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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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NEUTRON ACTIVATION STUDY OF REE ABUNDANCES IN BIOGENIC APATITE ACROSS THE CAMBRIAN//ORDOVICIAN BOUNDARY

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Chinese Science Bulletin 1989年第10期34卷 856-859页

作者：柴之芳马淑兰赵振华赵惠兰毛雪瑛马建国周瑶琪 Institute of High Energy Physics Academia Sinica Beijing Guiyang Institute of Geochemistry Academia Sinica

The biogenic apatites, like inarticulata and conodont, can be used as indicators in the study of sedimentary paleoenvironment, since they are highly enriched in REE and bring the elemental geochemical signature of primitive marine sedimentary environment. However, analytical methods with high sensitivity are indispensable to determine the REE abundances in such small fossil samples, usually several to tens of micrograms in weight. Recently, CHEN Jun-yuan et al. analyzed the

关键词： REE the Cambrian/Ordovician inarticulata and conodont neutron activation analysis.

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企业合作竞争系统自组织演化的动力学模型

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天津大学学报 2006年第B6期39卷 293-297页

作者：李振华赵黎明天津大学管理学院天津300072

为充分揭示企业合作竞争系统自组织演化的过程和机理,运用系统动力学的理论和方法,建立了企业合作竞争系统自组织演化的Logistic动力学模型．以含2个企业主体的模型为基础,进行了结构和稳定性分析,并利用计算机对其进行仿真模拟．结果表... 详细信息

为充分揭示企业合作竞争系统自组织演化的过程和机理,运用系统动力学的理论和方法,建立了企业合作竞争系统自组织演化的Logistic动力学模型．以含2个企业主体的模型为基础,进行了结构和稳定性分析,并利用计算机对其进行仿真模拟．结果表明,企业合作竞争系统的演化方向存在多种可能,演化结果与合作竞争效应紧密相关．努力放大系统中的合作效应,使有益的运行模式逐渐占据优势并形成序参量,可以引导系统向正确方向不断演化．

关键词：合作竞争系统系统动力学自组织演化仿真

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing huang Yonghua zhao Lei Xi zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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天水小陇山日本落叶松人工林土壤微生物类群生态特征研究

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土壤通报 2011年第5期42卷 1087-1092页

作者：王继伟巨天珍曹春樊振华赵继超西北师范大学地理与环境科学学院甘肃兰州730070

通过对国家级自然保护区天水小陇山李子与沙坝境内人工栽植的日本落叶松林地夏季土壤微生物数量、空间分布及多样性进行定位试验监测,结果表明,该区日本落叶松林土壤微生物类群主要以细菌为主,约占微生物总量的98%左右,其次为放线菌,真... 详细信息

通过对国家级自然保护区天水小陇山李子与沙坝境内人工栽植的日本落叶松林地夏季土壤微生物数量、空间分布及多样性进行定位试验监测,结果表明,该区日本落叶松林土壤微生物类群主要以细菌为主,约占微生物总量的98%左右,其次为放线菌,真菌最少,共分离鉴定出12种菌属。微生物数量在土层0~40 cm范围内变化剧烈,随土层的加深呈1~3个数量级下降,明显有别于其他林地微生物分布规律,或许说明土壤肥力随土层加深下降明显,且多样性指数波动较大,物种丰富度较低,该区土壤质量可能存在不良状况。

关键词：土壤微生物日本落叶松人工林

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan Song Yahong Cheng Tong Li zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu Xiao-Yu Chen Jie zhao Pin Li zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

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调节金属有机框架的配体场实现在工业电流密度下将CO_(2)高选择性还原为碳氢化合物

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Chinese Journal of Catalysis 2023年第10期53卷 102-108页

作者：薛欢黄嘉润王志烁赵振华石文廖培钦陈小明中山大学化学学院生物无机与合成化学教育部重点实验室广东广州510275 中山大学化学学院广东广州510275

电化学CO_(2)还原反应(eCO_(2)RR)利用可再生能源将CO_(2)转化为增值化学品,因而得到广泛关注.然而,目前已报道的电催化剂倾向于将CO_(2)转化为HCOOH和CO,而不是增值化学品.金属有机框架(MOF)由于具有较大的比表面积、可调的结构和丰富... 详细信息

电化学CO_(2)还原反应(eCO_(2)RR)利用可再生能源将CO_(2)转化为增值化学品,因而得到广泛关注.然而,目前已报道的电催化剂倾向于将CO_(2)转化为HCOOH和CO,而不是增值化学品.金属有机框架(MOF)由于具有较大的比表面积、可调的结构和丰富的活性位点,已被广泛应用于多相催化、气体储存和气体分离等领域.MOF是研究结构-性能关系的理想平台.金属多氮唑框架(MAF)是一类具有较好化学稳定性的MOF,但在电催化方面的研究很少.本文合成了三种具有相同四铜(Ⅱ)簇单元的金属多氮唑框架(Cu-BTP,Cu-BTTri和Cu-BTT),分别由吡唑、三氮唑和四氮唑衍生配体构成.配体的pKa值依次为H_(3)BTP(pKa=19.8)>H_(3)BTTri(pKa=13.9)>H3BTT(pKa=4.9),表明与BTTri3-和BTT3-相比,BTP3-具有最高的配体场强或配位能力.在相同条件下,对三种MAFs材料进行了电催化CO_(2)还原性能测试.其中,基于吡唑配体的Cu-BTP在流动电解池中电流密度可达1.25 A cm-2,碳氢产物的选择性达到82%(CH_(4)为60%,C_(2)H_(4)为22%).在1.25 A cm-2下连续运行60 h后,催化剂性能未见明显变化.三种MAFs材料对碳氢产物选择性的顺序为Cu-BTP(81%)>Cu-BTTri(60%)>Cu-BTT(49%),与配体的pKa顺序一致,说明配体场的场强对eCO_(2)RR的烃类产物选择性有重要影响.13CO_(2)同位素电化学实验证实了气液产物中的碳来自于CO_(2).X射线衍射图谱、扫描电镜、透射电镜、X射线吸收光谱和X射线光电子能谱结果表明,Cu-BTP具有较好的稳定性.密度泛函理论(DFT)计算揭示了三种MAFs的eCO_(2)RR反应机制.Cu-BTP(Cu:+0.95,N:-0.75)中铜离子和配位氮原子的电荷均低于Cu-BTTri(Cu:+0.99,N:-0.28)和Cu-BTT(Cu:+1.02,N:-0.16),该结果归因于配位N原子周围的电子密度与pKa数值呈正相关.最强的路易斯碱度和配体场场强导致Cu-BTP中金属簇的Cu-N4位点上电子密度最大,因此金属中心的路易斯碱度增强最多.相应地,Cu(Ⅱ)在Cu-BTP中的晶体场稳定化能值(218.48 kJ mol^(-1))大于Cu-BTTri(215.59 kJ mol^(-1))和Cu-BTT(208.23 kJ mol^(-1)),Cu-BTP的价带最大值(VBM)和导带最小值(CBM)的能级也最高.根据Koopmans定理,VBM越高说明催化剂的供电子能力越强,越高的VBM能级越靠近*CO的π*未占据轨道,这不仅有利于Lewis酸CO_(2)的吸附和活化,也有利于*CO和*CHO中间体通过π反键相互作用的吸附和活化.因此,*CO和*CHO在Cu-BTP,Cu-BTTri和Cu-BTT上的吸附能依次降低.总体而言,三种MAF金属中心的路易斯碱度依次为Cu-BTP>Cu-BTTri>Cu-BTT,与它们的eCO_(2)RR催化性能一致.综上,本文通过调节MAF的有机配体的场强度来调控eCO_(2)RR中金属活性位点与关键中间体(*CO,*CHO和*COCHO)的相互作用,进而生成碳氢化合物.其中,具有最强路易斯碱配体的MAF材料在安培级电流密度下对CO_(2)深度还原为碳氢化合物具有较高的选择性,为理性开发设计MOF及相应高性能电催化剂提供了新思路.

关键词：金属有机框架金属氮酸盐框架碳氢化合物电催化铜

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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基于响应面分析下中草药移栽机的优化设计

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农机化研究 2025年第1期47卷 135-141页

作者：赵厚睿刘臻湖北中医药大学武汉430065 湖北轻工职业技术学院武汉430070

通过响应面分析法对中草药移栽机进行优化设计,以提高中草药种植效率和质量。首先,选取移栽速度、移栽深度和移栽器械倾角3个因素作为设计变量,选取移栽成功率和移栽损伤率作为评价指标;在此基础上,设计了一个采用多种传感器组合的控制... 详细信息

通过响应面分析法对中草药移栽机进行优化设计,以提高中草药种植效率和质量。首先,选取移栽速度、移栽深度和移栽器械倾角3个因素作为设计变量,选取移栽成功率和移栽损伤率作为评价指标;在此基础上,设计了一个采用多种传感器组合的控制系统,采用模糊控制算法进行控制,并通过试验得到的数据进行响应面分析,得出了最优设计方案。研究结果表明:最优移栽速度为0.2 m/s,最优移栽深度为15 cm,最优移栽器械倾角为25°;通过优化设计,中草药移栽机的移栽成功率提高了11.8%,移栽损伤率降低了9.6%,取得了较好的效果。

关键词：移裁机响应面分析参数优化多传感器中草药

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