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鲤鲫人工多倍体谱系中同工酶和蛋白的基因表达

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水生生物学报 2002年第5期26卷 425-432页

作者：王小虎叶玉珍吴清江中国科学院水生生物研究所

通过对红鲤、红鲫、镜鲤、鲤鲫杂种二倍体一代 ,二代 ,鲤鲫杂种三倍体 ,鲤鲫复合三倍体 ,鲤鲫杂种四倍体一代 ,二代的同工酶及蛋白电泳谱型和扫描数据分析表明 :在鲤鲫人工多倍体谱系中 ,亲代的等位基因在杂交子代中共有四种表达模式 :(... 详细信息

通过对红鲤、红鲫、镜鲤、鲤鲫杂种二倍体一代 ,二代 ,鲤鲫杂种三倍体 ,鲤鲫复合三倍体 ,鲤鲫杂种四倍体一代 ,二代的同工酶及蛋白电泳谱型和扫描数据分析表明 :在鲤鲫人工多倍体谱系中 ,亲代的等位基因在杂交子代中共有四种表达模式 :( 1 )两亲本基因在子代中共同表达 ,即共显表达 ;( 2 )父本的基因表达受到部分或完全的抑制 ,即母本的基因优先得到表达 ;( 3)母本的基因表达受到抑制 ,父本的基因得到表达 ;( 4 )双亲本的基因表达均受到一定程度的抑制或都不表达。其中第一种表达模式是主要的模式。根据以上基因在杂交子代中的表达特点 ,可用同工酶和蛋白电泳图谱将鲤鲫人工多倍体谱系的各种生物型逐一加以区分。

关键词：人工多倍体谱系同工酶蛋白基因表达鲤鱼鲫鱼鲤鲫杂种

Reliable routing mechanism based on neighbor stability for MANET

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 33-39页

作者： wu Da-peng wu Mu-qing zhen Yan Broadband Communication Networks Lab Beijing University of Posts and Telecommunications Beijing 100876 China

One critical issue for routing in mobile Ad-hoc networks （MANETs） is how to select a reliable path that can last longer because mobility may cause frequent breakdown in radio links. A novel routing mechanism based on link lifetime estimation is proposed in this article. In this mechanism, the node＇s received signal strength is obtained continuously by using Newton interpolation polynomial, and by method of middle value and interception, the reference points are selected to estimate the link lifetime. With the constraint of link lifetime and hop counts, the source nodes set up the route hop by hop. The simulations show that link lifetime can be predicted regardless of mobility pattern. Moreover, the route discovery times and packet drop ratio can be reduced by the proposed mechanism, and thus improving the performance of MANETs.

关键词： Ad-hoc networks routing protocol link lifetime received signal strength interpolation polynomial

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu Kang He Chang-qing Liu Li-Fei Song zheng-Zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

An optimal pricing policy under a Markov chain model

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Science China Mathematics 2022年第5期65卷 1065-1080页

作者： Ruyi Liu Jingzhi Tie zhen wu qing Zhang School of Mathematics Shandong UniversityJinan 250100China Department of Mathematics University of GeorgiaAthensGA 30602USA

This paper is about an optimal pricing control under a Markov chain *** objective is to dynamically adjust the product price over time to maximize a discounted reward *** is shown that the optimal control policy is of... 详细信息

关键词： pricing control Markov chain model threshold policy

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高管限薪方式与国有企业高质量发展

经济问题 2025年第1期 70-78页

作者：吴秋生郑玥臻山西财经大学会计学院山西太原030012

2009年和2015年中华人民共和国人力资源和社会保障部和国务院国有资产监督管理委员会先后出台了国有企业高管限薪规定,采取了绝对限薪和相对限薪两种不同方式,因此,有必要明晰哪一种方式更有利于促进国有企业高质量发展。以2010—2023年... 详细信息

2009年和2015年中华人民共和国人力资源和社会保障部和国务院国有资产监督管理委员会先后出台了国有企业高管限薪规定,采取了绝对限薪和相对限薪两种不同方式,因此,有必要明晰哪一种方式更有利于促进国有企业高质量发展。以2010—2023年的A股国有企业为样本进行研究,结果表明:与绝对限薪相比,相对限薪更能够促进国有企业高质量发展,且相对限薪程度越高、内部控制质量越高,上述关系越明显。进一步研究发现,相对限薪促进国有企业发展质量提高是通过降低盈余管理、提高创新效率等路径实现的,且这种作用路径在产品市场竞争度高的国有企业和实体国有企业中更明显。研究结论对合理制定和有效实施限薪政策及提高企业内部控制质量,促进国有企业高质量发展具有启示意义。

关键词：绝对限薪相对限薪全要素生产率内部控制质量

Effect of reduction pretreatment process on evolution of micro-porosity in 42CrMo billet

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Journal of Iron and Steel Research International 2021年第4期28卷 413-423页

作者： zhen Ning Wei Yu Hong-qiang Liu qing-wu Cai Collaborative Innovation Centre of Steel Technology University of Science and Technology BeijingBeijing 100083China HBIS Group Co. Ltd.Shijiazhuang 050000HebeiChina

Reduction pretreatment(RP)process,which is implemented after the billet is completely solidified,is an alternative process to further improve billet *** element method and experiment were used to investigate the effect of the RP process on the internal quality of 42CrMo *** ultrasonic testing technology was used to study the influence of the RP process on the *** a three-dimensional finite element model,the mechanism of the RP process on the porosity closure was *** experimental results show that the RP process eliminates the macro-porosities of the billet *** number of micro-porosities in the billets is effectively reduced,and the increase in deformation contributes to the reduction in *** with isothermal rolling,the RP process leads to a larger equivalent strain and hydrostatic integration in the billet center because of the temperature gradient,and the effect of the temperature gradient is greater with the increase in *** closure effect of micro-porosity is related not only to the stress state,but also to the distribution of *** increase in three-dimensional compressive stress is beneficial to the porosity *** the micro-porosities distributed densely,excessive stress could induce micro-porosity coalescence,which has the risk of inducing cracks.

关键词： Reduction pretreatment Temperature gradient Large deformation Micro-porosity Ultrasonic testing

大比例浅水矩形水箱振动台试验研究及TLD等效线性化分析

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Some Results on Metric n-Lie Algebras

工程力学 2025年第1期42卷 143-151页

作者：肖从真巫振弘陈凯唐意严亚林中国建筑科学研究院有限公司北京100013 国家建筑工程技术研究中心北京100013

调谐液体阻尼器(TLD)是高层建筑减振的有效措施。该文进行了大比例浅水矩形水箱振动台试验研究，分析了将调谐液体阻尼器按等效线性化等效为单自由度系统的可行性。采用振动台试验得到目标水箱在0.6倍~1.4倍水体自振频率简谐激励荷载下... 详细信息

调谐液体阻尼器(TLD)是高层建筑减振的有效措施。该文进行了大比例浅水矩形水箱振动台试验研究，分析了将调谐液体阻尼器按等效线性化等效为单自由度系统的可行性。采用振动台试验得到目标水箱在0.6倍~1.4倍水体自振频率简谐激励荷载下，水体稳态振动时的水箱反力和频响函数;测量不同振动幅度下，水体的自振频率偏差;由水体自由振动衰减，测得5种不同网栅条件下的附加阻尼比;将风和地震荷载下某249 m高楼顶加速度作为水箱激励进行振动台混合试验，实测水箱反力和滞回曲线，并与等效线性化模型计算结果进行对比。结果表明，以最大变形割线刚度作为等效刚度、按等能量方法确定阻尼比的等效线性化模型基本可行，在简谐波和风荷载作用下较符合试验结果，在地震荷载下存在一定偏差。试验结果可为类似调谐液体阻尼器设计提供依据。

关键词：高层结构调谐液体阻尼器振动台试验附加阻尼比浅水水箱等效线性化

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Acta Mathematica Sinica,English Series 2012年第6期28卷 1209-1220页

作者： Rui Pu BAI Wan qing wu zhen Heng LI College of Mathematics and Computer Science Hebei University Department of Mathematical Sciences University of South Carolina Aiken

We study the structure of a metric n-Lie algebra G over the complex field C. Let G = S＋R be the Levi decomposition, where T4 is the radical of G and S is a strong semisimple subalgebra of G. Denote by re（G） the number of all minimal ideals of an indecomposable metric n-Lie algebra and R^⊥ the orthogonal complement of R. We obtain the following results. As S-modules, R^⊥ is isomorphic to the dual module of G/R. The dimension of the vector space spanned by all nondegenerate invariant symmetric bilinear forms on G is equal to that of the vector space of certain linear transformations on G; this dimension is greater than or equal to rn（G）＋ 1. The centralizer of T4 in G is equal to the sum of all minimal ideals; it is the direct sum of R^⊥and the center of G. Finally, G has no strong semisimple ideals if and only if R^⊥ R.

关键词： Metric n-Lie algebra minimal ideal metric dimension Levi decomposition

Sharp Estimates of p-Adic Hardy and Hardy-Littlewood-Pólya Operators

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Acta Mathematica Sinica,English Series 2013年第1期29卷 137-150页

作者： Zun Wei FU qing Yan wu Shan zhen LU Department of Mathematics Linyi University School of Mathematical Sciences Beijing Normal University

In this paper we get the sharp estimates of the p-adic Hardy and Hard^Littlewood-Pdlya operators on L^q （｜x｜apdx）. Also, we prove that the commutators generated by the p-adic Hardy operators （Hardy-Littlewood-Pdl... 详细信息

关键词： p-Adic Hardy operator p-Adic Hardy-Littlewood-P61ya operator central BMO function,Herz space