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Epileptic brain network mechanisms and neuroimaging techniques for the brain network

Neural Regeneration Research 2024年第12期19卷 2637-2648页

作者： Yi Guo Zhonghua Lin zhen fan Xin Tian Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Sichuan Provincial Center for Mental Health Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Geriatrics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurology Chongqing Key Laboratory of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal *** more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical *** increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic *** this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.

关键词： electrophysiological techniques epilepsy functional brain network functional magnetic resonance imaging functional near-infrared spectroscopy machine leaning molecular imaging neuroimaging techniques structural brain network virtual epileptic models

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Hydrometallurgical recovery of lithium carbonate and iron phosphate from blended cathode materials of spent lithium-ion battery

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Rare Metals 2024年第3期43卷 1275-1287页

作者： Shao-Le Song Run-Qing Liu Miao-Miao Sun Ai-Gang zhen fan-zhen Kong Yue Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083China Zhejiang Tianneng New Materials Co. Ltd.Huzhou313103China

The recycling of cathode materials from spent lithium-ion battery has attracted extensive attention,but few research have focused on spent blended cathode *** reality,the blended materials of lithium iron phosphate and ternary are widely used in electric vehicles,so it is critical to design an effective recycling *** this study,an efficient method for recovering Li and Fe from the blended cathode materials of spent LiFePO_(4)and LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)batteries is ***,87%A1 was removed by alkali ***,91.65%Li,72.08%Ni,64.6%Co and 71.66%Mn were further separated by selective leaching with H_(2)SO_(4)and H_(2)O_(2).Li,Ni,Co and Mn in solution were recovered in the form of Li_(2)CO_(3)and hydroxide ***,98.38%Fe was leached from the residue by two stage process,and it is recovered as FePO_(4)·2H_(2)O with a purity of 99.5%by *** and P were present in FePO_(4)·2H_(2)O in amounts of 28.34%and 15.98%,***,the drift and control of various components were discussed,and cost-benefit analysis was used to assess the feasibility of potential application.

关键词： Spent lithium-ion battery Blended cathode materials Recovery Lithium carbonate Iron phosphate

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Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-Yan HU Yan-Ling WANG zhen-Xing fan Xi-Peng SUN Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

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Recent advances in Ir/Ru-based perovskite electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 2891-2912页

作者： Zhi-Qi Jiang Cheng-zhen fan Jun-Yu Pan Li Shao Hao Chen Erum Pervaiz Yan Dong Tong-Zhou Wang Xue-Rong zheng Ji-Hong Li Yi-Da Deng School of Materials Science and Engineering Hainan University Department of Chemical Engineering School of Chemical and Materials Engineering (SCME)National University of Sciences & Technology (NUST) Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

Oxygen evolution reaction(OER) is a kinetically harsh four-electron anode reaction that requires a large overpotential to provide current and is of great importance in renewable electrochemical ***/Rubased perovskite oxides hold great significance for application as OER electrocatalysts,due to that their multimetal-oxide forms can reduce the use of noble metals,and their compositional tunability can modulate the electronic structure and optimize OER ***,high operating potentials and corrosive environments pose a serious challenge to the development of durable Ir-based and Ru-based perovskite *** efforts have been dedicated to improving the Ir/Ru-based perovskite activity to enhance the efficiency;however,progress in improving the durability of Ir/Ru-based perovskite electrocatalysts has been rather *** this review,the recent research progress of Ir/Ru-based perovskites is reviewed from the perspective of heteroatom doping,structural modulation,and formation of *** dissolution mechanism studies of Ir/Ru and experimental attempts to improve the durability of Ir/Ru-based perovskite electrocatalysts are *** and outlooks for further developing Ru-and Irbased perovskite oxygen electrocatalysts are also presented.

关键词： Oxygen evolution reaction Ir/Ru-based perovskites Stability Electrocatalysts

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A review of solid-state lithium metal batteries through in-situ solidification

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Science China Chemistry 2024年第1期67卷 67-86页

作者： Pan Xu Zong-Yao Shuang Chen-Zi Zhao Xue Li Li-zhen fan Aibing Chen Haoting Chen Elena Kuzmina Elena Karaseva Vladimir Kolosnitsyn Xiaoyuan Zeng Peng Dong Yingjie Zhang Mingpei Wang Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Ordos Carbon Neutral Research and Application Co. Ltd.Ordos City 017010China Ufa Institute of Chemistry UFRC RAS Ufa 450054Russia Institute for Carbon Neutrality Tsinghua UniversityBeijing 100084China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

High-energy-density lithium metal batteries are the next-generation battery systems of choice,and replacing the flammable liquid electrolyte with a polymer solid-state electrolyte is a prominent conduct towards realizing the goal of high-safety and high-specific-energy ***,the inherent intractable problems of poor solid-solid contacts between the electrode/electrolyte and the growth of Li dendrites hinder their practical *** in-situ solidification has demonstrated a variety of advantages in the application of polymer electrolytes and artificial interphase,including the design of integrated polymer electrolytes and asymmetric polymer electrolytes to enhance the compatibility of solid–solid contact and compatibility between various electrolytes,and the construction of artificial interphase between the Li anode and cathode to suppress the formation of Li dendrites and to enhance the high-voltage stability of polymer *** review firstly elaborates the history of in-situ solidification for solid-state batteries,and then focuses on the synthetic methods of solidified ***,the recent progress of in-situ solidification technology from both the design of polymer electrolytes and the construction of artificial interphase is summarized,and the importance of in-situ solidification technology in enhancing safety is ***,prospects,emerging challenges,and practical applications of in-situ solidification are envisioned.

关键词： in-situ solidification polymer electrolyte artificial solid electrolyte interphase rechargeable lithium metal batteries dendrite-free lithium metal anode

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空间权重选择的模拟研究——基于贝叶斯方法

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统计与决策 2024年第10期40卷 52-57页

作者：范真王西贝对外经济贸易大学国际经济研究院北京100029 中国人民银行北京市分行北京100045

文章在空间杜宾模型下讨论贝叶斯后验模型概率方法对空间权重矩阵的选择效果,并利用蒙特卡洛模拟验证了该方法的有效性。结果表明:贝叶斯后验模型概率方法对权重判别的准确性较高,且随样本量和时间的增加而提高,正确判别率与空间相关系... 详细信息

文章在空间杜宾模型下讨论贝叶斯后验模型概率方法对空间权重矩阵的选择效果,并利用蒙特卡洛模拟验证了该方法的有效性。结果表明:贝叶斯后验模型概率方法对权重判别的准确性较高,且随样本量和时间的增加而提高,正确判别率与空间相关系数的关系呈现“U”型特征;在对具有较强相关性的权重选择中,其判别能力下降,但效果仍优于ML法;在对有不同属性的静态空间权重的判别中,贝叶斯后验模型概率可快速达到100%;对于动态和静态空间权重的选择问题,该方法在存在较大正向空间相关性的情况下具有良好功效。

关键词：贝叶斯后验模型概率蒙特卡洛模拟空间权重矩阵

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A three-way electrolyte with ternary solvents for high-energy-density and long-cycling lithium-sulfur pouch cells

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SusMat 2024年第2期4卷 1-12页

作者： zheng Li Legeng Yu Chen-Xi Bi Xi-Yao Li JinMa Xiang Chen Xue-Qiang Zhang Aibing Chen Haoting Chen Zuoru Zhang Li-zhen fan Bo-Quan Li Cheng Tang Qiang Zhang Tsinghua Center for Green Chemical Engineering Electrification Beijing Key Laboratory of Green Chemical Reaction Engineering and TechnologyDepartment of Chemical EngineeringTsinghua UniversityBeijingChina School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina Institute of Advanced Materials and Technology University of Science and TechnologyBeijingChina Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuanChina Center for Next-Generation Energy Materials and School of Chemical Engineering Sungkyunkwan UniversityJangan-GuSuwon-SiGyeonggi-DoRepublic of Korea College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuangChina Ordos Carbon Neutral Research and Application Co. Ltd.Kangbashi DistrictOrdos CityInner MongoliaChina Institute for Carbon Neutrality Tsinghua UniversityBeijingChina

Lithium–sulfur(Li–S)batteries promise high-energy-density potential to exceed the commercialized lithiumion batteries but suffer from limited cycling lifespan due to the side reactions between lithium polysulfides(LiPSs)and Li metal ***,a three-way electrolyte with ternary solvents is proposed to enable high-energy-density and long-cycling Li–S pouch ***,ternary solvents composed of 1,2-dimethoxyethane,di-isopropyl sulfide,and 1,3,5-trioxane are employed to guarantee smooth cathode kinetics,inhibit the parasitic reactions,and construct a robust solid electrolyte interphase,*** cycling lifespan of Li–S coin cells with 50μm Li anodes and 4.0 mg cm^(−2) sulfur cathodes is prolonged from88 to 222 cycles using the three-way ***-heterogeneous solvation structure of LiPSs and organic-rich solid electrolyte interphase are identified to improve the cycling stability of Li metal ***,a 3.0 Ah-level Li–S pouch cell with the three-way electrolyte realizes a high energy density of 405 Wh kg^(−1) and undergoes 27 *** affords a three-way electrolyte recipe for suppressing the side reactions of LiPSs and inspires rational electrolyte design for practical high-energy-density and long-cycling Li–S batteries.

关键词： lithium metal anodes lithium-sulfur batteries pouch cells solid electrolyte interphase three-way electrolyte

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Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

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Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE Jun-yu SONG Jin-bin LI Long HE zhen-fan HUANG Zhuo-jian LIU zheng-lin CHEN Gui-rong WANG Hai-yan WEN Su-ru ZHOU Heng-li MA Hui-lin DU Qun WU Yong-qiang LI Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui fan Qiang Li Gong Li Dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li zhen Yang Qi An Hao-fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen zhen Chen Zeng-Qi Cui An-Chuan fan Chang-Qing Feng fan-zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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内镜下CCEST微创干预治疗胰胆管合流异常患者35例分析

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世界华人消化杂志 2024年第1期32卷 41-49页

作者：徐梦想范震赵敏楠浙江中医药大学第四临床医学院浙江省杭州市310053 杭州市第一人民医院消化科浙江省杭州市310022 杭州市富阳区第一人民医院浙江省杭州市311400

背景胰胆管合流异常(pancreaticobiliary maljunction,PBM)患者的共同通道(common channel,CC)过长导致Oddi括约肌的作用不直接影响到胰胆连接处,继而胰液和胆汁相互反流,造成胆道或胰腺的各种病理改变.探索内镜下微创缩短胰胆管CC通道... 详细信息

背景胰胆管合流异常(pancreaticobiliary maljunction,PBM)患者的共同通道(common channel,CC)过长导致Oddi括约肌的作用不直接影响到胰胆连接处,继而胰液和胆汁相互反流,造成胆道或胰腺的各种病理改变.探索内镜下微创缩短胰胆管CC通道在PBM中的应用及其机制变得尤为重要,为患者提供又一个治疗的技术选择.目的探讨经内镜下十二指肠乳头括约肌共同通道切开术(endoscopic common channel sphinctertomy,CCEST)微创干预治疗PBM患者的临床效果及安全性.方法观察分析CCEST内镜下微创干预治疗的35例PBM患者,其中BP型19例、PB型16例,复杂型0例.35例患者均行经内镜逆行胰胆管造影(endoscopic retrograde cholangiopancreatography,ERCP)下CCEST并分析内镜下微创干预治疗对PBM患者的影响作用及并发症等情况.结果35例PBM患者中,男性12例,女性23例,平均年龄为(46±26.38)岁(3岁-89岁).所有患者均给予内镜下CCEST,以缩短共同通道.35例PBM患者中合并胆、胰管结石患者18例(51.43%),14例患者首次ERCP取石成功,成功率为78%(14/18).ERCP微创干预治疗术后1 wk,35例患者中血清生化、C-反应蛋白(C-reactive protein,CRP)指标及胆汁淀粉酶较术前均明显下降(P<0.05).5例患者出现轻度ERCP术后胰腺炎,经对症治疗后均未出现术后出血、消化道穿孔和重症胰腺炎等严重并发症.经过对35例患者(22.05±10.67)mo的随访,其中1例术后确诊胆管癌而行外科手术;有4例患者因结石复发再次行ERCP治疗,也取得满意疗效.治疗总有效率为88.6%(31/35).结论PBM起病较隐匿,ERCP可协助明确PBM诊断.CCEST通过缩短胆胰管汇合部共同通道,早期改善PBM患者胆胰管引流,是内镜微创治疗PBM患者的有效安全方法.

关键词：胰胆管合流异常内镜下十二指肠乳头括约肌共同通道切开术胆胰疾病微创治疗

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