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Impact of Spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation:A Resting-State fMRI Study

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Chinese Journal of Integrative Medicine 2025年第2期31卷 108-117页

作者： ZHOU Xing-chen WU Shuang WANG Kai-zheng CHEN Long-hao WEI Zi-cheng LI Tao hua Zi-han XIA Qiong LYU Zhi-zhen LYU Li-jiang Department of Spine The Third Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou(310053)China Department of Spine The Third School of Clinical MedicineZhejiang Chinese Medicine UniversityHangzhou(310053)China Research Institute of Tuina(Spinal Disease) Zhejiang Chinese Medicine UniversityHangzhou(310053)China

Objective:To elucidate how spinal manipulative therapy(SMT)exerts its analgesic effects through regulating brain function in lumbar disc herniation(LDH)patients by utilizing resting-state functional magnetic resonance imaging(rs-f MRI).Methods:From September 2021 to September 2023,we enrolled LDH patients(LDH group,n=31)and age-and sex-matched healthy controls(HCs,n=28).LDH group underwent rs-f MRI at 2 distinct time points(TPs):prior to the initiation of SMT(TP1)and subsequent to the completion of the SMT sessions(TP2).SMT was administered once every other day for 30 min per session,totally 14 treatment sessions over a span of 4 *** did not receive SMT treatment and underwent only one f MRI ***,participants in LDH group completed clinical questionnaires on pain using the Visual Analog Scale(VAS)and the Japanese Orthopedic Association(JOA)score,whereas HCs did not undergo clinical scale *** effects on the brain were jointly characterized using the amplitude of low-frequency fluctuations(ALFF)and regional homogeneity(Re Ho).Correlation analyses were conducted between specific brain regions and clinical ***:Following SMT treatment,pain symptoms in LDH patients were notably alleviated and accompanied by evident activation of effects in the *** comparison to TP1,TP2 exhibited the most significant increase in ALFF values for Temporal_Sup_R and the most notable decrease in ALFF values for Paracentral_Lobule_L(voxelwise P30;FDR correction).Additionally,the most substantial enhancement in Re Ho values was observed for the Cuneus_R,while the most prominent reduction was noted for the Olfactory_R(voxelwise P30;FDR correction).Moreover,a comparative analysis revealed that,in contrast to HCs,LDH patients at TP1 exhibited the most significant increase in ALFF values for Temporal_Pole_Sup_L and the most notable decrease in ALFF values for Frontal_Mid_L(voxelwise P30;FDR correction).Fur

关键词： functional magnetic resonance imaging lumbar disc herniation spinal manipulative therapy pain

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Autocyclic switching processes and architecture of lobes in river-dominated lacustrine deltas

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Journal of Palaeogeography 2025年第1期14卷 126-140页

作者： zhen-hua Xu Sheng-He Wu Piret Plink-Bj?rklund Tao Zhang Da-Li Yue Qi-Hao Qian Qing Li Wen-Jie Feng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) College of Geosciences China University of Petroleum (Beijing) Department of Geology and Geological Engineering Colorado School of Mines Gas Production Plant 2 PetroChina Changqing Oilfield Company PetroChina Research Institute of Petroleum Exploration and Development College of Geosciences Yangtze University

River-dominated lacustrine deltas typically consist of multiple lobes due to autogenic lobe switching that occurs over short time scales. However, the switching patterns of multiple lobes in these deltas remain poorly understood, and the architectural features attributed to lobe switching are also lacking. By integrating Delft3D simulations, flume experiments, and modern deposit analysis, we proposed that autogenic lobe switching follows a cyclic pattern. Autocyclicity begins with the formation of an offshore lobe and concludes after a series of longshore lobe growth events, marked by longshore avulsions occurring along the sides of offshore distributary *** avulsions follow a sequence that usually occurs earlier distally than proximally and subsequently occurs on one longshore side and then on the other side. Each lobe begins with rapid growth, which gradually slows and then stops once a channel avulsion is influenced by the backwater effect that triggers lobe switching. Three signals indicate lobe switching: a decrease in progradation rate, foreset slope steepening coupled with topset slope gentling, and the deposition of mud-dominated sediments. The number of autocyclic events never exceeds *** first two autocyclicities contribute to more than 55% of delta length and 70% of delta area. The lobes are separated by 1-6 stages of mud-dominated accretion beds that exhibit a downstream-inclined shape and convexup or lateral overlapping pattern. This study conducts a coupled growth-geometric assessment to establish an architectural pattern for river-dominated lacustrine deltas. This architectural pattern offers valuable insights into predicting sandy lobe distribution in river-dominated lacustrine delta reservoirs, and the architecture of muddy accretion beds aids in predicting the rule of oil-water movement and distribution of remaining oil.

关键词： Autocyclic lobe switching River-dominated lacustrine delta Architecture Avulsion sequence Backwater effect

Role of two-dimensional shear wave elastography in predicting posthepatectomy liver failure:A step forwards in hepatic surgery

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 415-417页

作者： hua-zhen Deng Yu-Feng Liu Han-Wen Zhang Department of Radiology The First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen Second People’s HospitalShenzhen 518000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510282Guangdong ProvinceChina

This study explores the significance of using two-dimensional shear wave elastography(2D-SWE)to assess liver stiffness(LS)and spleen area(SPA)for predicting post-hepatectomy liver failure(PHLF).By providing a non-invasive method to measure LS,which correlates with the degree of liver fibrosis,and SPA,an indicator of portal hypertension,2D-SWE offers a comprehensive evaluation of a patient’s hepatic *** advancements are particularly crucial in hepatic surgery,where accurate preoperative assessments are essential for optimizing surgical outcomes and minimizing *** letter highlights the prac-tical implications of integrating 2D-SWE into clinical practice,emphasizing its potential to improve patient safety and surgical precision by enhancing the ability to predict PHLF and tailor surgical approaches accordingly.

关键词： Two-dimensional shear wave elastography Liver stiffness Spleen area Post-hepatectomy liver failure Non-invasive techniques Hepatic surgery

Discovery of primary lung cancer following resection of rectal cancer lung metastasis:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 173-179页

作者： Fei-Yan Zhou Fang-hua Song zhen-Hao Cheng Sen Wu Department of Oncology II Xinhua HospitalDalian UniversityDalian 116000Liaoning ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks high among the most common types of malignant *** primary cause of cancer-related mortality is metastasis,with lung metastases accounting for 32.9%of all cases of metastatic CRC(MCRC).However,cases of MCRC in the lungs,which present concurrently with primary peripheral lung adenocarcinoma,are exceptionally *** SUMMARY This report describes the case of a 52-year-old female patient who,following a colonoscopy,was diagnosed with moderately differentiated adenocarcinoma based on rectal mucosal biopsy findings.A preoperative chest computed tomography scan revealed a ground-glass nodule in the right lung and a small nodule(approximately 0.6 cm in diameter)in the extramural basal segment of the left lower lobe,which suggested multiple lung metastases from rectal *** treatment and follow-up led to a diagnosis of rectal cancer with left lung metastasis and peripheral adenocarcinoma of the lower lobe of the right *** This case report describes the therapeutic journey of a patient with lung metastasis from rectal cancer in addition to primary peripheral adenocarcinoma,thus underscoring the critical roles of multidisciplinary collaboration,personalized treatment strategies,and comprehensive patient rehabilitation guidance.

关键词： Rectal cancer Metastatic lung cancer Peripheral lung adenocarcinoma Double primary cancer Case report

Accumulation and Clearance of Polystyrene Microplastics in Brine Shrimp and the Responses of Microbiome and Metabolism

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huanjing Kexue/Environmental Science 2025年第3期46卷 1841-1849页

作者： Yan, zhen-hua Cheng, Xiao Hu, Tian-Hao Zhong, Qi-Han Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of Education Hohai University Nanjing210024 China College of Environment Hohai University Nanjing210024 China

To investigate the accumulation kinetics of microplastics（MPs）with different characteristics in zooplankton and the related biological effects，the accumulation and clearance of polystyrene microplastics（PS-MPs）with different concentrations and particle sizes in brine shrimp（Artemia saline）were analyzed under different nutritional conditions. The responses of microbial communities and metabolic functions in brine shrimp were revealed using the combination methods of microbiome and metabolome. The results showed that the accumulation and clearance rate of PS-MPs in brine shrimp increased with the increase in exposure concentrations，showing a concentration-dependent manner. On the contrary the accumulation and clearance of PS-MPs in brine shrimp were negatively correlated with their particle sizes. The nutritional condition did not alter the accumulation kinetics of PS-MPs in brine shrimp，indicating that short-term feeding may have had no effect on the uptake and clearance of PS-MPs in brine shrimp. Compared to that in the control，exposure to PS-MPs significantly enhanced the diversity of the microbial community in brine shrimp. The proportions of Proteobacteria and Acinetobacter were increased by 0.4 folds and 12.3 folds，respectively，whereas the proportions of Firmicutes and Bacillus were decreased by 43% and 86%，respectively. This finding indicates that PS-MPs may have caused an imbalance of the bacterial community in brine shrimp by inhibiting the beneficial bacteria and stimulating the harmful bacteria，thus disrupting the metabolic function in brine shrimp. In addition，exposure to PS-MPs resulted in a production of 2 311 different metabolites in brine shrimp and mainly disrupted the pyrimidine metabolism and the biosynthesis of dermal sulfate/chondroitin sulfate in brine shrimp，leading to toxicity in the shrimp. The accumulation and biological effects of MPs with different characteristics in zooplankton may further affect the stability of aquatic systems，leading to

关键词： Metabolites

Regulation of Yield and Eating and Cooking Quality in Rice Through Seed Albumin OsRAL5

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Rice science 2025年第1期32卷 6-10,I0010-I0016页

作者： ZHAO Chunfang HE Lei guan Ju LUO Lei ZHAO Ling ZHOU Lihui YAO Shu CHEN Tao ZHU zhen ZHAO Qingyong WANG Cailin ZHANG Yadong Key Laboratory of Jiangsu Province for Agrobiology/East China Branch of National Center of Technology Innovation for Saline-Alkali Tolerant Rice/Institute of Food Crops Jiangsu Academy of Agricultural ScienceNanjing 210014China

Seed storage proteins and their abundance are closely related to the formation of rice quality and grain size.A better understanding of the molecular basis of seed storage proteins will provide important information for developing new rice breeding *** this study,we report that a seed storage protein albumin,named OsRAL5,positively regulates rice quality and grain ***5 is specifically expressed during the grain-filling stage,suggesting its key role in regulating seed *** editing of OsRAL5 using the CRISPR/Cas9 system diminished grain size and weight,resulting in the development of white-core endosperm and a reduction in eating and cooking quality(ECQ).Conversely,the endosperm appearance became transparent,and both grain weight and ECQ improved in the OsRAL5 over-expressed *** major seed storage components differed significantly between the OsRAL5-edited(dOsRAL5-TS)and OsRAL5-overexpressed(OsRAL5-OE)lines compared with the wild *** protein and total lipid contents both decreased in the dOsRAL5-TS lines and increased in the OsRAL5-OE ***,the over-expression of OsRAL5 significantly increased nutritional content and simultaneously improved yield and *** results imply that OsRAL5 might be a promising candidate gene for breeding super rice varieties with increased yield potential and superior quality.

关键词： CRISPR/Cas9 breeding Albumin

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New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 122-132页

作者： Xin-Chang Shang-guan Jun-Rong Zhang Chao-Nan Lin Shuai Chen Yong Wei Wen-Xuan Chen Lin Pan Li-Qin huang Shao-hua zheng Xian-Qiang Chen Department of Emergency Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina College of Physics and Information Engineering Fuzhou UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer(OCRC).The existing assessment still relies on the colorectal obstruction scoring system(CROSS)which is based on a comprehensive analysis of patients’complaints and eating *** data collection relies on subjective descriptions and lacks objective ***,a scoring system for the evaluation of computed tomography-based obstructive degree(CTOD)is urgently required for *** To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term *** Of 173 patients were *** was obtained using k-means,the ratio of proximal to distal obstruction,and the proportion of nonparenchymal areas at the site of *** was integrated with the CROSS to analyze the effect of emergency intervention on ***-term and long-term outcomes were compared between the *** CTOD severe obstruction(CTOD grade 3)was an independent risk factor[odds ratio(OR)=3.390,95%confidence interval(CI):1.340-8.570,P=0.010]via multivariate analysis of short-term outcomes,while CROSS grade was *** the CTOD-CROSS grade system,for the non-severe obstructive(CTOD 1-2 to CROSS 1-4)group,the complication rate of emergency interventions was significantly higher than that of non-emergency interventions(71.4%vs 41.8%,P=0.040).The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group(35.7%vs 8.9%,P=0.020).However,CTOD grade was not an independent risk factor of overall survival and progression-free *** CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.

关键词： Obstructive colorectal cancer Scoring system Computed tomography-based obstructive degree Colorectal obstruction scoring system Emergency intervention

Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos

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Plant Diversity 2025年第1期47卷 68-81页

作者： Ling Mao Cen Guo Liang-Zhong Niu Yu-Jiao Wang Guihua Jin Yi-Zhou Yang Ke-Cheng Qian Yang Yang Xuemei Zhang Peng-Fei Ma De-Zhu Li zhen-hua Guo Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China Yunnan Key Laboratory of Dai and Yi Medicines Yunnan University of Chinese MedicineKunmingYunnan 650500China

Rapid growth is an innovative trait of woody bamboos that has been widely ***,the genetic basis and evolution of this trait are poorly *** advantage of genomic resources of 11 representative bamboos at different ploidal levels,we integrated morphological,physiological,and transcriptomic datasets to investigate rapid *** particular,these bamboos include two large-sized and a small-sized woody species,compared with a diploid herbaceous *** results showed that gibberellin A1 was important for the rapid shoot growth of the world's largest bamboo,Dendrocalamus sinicus,and indicated that two gibberellins(GAs)-related genes,KAO and SLRL1,were key to the rapid shoot growth and culm size in woody *** expression of GAs-related genes exhibited significant subgenome asymmetry with subgenomes A and C demonstrating expression dominance in the large-sized woody bamboos while the generally submissive subgenomes B and D dominating in the small-sized *** subgenome asymmetry was found to be correlated with the subgenome-specific gene structure,particularly UTRs and core *** study provides novel insights into the molecular mechanism and evolution of rapid shoot growth following allopolyploidization in woody bamboos,particularly via subgenome *** findings are helpful for understanding of how polyploidization in general and subgenome asymmetry in particular contributed to the origin of innovative traits in plants.

关键词： Allopolyploids GAs DEGs Culm sizes Rapid shoot growth Woody bamboos

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As-cast Ti_(x)(AlVCr)_(100−x)light-weight medium entropy alloys with high strength and uniform compressive plasticity

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 194-206页

作者： Ming-jie KAI Yu-jie MA Xiao-tian WANG Liang CHENG Jian-bo HU Yao-yao HU Tai-ran XU Gui-jiang LI Xiang-kang MENG zhen-hua CAO College of Materials Science and Engineering Nanjing Tech UniversityNanjing 210009China School of Intelligent Manufacturing and Information Jiangsu Shipping CollegeNantong 226010China Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China

The effect of Ti content on the microstructure and mechanical properties of as-cast light-weight Ti_(x)(AlVCr)_(100−x)medium entropy alloys was studied by compressive tests,X-ray diffraction,scanning electron microscopy and transmission electron *** results suggest that yield strength increases and then decreases with the increment of Ti *** Ti_(60)(AlVCr)_(40)alloy has the best combination of high strength of 1204 MPa and uniform plastic strain of 70%,possessing a high specific yield strength of 255 MPa·cm^(3)/*** enhancement of strength is mainly attributed to the synergic effects of solid-solution and coherent nano-precipitation strengthening,while dislocation motion such as dislocation pinning,entanglement and dislocation cells significantly increases the strain-hardening capacity.

关键词： TiAlVCr medium entropy alloy solid solution strengthening b2 precipitate strain hardening behavior