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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun zhen-ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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On-chip light control of semiconductor optoelectronic devices using integrated metasurfaces

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Opto-Electronic Advances 2025年第1期8卷 5-30页

作者： Cheng-Long zheng Pei-Nan ni Yi-yang Xie Patrice Genevet Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450052China Key Laboratory of Optoelectronics Technology Beijing University of TechnologyMinistry of EducationBeijing 100124China Colorado School of Mines 1523 Illinois St.GoldenCO 80401USA

Semiconductor optoelectronics devices,capable of converting electrical power into light or conversely light into electrical power in a compact and highly efficient manner represent one of the most advanced technologies ever developed,which has profoundly reshaped the modern life with a wide range of *** recent decades,semiconductor technology has rapidly evolved from first-generation narrow bandgap materials(Si,Ge)to the latest fourth-generation ultra-wide bandgap semiconductor(GaO,diamond,AlN)with enhanced performance to meet growing ***,merging semiconductor devices with other techniques,such as computer assisted design,state-of-the-art micro/nano fabrications,novel epitaxial growth,have significantly accelerated the development of semiconductor optoelectronics *** them,integrating metasurfaces with semiconductor optoelectronic devices have opened new frontiers for on-chip control of their electromagnetic response,providing access to previously inaccessible degrees of *** review the recent advances in on-chip control of a variety of semiconductor optoelectronic devices using integrated metasurfaces,including semiconductor lasers,semiconductor light emitting devices,semiconductor photodetectors,and low dimensional *** integration of metasurfaces with semiconductors offers wafer-level ultracompact solutions for manipulating the functionalities of semiconductor devices,while also providing a practical platform for implementing cuttingedge metasurface technology in real-world applications.

关键词： optoelectronics nanophotonics metasurfaces semiconductor

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Soil microbiomes divergently respond to heavy metals and polycyclic aromatic hydrocarbons in contaminated industrial sites

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Environmental Science and Ecotechnology 2022年第2期10卷 82-90页

作者： zhen-ni yang Ze-Shen Liu Ke-Huan Wang Zong-Lin Liang Rashidin Abdugheni Ye Huang Run-Hua Wang Hong-Lin Ma Xiao-Kang Wang Mei-Ling yang Bing-Ge Zhang De-Feng Li Cheng-Ying Jiang Philippe F.-X.Corvini Shuang-Jiang Liu State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China School of Life Sciences Hebei UniversityBaoding071002Hebei ProvinceChina School of Public Health Xuzhou Medical UniversityXuzhou221004Jiangsu ProvinceChina School of Life Sciences University of Applied Sciences and Arts Northwestern SwitzerlandMuttenz4132Switzerland State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityQingdao226237Shandong ProvinceChina

Contaminated sites from electronic waste(e-waste)dismantling and coking plants feature high concentrations of heavy metals(HMs)and/or polycyclic aromatic hydrocarbons(PAHs)in *** contamination(HMsþPAHs)hinders land reclamation and affects the microbial diversity and function of soil *** this study,we analyzed HM and PAH contamination from an e-waste dismantling plant and a coking plant and evaluated the influences of HM and PAH contamination on soil micro*** was noticed that HMs and PAHs were found in all sites,although the major contaminants of the e-waste dismantling plant site were HMs(such as Cu at 5,947.58±433.44 mg kg^(-1),Zn at 4,961.38±436.51 mg kg^(-1),and Mn at 2,379.07±227.46 mg kg^(-1)),and the major contaminants of the coking plant site were PAHs(such as fluorene at 11,740.06±620.1 mg kg^(-1),acenaphthylene at 211.69±7.04 mg kg^(-1),and pyrene at 183.14±18.89 mg kg^(-1)).The microbiomes(diversity and abundance)of all sites were determined via high-throughput sequencing of 16S rRNA genes,and redundancy analysis was conducted to investigate the relations between soil microbiomes and *** results showed that the microbiomes of the contaminated sites divergently responded to HMs and *** abundances of the bacterial genera Sulfuritalea,Pseudomonas,and Sphingobium were positively related to PAHs,while the abundances of the bacterial genera Bryobacter,nitrospira,and Steroidobacter were positively related to *** study promotes an understanding of how soil microbiomes respond to single and mixed contamination with HMs and PAHs.

关键词： Soil microbiomes Electronic waste Coking plant Heavy metal Polycyclic aromatic hydrocarbons

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In situ regeneration of catalyst for Fenton-like degradation by photogenerated electron transportation:Characterization,performance and mechanism comparison

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Chinese Chemical Letters 2025年第1期36卷 529-533页

作者： Ming-zhen Li yang Zhang Kun Li Ya-Nan Shang Yi-zhen Zhang Yu-Jiao Kan Zhi-yang Jiao Yu-Yuan Han Xiao-Qiang Cao College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China Engineering Research Center of Groundwater Pollution Control and Remediation Ministry of Education of ChinaBeijing Normal UniversityBeijing 100875China Environment Research Institute Shandong UniversityQingdao 266237China Institute of Yellow River Delta Earth Surface Processes and Ecological Integrity Shandong University of Science and TechnologyQingdao 266590China

Inactivation of carbon-based transition metal catalysts,which was caused by electron loss,limited their application in advanced oxidation ***,Co and TiO_(2) double-loaded carbon nanofiber material(Co@CNFs-TiO_(2))was synthesized in this *** and chemical catalytic systems were synergized *** was eliminated within 15 *** degradation rate remained above 90%after five cycles,and the 50%promotion proved the high stability of Co@CNFs-TiO_(2).The main reactive oxygen species in this system were sulfate radicals,whereas Co and TiO_(2) represented the active sites of the catalytic *** generated from TiO_(2) during the photocatalytic process were transferred to Co,which promoted the Co(Ⅲ)/Co(Ⅱ)cycle and maintained Co in a low-valence state,thereby stimulating the generation of sulfate *** this study,the effective regulation of reactive oxygen species in the reaction system was *** results provided a guidance for in situ electron replenishment and regeneration of carbon-based transition metal catalysts,which will expand the practical application of advanced oxidation processes.

关键词： Electron transportation Catalyst regeneration Peroxymonosulfate Co Photocatalytic

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Fabrication of ni-Zn spinel ferrite with superior magnetic performance from electric arc furnace dust and iron scale

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Journal of Iron and Steel Research International 2025年第1期32卷 105-114页

作者： yang Li Wei-zhe Jie Chang Chen Yi Su Wu Zhou Hua Zhang Hong-wei ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina The Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina

The ni-ZnFe_(2)O_(4)(nixZn_(1-x)Fe_(2)O_(4),x=0.4-0.7)spinel was synthesized using Zn2+extracted from electric arc furnace dust(EAFD),nickel chloride hexahydrate,and Fe^(3+)extracted from iron scale as raw *** zinc was selectively extracted from EAFD using CaO roasting followed by NH_(4)Cl solution *** ferric ion was leached from iron scale using HCl solution as acid *** experimental results demonstrate a high level of efficiency in the extraction of zinc,with a rate of 97.5%,and the leaching rate of ferric ion is 96.89%.The composition of the leaching solution is primary zinc and iron with low calcium,which is beneficial to the preparation of spinel *** influence of ni content(x)and calcination temperature on the synthesis and magnetic properties of nixZn_(1-x)Fe_(2)O_(4)compounds was investigated by X-ray diffraction,scanning electron microscopy,and vibrating sample *** results revealed that both ni content and calcination temperature significantly affect the synthesis and magnetic properties of spinel nixZn_(1-x)Fe_(2)O_(4).Under the conditions of ni content set at x=0.6,calcination temperature of 1100℃,and a duration of 2 h,a spinel nixZn_(1-x)Fe_(2)O_(4)with high saturation magnetization(Ms=65.7 A m2 kg-1)and low coercivity(Hc=0.056 A m^(-1))was obtained.

关键词： Electric furnace arc dust Iron scale Spinel ferrite Magnetic performance Calcination temperature

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碳酸乙烯酯添加剂对BMImBF_4离子液体作为镁沉积—溶解电解液的改性研究

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化学学报 2008年第2期66卷 175-180页

作者：努丽燕娜杜国栋冯真真沈佳妮杨军上海交通大学化学化工学院上海200240

利用恒电流沉积-溶解、交流阻抗、XRD和SEM方法研究了在室温下EC(碳酸乙烯酯)添加剂对BMImBF_4离子液体作为镁沉积电解液的改善情况.在Mg(CF_3SO_3)_2浓度为0.3 mol·L^(-1)的BMImBF_4电解液中加入w=5%(质量分数)的EC后,沉积—溶解循环... 详细信息

利用恒电流沉积-溶解、交流阻抗、XRD和SEM方法研究了在室温下EC(碳酸乙烯酯)添加剂对BMImBF_4离子液体作为镁沉积电解液的改善情况.在Mg(CF_3SO_3)_2浓度为0.3 mol·L^(-1)的BMImBF_4电解液中加入w=5%(质量分数)的EC后,沉积—溶解循环过程更加稳定,并且循环次数明显增加,可以达到265次以上;交流阻抗结果显示,膜电阻和电荷转移电阻有所减少;从SEM图可以观察到,在沉积初期原本枝晶态的镁在加入EC后以颗粒状沉积.可能是EC添加剂在反应中形成的低聚物覆盖在镁的表面,抑制了枝晶的形成.

关键词：离子液体 BMImBF4 碳酸乙烯酯沉积-溶解镁电池

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Improvement of photogrammetric joint roughness coefficient value by integrating automatic shooting parameter selection and composite error model

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 200-219页

作者： Qinzheng yang Ang Li Feng Dai zhen Cui Hongtian Wang School of Highway Chang’an UniversityXi’an710064China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

In order to improve the accuracy of the photogrammetric joint roughness coefficient(JRC)value,the present study proposed a novel method combining an autonomous shooting parameter selection algorithm with a composite error ***,according to the depth map-based photogrammetric theory,the estimation of JRC from a three-dimensional(3D)digital surface model of rock discontinuities was ***,an automatic shooting parameter selection algorithm was novelly proposed to establish the 3D model dataset of rock discontinuities with varying shooting parameters and target ***,the photogrammetric tests were performed with custom-built equipment capable of adjusting baseline lengths,and a total of 36 sets of JRC data was gathered via a combination of laboratory and field ***,by combining the theory of point cloud coordinate computation error with the equation of JRC calculation,a composite error model controlled by the shooting parameters was *** newly proposed model was validated via the 3D model dataset,demonstrating the capability to correct initially obtained JRC values solely based on shooting ***,the implementation of this correction can significantly reduce errors in JRC values obtained via photographic ***,our proposed error model was integrated into the shooting parameter selection algorithm,thus improving the rationality and convenience of selecting suitable shooting parameter combinations when dealing with target rock masses with different ***,the optimal combination of three shooting parameters was *** values resulting from various combinations of shooting parameters were verified by comparing them with 3D laser scan ***,the application scope and limitations of the newly proposed approach were further addressed.

关键词： Photogrammetry Shooting parameter JRC estimation 3D reconstruction

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Subsection cooling system of hot rolling silicon steel and its industrial application

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Journal of Iron and Steel Research International 2025年第1期32卷 159-170页

作者： Qiu-na Wang Ji-quan Sun Li-po yang Hai-shen Wang Li-jie Dong Jie-ming Li zhen-yang Zhi Yan-wen Bi National Engineering Research Center of Flat Rolling Equipment University of Science and Technology BeijingBeijing100083China Hot Rolling Department of Qian’an Iron and Steel Corporation Shougang Company LimitedTangshan064404HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

An online subsection cooling method for hot rolling silicon steel was designed to achieve local adjustment of transverse roll ***,it was able to meet the requirements of edge drop of the strip by using the features of online thermal ***,after the new subsection spray beam was installed at the exit of mill,the special local cooling rules were analyzed for altering the thermal crown of roll according to rolling process ***,the dynamic impact of subsection cooling on the local thermal crown could just be obtained according to the measured ***,the heat transfer coefficient was determined by different subsection cooling curves under varied rolling ***,the rolling rhythm and variable conditions were important dynamic factors of transient roll temperature in practical rolling ***,real-time calculation and presetting of the thermal crown were carried out to maximize special requirements of load roll gap on local strip *** this new method,the transient temperature and the thermal crown of roll could be quantitatively controlled *** the practical results showed that the predicted temperature was able to match the measured value by more than 95%.Meanwhile,the adjustable range of thermal crown increased by more than 2.5 ***,the qualification rate of strip edge crown has increased from the original 30%to over 70%.

关键词： Subsection cooling Thermal roll crown Multi-parameter coupling Hot rolling Silicon steel

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A Damage Control Model for Reinforced Concrete Pier Columns Based on Pre-Damage Tests under Cyclic Reverse Loading

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Structural Durability & Health Monitoring 2025年第2期19卷 327-346页

作者： Zhao-Jun Zhang Jing-Shui zhen Bo-Cheng Li De-Cheng Cai yang-yang Du Wen-Wei Wang Offshore Oil Engineering Co. Ltd.Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing21189China

To mitigate the challenges in managing the damage level of reinforced concrete(RC)pier columns subjected to cyclic reverse loading,this study conducted a series of cyclic reverse tests on RC pier *** analyzing the outcomes of destructive testing on various specimens and fine-tuning the results with the aid of the IMK(Ibarra Medina Krawinkler)recovery model,the energy dissipation capacity coefficient of the pier columns were able to be ***,utilizing the calibrated damage model parameters,the damage index for each specimen were *** on the obtained damage levels,three distinct pre-damage conditions were designed for the pier columns:minor damage,moderate damage,and severe *** study then predicted the variations in hysteresis curves and damage indices under cyclic loading *** experimental findings reveal that the displacement at the top of the pier columns can serve as a reliable indicator for controlling the damage level of pier columns ***,the calibrated damage index model exhibits proficiency in accurately predicting the damage level of RC pier columns under cyclic loading.

关键词： Reinforced concrete pier cyclic reverse load pre-damage damage index displacement control

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Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei ni Yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO Yi-Xiang CHEN Yunguo LI Wan-Cai LI Xuan GUO yang-yang WANG Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of ChinaHefei230026China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou510640China School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China State Key Lab of Superhard Materials Jilin UniversityChangchun130012China

In this work,we provide a comprehensive review on the formation,evolution,properties,and effects of supercritical *** Earth's interior,enhanced miscibility between H_(2)O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H_(2)O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems,typified by pegmatite system,is governed by meltfluid critical *** formation of supercritical geofluid in metamorphic systems,typified by subducted slab,is governed by the second critical end *** results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths,but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth.A major presence of both H_(2)O and depolymerized structural units(monomers,dimers,etc.)endows supercritical geofluid with unique physical properties including low density,low elastic moduli,low viscosity,high diffusivity,and high electrical *** geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth *** chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts,and this could give an explanation of the oxidation of arc *** separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt *** fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical *** geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab,and can be linked with intermediate-focus *** geofluid may have played a crucial role in the formation of pegmatites and associ

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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