检索结果-南通市图书馆

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

引用

Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG peng MENG CHEN LIN ZHONG LUJI HUANG FU CHENG XINDAN sheng XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel high-performance element in the electromagnetic finite-element method——node-edge element

引用

Journal of Systems Engineering and Electronics 2008年第5期19卷 878-881页

作者： sheng Xinqing peng zhen Center for Electromagnetic Simulation School of Information Science and Technology Beijing Inst. of Technology Beijing 100081 P. R. China

It is known in the computational electromagnetics （CEM） that the node element has a relative wellconditioned matrix, but suffers from the spurious solution problem; whereas the edge element has no spurious solutions, but usually produces an ill-conditioned matrix. Particularly, when the mesh is over dense, the iterative solution of the matrix equation from edge element converges very slowly. Based on the node element and edge element, a node-edge element is presented, which has no spurious solutions and better-conditioned matrix. Numerical experiments demonstrate that the proposed node-edge element is more efficient than now-widely used edge element.

关键词： node-edge element node element edge element matrix condition number.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于DMD的阿达玛变换型近红外光谱仪快速处理系统设计与实现

引用

光谱学与光谱分析 2025年第1期45卷 133-138页

作者：王硕谢振坤魏志鹏长春理工大学高功率半导体激光国家重点实验室吉林长春130022 长春理工大学中山研究院广东中山528437

数字微镜器件(DMD)的近红外光谱仪,具有波长重复性好、分辨率高和抗振动性好等优点,广泛应用于食品安全和农业生产等领域的研究。随着DMD的微小型近红外光谱仪发展逐渐趋于成熟,仪器的成本和性能仍然是研发的关键。尽管大部分将重点放... 详细信息

数字微镜器件(DMD)的近红外光谱仪,具有波长重复性好、分辨率高和抗振动性好等优点,广泛应用于食品安全和农业生产等领域的研究。随着DMD的微小型近红外光谱仪发展逐渐趋于成熟,仪器的成本和性能仍然是研发的关键。尽管大部分将重点放在了软件开发和检测方法的研究,而仪器硬件的处理速度至关重要。只有确保光谱仪能够快速准确的采集并传输数据,才能有效实现光谱分析。在多数研究中,阿达玛矩阵的生成和解码工作通常由上位机完成,并通过FLASH存储的方式导入模板。这种方式可能会限制采集一幅完整光谱数据的时间效率。为了提高光谱采集速度和信噪比,提出一种高速驱动DMD和快速数据采集的方法,并基于DMD微小型近红外光谱仪设计一套硬件电路系统。采用现场可编辑门阵列(FPGA)和ARM的架构,创新性地实现了奇偶阿达玛模板的生成与解码过程在嵌入式系统底层执行,加快了光谱分析的速度并提高信噪比。通过与市面上DMD型光谱仪对比,研究结果显示,所研发的光谱仪完成单次光谱的采集时间仅需214 ms,相比商用DMD型光谱仪,采集效率提升了4倍。在同等3 s的采集时间内,所研发光谱仪的信噪比为4600,相比商用DMD型光谱仪,信噪比提升了1.5倍。通过所研发的光谱仪对油菜籽样品进行光谱扫描,分析了油菜籽的脂肪、蛋白质和水分的含量,并采用偏最小二乘回归(PLSR)建立了相应的模型。油菜籽脂肪含量的校正相关系数为0.9865、预测相关系数为0.9672;蛋白质含量的校正相关系数为0.9854、预测相关系数系数为0.9636;水分含量的校正相关系数为0.9875、预测相关系数为0.9614。模型评估的结果表明,该光谱仪能够满足油菜籽成分检测的需求,验证该光谱仪在商业领域具有重要的应用价值。

关键词：数字微镜器件近红外光谱仪阿达玛信噪比嵌入式油菜籽

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高管限薪方式与国有企业高质量发展

引用

经济问题 2025年第1期 70-78页

作者：吴秋生郑玥臻山西财经大学会计学院山西太原030012

2009年和2015年中华人民共和国人力资源和社会保障部和国务院国有资产监督管理委员会先后出台了国有企业高管限薪规定,采取了绝对限薪和相对限薪两种不同方式,因此,有必要明晰哪一种方式更有利于促进国有企业高质量发展。以2010—2023年... 详细信息

2009年和2015年中华人民共和国人力资源和社会保障部和国务院国有资产监督管理委员会先后出台了国有企业高管限薪规定,采取了绝对限薪和相对限薪两种不同方式,因此,有必要明晰哪一种方式更有利于促进国有企业高质量发展。以2010—2023年的A股国有企业为样本进行研究,结果表明:与绝对限薪相比,相对限薪更能够促进国有企业高质量发展,且相对限薪程度越高、内部控制质量越高,上述关系越明显。进一步研究发现,相对限薪促进国有企业发展质量提高是通过降低盈余管理、提高创新效率等路径实现的,且这种作用路径在产品市场竞争度高的国有企业和实体国有企业中更明显。研究结论对合理制定和有效实施限薪政策及提高企业内部控制质量,促进国有企业高质量发展具有启示意义。

关键词：绝对限薪相对限薪全要素生产率内部控制质量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distribution behavior of phosphorus in the coal-based reduction of high-phosphorus-content oolitic iron ore

引用

International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 331-338页

作者： Yong-sheng Sun Yue-xin Han peng Gao Duo-zhen Ren College of Resources and Civil Engineering Northeastern University

This study focuses on the reduction of phosphorus from high-phosphorus-content oolitic iron ore via coal-based reduction. The distribution behavior of phosphorus （i.e., the phosphorus content and the phosphorus distribution ratio in the metal, slag, and gas phases） during reduction was investigated in detail. Experimental results showed that the distribution behavior of phosphorus was strongly influenced by the reduction temperature, the reduction time, and the C/O molar ratio. A higher temperature and a longer reaction time were more favor-able for phosphorus reduction and enrichment in the metal phase. An increase in the C/O ratio improved phosphorus reduction but also hin-dered the mass transfer of the reduced phosphorus when the C/O ratio exceeded 2.0. According to scanning electron microscopy analysis, the iron ore was transformed from an integral structure to metal and slag fractions during the reduction process. Apatite in the ore was reduced to P, and the reduced P was mainly enriched in the metal phase. These results suggest that the proposed method may enable utilization of high-phosphorus-content oolitic iron ore resources.

关键词： iron ores phosphorus ore reduction pyrometallurgy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modulation of d-orbital to realize enriched electronic cobalt sites in cobalt sulfide for enhanced hydrogen evolution in electrocatalytic water/seawater splitting

引用

Rare Metals 2024年第2期43卷 511-521页

作者： Jian-peng Sun Yu zheng Zi-sheng Zhang Xiang-Chao Meng Zi-zhen Li Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao266100China Shanxi Institute of Energy Taiyuan030600China Department of Chemical and Biological Engineering Faculty of EngineeringUniversity of OttawaOttawaONK1N6 N5Canada

Herein,a novel single-atomic Pt doping and interface-rich CoS/Co(OH)_(2)(Pt-CoS/Co(OH)_(2)/C)electrocatalyst has been successfully *** from precise regulation of d-orbital electronic structure modulation on Co site,Pt-CoS/Co(OH)_(2)/C exhibited remarkable HER activity and high stability for hydrogen evolution in splitting both water(73 mV@10 mA·cm^(−2)) and seawater(87 mV@10 mA·cm^(−2)).Notably,atomic Pt doping was introduced into CoS/Co(OH)_(2),which could produce local unbalanced Coulombic force and significantly increased the number of S vacancies,and then expose abundant Co ***,Co(OH)_(2) in Pt-CoS/Co(OH)_(2)/C could act as the adsorption sites for H_(2)O in hydrogen evolution reaction *** functional theory results also proved that atomic Pt doping,S vacancies and Co(OH)_(2) coupling could result in the formation of enriched electronic Co sites and optimize d_(z2) orbital electronic structure,and then realize the depth upward shift of d-band center and enhance the adsorption of H*on Co sites.

关键词： Electrocatalysts Hydrogen evolution reaction Pt-CoS/Co(OH)_(2) d-band center Electronic structure Water/seawater electrolysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recovery of iron from high phosphorus oolitic iron ore using coal-based reduction followed by magnetic separation

引用

International Journal of Minerals,Metallurgy and Materials 2013年第5期20卷 411-419页

作者： Yong-sheng Sun Yue-xin Han peng Gao Ze-hong Wang Duo-zhen Ren College of Resources and Civil Engineering Northeastern University

Oolitic iron ore is one of the most important iron resources. This paper reports the recovery of iron from high phosphorus oolitic iron ore using coal-based reduction and magnetic separation. The influences of reduction temperature, reduction time, C/O mole ratio, and CaO content on the metallization degree and iron recovery were investigated in detail. Experimental results show that reduced products with the metallization degree of 95.82% could be produced under the optimal conditions （i.e., reduction temperature, 1250℃; reduction time, 50 min; C/O mole ratio, 2.0; and CaO content, 10wt%）. The magnetic concentrate containing 89.63wt% Fe with the iron recovery of 96.21% was obtained. According to the mineralogical and morphologic analysis, the iron minerals had been reduced and iron was mainly enriched into the metallic iron phase embedded in the slag matrix in the form of spherical particles. Apatite was also reduced to phosphorus, which partially migrated into the metallic iron phase.

关键词： oolitic iron ore iron ore reduction magnetic separation phosphorus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kondo screening cloud in a superconductor with mixed s-wave and p-wave pairing states

引用

Chinese Physics B 2022年第10期31卷 478-487页

作者： zhen-zhen Huang Xiong-Tao peng Wan-sheng Wang Jin-Hua Sun School of Physical Science and Technology Ningbo UniversityNingbo 315211China

We study the Kondo screening of a spin-1/2 magnetic impurity coupled to a superconductor,which is fabricated by combination of an s-wave superconductor,a ferromagnet and a semiconductor with Rashba spin-orbit coupling(RSOC).The proximity induced superconducting states include the s-wave and p-wave pairing components with the aids of RSOC,and the ferromagnet induces a Zeeman field which removes the spin degeneracy of the quasiparticles in the triplet ***,the Kondo screening of magnetic impurity involves the orbital degrees of freedom,and is also affected by the Zeeman *** the variational method,we calculate the binding energy and the spin-spin correlation between the magnetic impurity and the electrons in the coexisting s-wave and p-wave pairing *** find that Kondo singlet forms more easily with stronger RSOC,but Zeeman field in general decreases the binding *** spin-spin correlation decays fast in the vicinity of the magnetic *** to the RSOC,the spatial spin-spin correlation becomes highly anisotropic,and the Zeeman field can induce extra asymmetry to the off-diagonal components of the spin-spin *** study can offer some insights into the studies of extrinsic topological superconductors fabricated from the hybrid structures containing chains of magnetic impurities.

关键词： Kondo effect Rashba spin-orbit couplings p-wave superconductors Anderson model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparative study on the removal technologies of 2-methylisoborneol(MIB) in drinking water

引用

Journal of Environmental Sciences 2006年第1期18卷 47-51页

作者： LIANG Cun-zhen WANG Dong-sheng GE Xiao-peng YANG Min SUN Wei State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Beijing 100085 China Department of Environmental Engineering Beijing Institute of Petrochemical Technology Beijing 102617 China

Removal of 2-methylisoborneol （MIB） in drinking water by ozone, powdered activated carbon （PAC）, potassium permanganate and potassium ferrate was investigated. The adsorption kinetics of MIB by both wood-based and coat-based PACs show that main removal of MIB occurs within contact time of 1 h. Compared with the wood-based PAC, the coat-based PAC evidently improved the removal efficiency of MIB. The removal percentage of trace MIB at any given time for a particular carbon dosage was irrelative to the initial concentration of MIB. A series of experiments were performed to determine the effect of pH on the ozonation of MIB. The results show that pH has a significant effect on the ozonation of MIB. It is conclusive that potassium permanganate and potassium ferrate are ineffective in removing the MIB in drinking water.

关键词： odor MIB ozonation powdered activated carbon potassium permanganate potassium ferrate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

带扇叶形锚固板钢筋机械锚固性能试验研究

引用

工程力学 2025年第1期42卷 74-82页

作者：吴琛姚鹏飞陈真锋邓芬福建理工大学福建省土木工程新技术与信息化重点实验室福州350118 锦曦控股集团有限公司福州350017

为避免型钢混凝土节点钢筋锚固时导致的大量型钢穿孔或钢筋焊接，设计一种新型扇叶形锚固板，并通过带扇叶形锚固板钢筋中心拔出试验，分析锚固板形式、钢筋直径、锚固长度对带锚固板钢筋机械锚固性能的影响。试验结果表明：带扇叶型锚... 详细信息

为避免型钢混凝土节点钢筋锚固时导致的大量型钢穿孔或钢筋焊接，设计一种新型扇叶形锚固板，并通过带扇叶形锚固板钢筋中心拔出试验，分析锚固板形式、钢筋直径、锚固长度对带锚固板钢筋机械锚固性能的影响。试验结果表明：带扇叶型锚固板钢筋可避开抗剪栓钉，具有施工方便的优点，同时拥有良好的锚固性能;当钢筋锚固长度为5d~7d时，发生混凝土劈裂破坏，当锚固长度为8d~12d时，发生钢筋拉断破坏，且钢筋的锚固系数大于1.25，具有良好的锚固性能;带扇叶形锚固板钢筋极限粘结强度随钢筋直径、钢筋锚固长度增大而减小，建议钢筋的锚固长度取为8d;提出了适用于带扇叶形锚固板钢筋极限粘结强度的计算公式，能较准确地反映扇叶形锚固板对混凝土产生的挤压和劈裂作用。

关键词：扇叶型锚固板中心拔出试验机械锚固性能极限粘结强度型钢混凝土节点

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：