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Growth and spectroscopic characterization of Pr3+:LiGd(MoO4)2 crystal

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Growth and spectroscopic characterization of Pr3+:LiGd(MoO4)...

Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

中国化学会第五届全国结构化学学术会议

作者： Pang zhen-Li~(a,b) Zhang Li-zhen~a lin Zhou-Bin~a wang Guo-Fu~(a*) a State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,P.O.Box 143,Fuzhou,Fujian 350002,China b Graduate School of the Chinese Academy of Science,Beijing 100039,China

Pr:LiGd(MoO) crystal with dimension of Φ=30 mm×38 mm was grown by the Czochralski ***(MoO) crystal melts at 1030℃.The hardness of Pr:LiGd(MoO) crystal is 369.1 *** spectroscopic properties of Pr:LiGd(MoO) crystals ...

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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-Yuan wang Jing-Hang wang Run-Kai Chen zhen Yuan Hao Cui Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu zheng Ruizhi Li Yin wang Peifeng Li Hai Zhu Dong wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-Hui lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-Fu wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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超大炮口动能电磁轨道炮设计与仿真

火炮发射与控制学报 2013年第3期34卷 10-14页

作者：周长军苏子舟张涛樵军谋林振旺西北机电工程研究所陕西咸阳712099

论证了1门200mm口径超大炮口动能电磁轨道炮用以进行高超声速发射,目标是将20kg弹丸的初速提高到2 500m/s,其炮口动能将超过62MJ。通过多个不同算例的计算,综合考虑电枢受力、电流密度与峰值电流、电感梯度和技术风险等因素,最终选择了... 详细信息

论证了1门200mm口径超大炮口动能电磁轨道炮用以进行高超声速发射,目标是将20kg弹丸的初速提高到2 500m/s,其炮口动能将超过62MJ。通过多个不同算例的计算,综合考虑电枢受力、电流密度与峰值电流、电感梯度和技术风险等因素,最终选择了一种简单轨道炮结构。基于200MJ电容器组储能式脉冲电源系统,建立了轨道炮系统仿真模型并进行了分析,设计的发射器身管长为8m,铜轨道电感梯度约为0.4μH/m,峰值电流约为7MA,有效电流不低于6MA,弹丸炮口初速可达到2 540m/s,炮口动能达到64MJ,系统效率为31.8%。

关键词：电磁轨道炮仿真炮口动能

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-Ping Guo Yan-Mei Lu Bei-lin wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(Plinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

基于阳极氧化法的纳米结构加工和纳米器件的制备

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微电子技术 2001年第5期29卷 17-21页

作者：王振霖王太宏中国科学院物理研究所北京100080

本文报导了阳极氧化法实现纳米加工的技术研究和在纳米器件研究中的应用 ,特别讨论了实验装置的改进。

关键词：阳极氧化纳米结构纳米器件加工工艺

苦参碱诱导宫颈癌SiHa细胞凋亡的相关机制研究

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实用中西医结合临床 2016年第8期16卷 1-4页

作者：周美英魏林珍王海琳张爱笠甄洁玉甘肃省人民医院妇产科兰州730000 甘肃中医药大学兰州730000

目的:观察苦参碱体外诱导宫颈癌SiHa细胞凋亡效应并对其可能的作用机制进行初步探讨。方法:将不同浓度(0.00、0.25、0.50、1.00、2.00 mg/ml)的苦参碱分别作用于体外培养的宫颈癌细胞,在不同时间点(24、48、72 h),采用MTT法检测细胞的... 详细信息

目的:观察苦参碱体外诱导宫颈癌SiHa细胞凋亡效应并对其可能的作用机制进行初步探讨。方法:将不同浓度(0.00、0.25、0.50、1.00、2.00 mg/ml)的苦参碱分别作用于体外培养的宫颈癌细胞,在不同时间点(24、48、72 h),采用MTT法检测细胞的增殖情况;采用Annexin-Ⅴ和PI双染法在流式细胞仪上检测细胞的凋亡率;采用Western blot检测细胞中凋亡相关蛋白Caspase-3的表达。结果:各组苦参碱对SiHa细胞的增殖均有抑制作用,MTT和流式细胞结果显示,不同浓度的苦参碱对细胞生长抑制率与对照组相比存在明显差异(P<0.05),呈剂量效应正相关及时间效应正相关。加入Caspase-3抑制剂Z-DEVD-FMK后,各组细胞凋亡率与只加苦参碱组相比凋亡率下降。Western blot检测结果显示Caspase-3蛋白水平随苦参碱浓度的提高而增加(P<0.05)。结论:苦参碱可诱导宫颈癌SiHa细胞的增殖,促进其凋亡,其作用机制可能与提高Caspase-3活性有关。

关键词：苦参碱宫颈癌细胞增殖细胞凋亡 Z-DEVD-FMK Caspase-3

A dynamic coupling numerical model for pollutant transport under wave condition

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Acta Mechanica Sinica 2015年第1期31卷 53-61页

作者： Yong Li Mian lin zhen wang Institute of Mechanics Chinese Academy of Sciences

In order to study the diffusion, migration, and distribution of pollutants among overlying waterbody and porous seabed under wave conditions, a dynamic coupling numerical model is proposed. In this model, the coupling between wave field of overlying waterbody and seepage of porous bed, the capture and release of pollutants in porous media, and the transport process between the two different regions are taken into account. We use the unified equa tions for pressure correction and pollutant concentration to solve the numerical model, which avoids repeated iteration on the interface boundary. The model is verified by several case studies. Afterwards, the processes involving release of pollutant from porous seabed and transportation to overly ing waterbody under different wave conditions are investi gated. The results show that the water depth, wave height, and wave period have great influences on the release, cap ture, and transport processes for phosphorus pollutant.

关键词： Wave Pollutant Transport process Dynamiccoupling model Numerical analysis