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Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments

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Acta Metallurgica Sinica(English Letters) 2019年第9期32卷 1075-1088页

作者： Jun-Lei Li Shuai Wang Fang Cao Xiao Lin Xiao-Wei Wei zhen-hua zhao Xiao-Jie Dou Wei-Ting Yu Ke Yang De-Wei zhao Department of Orthopaedics Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215006China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect ***,insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic *** solve this problem,many studies have been carried out to improve the bioactivity of porous titanium scaff old by surface *** this study,porous Ti6Al4V scaff olds were fabricated using additive manufacturing *** architectures were built up based on a diamond pore structure ***–acid-heat(AH)treatment was applied to create a TiO2 layer on the porous Ti6Al4V scaff old(AH-porous Ti6Al4V).Subsequently,a hydrothermal treatment was employed to enable the formation of HA coating with nanopillar-like morphology on the alkali–acid-heat-treated surface(HT/AH-porous Ti6Al4V).The effects of surface modifications on apatite-forming ability,protein adsorption,cell attachment,cell proliferation and osteogenic gene expression were studied using apatite-forming ability test,protein adsorption assay and in vitro cell culture *** was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and *** vitro studies indicated that the mesenchymal stem cells(MSCs)cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V.

关键词： Additive manufacturing Biomaterials Porous titanium scaffold HA coating

Imaging findings of primary gastric plasmacytoma:A case report

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World Journal of Gastroenterology 2014年第29期20卷 10202-10207页

作者： zhen-hua zhao Jian-Feng Yang Jin-Dao Wang Jian-Guo Wei Fang Liu Bo-Yin Wang Department of Radiology Shaoxing People’s Hospital Shaoxing Hospital of Zhejiang University Department of Gastroenterology Shaoxing People’s Hospital Department of Pathology Shaoxing People’s Hospital

Primary gastric plasmacytoma (GP) is a rare extramedullary plasmacytoma with clinical and imaging features that are common among other gastric tumors, such as gastric adenocarcinomas, gastric stromal tumors, and lymphomas. Here, we present a histologically conﬁrmed case of primary GP examined with biphasic computed tomography (CT), magnetic resonance imaging (MRI), and endosonography. A well-circumscribed extraluminal mass appearing as homogeneous attenuation/intensity with gradual enhancement was identified on biphasic enhancement CT and MRI. This mass was hyperintense on diffusion-weighted imaging and hypointense on the apparent diffusion coefficient map, implying that water diffusion in the mass was restricted. In addition, endosonography indicated a low echogenic mass in the gastric wall. These imaging findings increase the available knowledge about imaging of this disease and provide valuable information for differentiating primary GP from common gastric tumors.

关键词： Stomach Plasmacytoma Computed tomography, X-ray Magnetic resonance imaging Diffusion Endosonography

Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第13期22卷 3652-3662页

作者： Jian-Feng Yang zhen-hua zhao Yu Zhang Li zhao Li-Ming Yang Min-Ming Zhang Bo-Yin Wang Ting Wang Bao-Chun Lu Department of Radiology Second Affliated Hospital College of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University) Shaoxing 312000 Zhejiang Province China Department of Radiology Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University) Shaoxing 312000 Zhejiang Province China Department of Hepatobiliary Surgery Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University) Shaoxing 312000 Zhejiang Province China

AIM: To investigate the feasibility of a dual-input two-compartment tracer kinetic model for evaluating tumorous microvascular properties in advanced hepatocellular carcinoma(HCC). METHODS: From January 2014 to April 2015, we prospectively measured and analyzed pharmacokinetic parameters [transfer constant(K_(trans)), plasma flow(F_p), permeability surface area product(PS), efflux rate constant(k_(ep)), extravascular extracellular space volume ratio(V_e), blood plasma volume ratio(V_p), and hepatic perfusion index(HPI)] using dual-input two-compartment tracer kinetic models [a dual-input extended Tofts model and a dual-input 2-compartment exchange model(2CXM)] in 28 consecutive HCC patients. A well-known consensus that HCC is a hypervascular tumor supplied by the hepatic artery and the portal vein was used as a reference standard. A paired Student's t-test and a nonparametric paired Wilcoxon rank sum test were used to compare the equivalent pharmacokinetic parameters derived from the two models, and Pearson correlation analysis was also applied to observe the correlations among all equivalent parameters. The tumor size and pharmacokinetic parameters were tested by Pearson correlation analysis, while correlations among stage, tumor size and all pharmacokinetic parameters were assessed by Spearman correlation analysis. RESULTS: The F_p value was greater than the PS value(F_P = 1.07 m L/m L per minute, PS = 0.19 m L/m L per minute) in the dual-input 2CXM; HPI was 0.66 and 0.63 in the dual-input extended Tofts model and the dualinput 2CXM, respectively. There were no significant differences in the K_(ep), V_p, or HPI between the dual-input extended Tofts model and the dual-input 2CXM(P = 0.524, 0.569, and 0.622, respectively). All equivalent pharmacokinetic parameters, except for V_e, were correlated in the two dual-input two-compartment pharmacokinetic models; both Fp and PS in the dualinput 2CXM were correlated with K_(trans) derived from the dual-input extended Tofts

关键词： Hepatocellular carcinoma Dynamic contrastenhanced magnetic resonance imaging Pharmacokinetics

Precisely Tailoring the First Coordination Shell of Metal Centers in Porous Nitrogen-Doped Carbon Promoting Electroreduction of CO_(2)Under Neutral Condition

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CCS Chemistry 2024年第8期6卷 1978-1986页

作者： Cheng-Peng Liang Jia-Run huang Hao-Lin Zhu zhen-hua zhao Can Yu Pei-Qin Liao Xiao-Ming Chen MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular EngineeringSchool of ChemistrySun Yat-sen UniversityGuangzhouGuangdong 510275 Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049

Precise regulation of the coordination environment of a metal active center is very important but remains a ***,single-atom Ni catalysts with a combined N-and C-coordination structure(Ni-NC_(3))and N-coordination structure(Ni-N4)were prepared by modulating the side groups of organic ligands in the corresponding precursor metal–azolate *** with the Ni-N4 site,the d-band center of 3d orbitals of the Ni atom in Ni-NC_(3)was more significantly shifted to the Fermi energy level;thus,the Ni-NC_(3)catalytic site was superior to activating CO_(2)molecule into the*COOH *** a result,Ni-NC_(3)exhibited an exceptionally high performance for CO_(2)-to-CO conversion with a Faradaic efficiency of 98.4%,an energy efficiency of>50%,as well as an industrial current density of∼300 mA cm^(−2) in neutral *** high performance could be retained for at least 70 *** work reveals the importance of modulating the coordination environment in the electrochemical CO_(2)reduction reaction and provides a possible way to rational design of electrocatalysts for highly efficient conversion of CO_(2)to target products.

关键词： single-atom Ni catalysts first coordination shell porous nitrogen-doped carbon electrochemical CO_(2)reduction reaction coordination environment

Towards the meV limit of the effective neutrino mass in neutrinoless double-beta decays

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Chinese Physics C 2020年第3期44卷 1-11页

作者： Jun Cao Guo-yuan huang Yu-Feng Li Yifang Wang Liang-Jian Wen Zhi-zhong Xing zhen-hua zhao Shun Zhou Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics Liaoning Normal UniversityDalian 116029China

We emphasize that it is extremely important for future neutrinoless double-beta(0νββ)decay experiments to reach the sensitivity to the effective neutrino mass|mββ|≈1 *** such a sensitivity,it is highly possible to discover the signals of 0νββ *** no signal is observed at this sensitivity level,then either neutrinos are Dirac particles or stringent constraints can be placed on their Majorana *** this paper,assuming the sensitivity of|mββ|≈1 meV for future 0νββ decay experiments and the precisions on neutrion oscillation parameters after the JUNO experiment,we fully explore the constrained regions of the lightest neutrino mass m1 and two Majorana-type CP-violating phases{ρ,σ}.Several important conclusions in the case of normal neutrino mass ordering can be ***,the lightest neutrino mass is severely constrained to a narrow range m1∈[0.7,8]meV,which together with the precision measurements of neutrino mass-squared differences from oscillation experiments completely determines the neutrino mass spectrum m2∈[8.6,11.7]meV ing phases is limited to ρ∈[130°,230°],which cannot be obtained from any other realistic ***,the sum of three neutrino masses is found to beΣ≡m1+m2+m3∈[59.2,72.6]meV,while the effective neutrino mass for beta decays turns out to be mβ≡(|Ue1|2m1^2+|Ue2|2m2^2+|Ue3|2m3^2)1/2∈[8.9,12.6]*** observations clearly set up the roadmap for future non-oscillation neutrino experiments aiming to solve the fundamental problems in neutrino physics.

关键词： neutrinoless double-beta decays absolute neutrino masses Majorana CP phases

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Altered surfactant protein A gene expression and protein homeostasis in rats with emphysematous changes

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Chinese Medical Journal 2008年第13期121卷 1177-1182页

作者： HU Qiong-jie XIONG Sheng-dao ZHANG Hui-lan SHI Xue-mei XU Yong-jian ZHANG zhen-xiang zhen Guo-hua zhao Jian-ping Department of Respiratory Medicine Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background The decrease of surfactant protein （SP） secreted by the alveolar type Ⅱ cell is one of the important causes of limiting air of pulmonary emphysema. However, the SP-A gene and protein changes in this disease are rarely studied. This study was undertaken to investigate alterations in SP-A gene activity and protein, and to explore their roles in the pathogenesis of emphysematous changes. Methods Twenty Wistar rats were divided randomly into a normal control group （n=10） and a cigarette smoking （CS）＋ lipopolysaccharide （LPS） group （n=10）. Ultra-structural changes were observed under an electron microscope. The number of cells positive for SP-A was measured by immunohistochemistry. The mRNA expression and protein level of SP-A in the lung tissues were determined by quantitative polymerase chain reaction （qPCR） and Western blot separately. The protein level of SP-A in lavage fluid was determined by Western blot. Results The number of cells positive for SP-A of the CS＋LPS group （0.35±0.03） was lower than that of the blank control group （0.72±0.06, P 〈0.05）. The level of SP-A in the lung tissues of rats in the CS＋LPS group （0.2765±0.0890） was lower than that in the blank control group （0.6875±0.1578, P 〈0.05）. The level of SP-A in the lavage fluid of rats in the CS＋LPS group （0.8567±0.1458） was lower than that in the blank control group （1.3541±0.2475, P 〈0.05）. The lung tissues of rats in the CS＋LPS group showed an approximate increase （0.4-fold） in SP-A mRNA levels relative to β-actin mRNA （P 〈0.05）. Conclusions The changes of SP-A may be related to emphysematous changes in the lung. And cigarette smoke and LPS alter lung SP-A gene activity and protein homeostasis.

关键词： emphysema alveolar type Ⅱ cells surfactant protein A gene homeostasis

Study of the Relationship between Carotid Intima-media Thickness and Traditional Chinese Medicine Syndrome of Dyslipidemia

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Chinese Journal of Integrative Medicine 2009年第2期15卷 112-116页

作者：雷燕王振华赵浩刘剑刚 Xiyuan Hospital China Academy of Chinese Medical Sciences

Objective:The study aimed to explore the relationship between the carotid intima-media thickness (IMT),lipids,high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy) and other indices of laboratory and the traditional Chinese medicine(TCM) syndrome of ***:A total of 152 dyslipidemia patients and 8 healthy people(taken as the control group) were *** to the theory of the TCM syndrome,152 dyslipidemia patients were assigned to 4 groups:the stagnation of phlegm(SP) group,t...

关键词： dyslipidemia traditional Chinese medicine syndrome carotid ultrasonic test carotid intimamedia thickness triglyceride blood rheology

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论文化创意产业的“地方化”发展策略

包装工程 2017年第4期38卷 62-65页

作者：徐振华赵宇华沈阳航空航天大学沈阳110136 辽宁工程技术大学葫芦岛125105

目的研究文化创意产业的"地方化"发展策略。方法基于对文化的整体观照和经济全球化背景的考量,认为文化创意产业发展应该遵循以具体文化资源为依托,以具有相关文化背景的行为人为主体,以带动就业、创造财富并实现全面生活环境提升为目标... 详细信息

目的研究文化创意产业的"地方化"发展策略。方法基于对文化的整体观照和经济全球化背景的考量,认为文化创意产业发展应该遵循以具体文化资源为依托,以具有相关文化背景的行为人为主体,以带动就业、创造财富并实现全面生活环境提升为目标的"地方化"策略。结论 "地方化"发展策略要确立并导入核心文化元素,做好创意产业生态布局的设计,立足生活内涵的文创社区建设,实现艺术、生活与经济的良性共进模式。

关键词：文化创意产业 “地方化” 文化元素产业生态