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Prediction and optimization of flue pressure in sintering.process based on SHAP

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International Journal of Minerals,Metallurg. and Materials 2025年第2期32卷 346-359页

作者： Ming.u Wang.Jue Tang.Mansheng.Chu Quan Shi zhen Zhang School of Metallurg. Northeastern UniversityShenyang 110819China Liaoning.Low-Carbon Steelmaking.Technolog. Eng.neering.Research Center Northeastern UniversityShenyang 110819China Eng.neering.Research Center of Frontier Technolog.es for Low-Carbon Steelmaking.Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targ.ted adjustment ***,the sintering.process data were collected and processed.A flue pressure prediction model was then constructed after comparing.different feature selection methods and model alg.rithms using.SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error rang. of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering.operation parameters on flue pressure,the relation-ship between the numerical rang. of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a sing.e sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judg.ent *** operating.parameter combination was then *** flue pressure was increased by 5.87%during.the verification process,achieving.a g.od optimization effect.

关键词： sintering.process flue pressure shapley additive explanation prediction optimization

Dynamic Reg.lation of Hydrog.n Bonding.Networks and Solvation Structures for Synerg.stic Solar‑Thermal Desalination of Seawater and Catalytic Deg.adation of Org.nic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming.Yuan Yu Jing.Wu g.ang.Yin Fan‑zhen Jiao Zhong.zhen Yu Jin Qu Beijing.Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Org.nic‑Inorg.nic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Althoug. solar steam g.neration strateg. is efficient in desalinating.seawater,it is still challeng.ng.to achieve continuous solar-thermal desalination of seawater and catalytic deg.adation of org.nic ***,dynamic reg.lations of hydrog.n bonding.networks and solvation structures are realized by desig.ing.an asymmetric bilayer membrane consisting.of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrog.n bonding.networks inside the membrane can be tuned by the rich surface–OH g.oups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ g.nerated during.the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can reg.late the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering.the de-solvation of the solvated Na^(+)and subsequent nucleation/g.owth of ***,the heat g.nerated by the solar-thermal energ. conversion can accelerate the reaction kinetics and enhance the catalytic deg.adation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synerg.stic solar thermal desalination of seawater/brine and catalytic deg.adation of org.nic pollutants.

关键词： Solar steam g.neration Seawater desalination Catalytic deg.adation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Pathog.nesis, diag.osis, and treatment of epilepsy: electromag.etic stimulation-mediated neuromodulation therapy and new technolog.es

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Neural Reg.neration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen g. Hua Yan Ding.ing.Shen Xiaosong.g. Academy of Medical Eng.neering.and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug.Delivery Systems of Zhejiang.Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong.University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing.and multifactorial neurolog.cal *** reg.rding.the accurate diag.osis,prog.osis,and in-depth pathog.nesis are crucial for the precise and effective treatment of *** pathog.nesis of epilepsy is complex and involves alterations in variables such as g.ne expression,protein expression,ion channel activity,energ. metabolites,and g.t microbiota *** results are lacking.for conventional treatments for *** resection of lesions,drug.therapy,and non-drug.interventions are mainly used in clinical practice to treat pain associated with ***-pharmacolog.cal treatments,such as a ketog.nic diet,g.ne therapy for nerve reg.neration,and neural reg.lation,are currently areas of research *** review provides a comprehensive overview of the pathog.nesis,diag.ostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including.percutaneous vag.s nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial mag.etic stimulation and transcranial direct current *** studies have shown that electromag.etic stimulation-mediated neuromodulation therapy can markedly improve neurolog.cal function and reduce the frequency of epileptic ***,many new technolog.es for the diag.osis and treatment of epilepsy are being.***,current research is mainly focused on analyzing.patients’clinical manifestations and exploring.relevant diag.ostic and treatment methods to study the pathog.nesis at a molecular level,which has led to a lack of consensus reg.rding.the mechanisms related to the disease.

关键词： diag.osis drug.treatment electroencephalog.aphy epilepsy monitoring epilepsy nerve reg.neration neurostimulation non-drug.interventions pathog.nesis prediction

Brain reg.on-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Reg.neration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang.Zeng.Wei Tan Xing.ing.Chen Shuyuan Bai Qiong.Wu Yushan Chen zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technolog. Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina g.riatric Hospital Affiliated to Wuhan University of Science and Technolog. WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain reg.on–specific,particularly involving.the corticolimbic system,including.the ventral teg.ental area,nucleus accumbens,prefrontal cortex,amyg.ala,and *** how brain-derived neurotrophic factor participates in stress processing.in different brain reg.ons will deepen our understanding.of social stress *** this review,we discuss the expression and reg.lation of brain-derived neurotrophic factor in stress-sensitive brain reg.ons closely related to the pathophysiolog. of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B sig.aling.pathway and the ventral teg.ental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain reg.ons of the corticolimbic ***,BDNF mig.t be a biolog.cal indicator reg.lating.stress-related processes in various brain reg.ons.

关键词： amyg.ala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral teg.ental area

Integ.ation of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑Rg. for Boosting.Electromag.etic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang.Yuefeng.Yan zhen Wang.g.ansheng.Ma Dechang.Jia Xiaoxiao Huang.Yu Zhou State Key Laboratory of Precision Welding.Joining.of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Eng.neering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integ.ation Materials&g.een Manufacturing.Technolog. Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing.effective strateg.es to reg.late g.aphene’s conduction loss and polarization has become a key to expanding.its application in the electromag.etic wave absorption(EMWA)*** on the unique energ. band structure of g.aphene,reg.lating.its bandg.p and electrical properties by introducing.heteroatoms is considered a feasible ***,metal-nitrog.n doping.reduced g.aphene oxide(M–N-Rg.)was prepared by embedding.a series of sing.e metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in Rg. using.an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching.for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-Rg. reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 g.z(1.89 mm)even with a low filler loading.of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron mig.ation within the Fe further leads to conduction loss,thereby synerg.stically promoting.energ. *** study demonstrates the effectiveness of metal-nitrog.n doping.in reg.lating.the g.aphene′s dielectric properties,which provides an important basis for further investig.tion of the loss mechanism.

关键词： Electromag.etic wave absorption Fe-N-Rg. Dipole polarization Conduction loss Impedance matching

Liver as a new targ.t org.n in Alzheimer's disease:insig.t from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Reg.neration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing.Liu Hong.i Li Lemei Zhu Ling.eng.Zeng.zhen Zhang.Weijun Peng Department of Integ.ated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yang.heng.Colleg. of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuang.ao Shanhaig.an Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropatholog.es,such as amyloid plaques,synaptic and neuronal deg.neration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral org.ns,targ.ting.amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral org.n involved in amyloid-beta metabolism,playing.a crucial role in the pathophysiolog. of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying.causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring.normal cholesterol metabolism in the liver could represent a promising.therapeutic strateg. for addressing.Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Exosomes:the next-g.neration therapeutic platform for ischemic stroke

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Neural Reg.neration Research 2025年第5期20卷 1221-1235页

作者： Wenjing.Yin Hong.in Ma Yang.Qu Jiaxin Ren Ying.ing.Sun zhen-Ni g.o Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strateg.es for ischemic stroke fall short of the desired objective of neurolog.cal functional ***,there is an urg.nt need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate sig.al transduction between cells under physiolog.cal and patholog.cal *** have low immunog.nicity,g.od stability,hig. delivery efficiency,and the ability to cross the blood–brain *** physiolog.cal properties of exosomes have the potential to lead to new breakthroug.s in the treatment of ischemic *** rapid development of nanotechnolog. has advanced the application of eng.neered exosomes,which can effectively improve targ.ting.ability,enhance therapeutic efficacy,and minimize the dosag.s *** in technolog. have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strateg.es for ischemic stroke,including.their antiinflammation,anti-apoptosis,autophag.-reg.lation,ang.og.nesis,neurog.nesis,and g.ial scar formation reduction ***,it is worth noting.that,despite their sig.ificant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing.hig.ly purified *** optimization strateg.es should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diag.ostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding.of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture eng.neering exercise exosomes ischemic stroke mesenchymal stem cells microg.ia neuroprotection stents

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu Yifei Yang.Yike Jing.zhen Zeng.Xuesong.Yi Wei Sun Fei Yang Key Laboratory of Ag.o-Forestry Environmental Processes and Ecolog.cal Reg.lation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising.approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and slug.ish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg.h^(-1)·cm^(-2)with a hig. Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination lig.nds and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxyg.nation and hydrog.nation steps during.NO3-conversion,thereby,effectively reducing.the energ. barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational desig. of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

Characteristic chang.s in astrocyte properties during.astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Reg.neration Research 2025年第6期20卷 1801-1815页

作者： Qing.He zhen Wang.Yuchen Wang.Meng.ie Zhu Zhile Liang.Kang.ong.Zhang.Yug. Xu g.ng.Chen g.M Institute of CNS Reg.neration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recog.ized as a potential new therapeutic intervention for neural injury and deg.nerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing.the converted neurons to pre-existing.neurons mis-expressing.transg.nes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting.in a series of sig.ificant chang.s in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes g.adually adopted neuronal morpholog., and the neural transcription factors was g.adually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a prog.essive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet sig.al), CX43(g.p junction sig.al), and S100β. Importantly, none of these chang.s could be attributed to transg.ne leakag. into preexisting.neurons. Therefore, our finding. sug.est that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 g.p junction g.ia-to-neuron conversion neural reg.neration NeuroD1 reprog.amming