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Mechanical performance of 22SiMn2TiB steel welded with lowtransformation- temperature filler wire and stainless steel filler wire

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Journal of Iron and Steel Research International 2024年第4期31卷 967-981页

作者： Zi-dong Lin Kai-jie Song zhen Sun Zi-qian Zhu Xue-feng Zhao Constantinos Goulas wei Ya Xing-hua Yu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Design Production and Management Faculty of Engineering Technology.University of TwenteEnschede 7500 AETheNetherlands Rotterdam Additive Manufacture Fieldlab(RAMLAB) Rotterdam 3089 JWTheNetherlands

TX-80 low-transformation-temperature(LTT)welding wire was used to replace the traditional ER 307Si welding wire to realize the connection of 22SiMn2TiB armor steel in manual overlay *** previously existing issues,such as welding cracks,large welding deformation,and severe welding residual stress,were solved to ensure good strength and ductility *** particular,with the same welding conditions,TX-80 LTT wire eliminates welding *** reduces the welding deformation no matter the base pretreatment of pre-setting angle or no pre-setting *** comparison,it was found that the microstructure at the TX-80 weld is mainly composed of martensite and a small amount of retained *** contrast,the microstructure of the ER 307Si weld consists of a large amount of austenite and a small amount of skeleton-like *** variation trend of residual stress and microhardness from the weld to the base were investigated and compared with the mechanical properties of base *** TX-80 and the ER 307Si tensile samples elongation is 6.76%and 6.01%,while the ultimate tensile strengths are 877 and 667 MPa,*** average impact toughness at room temperature of the ER 307Si weld is 143.9 J/cm^(2),much higher than that of the TX-80 weld,which is only 36.7 J/cm^(2).The relationship between impact and tensile properties with microstructure species and distribution was *** addition,the fracture surface of the tensile and the impact samples was observed and *** dimples,fewer pores,larger radiation zone,and shear lips of TX-80 samples indicate better tensile ductility and worse impact toughness than those of ER 307Si weld.

关键词： Low-transformation-temperature material 22SiMn2TiB steel Welding deformation Residual stress Martensitic transformation Mechanical property

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Ex vivo liver resection and auto-transplantation as an alternative for the treatment of liver malignancies: Progress and challenges

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 117-122页

作者： Xin Yang lu lu Wen-wei Zhu Yi-Feng Tao Cong-Huan Shen Jin-Hong Chen zheng-Xin Wang lun-Xiu Qin Hepatobiliary Surgery and Liver Transplantation Centers Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan UniversityShanghai 200040China

Hepatectomy is still the major curative treatment for patients with liver ***,it is still a big challenge to remove the tumors in the central posterior area,especially if their location involves the retrohepatic inferior vena cava and hepatic *** vivo liver resection and auto-transplantation(ELRA),a hybrid technique of the traditional liver resection and transplantation,has brought new hope to these patients and therefore becomes a valid alternative to liver *** to its technical difficulty,ELRA is still concentrated in a few hepatobiliary centers that have experienced surgeons in both liver resection and liver *** efficacy and safety of this technique has already been demonstrated in the treatment of benign liver diseases,especially in the advanced alveolar ***,the application of ELRA for liver malignances has gained more ***,standardization of clinical practice norms and international consensus are still *** prognostic impact in these oncologic patients also needs further *** this review,we summarized the principles and recent progresses on ELRA.

关键词： Ex vivo liver resection Liver auto-transplantation Oncology Liver malignancies

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Regulating composition and structure of coal-based graphene and its electrochemical characteristics

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Clean Energy 2024年第5期8卷 265-276页

作者： Wenfeng Liu Jun Li Yating Zhang Keke Li zhen Liu Cliff Yi Guo Jingjing Wang Linlin wei China Energy Investment Corporation No.22XiBinhe RoadAndingmenDongcheng DistrictBeijing100011China National Institute of Clean-and-Low-Carbon Energy China Energy Investment CorporationBinhe Road No.9Future Science&Technology CityChangping DistrictBeijing102211China of Chemistry and Chemical Engineering Xi’an University of Science and TechnologyNo.58Yanta RoadXi'anShaanxi Province710054China

Coal,a carbon-rich mineral with plentiful reserves,serves not only as a fuel but also as a raw material,presenting lower pollution emissions in the latter *** a materials chemistry standpoint,coal is a viable raw material for graphene *** study develops a promising and sustainable method to convert coal into graphene,leveraging its unique macromolecular aromatic struc-ture and high carbon *** investigation includes an analysis of the lateral size,morphology,and chemical composition of coal-derived graphene using techniques such as X-ray diffraction,Raman spectroscopy,X-ray photoelectron spectroscopy,and op-tical *** confirm that coal can effectively replace natural graphite flakes in graphene production,with the derived graphene featuring three to six exfoliated layers and an oxygen content below 5.5%.While the graphene from coal shares a similar morphology to that derived from graphite,it exhibits more structural ***,the macroscopic size of the coal does not influence the microscopic composition and structure of the ***,the thermal reduction method for oxidized graphene proves more effective at repairing structural defects than chemical *** coal-derived graphene as a supercapacitor electrode demonstrates excellent cycling stability and ultra-high capacitance storage *** H-CG-325 shows the highest dis-charge area-specific capacitance across various current *** an increased current density of 10 A/g,the H-CG-325 maintains 80.6%of its initial capacitance of 79 F/g observed at 1 A/*** tests reveal that coal-based graphene holds significant potential as a supercapacitor material,indicating promising applications in energy storage and conversion.

关键词： coal graphene graphene oxide chemical reduction high-temperature reduction

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Research on Digital Twin System Platform Framework and Key Technologies of Unmanned Ground Equipment

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Complex System Modeling and Simulation 2024年第2期4卷 109-123页

作者： Kunyu Wang Lin Zhang Cheng Xu Han lu zhen Chen Hongbo Cheng Rui Guo the School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China the State Key Laboratory of Intelligent Manufacturing System Technology Beijing 100854China the Beijing Institute of Electronic System Engineering Beijing 100854China

As an emerging technology,digital twin is expected to bring novel application modes to the whole life cycle process of unmanned ground equipment,including research and development,design,control optimization,operation and maintenance,*** highly dynamic,complex,and uncertain characteristics of unmanned ground equipment and the battlefield environment also pose new challenges for digital twin *** from the new challenges faced by the digital twin of unmanned ground equipment,this paper designs a service-oriented cloud-edge-end collaborative platform architecture of the digital twin system of unmanned ground equipment,and further analyzes several key technologies supporting the implementation of the platform architecture.

关键词： unmanned ground equipment digital twin native cloud platform Modeling and Simulation(M&S) artificial intelligence

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Pig pangenome graph reveals functional features of non‑reference sequences

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Journal of Animal Science and Biotechnology 2024年第3期15卷 956-970页

作者： Jian Miao Xingyu wei Caiyun Cao Jiabao Sun Yuejin Xu Zhe Zhang Qishan Wang Yuchun Pan zhen Wang College of Animal Sciences Zhejiang UniversityHangzhou 310058ZhejiangChina Yazhou Bay Science and Technology City Hainan Institute of Zhejiang UniversityYazhou DistrictBuilding 11Yongyou Industrial ParkSanya 572025HainanChina

Background The reliance on a solitary linear reference genome has imposed a significant constraint on our compre-hensive understanding of genetic variation in *** constraint is particularly pronounced for non-reference sequences(NRSs),which have not been extensively *** In this study,we constructed a pig pangenome graph using 21 pig assemblies and identified 23,831 NRSs with a total length of 105 *** findings revealed that NRSs were more prevalent in breeds exhibiting greater genetic divergence from the reference ***,we observed that NRSs were rarely found within coding sequences,while NRS insertions were enriched in immune-related Gene Ontology ***,our investigation also unveiled a close association between novel genes and the immune capacity of *** observed substantial differences in terms of frequencies of NRSs between Eastern and Western pigs,and the heat-resistant pigs exhibited a substantial number of NRS insertions in an 11.6 Mb interval on chromosome ***,we discovered a 665 bp insertion in the fourth intron of the TNFRSF19 gene that may be associated with the ability of heat tolerance in South-ern Chinese *** Our findings demonstrate the potential of a graph genome approach to reveal important functional features of NRSs in pig populations.

关键词： Heat tolerance Immune ability Non-reference sequences Pig pangenome

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Aggregation-induced T_(1)/T_(2) contrast enhancement for magnetic resonance imaging-guided intraoperative surgery

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Science China Chemistry 2024年第6期67卷 2046-2055页

作者： Wenbo Sun Bin Yu Dianshuai Huang Chunhuan Jiang wei Wang Jianhua Liu Zonghua Wang Lehui lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China College of Chemistry and Chemical Engineering Shandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsQingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and TreatmentQingdao UniversityQingdao266071China Department of Radiology Second Hospital of Jilin UniversityChangchun130041China

Magnetic resonance imaging(MRI)plays an important role in precision medicine that is hampered by the lack of contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic ***,we demonstrate a DNA-based MRI probe that overcomes previous single-mode enhancement and provides a mechanism of action for aggregationinduced dual-modal MRI signal enhancement.A facile method is developed to produce aggregated T_(1)/T_(2)dual-modal NaGdF_(4):Dy@PDA-DNA(PDA=polydopamine)MRI *** aggregated,this probe can further amplify MRI signal intensity and exhibit improved geometrical and positional stability in *** performance of the NaGdF_(4):Dy@PDA-DNA MRI probe toward MRI-guided preoperative planning and visualization-guided surgery is verified using an orthotopic tumor-bearing mouse *** result shows that the rapid metabolism of the degraded probe leads to the mitigation of long-term toxic ***,the developed high-performance MRI probe is of great significance for enhancing MRI diagnostic accuracy into precision medical therapeutic interventions.

关键词： MRI probe DNA aggregation-induced T_(1)/T_(2)contrast enhancement precision medicine degradable probe

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Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu wei Liu Peng Zhao Feifei Lv Jie Sun Hongjun Li zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

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Layered Potassium Titanium Niobate/Reduced Graphene Oxide Nanocomposite as a Potassium‑Ion Battery Anode

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Nano-Micro Letters 2024年第1期16卷 1-16页

作者： Charlie A.F.Nason Ajay Piriya Vijaya Kumar Saroja Yi lu Runzhe wei Yupei Han Yang Xu Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUK

With graphite currently leading as the most viable anode for potassium-ion batteries(KIBs),other materials have been left relatively *** metal oxides are among these,with many positive attributes such as synthetic maturity,longterm cycling stability and fast redox ***,to address this research deficiency we report herein a layered potassium titanium niobate KTiNbO5(KTNO)and its rGO nanocomposite(KTNO/rGO)synthesised via solvothermal methods as a high-performance anode for *** effective distribution across the electrically conductive rGO,the electrochemical performance of the KTNO nanoparticles was *** potassium storage performance of the KTNO/rGO was demonstrated by its first charge capacity of 128.1 mAh g^(−1) and reversible capacity of 97.5 mAh g^(−1) after 500 cycles at 20 mA g^(−1),retaining 76.1%of the initial capacity,with an exceptional rate performance of 54.2 mAh g^(−1)at 1 A g^(−1).Furthermore,to investigate the attributes of KTNO in-situ XRD was performed,indicating a low-strain ***-situ X-ray photoelectron spectra further investigated the mechanism of charge storage,with the titanium showing greater redox reversibility than the *** work suggests this lowstrain nature is a highly advantageous property and well worth regarding KTNO as a promising anode for future high-performance KIBs.

关键词： Potassium-ion batteries Intercalation Transition metal oxides Anodes Nanocomposite

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Percutaneous ultrasound-guided coaxial core needle biopsy for the diagnosis of multiple splenic lesions: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 616-621页

作者： Sha-Hong Pu Wu-Yong-Ga Bao zhen-Peng Jiang Rui Yang Qiang lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The overlap of imaging manifestations among distinct splenic lesions gives rise to a diagnostic ***,a definitive diagnosis primarily relies on his-tological *** ultrasound(US)-guided coaxial core needle biopsy(CNB)not only procures sufficient tissue to help clarify the diagnosis,but reduces the incidence of puncture-related *** SUMMARY A 41-year-old female,with a history of pulmonary tuberculosis,was admitted to our hospital with multiple indeterminate splenic ***-scale ultrasono-graphy demonstrated splenomegaly with numerous well-defined hypoechoic *** contrast-enhanced computed tomography(CT)showed an en-larged spleen with multiple irregular-shaped,peripherally enhancing,hypodense *** emission CT revealed numerous abnormal hyperglycemia *** imaging findings strongly indicated the possibility of infectious disease as the primary concern,with neoplastic lesions requiring *** obtain the precise pathological diagnosis,the US-guided coaxial CNB of the spleen was ca-rried *** patient did not express any discomfort during the *** Percutaneous US-guided coaxial CNB is an excellent and safe option for obtaining precise splenic tissue samples,as it significantly enhances sample yield for exact pathological analysis with minimum trauma to the spleen parenchyma and sur-rounding tissue.

关键词： Spleen Splenic disease Ultrasound Biopsy Ultrasound-guided coaxial core needle biopsy Case report

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Phase transition of multi-component(TiZrVNb)C ceramics—Part I:Phase decomposition induced by carbon content

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Journal of Advanced Ceramics 2024年第5期13卷 679-688页

作者： Qingyi Kong Rao Zhang Lei Chen Sijia Huo Wenyu lu Yujin Wang Boxin wei Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structure‒Function Integrated Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Phase decomposition can effectively enhance the mechanical properties of carbide ceramics and can overcome the difficulty of enhancing the mechanical properties of single-phase multicomponent carbide *** this work,a series of nonstoichiometric(TiZrVNb)Cx ceramics were prepared by spark plasma sintering(SPS)at different *** effects of the carbon content on the phase composition,microstructure evolution,and mechanical properties were investigated in *** decomposition occurred with decreasing carbon *** different solid solutions of(Ti,V)-rich and Zr-rich phases formed from the decomposition of equimolar single-phase solid solutions,namely,the Zr-poor phase and Zr-rich phase,*** distribution of Nb element is relatively *** semicoherent interfaces between the Zr-poor phase and the Zr-rich phase can harden and strengthen effectively under the synergistic effect of grain *** with phase decomposition structures have apparent advantages compared to single-phase high-entropy *** work provides an important train of thought for the microstructure tailoring and properties optimization of multi-component carbide ceramics.

关键词： multicomponent ceramics nontoichiometry microstructure evolution phase decomposition mechanical properties

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