检索结果-南通市图书馆

Spatial Characteristics and Influencing Factors of Urban Resilience from the Perspective of Daily Activity:A Case Study of Nanjing,China

引用

Chinese Geographical Science 2021年第3期31卷 387-399页

作者： SUN Honghu zhen feng School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Provincial Engineering Laboratory of Smart City Design Simulation&Visualization JiangsuNanjing UniversityNanjing 210093China

Based on the connotation of urban resilience and the main contradictions of China's urbanization,urban resilience is placed within the main daily activities contradictory scene of the urban man-land system to build a theoretical framework of urban activity *** on geographic big data,this study identifies the spatial characteristics of activity resilience,reveals the impact of activity environment on activity resilience in Nanjing,and proposes *** main conclusions are as follows.1)Activity resilience presents a composite spatial structure of circles and clusters,and most areas are resilient but at a low level.2)There are significantly positive and negative global autocorrelation between activity resilience and activity scale,and activity ***,there also exists a local spatial autocorrelation with the opposite positive and negative trends.3)Activity environment has a significant effect on activity resilience,and the degree and direction of influence among different dimensions and regions are heterogeneous.4)For activity resilience,it is necessary to increase the matching degree between the scale and stability of activities,and reduce the excessive concentration and flow of *** the activity environment,it is necessary to improve the accessibility of the ecological environment,strengthen the high-quality supply of the infrastructure environment,optimize the balance of the location environment,and promote the inclusiveness of the social environment.

关键词： urban resilience daily activity contradiction between supply and demand big data spatial characteristics Nanjing China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanisms responsible for the effect of median nerve electrical stimulation on traumatic brain injuryinduced coma: orexin-A-mediated N-methyl-Daspartate receptor subunit NR1 upregulation

引用

Neural Regeneration Research 2016年第6期11卷 951-956页

作者： zhen feng Qing Du Department of Rehabilitation the First Affiliated Hospital of Nanchang University

Electrical stimulation of the median nerve is a noninvasive technique that facilitates awakening from coma. In rats with traumatic brain injury-induced coma, median nerve stimulation markedly enhances prefrontal cortex expression of orexin-A and its receptor, orexin receptor 1. To further understand the mechanism underlying wakefulness mediated by electrical stimulation of the median nerve, we evaluated its effects on the expression of the N-methyl-D-aspartate receptor subunit NR1 in the prefrontal cortex in rat models of traumatic brain injury-induced coma, using immunohistochemistry and western blot assays. In rats with traumatic brain injury, NR1 expression increased with time after injury. Rats that underwent electrical stimulation of the median nerve（30 Hz, 0.5 ms, 1.0 m A for 15 minutes） showed elevated NR1 expression and greater recovery of consciousness than those without stimulation. These effects were reduced by intracerebroventricular injection of the orexin receptor 1 antagonist SB334867. Our results indicate that electrical stimulation of the median nerve promotes recovery from traumatic brain injury-induced coma by increasing prefrontal cortex NR1 expression via an orexin-A-mediated pathway.

关键词： stimulation traumatic median cortex subunit minutes NMDAR markedly antagonist aspartate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Information Technology on Social Spatial Behaviors of Urban Residents——Case of Nanjing City in China

引用

Chinese Geographical Science 2008年第4期18卷 316-322页

作者： zhen feng WEI Zongcai School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China Guangzhou Urban Planning ＆ Design Survey Research Institute Guangzhou 510060 China

Taking Nanjing as a case, the paper explains the spatial behavior differences existing in the information technology use among different groups of residents and households, by virtue of analyzing the survey data of urban households in the 11 districts of Nanjing, from the social, spatial, life and other non-technical angles. Also it makes various analyses and evaluation quantitatively and qualitatively on the social and spatial effect of information technology. The results show that the new technology is changing the social spatial behaviors of urban residents. New behavioral spaces of urban family such as telecommuting, email and QQ have begun to emerge. With the help of Internet, the communication scope of families has expanded greatly, and more new forms of publicizing community information have begun to emerge. Telecommunication contact forms have been developing swiftly, and their frequencies of contact have been increasing dramatically.

关键词： information technology households social and spatial behavior social and spatial effect Nanjing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex

引用

Neural Regeneration Research 2018年第2期13卷 244-251页

作者： Xiao-yang Dong zhen feng Department of Rehabilitation Medicine the First Affiliated Hospital of Nanchang University

Orexins, produced in the lateral hypothalamus, are important neuropeptides that participate in the sleep/wake cycle, and their expres- sion coincides with the projection area of the vagus nerve in the brain. Vagus nerve stimulation has been shown to decrease the amounts of daytime sleep and rapid eye movement in epilepsy patients with traumatic brain injury. In the present study, we investigated whether vagus nerve stimulation promotes wakefulness and affects orexin expression. A rat model of traumatic brain injury was established using the free fall drop method. In the stimulated group, rats with traumatic brain injury received vagus nerve stimulation （frequency, 30 Hz, current, 1.0 mA; pulse width, 0.5 ms; total stimulation time, 15 minutes）. In the antagonist group, rats with traumatic brain injury were intracerebroventricularly injected with the orexin receptor type 1 （OXIR） antagonist SB334867 and received vagus nerve stimulation. Changes in consciousness were observed after stimulation in each group. Enzyme-linked immunosorbent assay, western blot assay and immunohistochemistry were used to assess the levels of orexin-A and OX1R expression in the prefrontal cortex. In the stimulated group, consciousness was substantially improved, orexin-A protein expression gradually increased within 24 hours after injury and OX1R expres- sion reached a peak at 12 hours, compared with rats subjected to traumatic brain injury only. In the antagonist group, the wake-promoting effect of vagus nerve stimulation was diminished, and orexin-A and OX1R expression were decreased, compared with that of the stim- ulated group. Taken together, our findings suggest that vagus nerve stimulation promotes the recovery of consciousness in comatose rats after traumatic brain injury. The upregulation of orexin-A and OXIR expression in the prefrontal cortex might be involved in the wake-promoting effects of vagus nerve stimulation.

关键词： nerve regeneration brain injury orexin-A orexin receptor type 1 vagus nerve stimulation traumatic brain injury wake-promoting coma wakefulness prefrontal cortex neurotransmitter neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Determination of operational parameters of anaerobic phase for enhanced phosphorus removal in MBR

引用

Journal of Environmental Sciences 2004年第1期16卷 67-72页

作者： HESheng-bing WANGBao-zhen WANGLin JIANGYi-feng WaterPollutionControlResearchCenter HarbinInstituteofTechnologyHarbin150090China

Two runs of experiments were carried out to obtain an understanding of phosphorus release and uptake under the anaerobic condition and then the aerobic condition respectively. Under anaerobic condition, it was found that the extent of phosphorus release appeared to increase with the increase of the initial organic loading rate when the initial organic loading rate was up to 0.1 gSCOD/gMLSS. When the initial organic loading rate was higher than 0.1 gSCOD/gMLSS, the amount of phosphorus release per unit mass of MLSS reached nearly a same stationary value, and it seemed this is not affected by organic loading rate when there is external available substrate remained. In addition, the effect of NOx-N on the phosphorus release and uptake was also investigated, it was proved that the denitrifiers has an advantage over polyphosphate accumulating bacteria in competition for organic substrate under anoxic condition. Therefore, the existence of NOx-N is disadvantageous to the phosphorus release. Based upon the above investigations, the process configuration of membrane bioreactor(MBR) in combination with anaerobic phase was proposed to enhance the removal of phosphorus in treating domestic wastewater. During the experimental period of four months, average removals of 92.50%, 84.25%, 100%, 94.09% and 85.33% were achieved for COD, TP, SS, NH_3-N and TN respectively.

关键词： wastewater treatment MBR anaerobic phosphorus removal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Endoscopic submucosal dissection combined with adjuvant chemotherapy for early-stage neuroendocrine carcinoma of the esophagus:A case report

引用

World Journal of Clinical Cases 2022年第10期10卷 3164-3169页

作者： Nan Tang zhen feng Department of Gastroenterology Shanghai Xuhui Center HospitalShanghai 200031China

BACKGROUND Neuroendocrine carcinoma(NEC)of the esophagus is rare and highly aggressive,and lacks biological ***,there are no established standard treatments for this *** this report,we describe a patient with large-cell NEC of the esophagus who was successfully treated using endoscopic submucosal dissection(ESD)combined with adjuvant *** SUMMARY A 55-year-old woman presented with intermittent mild dysphagia for 2 *** revealed a disc-shaped protruding lesion about 18 mm×18 mm in size on the upper *** ultrasonography demonstrated that the bulged lesion originated from the muscularis *** assessed en bloc resections using ESD for therapeutic diagnosis to devise a safe and appropriate *** examination revealed a poorly differentiated neoplasm comprising of large cells with marked nuclear atypia and multifocal *** addition,the specimens had a negative horizontal margin and vertical *** of invasion was classified as submucosa 2(SM2)without lymphovascular *** histopathological results were consistent with a diagnosis of esophageal NEC,large cell *** therapy has been considered for ESD patients with SM2/SM3 lesions and patients with poorly differentiated *** comprehensive consideration,we initiated combination treatment,i.e.,ESD plus adjuvant *** patient remained disease-free at the 2-year *** En bloc resection approach using ESD may play a vital role as a diagnostic and therapeutic modality for esophageal NEC.

关键词： Esophagus Neuroendocrine carcinoma Endoscopy Dissection Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Induction of Apoptosis by L-NMMA,via FKHRL1/ROCK Pathway in Human Gastric Cancer Cells

引用

Biomedical and Environmental Sciences 2006年第4期19卷 285-291页

作者： YONG-ZHONG WANG zhen-QING feng Department of Pathology Nanjing Medical University Nanjing 210029 Jiangsu China

Objective To investigate the apoptosis-inducing effect of endogenous nitric oxide （NO） suppression in gastric cancer cells and its mechanisms. Methods Apoptosis of gastric cancer cells was detected by flow cytometry. Expression of phosphorylated FKHRL1 （thr-32, ser-253） and FKHRL1 in gastric cancer cells was analyzed using Western blotting. Immunofluorescence assay was performed to localize the intracellular phosphorylated FKHRL1 （thr-32, ser-253） and FKHRL 1. Transfection of FKHRL1-HA wild type and mutant FKHRL1-HA T32A constructs was performed by lipofectamine plus reagent. NO generation was determined by Griess reaction. Results Gastric cancer cells were significantly apoptotic after treatment with NG-monomethyl-L-arginine （L-NMMA, a nitric oxide synthase inhibitor）, compared with the control （P〈0.01）. The apoptosis of gastric cancer cells induced by L-NMMA was dose-dependent and time-independent. However, the Z-DEVD-fmk, a caspase-3, 6, 7, 8, l0 inhibitor, did not prevent the apoptosis. The immunofluorescence assays showed that FKHRL1 protein was strongly expressed in the nucleu and p-FKHRL1 thr-32 protein was ：strongly expressed in the cytoplasm of SGC-7901 cells when endogenous nitric oxide generation was blocked by L-NMMA, but no change in FKHRL1 ser-253 phosphorylation. Nevertheless, ROCK protein was strongly expressed in p-FKHRL1 thr-32-positive SGC-7901 cells. The wortmannin, an inhibitor of phosphoinositol-3-OH kinase （PI3K）, did not block the phosphorylated FKHRL1 thr-32 protein induced by L-NMMA. However, Y-27632, a specific inhibitor of the protein kinase ROCK, significantly blocked apoptosis induced by phosphorylated FKHRL1 thr-32 （P〈0.01）, which was mediated by L-NMMA. A significant decrease in NO generation （P〈0.01） and a significant increase in apoptosis （P〈0.01） were observed when FKHRL1-HA wild-type cells were transfected, which caused increased FKHRL1 thr-32 phosphorylation. Conclusions L-NMMA triggers gastric carcinoma cell apoptosis, possibly

关键词： Gastric carcinoma Nitric oxide FKHRL1 Apoptosis Signaling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vanadium-Doped Semi-Insulating 6H-SiC for Microwave Power Device Applications

引用

Journal of Materials Science & Technology 2009年第1期25卷 102-104页

作者： Liana Ning Zhihong feng Yingmin Wang Kai Zhang zhen feng State Key Laboratory of Crystal Materials Shandong University Jinan 250100 Hebei Semiconductor Research Institute Shijiazhuang 050051 China

Two-inch semi-insulating SiC bulk crystals with resistivity higher than 1 × 10^6 Qcm were achieved by vanadium doping during sublimation. Secondary-ion-mass-spectrometry （SIMS） was employed to determine the concentration of impurities in the crystals, such as B, AI, V and N. These results indicated that the concentration of nitrogen and aluminum kept on decreasing and the concentration of B and V was almost constant during the whole growth. An inner crucible was used to control the exhausting of vanadium, which made the uniformity of the high resistivity （〉1×10^6 Ωcm） in the wafer up to 80%. High-performance AlGaN/GaN high-electronmobility-transistor （HEMT） materials and devices were grown and fabricated on semi-insulating 6H-SiC sub- strates. The two-dimensional electron gas （2DEG） mobility at room-temperature was 1795 cm^2/V-s. The charge carrier concentration of the substrate determined by capacitance-voltage （C-V） test was 7.3×10^15 cm^-3. The device with a gate width of I mm exhibits a maximum output power of 5.5 W at 8 GHz, which proves the semi-insulating property of the substrates indirectly.

关键词： Silicon Carbide Semi-insulating Vanadium-doped AlGaN/GaN HEMT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phagocytic Uptake of Nosema bombycis (Microsporidia) Spores by Insect Cell Lines

引用

Journal of Integrative Agriculture 2012年第8期11卷 1321-1326页

作者： CAI Shun-feng LU Xing-meng QIU Hai-hong LI Ming-qian feng zhen-zhen Laboratory of Invertebrate Pathology Zhejiang UniversityHangzhou 310058P.R.China

Microsporidia are highly specialized obligate intracellular parasites that can infect a wide variety of animals ranging from protists to mammals. The classical concept of the parasite invasion into a host cell involves its polar tube acting as a needle-syringe system. However, recent studies show microsporidian spores can also gain access to host cells by phagocytosis. The present study investigated the phagocytic uptake process of causative agent of the pebrine disease, Nosema bombycis, in several insect cell lines. We observed KOH-treated spores and cold-storaged spores can be easily uptaken by all the studied cell types 4 h post inoculation. In contrast, large numbers of freshly recovered spores remained in the culture medium. To further investigate the intracellular fates of KOH-treated spores and cold-storaged spores, electron and fluorescence microscopy were performed. No intracellular germination or subsequent parasite development were observed. Intracellular spores can be detected in host cells by polyclonal antibody 7 d post inoculation, suggesting phagocytized N. bombycis could not be digested by these non-professional phagocytes. Our results suggest that, phagocytic uptake of N. bombycis spores might represent a defense mechanism of the host cells and the intact spore wall barrier enable freshly recovered spores to keep resistance to this mechanism.

关键词： Microsporidia Nosema bombycis phagocytosis cell invasion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Which Neighborhoods Have Easier Access to Online Home Delivery Services?A Spatiotemporal Accessibility Analysis in Nanjing,China

引用

Chinese Geographical Science 2024年第4期34卷 722-738页

作者： KONG Yu zhen feng ZHANG Shanqi SHEN Lizhen School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Provincial Engineering Research Center of Smart City Planning and Digital Governance Nanjing 210093China

The rise in online home delivery services(OHDS)has had a significant impact on how urban services are supplied and used in recent *** on the spatial accessibility of OHDS are emerging,but few is known about the temporal dimension of OHDS accessibility as well as the geographic and socioeconomic differences in the spatiotemporal accessibility of *** study measures the spatiotemporal accessibility of four types of OHDS,namely leisure,fresh and convenient,medical,and catering *** geographic and socioeconomic disparities in the spatiotemporal accessibility of these four types of OHDS are then identified using spatial statistical methods and the Kruskal-Wallis test(K-W test).The case study in Nanjing,China,suggests that:1)spatiotemporal accessibility better reflects the temporal variation of OHDS accessibility and avoids overestimation of OHDS accessibility when only considering its spatial dimension.2)The spatiotemporal accessibility of OHDS varies geographically and *** located in the main city or neighborhoods with higher housing prices,higher population density,and higher point of interest(POI)mix have better OHDS spatiotemporal *** study contributes to the understanding of OHDS accessibility from a spatiotemporal perspective,and the empirical insights can assist policymakers in creating intervention plans that take into account variations in OHDS spatiotemporal accessibility.

关键词： online home delivery services(OHDS) spatiotemporal accessibility neighborhoods accessibility differences Nanjing City China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：