasons, but the removal rate of TN （total nitrogen） was very low. The results of this study also indicated that the capability of purification was the worst in winter. Cultivating with plants could improve the treated effluent quality fTom the hybrid systems. The results of the operation of the horizontal-flow and vertical-flow cells （hybrid systems） showed that the removal efficiencies of the organics, TP and TN in horizontal-flow and vertical-flow cells were improved significantly with the extension of HRT under the same season. The removal rate of 3 d HRT was obviously higher than that of 1 d HRT, and the removal rate of 5 d HRT was better than that of 3 d HRT, but the removal efficiency was not very obvious with the increment of HRT. Therefore, 3 d HRT might be recommended in the actual operation of the hybrid systems for economic and technical reasons.

关键词： constructed wetlands hybrid system horizontal-flow vertical-flow removal efficiency septic tank effluent

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Pairwise tagging framework for end-to-end emotion-cause pair extraction

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Frontiers of Computer Science 2023年第2期17卷 111-120页

作者： zhen WU xinyu DAI Rui xia National Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210023China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210023China

Emotion-cause pair extraction(ECPE)aims to extract all the pairs of emotions and corresponding causes in a *** generally contains three subtasks,emotions extraction,causes extraction,and causal relations detection between emotions and *** works adopt pipelined approaches or multi-task learning to address the ECPE ***,the pipelined approaches easily suffer from error propagation in real-world *** multi-task learning cannot optimize all tasks globally and may lead to suboptimal extraction *** address these issues,we propose a novel framework,Pairwise Tagging Framework(PTF),tackling the complete emotion-cause pair extraction in one unified tagging *** prior works,PTF innovatively transforms all subtasks of ECPE,i.e.,emotions extraction,causes extraction,and causal relations detection between emotions and causes,into one unified clause-pair tagging *** this unified tagging task,we can optimize the ECPE task globally and extract more accurate emotion-cause *** validate the feasibility and effectiveness of PTF,we design an end-to-end PTF-based neural network and conduct experiments on the ECPE benchmark *** experimental results show that our method outperforms pipelined approaches significantly and typical multi-task learning approaches.

关键词： emotion-cause pair extraction pairwise tagging framework end-to-end neural network

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