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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Higher Order Willmore Hypersurfaces in Euclidean Space

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Acta Mathematica Sinica,English Series 2009年第1期25卷 77-84页

作者： zhen guo Department of Mathematics Yunnan Normal University Kunming 650092 P. R. China

Let x ： Mn^n→ R^n＋1 be an n（≥2）-dimensional hypersurface immersed in Euclidean space Rn＋1. Let σi（0≤ i≤ n） be the ith mean curvature and Qn = ∑i=0^n（-1）^i＋1 （n^i）σ1^n-iσi. Recently, the author showed that Wn（x） = ∫M QndM is a conformal invariant under conformal group of R^n＋1 and called it the nth Willmore functional of x. An extremal hypersurface of conformal invariant functional Wn is called an nth order Willmore hypersurface. The purpose of this paper is to construct concrete examples of the 3rd order Willmore hypersurfaces in Ra which have good geometric behaviors. The ordinary differential equation characterizing the revolutionary 3rd Willmore hypersurfaces is established and some interesting explicit examples are found in this paper.

关键词： higher-order Willmore functional conformal invariant 3rd order Willmore hypersurface

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Permian–Triassic Climatic and Environmental Extremes and Biotic Response (IGCP 630:2014–2018):Goals and Achievements

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Acta Geologica Sinica(English Edition) 2019年第3期93卷 780-782页

作者： CHEN Zhongqiang guo zhen State Key Laboratory of Biogeology & Environmental Geology China University of Geosciences

IGCP 630,with its full title of"Permian-Triassic(P-Tr)climatic and environmental extremes and biotic response",is an International Geoscience Program project sponsored by the United Nation Educational,Scientific&Cultural Organization(UNESCO)and International Union of Geological Sciences(IUGS).This project was approved in 2014 and ended in 2018,and has applied for one-year extension in *** 630 consists of 150 geoscientists across multidisciplinary geosciences from 27 countries around the world.

关键词： Permian-Triassic Climatic Environmental Extremes Biotic Response

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Construction of a Bacterial Artificial Chromosome Library of TM-1,a Standard Line for Genetics and Genomics in Upland Cotton

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Journal of Integrative Plant Biology 2009年第1期51卷 107-112页

作者： Yan Hu Wang-zhen guo Tian-zhen Zhang National Key Laboratory of Crop Genetics & Germplasm Enhancement Cotton Research Institute Nanjing Agricultural University Nanjing 210095 China

A bacterial artificial chromosome （BAC） library was constructed for Gossypium hirsutum acc. TM-1, a genetic and genomic standard line for Upland cotton. The library consists of 147 456 clones with an average insert size of 122.8 kb ranging from 97 to 240 kb. About 96.0% of the clones have inserts over 100 kb. Therefore, this library represents theoretically 7.4 haploid genome equivalents based on an AD genome size of 2 425 Mb. Clones were stored in 384 384- well plates and arrayed into multiplex pools for rapid and reliable library screening. BAC screening was carried out by four-round poiymerase chain reactions using 23 simple sequence repeats （SSR） markers, three sequence-related amplified polymorphism markers and one pair of primers for a gene associated with fiber development to test the quality of the library. Correspondingly, in total 92 positive BAC clones were identified with an average four positive clones per SSR marker, ranging from one to eight hits. Additionally, since these SSR markers have been localized to chromosome 12 （A12） and 26 （D12） according to the genetic map, these BAC clones are expected to serve as seeds for the physical mapping of these two homologous chromosomes, sequentially map-based cloning of quantitative trait loci or genes associated with important agronomic traits.

关键词： bacterial artificial chromosome library polymerase chain reaction screening simple sequence repeats markers TM-1 upland cotton.

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Quantitative Trait Loci Mapping of Leaf Morphological Traits and Chlorophyll Content in Cultivated Tetraploid Cotton

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Journal of Integrative Plant Biology 2005年第11期47卷 1382-1390页

作者： Xian-Liang SONG Wang-zhen guo Zhi-guo HAN Tian-zhen ZHANG State Key Laboratory of Crop Genetics and Germplasm Enhancement Cotton Research Institute Nanjing Agricultural University Nanjing 210095 China Shandong Agricultural University College of Agronomy Taian 271018 China

Genetic mapping provides a powerful tool for quantitative trait loci （QTL） analysis at the molecular level. A simple sequence repeat （SSR） genetic map containing 590 markers and a BCI population from two cultivated tetraploid cotton （Gossypium hirsutum L.） cultivars, namely TM-1 and Hai 7124 （G. barbadense L.）, were used to map and analyze QTL using the composite interval mapping （CIM） method. Thirty one QTLs, 10 for lobe length, 13 for lobe width, six for lobe angle, and two for leaf chlorophyll content, were detected on 15 chromosomes or linkage groups at logarithm of odds （LOD）≥2.0, of which 15 were found for leaf morphology at LOD≥3.0. The genetic effects of the QTL were estimated. These results are fundamental for marker-assisted selection （MAS） of these traits in tetraploid cotton breeding.

关键词： chlorophyll cotton leaf morphology quantitative trait locus mapping simple sequencerepeat.

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Double-Frequency Microseisms on the Thick Unconsolidated Sediments in Eastern and Southeastern Coasts of United States: Sources and Applications on Seismic Site Effect Evaluation

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Journal of Earth Science 2021年第5期32卷 1190-1201页

作者： zhen guo Yu Huang Adnan Aydin College of Civil Engineering Tongji UniversityShanghai 200092China Shanghai Sheshan National Geophysical Observatory Shanghai 201602China Key Laboratory of Geotechnical and Underground Engineering of the Ministry of Education Tongji UniversityShanghai 200092China Department of Geology and Geological Engineering the University of MississippiMS 38677USA

This study presents a systematic analysis of double-frequency(DF) microseisms recorded on the unconsolidated sediments in the eastern and southeastern coasts of United States. For all recordings, the site effect parameters(predominant frequency(f_(0)), amplification factor and unconsolidated sediment thickness(UST)) are obtained by Nakamura method and the DF spectra are classified into five groups in terms of the DF peak patterns and the recording locations relative to the coastline. The frequencies and energy levels of the DF peaks in horizontal direction and the amplification factors are associated with the UST which is resulted from seismic site effect. By polarization analysis, the primary vibration directions of the DF peaks are identified and presented as great circles passing through the recording stations intersecting mainly along the continental slope. Correlation analyses of time histories of the DF energy and the ocean wave climate observed at buoys show that the low(0.2 Hz) frequency DF microseisms are generated in the deep ocean and the continental shelf respectively. It is concluded that the continental slope plays a significant role in the generation of DF microseisms as it causes reflection of waves from the open ocean, initiating standing waves.

关键词： seismic site effect double-frequency microseisms unconsolidated sediments continental slope ocean wave

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A Classical Theory for the Raman Optical Activity

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Chinese Physics Letters 1998年第10期15卷 753-755页

作者： MA Shu-guo WU guo-zhen Department of Physics Tsinghua UniversityBeijing 100084 Center for Advanced Study Tsinghua UniversityBeijing 100084

A classical theory for the Raman optical activity(ROA)is proposed based on a picture that for a normal mode,atoms of a molecule with partial residual charges act as oscillating dipoles around their equilibrium positions,which also induce magnetic moments on the other atoms(dipoles),*** the resulting coupling between electric dipoles and magnetic moments of the molecule contributes to the optical *** its crude approximation,this model offers a physical essence for ROA and produces results that are of quality comparable to the complicated quantum-chemical calculation,as far as the sign of the circular intensity difference for the ROA is concerned.

关键词： dipole oscillating magnetic

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Phylogenomic analyses reveal intractable evolutionary history of a temperate bamboo genus (Poaceae: Bambusoideae)

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Plant Diversity 2019年第4期41卷 213-219页

作者： Cen guo zhen-Hua guo De-Zhu Li Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan650201China

Shibataea is a genus of temperate bamboos(Poaceae:Bambusoideae)endemic to China,but little is known about its phylogenetic position and interspecific *** elucidate the phylogenetic relationship of the bamboo genus Shibataea,we performed genome-scale phylogenetic analysis of all seven species and one variety of the genus using double digest restriction-site associated DNA sequencing(dd RAD-seq)and whole plastid genomes generated using genome *** phylogenomic analyses based on dd RAD-seq and plastome data congruently recovered Shibataea as *** nuclear data resolved *** as the earliest diverged species,followed by ***,while the rest of Shibataea can be further divided into two ***,the plastid and nuclear topologies conflict *** comparing the results of network analysis and topologies reconstructed from different datasets,we identify *** as the most admixed species,which may be caused by incomplete lineage sorting(ILS)or interspecific gene flow with four sympatric *** study highlights the power of dd RAD and plastome data in resolving complex relationships in the intractable bamboo genus.

关键词： Shibataea ddRAD-seq Genome skimming Phylogeny Incongruence

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Research on Test Technology of RFID System

Research on Test Technology of RFID System

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第25届中国控制与决策会议

作者： zhen-jun guo Institute of Information and Technology Guilin University of Electronic Technology Graduate University of Chinese Academy of Sciences

ISBN: (纸本)9781467355339

On the basis of the RFID testing standards theoretical analysis,it designs a RFID system test platform based on the embeddedLinux. It carries on the design development by hardware system’s design of test platform,the software development platform construction and the application software system’s design. It designs the application software system of test platform by Qt, and gives the application software test process,it electively assess the RFID system performance. The article analyzesthe influence to the overall system performance,and carries on separately thesimulation testtothe RFID system from encoding method, CRC verification code and negative carrier modulation depth.

关键词： RFID test platform Performance test Uniform test

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Research on Key Technologies and Application of Internet of Things

Research on Key Technologies and Application of Internet of ...

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第25届中国控制与决策会议

作者： zhen-jun guo Institute of Information and Technology Guilin University of Electronic Technology Graduate University of Chinese Academy of Sciences

ISBN: (纸本)9781467355339

Three partssuch as: EPC middleware, ONS and EPC Information Service were studiedin depthin this *** an EPC Middleware System,an ONS system,an EPC Information Services ystem were designed *** more complete information network system hasbeen established, which providesa platform for "Internet of Things" rapidly extended to the enterprise and information-sharing among *** middleware system isalink between RFID equipmentand enterprise *** provides connections to RFID equipment,puts EPC information into networks,checks EPC, lters EPC,bu ers EPC,*** system nds out the addresses of EPCIS servers through pretreatsintg EPC,and sends the addresses to EPC *** system accesses to the corporate databases,provides externa services for quering item information. Finally in laboratory,a simulation platform was set up , and it veri ed the easibility of *** test results show that EPC middleware, when it’s work parameters has been adjusted according to the environment, can quickly, accurately eliminate redundancy brought along by dumb *** Information Server can accurately, safely return information of items.

关键词： Internet of Things middleware EPC Information Service

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