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Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury：mechanisms of brain tissue repair

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Neural Regeneration Research 2016年第3期11卷 435-440页

作者： zhen-qiang zhang Jun-ying Song Ya-quan Jia Yun-ke zhang Henan University of Traditional Chinese Medicine Zhengzhou Henan Province China First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou Henan Province China

Buyanghuanwu decoction has been shown to protect against cerebral ischemia/reperfusion injury,but the underlying mechanisms remain *** this study,rats were intragastrically given Buyanghuanwu decoction,15 m L/kg,for 3 days.A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery *** rats administered Buyanghuanwu decoction,infarct volume was reduced,serum vascular endothelial growth factor and integrin αvβ3 levels were increased,and brain tissue vascular endothelial growth factor and CD34 expression levels were increased compared with untreated *** effects of Buyanghuanwu decoction were partially suppressed by an angiogenesis inhibitor（administered through the lateral ventricle for 7 consecutive days）.These data suggest that Buyanghuanwu decoction promotes angiogenesis,improves cerebral circulation,and enhances brain tissue repair after cerebral ischemia/reperfusion injury.

关键词： nerve regeneration Buyanghuanwu decoction cerebral ischemia/reperfusion injury ischemic cerebrovascular disease integrin αvβ3 vascular endothelial growth factor angiogenesis CD34 neural regeneration

Study on the liquid metal flow field in FC-mold of slab continuous casting

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Advances in Manufacturing 2015年第3期3卷 212-220页

作者： zhen-qiang zhang Jian-Bo Yu Zhong-Ming Ren Kang Deng School of Materials Science and Engineering Shanghai University

The flow pattern and the velocity distribution of a liquid metal in the flow control mold （FC-mold） were investigated with a mercury model by analogy to the molten steel during continuous casting. The velocity measurement was conducted by the ultrasonic Doppler velocimeter （UDV） under various magnetic distributions and flux densities. The impingement intensity and the scouring intensity of the liquid metal to the narrow wall of the mold were calculated based on the measured data, and the influence of the magnetic flux density on the liquid metal flow in the mold was analyzed. The results showed that the surface of the liquid metal became more active when only the lower magnet was assembled, and the surface fluctuation was suppressed when further applying the upper magnetic field. It was indicated that when the upper and lower magnetic flux densities were 0.18 T and 0.5 T, respectively, the optimum conditions could be obtained, under which the free surface fluctuation could be suppressed, and a flow recirculation could rapidly form.

关键词： FC-mold Continuous casting Electromagnetic brake - Magnetic flux intensity

Effect of final electromagnetic stirring on solidification microstructure of GCr15 bearing steel in simulated continuous casting

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Journal of Iron and Steel Research International 2020年第2期27卷 141-147页

作者： Dan-qing Jiang Rui Wang Qiong zhang zhen-qiang zhang Ting-sheng Tu Jiang Wang Zhong-ming Ren School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The effect of final electromagnetic stirring on the solidification structure,element segregation,and carbides of GCrl5 bearing steel was *** experiment of continuous casting of the steel was carried out by using a continuous casting physical simulation apparatus with the final electromagnetic *** liquid core profile was revealed by the pour-out method during the solidification *** ingots were produced under different electromagnetic stirring parameters for *** results show that,at the final stage of solidification,intense electromagnetic stirring exacerbates the central carbon segregation,resulting in more serious precipitation of the primary *** is also found that the carbides in the segregation area are dominantly M3C type,together with a small amount of M7C3-type and M3C2-type *** this physical simulation model,the optimal stirring parameters to obtain a fine and homogeneous structure are the liquid pool width of 15 mm,current intensity of 150 A,and stirring frequency of 5 Hz.

关键词： GCrl5 bearing steel Solidification structure Continuous casting Final electromagnetic stirring Segregation Carbide

Grain Refinement During Directionally Solidifying GCr18Mo Steel at Low Pulling Speeds Under an Axial Static Magnetic Field

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Acta Metallurgica Sinica(English Letters) 2018年第7期31卷 681-691页

作者： Yuan Hou zhen-qiang zhang Wei-Dong Xuan Jiang Wang Jian-Bo Yu Zhong-Ming Ren State Key Laboratory of Advanced Special Steel and School of Materials Science and Engineering Shanghai University

The present work investigates how axial static magnetic field affects the solidification structure and the solute distribution in directionally solidified GCr18Mo steel. Experimental results show that grain refinement and the colunmar to equiaxed transition is enhanced with the increases in the magnetic field intensity （B） and temperature gradient （G） and the decrease in the growth speed. This phenomenon is simultaneously accompanied by more uniformly distributed alloying elements. The corresponding numerical simulations verify a thermoelectric （TE） magnetic convection pattern in the mushy zone due to the interaction between the magnetic field and TE current. The TE magnetic convection in the liquid should be responsible for the motion of dendrite fragments. The TE magnetic force acting on the dendrite is one of the driving forces trigging fragmentation.

关键词： GCr18Mo steel Grain refinement Axial static magnetic field Columnar to equiaxed transitionThermoelectric magnetic force

Influence of mechanical reduction amount on internal quality of continuous casting billets by thermal and numerical simulation

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Journal of Iron and Steel Research International 2023年第6期30卷 1234-1243页

作者： Dan-qing Jiang Shu-jian Sun Han Wu Yang-jian Xu Fu-hai Zhu zhen-qiang zhang Jiang Wang Zhong-ming Ren School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

With establishment of thermal and numerical simulation models,the influence of reduction amount on solidification structure,segregation and shrinkage porosity of continuous casting(CC)billets was *** thermal–mechanical coupled simulation results indicated that with an increase in reduction amount,the temperature in the central area decreases,and the reduction efficiency firstly increases and then decreases,reaching the maximum value at reduction amount of 6 *** analysis showed that increasing the reduction amount is beneficial for the refinement of central solidification ***,the internal cracks are more likely to appear at higher reduction *** X-ray computerized tomography results revealed that a higher reduction amount can significantly reduce the volume fraction and equivalent diameter of the central shrinkage porosities of CC billets and increase the sphericity of ***,the macrosegregation of carbon along the central line is improved as the reduction amount increases;while the reduction amount exceeds 8 mm,the segregation degree will not change any more.

关键词： Mechanical reduction Solidification structure Porosity Thermal simulation Continuous casting billet

Synthesis of cerium oxalate hydrate by precipitation technique under external magnetic field

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Rare Metals 2023年第3期42卷 1028-1035页

作者： Jian-Bo Yu Zhi-Gang Yang Zhi-Hao Wang Ting-Sheng Tu zhen-qiang zhang Jing-Yun Li Yun-Bo Zhong Zhong-Ming Ren State Key Laboratory of Advanced Special Steels School of Material Science and EngineeringShanghai UniversityShanghai 200072China School of Material Science and Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China

Cerium oxalate hydrate particles were synthesized by precipitation technique under external magnetic field with respective intensities of 0,0.1,0.3,and 0.6 *** particle morphologies were investigated by scanning electron microscopy(SEM)and transmission electron microscope(TEM).Results show that external magnetic field has a great influence on the growth behavior of cerium oxalate hydrate ***-like and plate-like cerium oxalate hydrate particles with smaller size are formed without the applying of external magnetic ***,the extremely big rod-like particles with the average size of 12.47μm were prepared under external magnetic field of 0.6 *** increasing magnetic field intensity makes the grain grow *** analysis supports the presence of 8.5 H_(2)O molecules associated with cerium ***,the growth mechanism of cerium oxalate hydrate under external magnetic field was briefly discussed.

关键词： Cerium oxalate hydrate Precipitation technique Magnetic field Grain Growth

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu Quan Shi zhen zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Anti-inflammatory Effects of Liuwei Dihuang Wan on Aβ25-35-induced BV2 cells

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Anti-inflammatory Effects of Liuwei Dihuang Wan on Aβ25-35-...

Research on Knowledge Reuse Based on Knowledge Scenario

第十三届全国免疫学学术大会

作者： Junying Song Yong YUAN Ya-quan JIA Zi-chuang WANG zhen-qiang zhang Henan University of Chinese Medicine The second Affiliated hospital of Henan University of TCM

Objective: The β-amyloid protein(Aβ)-induced neurotoxicity is considered to be the main causative factor for Alzheimer’s disease(AD).Liuwei Dihuang Wan(LDW) is popular Chinese herbal formula, which is described as an anti-inflammatory prescription in ancient Chinese herbal *** this study, we investigated the inhibitory effects of LDW drug serum on Aβ-induced nervous inflammation in BV-2 cells and the related inflammatory ***: The serum of mice was prepared by the method of serum pharmacology of traditional Chinese *** control group, Aβ group and Aβ+ serum group were set *** effect of LDW on BV-2 cell activity was determined by *** expressiones of TBP2 and NLRP3 in the cells of different treatment groups were determined by Quantitative Real-time PCR and Western *** used to localize the TBP2 and NLRP3 antigen in ***:(1) LDW drug serum significantly inhibited Aβ-induced toxicity;(2) LDW drug serum attenuated the mRNA of TBP2 and NLRP-3 which were induced by Aβ;(3) LDW drug serum decreased Aβ-induced expression of TBP2and NLRP3;(4) The fluorescence intensity of LDW drug serum group was lower than control ***: These data suggest that LDW could protect BV-2 cells against Aβ-induced nervous inflammation through enhancing intracellular antioxidant activity and regulating TBP2 and NLRP3 mediated signal *** might be a potentially therapeutic agent for AD treatment.

关键词： Alzheimer’s disease β-amyloid Immunofluorescence Liuwei Dihuang Wan TBP2 NLRP3

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Research on Knowledge Reuse Based on Knowledge Scenario