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基于特征性离子快速筛查和识别色胺类新精神活性物质

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质谱学报 2021年第3期42卷 197-206,I0001页

作者：钱振华花镇东公安部物证鉴定中心北京100038 公安部禁毒情报技术中心北京100193

采用气相色谱-质谱(GC-MS)法和超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS)法分析2015~2019年国内检测发现的11种色胺类新精神活性物质。GC-MS在电子轰击源(EI)模式下采集数据,UPLC-QTOF MS在电喷雾正离子(ESI^(+))-碰撞诱导... 详细信息

采用气相色谱-质谱(GC-MS)法和超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS)法分析2015~2019年国内检测发现的11种色胺类新精神活性物质。GC-MS在电子轰击源(EI)模式下采集数据,UPLC-QTOF MS在电喷雾正离子(ESI^(+))-碰撞诱导解离(CID)模式下采集数据。通过对目标物质谱裂解产生的特征性离子进行分析,推测了色胺类新精神活性物质可能的碎裂途径,建立了一种快速、便捷筛查和识别色胺类新精神活性物质的方法。

关键词：气相色谱-质谱(GC-MS) 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS) 色胺类新精神活性物质碎裂途径

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Clinical Profile and Significance of Mucocutaneous Lesions of Primary Sjogren＇s Syndrome： A Large Cross-sectional Study with 874 Patients

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Chinese Medical Journal 2017年第20期130卷 2423-2428页

作者： Lei Xuan Yi-dong Zhang Li Li Yue-Ping Zeng Hao-Ze Zhang Jing Wang zhen-hua dong Department of Traditional Chinese Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Traditional Chinese Medicine Peking Union Medical College Beijing 100730 China Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Rheumatology Peking University First Hospital Beijing 100034 China

Background： Mucocutaneous lesions are common features of primary Sjogren＇s syndrome （pSS）, but only a few studies have focused on them. To demonstrate the profile ofmucocutaneous lesions ofpSS and further explore their potential clinical significance, we perfermed a cross-sectional study on 874 patients. Methods： Demographic data, clinical manifestations, and laboratory results of 874 pSS patients were collected. Patients were divided into two groups according to the presence of mucocutaneous lesions. Differences in primary symptoms and systemic impairments between the two groups were analyzed. Results of laboratory tests were also compared alter excluding those who had taken corticosteroid from both groups. One-year follow-up was done, and occurrences of various new complications were compared. Results： Among the 874 pSS patients, 181 patients had mucocutaneous lesions, accounting for 20.7%. Multiple mucocutaneous manifestations were displayed, and the top four most common types of lesions were purpuric eruptions （39.8%）, urticaria （23.8%）, Raynaud＇s phenomenon （14.9%）, and angular stomatitis （9.9%）. Incidences of pulmonary interstitial fibrosis, pulmonary bullae, leukopenia, and anemia were significantly higher among patients with mucocutaneous lesions （P 〈 0.05）. Increase in lgG and decrease in C4 among patients with mucocutaneous lesions displayed statistical significance after excluding patients from both groups who had taken corticosteroid （P 〈 0.05）. Alter one-year follow-up, patients with mucocutaneous lesions presented a slightly higher incidence of new complications compared to those without. Conclusions： Mucocutaneous manifestations ofpSS patients were common and diverse. Patients with mucocutaneous manifestations had more systemic damages, higher level of IgG, and lower level of serum C4, suggesting a higher activity of the primary disease.

关键词： Clinical Features: Clinical Significance: Mucocutaneous Lesions: Primary Sjogren's Syndrome

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U系列新型合成阿片类物质的质谱特征

质谱学报 2021年第1期42卷 84-92,I0004页

作者：钱振华贾薇花镇东刘翠梅公安部物证鉴定中心北京100038 公安部禁毒情报技术中心北京100193

采用气相色谱-质谱联用法(GC-MS)和超高效液相色谱-串联四极杆飞行时间质谱法(UPLC-QTOF MS)分析国际药物滥用市场最新流行的U系列新型合成阿片类物质,分别在电子轰击源(EI)和电喷雾正离子(ESI^+)-碰撞诱导解离(CID)模式下采集数据。EI... 详细信息

采用气相色谱-质谱联用法(GC-MS)和超高效液相色谱-串联四极杆飞行时间质谱法(UPLC-QTOF MS)分析国际药物滥用市场最新流行的U系列新型合成阿片类物质,分别在电子轰击源(EI)和电喷雾正离子(ESI^+)-碰撞诱导解离(CID)模式下采集数据。EI模式下,U系列新型合成阿片类物质的分子离子峰丰度较低,几乎都出现了m/z 84、125(或者m/z 112、153)的峰;ESI^+模式下,U系列新型合成阿片类物质的碎裂主要发生在酰胺基的两端及内部,二级质谱图中除准分子离子峰([M+H]^+)外,至少还会出现5个峰,分别为离子碎片A~E,其中A为基峰,A比B的质量数多80,C比D的质量数多28,E的精确质量数为81.069 9。通过总结该类物质在两种模式下获得的碎片离子与分子结构的关系,推测其可能的碎裂途径,并归纳了通过谱图推导未知U系列新型合成阿片类物质结构的方法,可为该类物质的鉴定提供参考。

关键词：气相色谱-质谱(GC-MS) 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS) U系列新型合成阿片类物质新精神活性物质碎裂途径

Clostridium difficile infection following colon subtotal resection in a patient with gallstones: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3048-3056页

作者： Feng Ke zhen-hua dong Fan Bu Cheng-Nan Li Qi-Tong He Zhi-Cheng Liu Ji Lu Kai Yu Da-Guang Wang He-Nan Xu Chang-Tao Ye Department of General Surgery Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Department of Gastrointestinal Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Plastic and Aesthetic Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Encephalopathy Rehabilitation Chaoyi HospitalYanbian Korean Autonomous PrefectureYanji 133000Jilin ProvinceChina Department of Urology The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

BACKGROUND Clostridium difficile(***)infection(CDI)is a rare clinical disease caused by changes in the intestinal microenvironment,which has a variety of causes and a poor prognosis,and for which there is no standardized clinical *** SUMMARY A patient experienced recurrent difficulty in bowel movements over the past ***,symptoms worsened within the last ten days,leading to a clinic visit due to *** patient was subsequently referred to our ***,the patient was diagnosed with obstructed colon accom-panied by *** antibiotics were administered both before and after surgery to prevent *** the fourth day post-surgery,symptoms of CDI *** cultures confirmed the presence of *** *** involved a combination of vancomycin and linezolid,resulting in the patient's successful recovery upon ***,the patient failed to adhere to the prescribed medication after discharge and was discovered deceased during a follow-up two months *** CDI is the leading cause of nosocomial post-operative care,with limited clinical cases and poor patient prognosis,and comprehensive clinical treatment guidelines are still *** infection can be triggered by a variety of factors,including intestinal hypoxia,inappropriate antibiotic use,and bile acid circulation *** patients with chronic bowel disease and related etiologies,prompt preoperative attention to possible CDI and preoperative bowel preparation is *** and prolonged medication should be maintained in the treatment of CDI to prevent recurrence of the disease.

关键词： Cholecystolithiasis Clostridium difficile Bile acid circulation Intestinal microenvironment Case report

便携式拉曼光谱仪用于合成大麻素类物质快速定性分析探究

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光谱学与光谱分析 2023年第1期43卷 145-150页

作者：胡爽刘翠梅贾薇花镇东北京警察学院北京102202 公安部禁毒情报技术中心毒品监测管控与禁毒关键技术公安部重点实验室北京100193

我国于2021年7月将合成大麻素类物质整类列入管制,在一线查缉现场对疑似合成大麻素样品进行快速定性分析是办案民警的迫切需求。研究系统考察了拉曼光谱对合成大麻素的整体区分能力,比较了四款手持式拉曼光谱仪分析实际缴获样品时的结... 详细信息

我国于2021年7月将合成大麻素类物质整类列入管制,在一线查缉现场对疑似合成大麻素样品进行快速定性分析是办案民警的迫切需求。研究系统考察了拉曼光谱对合成大麻素的整体区分能力,比较了四款手持式拉曼光谱仪分析实际缴获样品时的结果差异,探讨了制约拉曼光谱在一线查缉现场广泛应用的原因。ProTT-EZRaman-A7便携式拉曼光谱仪的整体性能介于台式拉曼和手持式拉曼之间,选用该仪器采集了90种合成大麻素对照品的拉曼光谱,并利用兼容性强的KnowItAll软件建立了90种合成大麻素通用拉曼光谱库。分析90种合成大麻素的拉曼光谱,结果表明,当不存在荧光干扰时,拉曼光谱可以区分所有合成大麻素物质,但对部分结构相差一个甲基、卤素原子等的结构类似物区分度欠佳。不同款拉曼光谱仪的性能差异大,为考察其原因,本研究选用了四款手持式拉曼光谱仪分别对120份实际缴获合成大麻素样品进行了测定,随后使用KnowItAll软件并选用包含90种合成大麻素的通用拉曼光谱库对每张光谱图进行谱库检索。四款手持式拉曼光谱仪的正确匹配率分别为71.7%,68.3%,46.7%和24.2%。抗荧光干扰能力和分辨率的不同是造成不同拉曼光谱仪匹配结果差异的主要原因。便携式拉曼光谱仪具有操作简单、测样速度快,可用于一线查缉站点快速检测的优点,但考虑到实际缴获样品的纯度未知且可能存在荧光干扰,不同拉曼光谱仪的抗荧光干扰能力、分辨率及谱库完备程度均不同,因此现阶段拉曼光谱的测试结果只能作为定性初筛使用。该研究内容为法庭科学实验室和一线办案民警正确理解和应用拉曼光谱测试结果提供了指导。

关键词：便携式拉曼光谱仪手持式拉曼光谱仪新精神活性物质合成大麻素结构类似物定性分析

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红外光谱用于新精神活性物质快速定性分析

光谱学与光谱分析 2020年第12期40卷 3925-3929页

作者：刘翠梅韩煜贾薇花镇东公安部禁毒情报技术中心毒品监测管控与禁毒关键技术公安部重点实验室北京100193

分析了301种新精神活性物质(NPS)对照品的红外光谱,其中包括合成大麻素类100种、合成卡西酮类81种、苯乙胺类42种、色胺类9种、苯环利定类7种、哌嗪类5种、氨基茚类2种、其他类55种(含芬太尼类24种)。考察了红外光谱对NPS的整体区分能... 详细信息

分析了301种新精神活性物质(NPS)对照品的红外光谱,其中包括合成大麻素类100种、合成卡西酮类81种、苯乙胺类42种、色胺类9种、苯环利定类7种、哌嗪类5种、氨基茚类2种、其他类55种(含芬太尼类24种)。考察了红外光谱对NPS的整体区分能力以及红外光谱法定性鉴定NPS的判定依据。研究结果表明,红外光谱可实现对所有NPS的区分。对于97%的NPS具有较高的区分度,其中包括了烷基链上不同位置取代、苯环上不同位置取代、苯环上不同取代基取代等NPS结构类似物;某些差异仅为一个甲基或卤素原子的NPS类似物红外光谱相似度高,但也可实现区分。匹配度系数法是谱库检索最常用的方法,操作简单,但匹配度系数的计算结果由谱图质量、软件、算法等多个因素决定,因此难以确定普适性的阳性检出阈值。相比较于匹配度系数法,采用特征吸收峰法对NPS进行定性鉴定,结果更加准确可靠。一般情况下,在其对照品红外光谱图的2 500~650 cm^-1范围内选取8个相对强度较高的吸收峰作为特征吸收峰;针对某些结构类似物,需选取一些强度较低、但能将它与其类似物区分开的吸收峰作为特征吸收峰。只有当所有特征吸收峰均检出时,才能给出阳性检出结论。根据上述原则,确定了我国已列管168种NPS的特征吸收峰,并制定了公共安全行业标准《法庭科学疑似毒品中2-氟苯丙胺等168种新精神活性物质检验气相色谱-质谱、红外光谱和液相色谱法》。采用基于特征吸收峰的红外光谱法对NPS进行快速定性分析,将极大提高NPS定性检验的鉴定效率、降低鉴定成本。

关键词：傅里叶变换红外光谱新精神活性物质结构类似物匹配度系数法特征吸收峰法

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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芬太尼类物质卡芬太尼的定性检验方法研究

分析试验室 2019年第3期38卷 270-274页

作者：钱振华陈月猛花镇东公安部物证鉴定中心北京100038 贵州省贵阳市公安局禁毒支队贵阳550018 公安部禁毒情报技术中心北京100193

报道中国首次缴获的芬太尼类物质卡芬太尼,建立其气相色谱-质谱(GC-MS)、超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF MS)和红外光谱(FTIR)定性检验方法。未知样品用甲醇和水提取,取上清液,采用GC-MS和UPLC-Q-TOF MS进行分析;样品... 详细信息

报道中国首次缴获的芬太尼类物质卡芬太尼,建立其气相色谱-质谱(GC-MS)、超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF MS)和红外光谱(FTIR)定性检验方法。未知样品用甲醇和水提取,取上清液,采用GC-MS和UPLC-Q-TOF MS进行分析;样品粉末置于衰减全反射(ATR)附件中,进行FTIR采集。GC-MS检测,保留时间为13. 05 min的未知组分的质谱碎片主要特征离子峰有m/z 303,105,243,187,96,154。UPLC-Q-TOF MS检测,保留时间为3. 976 min的未知组分的准分子离子峰为m/z 395. 2325,碰撞诱导解离(CID)模式下二级质谱主要离子有m/z 335. 2117,279. 1856,246. 1490,146. 0966,134. 0966,113. 0599。FTIR检测,在1724,1635,1593,1352,1225,704 cm-1等处出现吸收峰。经NIST谱库检索、已报道文献中信息比对及对其高分辨质谱数据的解析,鉴定为卡芬太尼。该方法可以用于实际案件的检测。

关键词：芬太尼类卡芬太尼气相色谱质谱联用(GC-MS) 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-Q-TOF MS) 红外光谱(FTIR)