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Is combined extra-hepatic bile-duct resection justified for advanced gallbladder carcinoma?

Gastroenterology Report 2019年第6期7卷 426-433,I0002页

作者： Jun-Ke Wang Wen-Jie Ma zhen-ru wu Qin Yang Hai-Jie Hu Fei Liu Fu-Yu Li Department of Biliary Surgery West China HospitalSichuan UniversityChengduSichuanP.R.China Laboratory of Pathology West China HospitalSichuan UniversityChengduSichuanP.R.China

Background:Whether the extra-hepatic bile duct(EHBD)should be routinely resected for gallbladder carcinoma(GBC)remains *** current study aimed to determine the clinical impact of combined EHBD resection during curative surgery for advanced ***:In total,213 patients who underwent curative surgery for T2,T3 or T4 GBC were *** clinicopathological features were compared between the patients treated with EHBD resection and those without EHBD ***,univariable and multivariable Cox-proportional hazards regression models were used to identify risk factors for overall survival(OS).Results:Among the 213 patients identified,87(40.8%)underwent combined EHBD *** with patients without EHBD resection,patients with EHBD resection suffered more post-operative complications(33.3%vs.21.4%,P=0.046).However,the median OS of the EHBD resection group was longer than that of the non-EHBD resection group(25 vs.11 months,P=0.008).Subgroup analyses were also performed according to tumor(T)category and lymph-node *** median OS was significantly longer in the EHBD resection group than in the non-EHBD resection group for patients with T3 lesion(15 vs.7 months,P=0.002),T4 lesion(11 vs.6 months,P=0.021)or lymph-node metastasis(12 vs.7 months,P<0.001).No survival benefit of EHBD resection was observed in GBC patients with T2 lesion or without lymph-node metastasis.T category,lymph-node metastasis,margin status,pre-operative CA19-9 level and EHBD resection were identified as independent prognostic factors for OS of patients with advanced GBC(all P values<0.05).Conclusions EHBD resection can independently affect the OS in advanced *** GBC patients with T3 lesion,T4 lesion and lymph-node metastasis,combined EHBD resection is justified and may improve OS.

关键词： gallbladder carcinoma curative surgery extra-hepatic bile-duct resection overall survival

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Decreased expression of HDAC8 indicates poor prognosis in patients with intrahepatic cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 464-470页

作者： Yong-Jie Zhu Qing Xu Ming-Yang Shao Xiao-Yue Cao zhen-ru wu Yu-Wei Chen Hong Bu Yu-Jun Shi Laboratory of Pathology West China HospitalSichuan University37 Guoxue RoadChengdu 610041China Key Laboratory of Transplant Engineering and Immunology NHCWest China HospitalSichuan UniversityChengdu 610041China Department of Pathology West China HospitalSichuan UniversityChengdu 610041China

Background: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant primary tumor in the liver, and the rates of incidence and mortality are rapidly increasing globally. Histone deacetylase 8 (HDAC8) is a transcriptional regulator and is associated with tumorigenesis of several tumor types. This study aimed to evaluate the correlation between HDAC8 expression and clinicopathological parameters in ICC patients. Methods: ICC tissues and corresponding nonmalignant bile duct tissues were obtained from 60 patients. HDAC8 and Ki-67 expression were evaluated by immunohistochemistry staining. HDAC8 expression and the clinicopathological features and prognosis of the patients were analyzed. The mRNA level of HDAC8 in ICC was further analyzed using data from The Cancer Genome Atlas (TCGA). Results: The expression of HDAC8 were lower in ICC tissues (39/60, 65%) than in the corresponding nonmalignant bile duct tissues (54/60, 90%)( P = 0.001). Low HDAC8 expression in ICC was significantly associated with lymph node metastases (47.6% vs. 17.9%, P = 0.015). In addition, the positive cells rate of HDAC8 was statistically and negatively correlated with the Ki-67 index in ICC lesions ( r =?0.7660, P < 0.001). Importantly, the overall survival rate and recurrence-free survival rate in ICC patients with low HDAC8 expression were lower than those with high HDAC8 expression ( P = 0.008 and P = 0.011, respectively). Conclusions: Decreased HDAC8 expression in ICC is related to poor prognosis, and HDAC8 may be an independent prognostic indicator of ICC patients after curative resection.

关键词： Intrahepatic cholangiocarcinoma HDAC8 Prognosis

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Elevated expression of Gsα in intrahepatic cholangiocarcinoma associates with poor prognosis

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 638-644页

作者： Xiao-Yue Cao Hong-Jie Ji Yong-Jie Zhou Xu-Feng Lu Jun-Yi Shen zhen-ru wu Hong Bu Yu-Jun Shi Laboratory of Pathology West China Hospital Sichuan University Chengdu 610041 China Key Laboratory of Transplant Engineering and Immunology NHFPCWest China Hospital Sichuan University Chengdu 610041 China Department of Liver Surgery & Liver Transplantation Center West China Hospital Sichuan University Chengdu 610041 China Department of Pathology West China Hospital Sichuan University Chengdu 610041 China

BACKGROUND:The stimulatory G protein α subunit(Gsα)plays important roles in diverse cell processes including tu morigenesis. Activating mutations in Gsα gene(GNAS) have been reported to be associated with poor prognosis in various human carcinomas. Furthermore, Gsα signaling is crucial in promoting liver regeneration by interacting with growth factor signaling, indicating that Gsα might play a promoting role in cancer development. However, little is known about the correlation between Gsα levels and clinicopathological pa rameters in intrahepatic cholangiocarcinoma(ICC). METHODS:We performed immunoblotting to examine the expression levels of Gsα and Ki67 proteins in tumor tissues and the corresponding adjacent tissues. A total of 74 pair of specimens resected from 74 ICC patients were examined. The association between Gsα levels and clinicopathological find ings and prognosis of the patients was ***:Western blotting demonstrated that the expression of Gsα was significantly higher in ICC tissues compared with that in their corresponding adjacent tissues. Gsα protein was highly expressed in about half of ICC tissues(48.6%, 36/74)while only 28.4%(21/74) of tumor adjacent tissues showed Gsα high expression(P=0.011). High Gsα expression in ICC was significantly associated with the numbers of tumor nodules(P=0.037) and lymph node metastases(P=0.010)Moreover, the level of Gsα was significantly and positivelycorrelated with Ki67 expression(P<0.001). In addition, the recurrence-free survival rate and overall survival rate in the Gsα high group were significantly lower than those in the Gsα low group(P=0.004 and P=0.005, respectively).CONCLUSIONS:High Gsα expression is correlated with poor prognosis in ICC patients. Gsα might serve as a potential prognostic indicator of ICC.

关键词： Gsα intrahepatic cholangiocarcinoma immunohistochemistry prognosis

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High Performance Microwave Absorption Material Based on Metal-Backboned Polymer

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Chinese Journal of Polymer Science 2024年第12期42卷 1881-1887,I0006页

作者： Jia-Ning Xu Kai-Wen Zeng Yi-Feng Zhang Yi-Bei Yang Zi-Wei Liu Yue Liu Jia-Jia Wang Kai-Lin Zhang Yan-ru-zhen wu Hao Sun Hui-Sheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceInstitute of Fiber Materials and Devicesand Laboratory of AdvancedMaterialsFudanUniversityShanghai200438China Frontiers Science Center for Transformative Molecules Schoolof Chemistry and Chemical Engineeringand Zhangjiang Institute for Advanced StudyShanghai JiaoTongUniversityShanghai200240China

Metal-backboned polymers with anisotropy microstructures are promising for conductive,optoelectronic,and magnetic functional ***,the structure-property relationships governing the interplay between the chemical structure and electromagnetic property of the metal-backboned polymer have been rarely *** we report a carbon/nickel hybrid from metal-backboned polymer to serve as electromagnetic wave-absorbing materials,which exhibit high microwave absorption capacity and tunable absorption *** presence of nickel backbones promote the generation of heterogeneous interfaces with carbon during calcination,thereby enhancing the wave-absorbing capacity of the carbon/nickel *** C/Ni hybrids show a minimal reflection loss of-49.1 dB at 13.04 GHz,and its frequency of the absorption band can be adjusted by controlling the thickness of the absorption layer.

关键词： Nickel Metal-backboned polymer Carbon Hybrid material

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Standard liver weight model in adult deceased donors with fatty liver: A prospective cohort study

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World Journal of Gastroenterology 2021年第39期27卷 6701-6714页

作者： Bo Li Pan-Yu Chen Yi-Fei Tan He Huang Min Jiang zhen-ru wu Chen-Hao Jiang Dao-Feng zheng Diao He Yu-Jun Shi Yan Luo Jia-Yin Yang Department of Liver Surgery Liver Transplantation CentreWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Laboratory of Liver Transplantation Frontiers Science Center for Disease-related Molecular NetworkWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Operating Room West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Epidemiology and Health Statistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Laboratory of Pathology Key Laboratory of Transplant Immunology and EngineeringNational Health CommissionWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Standard liver weight(SLW)is frequently used in deceased donor liver transplantation to avoid size mismatches with the ***,some deceased donors(DDs)have fatty liver(FL).A few studies have reported that FL could impact liver *** the best of our knowledge,there are no relevant SLW models for predicting liver *** To demonstrate the relationship between FL and total liver weight(TLW)in detail and present a related SLW *** We prospectively enrolled 212 adult DDs from West China Hospital of Sichuan University from June 2019 to February 2021,recorded their basic information,such as sex,age,body height(BH)and body weight(BW),and performed abdominal ultrasound(US)and pathological biopsy(PB).The chi-square test and kappa consistency score were used to assess the consistency in terms of FL diagnosed by US relative to *** linear regression analysis was used to explore the variables related to *** linear regression analysis was used to formulate SLW models,and the root mean standard error and interclass correlation coefficient were used to test the fitting efficiency and accuracy of the model,***,the optimal formula was compared with previous *** Approximately 28.8%of DDs had *** had a high diagnostic ability(sensitivity and specificity were 86.2%and 92.9%,respectively;kappa value was 0.70,P<0.001)for livers with more than a 5%fatty *** linear regression analysis showed that sex(R2,0.226;P<0.001),BH(R2,0.241;P<0.001),BW(R2,0.441;P<0.001),BMI(R2,0.224;P<0.001),BSA(R2,0.454;P<0.001)and FL(R2,0.130;P<0.001)significantly impacted *** addition,multiple linear regression analysis showed that there was no significant difference in liver weight between the DDs with no steatosis and those with steatosis within 5%.Furthermore,in the context of hepatic steatosis,TLW increased positively(nonlinear);compared with the TLW of the non-FL group,the TLW of the groups with hepatic steatosi

关键词： Standard liver weight Body surface area Fatty liver Sex Deceased donors

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Effectiveness of additional resection of the invasive cancer-positive proximal bile duct margin in cases of hilar cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 251-269页

作者： Wen-Jie Ma zhen-ru wu Anuj Shrestha Qin Yang Hai-Jie Hu Jun-Ke Wang Fei Liu Rong-Xing Zhou Quan-Sheng Li Fu-Yu Li Department of Biliary Surgery West China HospitalSichuan UniversityChengdu 610041China Laboratory of Pathology West China HospitalSichuan UniversityChengdu 610041China Department of General Surgery Andaki Medical CollegePokharaNepal

Background: The survival benefits of additional resection of the positive proximal ductal margin (PM) in hilar cholangiocarcinoma (HCCA) remains controversial. This retrospective study investigated the effectiveness of additional resection of the invasive cancer PM under different levels of preoperative carbohydrate antigen 19-9 (CA19-9). Methods: Patients who underwent hepatectomy for HCCA from 2000 to 2017 were analyzed. Surgical variables, resection margin status, length of the PM (LPM), prognostic factors, and survival were evaluated. Results: A total of 228 patients were enrolled: 175 PM(?) without additional resection patients (group A), 21 PM(?) after additional resection (group B), 16 PM(+) without additional resection (group C), and 16 PM(+) after additional resection (group D). The median survival of group B (20.99 months) was similar to that of group A (23.00 months;P=0.16), and both were significantly better than those of group C (11.60 months) and D (9.50 months), especially when preoperative CA19-9>150 U/mL (P10 mm was significantly better compared with those with an LPM ≤10 mm, especially when preoperative CA19-9 was >150 U/mL (P10 mm group, the survival of group B was comparable with that of group A (P>0.05). Conclusions: HCCA patients could get a survival benefit from a negative PM resulting from additional resection. Survival could be comparable with that of negative PM without additional resection among HCCA patients. An LPM >10 mm is possibly more associated with better survival compared with whether additional resection of the positive PM is performed under different levels of preoperative CA19-9.

关键词： Klatskin tumor margins of excision bile ducts antigens neoplasm carbohydrate antigen 19-9 (CA19-9)

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing wu Guang Yin Fan‑zhen Jiao Zhong‑zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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WD智能天然源面波数据采集处理系统及其应用试验

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物探与化探 2016年第5期40卷 1007-1015页

作者：刘云祯梅汝吾叶佩金荣杰北京市水电物探研究所北京100027 中国国土资源航空物探遥感中心北京100083

我国自主研发的WD智能天然源面波数据采集处理系统,改变了迄今为止现场仪器只采集天然微振动波形记录的现状。该系统利用大数据计算、筛选、叠加、归一化等技术,创先性研制出现场仪器在采集微震信号的同时,可直接显示勘探成果的面波频... 详细信息

我国自主研发的WD智能天然源面波数据采集处理系统,改变了迄今为止现场仪器只采集天然微振动波形记录的现状。该系统利用大数据计算、筛选、叠加、归一化等技术,创先性研制出现场仪器在采集微震信号的同时,可直接显示勘探成果的面波频散曲线;信号采集过程中,无需震源,无需人工控制;装置系统安置在地面,10-30min可获得上百米深度地层的面波频散曲线,得知土层软硬。在不同岩性地区的试验结果证实,该系统能快速、准确地进行地层划分,操作便捷,适应性强,为天然源面波勘探广泛应用于工程勘查提供了技术保障。

关键词：天然源面波勘探 WD智能勘探仪天然源面波数据采集系统工程勘查无源勘探

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