检索结果-南通市图书馆

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2024年

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun shao-zhen Jiang Dan Luo Ling Chen zheng-Jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical Analysis School of Basic Medical Sciences Fudan University Department of Basic Medical Sciences School of Medicine Tsinghua University

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid （CSF） flow by beating their motile cilia coordinately. The ependymal denudation or ciliary dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of Gprotein signaling 22 （RGS22） results in severe congenital hydrocephalus in both mice and rats. Interestingly, RGS22 is specifically expressed in ependymal cells within the brain. Using conditional knock-out mice, we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus. Mechanistically, we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis. This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor （LPAR） signaling under Rgs22–/–condition, as the LPAR blockade effectively alleviates hydrocephalus in Rgs22–/–rats. Therefore, our findings unveil a previously unrecognized role of RGS22 in the central nervous system, and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词：

基于CT增强图像纹理特征预测结直肠癌Ki-67表达的可行性研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界复合医学 2024年第5期10卷 172-175页

作者：邵针屈鹏济宁市兖州区人民医院影像科山东济宁272100

目的探讨基于CT增强图像纹理特征预测结直肠癌的可行性。方法回顾性选取2021年2月—2022年12月济宁市兖州区人民医院病理诊断为结直肠癌的48例患者的临床资料为A组,35名健康体检人群的临床资料为B组,比较两组CT图像纹理特征与临床数据... 详细信息

目的探讨基于CT增强图像纹理特征预测结直肠癌的可行性。方法回顾性选取2021年2月—2022年12月济宁市兖州区人民医院病理诊断为结直肠癌的48例患者的临床资料为A组,35名健康体检人群的临床资料为B组,比较两组CT图像纹理特征与临床数据,采用二元Logistic回归筛选预测结直肠癌的独立风险因素并建立模型。对独立风险因素与二元回归预测模型进行受试者操作特征(receiver operating characteristic,ROC)曲线分析诊断效能。结果两组患者年龄、性别、糖类抗原199、糖类抗原242、癌胚抗原比较,差异无统计学意义(P均>0.05)。使用MaZda4.7内置最小平均相关系数与最小分类误差法降为后获得5个纹理特征,二元Logistic回归方程显示游程不均匀性、紧密度、惯性为预测结直肠癌Ki-67表达的独立风险因素,建立模型为:Logit(P)=1.433+Run Length游程不均匀性×4.114+紧密度×3.015+惯性×2.356,ROC曲线下面积为0.944,取阈值31.804的灵敏度及特异度为91.7%、88.9%。结论基于CT增强图像纹理特征预测结直肠癌,可为评估结直肠癌增殖程度和治疗预后提供无创性检测手段。

关键词： CT增强图像纹理特征结直肠癌预测模型

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

基于数据驱动的水泥企业碳排放预测模型研究

武汉理工大学学报 2024年第3期46卷 32-39页

作者：詹家干邵臻合肥工业大学管理学院合肥230002 安徽海螺集团有限责任公司芜湖241000

为解决目前水泥企业碳排放预测中存在的影响因素多、预测精度低问题,借助大数据机器学习技术,尝试构建了多种预测模型。结果表明:线性回归模型对企业碳排放预测误差达12.78%,机器学习模型可降低至9%,而通过智能烟花算法改进的BP(Back Pr... 详细信息

为解决目前水泥企业碳排放预测中存在的影响因素多、预测精度低问题,借助大数据机器学习技术,尝试构建了多种预测模型。结果表明:线性回归模型对企业碳排放预测误差达12.78%,机器学习模型可降低至9%,而通过智能烟花算法改进的BP(Back Propagation)网络模型可将误差降低至6%,能够较好地满足实际应用需求。进一步分析发现:对于企业碳排放量,“熟料产量和净购入电量”两因素影响最为显著,而提高替代燃料使用率则是当前实现节能减排的主要途径。

关键词：水泥生产碳排放智能算法统计预测

在线全文

学校读者我要写书评

暂无评论

急性冠脉综合征“寒热”的研究进展

中国实验方剂学杂志 2024年第6期30卷 246-252页

作者：王雪娇邵祯孟超姜春云陈恒文李军中国中医科学院广安门医院北京100053 北京中医药大学北京100029

寒热是中医八纲辨证的一对纲领,可以反映疾病中机体阴阳的盛衰、病邪性质的属阴属阳。目前中医对于急性冠脉综合征寒热的认识尚不统一,对于寒热病邪的强调有所偏颇,量表中寒热证候要素体现不全面等。鉴于此,该文通过文献研究从病因病机... 详细信息

寒热是中医八纲辨证的一对纲领,可以反映疾病中机体阴阳的盛衰、病邪性质的属阴属阳。目前中医对于急性冠脉综合征寒热的认识尚不统一,对于寒热病邪的强调有所偏颇,量表中寒热证候要素体现不全面等。鉴于此,该文通过文献研究从病因病机、证候要素及以药测证等角度对其寒热进行梳理。总结为从病因角度分析外感寒邪、热邪均可增加急性冠脉综合征的发病风险,既往多认为急性冠脉综合征在冬春等寒冷季节时高发,在此认识基础上,补充炎热天气也会诱发急性冠脉综合征,并且不同温度对不同年龄段、不同基础疾病患者影响不同。并强调了新时代下人为“寒邪”如过食生冷、制冷空调等作为新的致病因素;从病机角度梳理提出,在传统“阳微阴弦”“痰瘀虚滞”认识基础上,阴寒、火热病机均可以引发心脉痹阻、不通则痛,以及当急性冠脉综合征表现为“啖蒜状”的热郁寒束病机时需与胃食管反流疾病相鉴别。并且区别了阴寒凝结和脉滞风阻病机,二者病因病性不同。且急性冠脉综合征符合风性“善行而数变”的特点,可以用风药协助治疗;从证候要素角度梳理寒凝、热蕴、毒等证候要素,基础证候要素及其单元组合形式的使用更便于临床和科研的交流使用;并且以药测证可知,急性冠脉综合征处方用药的寒热属性可从温度敏感相关的瞬时受体电位(TRP)离子通道角度得以阐释,进而反证其寒热病机。

关键词：急性冠脉综合症寒热病因病机证候要素瞬时受体电位(TRP)离子通道

A dynamic cellular vertex model of growing epithelial tissues

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2017年第2期33卷 250-259页

作者： shao-zhen Lin Bo Li Xi-Qiao Feng Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China

Intercellular interactions play a significant role in a wide range of biological functions and processes at both the cellular and tissue scales, for example, embryogenesis, organogenesis, and cancer invasion. In this paper, a dynamic cellular vertex model is presented to study the morphomechanics of a growing epithelial monolayer. The regulating role of stresses in soft tissue growth is revealed. It is found that the cells originating from the same parent cell in the monolayer can orchestrate into clustering patterns as the tissue grows. Collective cell migration exhibits a feature of spatial correlation across multiple cells. Dynamic intercellular interactions can engender a variety of distinct tissue behaviors in a social context. Uniform cell proliferation may render high and heterogeneous residual compressive stresses, while stress-regulated proliferation can effectively release the stresses, reducing the stress heterogeneity in the tissue. The results highlight the critical role of mechanical factors in the growth and morphogenesis of epithelial tissues and help understand the development and invasion of epithelial tumors.

关键词： Soft tissue Cellular vertex model Cell Morphogenesis

A New Approach for Controlling Chaos Based on Direct Optimizing Predictive Control

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2006年第3期45卷 473-476页

作者： LI Dong-Mei YANG shao-zhen School of Economy and Management Hebei University of Science and Technology Shijiazhuang 050018 China

We introduce the predictive control theory into predictive control algorithm based on a neural network model the study of chaos control and propose a direct optimizing The proposed control system stabilizes the chaotic motion in an unknown chaotic system onto the desired target trajectory. Compared with the existing similar algorithms, the proposed control system has faster response, so it requires much shorter time for the stabilization of the chaotic systems. The proposed approach can control hyperchaos and the algorithm is simple. The convergence of the control algorithm and the stability of the control system can be guaranteed. The theoretic analysis and simulations demonstrate the effectiveness of the algorithm.

关键词： vchaos control predictive control chaotic system neural networks

An introduction to computational tools for differential binding analysis with ChlP-seq data

在线全文

学校读者我要写书评

暂无评论

Frontiers of Electrical and Electronic Engineering in China 2017年第3期5卷 226-235页

作者： Shiqi Tu zhen shao CAS Key Laboratory of Computational Biology Collaborative Innovation Center for Genetics and Developmental Biology CAS- Max Planck Society Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China. Graduate university of Chinese Academy of Sciences Beijing 100049 China

Background： Gene transcription in eukaryotie cells is collectively controlled by a large panel of ehromatin associated proteins and ChIP-seq is now widely used to locate their binding sites along the whole genome. Inferring the differential binding sites of these proteins between biological conditions by comparing the corresponding ChIP-seq samples is of general interest, yet it is still a computationally challenging task. Results： Here, we briefly review the computationhl tools developed in recent years for differential binding analysis with ChIP-seq data. The methods are extensively classified by their strategy of statistical modeling and s＇cope of application. Finally, a decision tree is presented for choosing proper tools based on the specific dataset. Conclusions： Computational tools for differential binding analysis with ChIP-seq data vary significantly with respect to their applicability and performance. This review can serve as a practical guide for readers to select appropriate tools for their own datasets.

关键词： ChIP-seq peak calling differential binding analysis computational tools

AcrySof phakic angle-supported intraocular lens for the correction of high to extremely high myopia:one-year follow-up results

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2012年第3期5卷 360-365页

作者： Rui-Bo Yang shao-zhen Zhao Tianjin Medical University Eye Center and College of Optometry Tianjin 300384 China

AIM: To assess the safety, efficacy and predictability of the AcrySof phakic angle-supported intraocular lens (IOL) (Alcon Inc., U.S.A.) for correction of high-to-extremely high myopia in adults. METHODS: In this prospective study performed in Tianjin Medical University Eye Center & College of Optometry, Tianjin, China, 25 eyes of 13 patients were implanted with AcrySof phakic angle-supported IOLs and followed for 1 year postoperatively. Preoperative manifest refractive sphere was (-12.08 +/- 2.44) diopters (D) and cylinder was (-1.35 +/- 0.62)D. Visual acuity, predictability and stability of manifest refraction spherical equivalent (MRSE), adverse events, and endothelial cell density were analyzed during 1-year of follow-up. RESULTS: After 1 year of follow-up, no eyes lost 1 line (best spectacle-corrected visual acuity)BSCVA; an uncorrected visual acuity (UCVA) of 20/20 or better was achieved in 60% of eyes; 100% had an UCVA of 20/40 or better; a BSCVA of 20/30 or better was achieved by 100% of eyes; 84% had a BSCVA of 20/20 or better. The overall mean percentage change in endothelial cell density 1 year after surgery was (-0.27 +/- 3.60)%. Two eyes (8%) had increased intraocular pressure (IOP) on the day of surgery. No pupil ovalization, pupillary block, or retinal detachment events were observed. CONCLUSION: After 1 year of follow-up, the implantation of AcrySof phakic angle-supported IOL is proved to be safe, effective and predictable with minimal complications in patients with high-to-extremely high myopia. Due to the limitation of visiting time, long-term of clinical investigation is necessary to verify the safety and efficacy of this IOL.

关键词： phakic eye lens intraocular high myopia foldable angle-supported

Temperature and pH Dually-responsive Poly(β-amino ester) Nanoparticles for Drug Delivery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2017年第4期35卷 534-546页

作者：卢小菊 xiang-yu yang yuan meng shao-zhen li School of Chemical and Material Engineering and Institute of Quantum Materials Hubei Polytechnic University Huangshi 435003 China

Stimuli-responsive polymers have undoubtedly been of great interest in the past decades due to a variety of their potential applications in biomedical territory. However, their non-degradability limits their in vivo applications. Herein, we report a novel pH and temperature dual-stimuli responsive-poly（β-amino ester）. The pH/temperature sensitivities are interrelated and can be easily tuned by changing PEG-diacrylate chain length and the percentage of biamines in the feed ratio. These dual-responsive polymers are very useful in drug delivery. Reaction of methyl ether poly（ethylene glycol）（MPEG） and poly（β-amino ester） resulted in an amphiphilic MPEG-PBAE block copolymer which could form nanoparticles by self- assembly. A hydrophobic drug （DOX） was loaded in the self-assembled nanoparticles at low temperature without using organic solvents. The loaded drug was released very slowly and steadily at 37 ℃ under physiological conditions （pH 7.4）, but rapidly released from the micelles in weakly acidic environments （pH 6.4 and 5.0） for intracellular drug release. Thus, these poly（fl-amino ester） polymers constitute ideal drug carriers since their thermal sensitivity allows the drug loadings without using organic solvent and their pH sensitivity permits fast intracellular drug release.

关键词： Temperature-sensitive pH-sensitive Nanoparticles Drug delivery