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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan Wei-hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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反应气中水对钼基甲烷化催化剂性能的影响

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燃料化学学报 2017年第6期45卷 689-696页

作者：李振花刘晨谢春芳王玮涵王保伟马新宾天津大学化工学院绿色合成与转化教育部重点实验室天津300072

在反应温度550℃、空速5 500 h^(-1)、H_2S体积分数1.2%下对所研制的钼基催化剂进行了耐硫甲烷化活性评价,考察了反应气中添加H_2O对Mo基催化剂耐硫甲烷化活性的影响。结果表明,反应气中添加水对Al_2O_3负载的Mo基催化剂可造成不可逆失... 详细信息

在反应温度550℃、空速5 500 h^(-1)、H_2S体积分数1.2%下对所研制的钼基催化剂进行了耐硫甲烷化活性评价,考察了反应气中添加H_2O对Mo基催化剂耐硫甲烷化活性的影响。结果表明,反应气中添加水对Al_2O_3负载的Mo基催化剂可造成不可逆失活,而添加Co助剂及采用铈铝复合载体的催化剂其稳定性、活性得到了改善和提高。Co的添加能保护Mo基催化剂上的活性组分MoS_2,抑制添加水导致的不可逆失活。当反应气中加入水时,催化剂上主要发生水汽变换反应,且随着水含量升高,水汽变换反应速率增大,会严重影响甲烷化反应的进行。此外,随着水含量的增加,其对催化剂的耐硫甲烷化活性和稳定性的影响程度变大。

关键词：耐硫甲烷化 Mo基催化剂水水煤气变换失活

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Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-hua chen Ming-Yuan Kang Yi-Ting Chang Sheng-Yang huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

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Brazed joints of CBN grains and AISI 1045 steel with AgCuTi-TiC mixed powder as filler materials

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International Journal of Minerals,Metallurgy and Materials 2011年第6期18卷 717-724页

作者： Wen-feng Ding Jiu-hua Xu zhen-zhen chen Hong-hua Su Yu-can Fu College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The brazing process of cubic boron nitride （CBN） grains and AISI 1045 steel with AgCuTi-TiC mixed powder as a filler material was carried *** joining strength and the interfacial microstructure were *** experimental results indicate that the spreading of the molten filler material on AISI 1045 steel is decreased with the increase of TiC content.A good interface is formed between the TiC particulates and AgCuTi alloy through the wetting *** the case of AgCuTi＋16wt% TiC,the strength of the brazed steel-to-steel joints reached the highest value of 95MPa dependent upon the reinforcement effect of TiC particles within the filler *** resultants of TiB2,TiB,and TiN are produced at the interface of the CBN grains and the AgCuTi-TiC filler layer by virtue of the interdiffusion of B,N,and Ti atoms.

关键词： grinding wheels cubic boron nitride brazing filler metals shear strength interfaces

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Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

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Anti-saturation fault-tolerant adaptive torsional vibration control with fixed-time prescribed performance for rolling mill main drive system

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Journal of Iron and Steel Research International 2024年第3期31卷 660-669页

作者： Shuang Liu chen Du Cong Zhang zhen-hua Bai Key Lab of Industrial Computer Control Engineering of Hebei Province Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina

An anti-saturation fault-tolerant adaptive torsional vibration control method with fixed-time prescribed performance for the rolling mill main drive system(RMMDS)was investigated,which is affected by control input saturation,actuator faults,sensor measurement errors,and parameter ***,we gave a continuously differentiable saturation function to approximate the control input saturation characteristic of the RMMDS,translating the saturation characteristic into the matched uncertainty and unknown time-varying gain in the ***,an RMMDS mathematical model with unmatched uncertainty and unknown time-varying gain was developed,taking into account the presence of control input saturation,actuator faults,sensor measurement errors,and parameter *** on the established mathematical model,an error transformation model of the roll speed tracking was constructed by the equivalent error transformation *** to the error transformation model,a barrier Lyapunov function and a novel adaptive controller were studied to ensure that the roll speed tracking error always evolves inside a fixed-time asymmetric ***,numerical simulations were performed in Matlab/Simulink to verify the effectiveness and superiority of the proposed control method in suppressing the RMMDS torsional vibration.

关键词： Fixed-time prescribed performance Control input saturation Actuator fault Unknown time-varying gain Adaptive control Asymmetric constraint

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Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-Yuan Wang Jing-Hang Wang Run-Kai chen zhen Yuan Hao Cui Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

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夏秋季太湖4个控藻区鳙体内微囊藻毒素累积分析

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大连海洋大学学报 2017年第3期32卷 334-341页

作者：高鸽周游王小林沈振华陈永进徐东坡南京农业大学无锡渔业学院江苏无锡214081 中国水产科学研究院淡水渔业研究中心农业部长江下游渔业资源环境科学观测实验站江苏无锡214081 江苏省太湖渔业管理委员会办公室江苏苏州215004

为探讨微囊藻毒素(Microcystin,MCs)对水产品食用安全性的影响,于2015年6月向太湖4个控藻区(竺山湖、月亮湾、三国城、乌龟山)水体中投放规格约3 g/尾的鳙Aristichthys nobilis幼鱼,8—11月每月中旬从各控藻区固定采集鳙样本15尾,分别... 详细信息

为探讨微囊藻毒素(Microcystin,MCs)对水产品食用安全性的影响,于2015年6月向太湖4个控藻区(竺山湖、月亮湾、三国城、乌龟山)水体中投放规格约3 g/尾的鳙Aristichthys nobilis幼鱼,8—11月每月中旬从各控藻区固定采集鳙样本15尾,分别测定水体、鳙不同组织和器官中MCs的含量,并结合各控藻区的水质指标分析了MCs在鳙体内的累积规律及影响因子。结果表明:4个控藻区鳙不同组织和器官中总MCs含量依次为肌肉>肝胰脏>血清,且肌肉、肝胰脏中累积的总MCs极显著高于血清(P0.05);鳙肌肉、肝胰脏和血清中MCs的累积月份间有极显著性差异(P<0.01);水温和藻类胞内MCs含量对血清、肝胰脏和肌肉中MCs的累积均有极显著影响(P<0.01),体长对血清、肝胰脏中的MCs累积也有极显著影响(P<0.01);蓝藻爆发期间,MCs含量较高,据世界卫生组织(WHO)建议的MC-LR日允许摄入量,4个湖区中每日人均可摄入鳙肉229.62~977.20 g,并不会给人类健康造成危害。本研究可为微囊藻毒素在鳙体内不同组织、器官的积累效应和水产品食用安全风险评估提供理论依据。

关键词：微囊藻毒素鳙累积太湖水质指标

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu Wen-Jia chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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High-resolution Absorption Spectra of Acetylene in 142.8-152.3 nm

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Chinese Journal of Chemical Physics 2008年第5期21卷 415-420页

作者： Ya-hua Hu chen zhen Jing-hua Dai Xiao-guo Zhou Shi-lin Liu Hefei National Laboratory for Physical Sciences at Microscale Department of Chemical Physics University of Science and Technology of China Hefei 230026 China

The absorption spectra of acetylene molecules was measured under jet-cooled conditions in the wavelength range of 142.8-152.3 nm, with a tunable and highly resolved vacuum ultraviolet （VUV） laser generated by two-photon resonant four wave difference frequency mixing processes. Due to the sufficient vibrational and rotational cooling effect of the molecular beam and the higher resolution VUV laser, the observed absorption spectra exhibit more distinct spectral features than the previous works measured at room temperature. The major three vibrational bands are assigned as a C-C symmetry stretching vibrational progress （v2=0.2） of the C^1Πu state of acetylene. The observed shoulder peak at 148,2 nm is assigned to the first overtone band of the trans-bending mode V4 of the C^1Πu state of acetylene. Additionally, the two components, 4^20（μ^1Π） and 4^20（k^1Πu）, are suggested to exhibit in the present absorption spectra, due to their Renner-Teller effect and transition selection rule. All band origins and bandwidths are obtained subsequently, and it is found that bandwidths are broadened and lifetimes decrease gradually with the excitation of vibration.

关键词： Acetylene Vacuum ultraviolet Absorption spectrum

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