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Emerging strategies for nerve repair and regeneration in ischemic stroke:neural stem cell therapy

Neural Regeneration Research 2024年第11期19卷 2430-2443页

作者： Siji Wang Qianyan He Yang Qu Wenjing Yin Ruoyu Zhao Xuyutian Wang Yi Yang zhen-ni Guo Stroke Center Department of Neurologythe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of Neurologythe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Breast Surgery General Surgery Centerthe First Hospital of Jilin UniversityChangchunJilin ProvinceChina

Ischemic stroke is a major cause of mortality and disability worldwide,with limited treatment options available in clinical practice.The emergence of stem cell therapy has provided new hope to the field of stroke treatment via the restoration of brain neuron function.Exogenous neural stem cells are beneficial not only in cell replacement but also through the bystander effect.Neural stem cells regulate multiple physiological responses,including nerve repair,endogenous regeneration,immune function,and blood-brain barrier permeability,through the secretion of bioactive substances,including extracellular vesicles/exosomes.However,due to the complex microenvironment of ischemic cerebrovascular events and the low survival rate of neural stem cells following transplantation,limitations in the treatment effect remain unresolved.In this paper,we provide a detailed summary of the potential mechanisms of neural stem cell therapy for the treatment of ischemic stroke,review current neural stem cell therapeutic strategies and clinical trial results,and summarize the latest advancements in neural stem cell engineering to improve the survival rate of neural stem cells.We hope that this review could help provide insight into the therapeutic potential of neural stem cells and guide future scientific endeavors on neural stem cells.

关键词： bystander effect cell replacement extracellular vesicles ischemic stroke neural stem cells neural stem cell engineering

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Tourism Route Recommendation Based on A Multi-Objective Evolutionary Algorithm Using Two-Stage Decomposition and Pareto Layering

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 486-500页

作者： Xiaoyao zheng Baoting Han zhen ni IEEE the School of Computer and Information Anhui Normal UniversityWuhu 241002China the Department of Electrical Engineering and Computer Science Florida Atlantic UniversityBoca Raton FL33431 USA

Tourism route planning is widely applied in the smart tourism field.The Pareto-optimal front obtained by the traditional multi-objective evolutionary algorithm exhibits long tails,sharp peaks and disconnected regions problems,which leads to uneven distribution and weak diversity of optimization solutions of tourism routes.Inspired by these limitations,we propose a multi-objective evolutionary algorithm for tourism route recommendation(MOTRR)with two-stage and Pareto layering based on decomposition.The method decomposes the multiobjective problem into several subproblems,and improves the distribution of solutions through a two-stage method.The crowding degree mechanism between extreme and intermediate populations is used in the two-stage method.The neighborhood is determined according to the weight of the subproblem for crossover mutation.Finally,Pareto layering is used to improve the updating efficiency and population diversity of the solution.The two-stage method is combined with the Pareto layering structure,which not only maintains the distribution and diversity of the algorithm,but also avoids the same solutions.Compared with several classical benchmark algorithms,the experimental results demonstrate competitive advantages on five test functions,hypervolume(HV)and inverted generational distance(IGD)metrics.Using the experimental results of real scenic spot datasets from two famous tourism social networking sites with vast amounts of users and large-scale online comments in Beijing,our proposed algorithm shows better distribution.It proves that the tourism routes recommended by our proposed algorithm have better distribution and diversity,so that the recommended routes can better meet the personalized needs of tourists.

关键词： Evolutionary algorithm multi-objective optimization Pareto optimization tourism route recommendation two-stage decomposition

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Atmospheric chemistry of 2-nitrobenzaldehyde:Initiated by photo-excitation,OH-oxidation,and small TiO_(2) clusters adsorption catalysis

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Journal of Environmental Sciences 2024年第5期139卷 123-137页

作者： Feng-Yang Bai Xiang-Huan Liu Ting-Ting Meng Zhou Yu Yi-Chen Wang Shuang ni zhen Zhao Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China

The fate of 2-nitrobenzaldehyde(2-NBA)is of interest in atmospheric chemistry as it is a semi-volatile organic compound with high photosensitivity.This study presents a quantum chemical study of the gas-phase reactions of 2-NBA photo-excitation and OH-oxidation in the absence and presence of small TiO_(2) clusters.To further understand the unknown photolysis mechanism,the photo-reaction pathways of ground singlet state and the lying excited triplet state of 2-NBA were investigated including the initial and subsequent reactions of proton transfer,direct CO,NO_(2),and HCO elimination routes in the presence of O_(2) and NO.Meanwhile,the OH-mediated degradation of 2-NBA proceeded via five H-extraction and six OH-addition channels by indirect mechanism,which follows a succession of reaction steps initiated by the formation of weakly stable intermediate complexes.The H-extraction from the-CHO group was the dominant pathway with a negative activation energy of-1.22 kcal/mol.The calculated rate coefficients at 200–600 K were close to the experimental data in literature within 308-352 K,and the kinetic negative temperature independence was found in both experimental literature and computational results.Interestingly,2-NBA was favored to be captured onto small TiO_(2) clusters via six adsorption configurations formed via various combination of three types of bonds of Ti…O,Ti…C,and O…H between the molecularly adsorbed 2-NBA and TiO_(2) clusters.Comparison indicted that the chemisorptions of aldehyde oxygen have largest energies.The results suggested adsorption conformations have a respectable impact on the catalysis barrier.This study is significant for understanding the atmospheric chemistry of 2-nitrobenzaldehyde.

关键词： 2-nitrobenzaldehyde OH radical oxidation Rate coefficient Photolysis mechanism Adsorption catalysis

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Status and progress of metal-supported solid oxide fuel cell: Towards large-scale manufactory and practical applications

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Energy Reviews 2024年第1期3卷 1-23页

作者： Haoran Xu Yu Han Jing Zhu Meng ni zhen Yao State Key Laboratory of Clean Energy Utilization Zhejiang University38 Zheda RoadHangzhou310027China Department of Building and Real Estate Research Institute for Sustainable Urban Development(RISUD)&Research Institute for Smart Energy(RISE)Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Fakultät für Physik Universität BielefeldUniversitätsstr.2533615BielefeldGermany

Metal-supported solid oxide fuel cells(MS-SOFCs)own advantages of high performance,fast start-up,thermal cycle stability,easy sealing,and reduced material cost.In recent years,significant progress has been made in the development of MS-SOFCs,particularly with respect to improved electrochemical performance,long-term stability,and industrial production.Previous studies have mainly focused on stainless steel-based MS-SOFCs,with an emphasis on the development of low-temperature preparation processes,antioxidant coatings,stable electrodes,and the direct utilization of hydrocarbon fuels.Notably,Ceres Power and GE have successfully commercialized MS-SOFCs and have constant cooperated with several institutions and companies,such as Jülich Research Center,Weichai and Cummins,to promote the performance and expand the market of MS-SOFC.Looking ahead,this review paper provides an outlook on future research directions in this rapidly evolving field.

关键词： Metal support Solid oxide fuel cell High performance Long-term stability

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Carbon-coated hybrid crystals with fast electrochemical reaction kinetics for ultra-stable and high-load sodium-ion batteries

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Rare Metals 2024年第2期43卷 647-657页

作者： Chuan Ou Ming-Dong Tan zhen-Bang Li Zhao-Jie Li Fei Tian zheng-Ping Qiao Dan-ni Lei Cheng-Xin Wang State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhou510275China

Owing to its high theoretical capacity and low cost,Sn has attracted significant attention in sodium-ion batteries.However,the slow kinetics of electrochemical reactions and the rapid decay of capacity resulting from drastic changes in the volume of Sn,as well as persistent side reactions between Sn and the organic electrolyte during the(de)sodium process,have limited its commercialization.To improve the electrochemical performance of Sn-based materials,the bottom-up method is normally used to prepare carbon-coated nanoparticles.However,its complex preparation processes and harsh conditions make it unsuitable for practical applications.Herein,a carbon-coated hybrid crystal composite(Sn/SnO_(x)@C)was prepared using an up-bottom method with commercial Sn/SnO nanoparticles.Various effects accelerate the electrochemical kinetics and inhibit the coarsening of Sn crystals.The Sn/SnO_(x)@C composite electrode exhibited capacity retention of 80.7%even after approximately 1000 cycles(360.4 mAh·g^(−1)) at a current density of 1 A·g^(−1).The high-load Na_(3)V_(2)(PO4)3||Sn/SnO_(x)@C full cell presents a capacity retention rate of 91.7%after 150 cycles at the current density of 0.5 A·g^(−1).This work may significantly accelerate the commercialization of the Sn/SnO_(x)@C composite in sodium-ion batteries with high energy density.

关键词： Sodium-ion batteries(SIBs) Sn-based anode Ultraviolet curing Up-bottom method

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Adaptive composite frequency control of power systems using reinforcement learning

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CAAI Transactions on Intelligence Technology 2022年第4期7卷 671-684页

作者： Chaoxu Mu Ke Wang Shiqian Ma Zhiqiang Chong zhen ni School of Electrical and Information Engineering Tianjin UniversityTianjinChina State Grid Tianjin Electric Power Company Electric Power Research Institute TianjinChina Department of Electrical Engineering and Computer Science Florida Atlantic UniversityBoca RatonFLUSA

With the incorporation of renewable energy,load frequency control(LFC)becomes more challenging due to uncertain power generation and changeable load demands.The electric vehicle(EV)has been a popular transportation and can also provide flexible options to play a role in frequency regulation.In this paper,a novel adaptive composite controller is designed to solve the LFC problem for the interconnected power system with electric vehicles and wind turbine.EVs are used as regulation resources to effectively compensate the power mismatch.First,the sliding mode controller is developed to reduce the random influences caused by the wind turbine generation system.Second,an auxiliary controller with reinforcement learning is proposed to produce adaptive control signals,which will be attached to the primary proportion-integration-differentiation control signal in a realtime manner.Finally,by considering random wind power,load disturbances and output constraints,the proposed scheme is verified on a two-area power system under four different cases.Simulation results demonstrate that the proposed adaptive composite frequency control scheme has a competitive performance with regard to dynamic performance.

关键词： power composite attached

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional recovery.Therefore,there is an urgent need to develop new methods for the treatment of this condition.Exosomes are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological conditions.They have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain barrier.These physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic stroke.The rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages needed.Advances in technology have also driven clinical translational research on exosomes.In this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction effects.However,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified exosomes.Future optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic stroke.Ultimately,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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道德生物增强:弱还原论版本的自然主义道德观

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科学学研究 2024年第6期42卷 1145-1151页

作者：胡珍妮东南大学人文学院江苏南京211189

道德生物增强借助非传统的生物医学手段来干预主体的道德情感,在本质上呈现为道德自然主义的哲学进路。然而,一些学者热衷于将该进路归结为一种立场强硬的还原论观点,并从科学上和哲学上来批判道德自然主义的还原论限度,进而否认道德生... 详细信息

道德生物增强借助非传统的生物医学手段来干预主体的道德情感,在本质上呈现为道德自然主义的哲学进路。然而,一些学者热衷于将该进路归结为一种立场强硬的还原论观点,并从科学上和哲学上来批判道德自然主义的还原论限度,进而否认道德生物增强的合法性。此论断忽视了在道德生物增强的讨论语境中,还原论在本体论和方法论意义上具有不同的形相。道德生物增强在方法论的层面主张还原论对于人类道德现象研究的必要性和重要性,而在本体论的层面试图构建一幅科学与人文融合发展的非还原论图景。在此基础上,道德生物增强从根本上呈现为一种弱还原论版本的自然主义道德观,并由此确立了自身的存在论空间与理论合法性。

关键词：道德生物增强道德自然主义弱还原论

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16世纪中国博古图与西方静物画中的物比较

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艺术百家 2024年第2期40卷 1-8页

作者：倪爱珍江西省社会科学院文学与文化研究所江西南昌330077

中国博古图与西方静物画的兴盛都始于16世纪前后,都以静物为表现对象,但又有所不同。从物的属性来看,博古图中的物与人们的精神需求紧密相关,其主要功能经历了从宋代的正经补史到明代的雅文化象征再到清代的吉祥文化寓意的变迁;在西方... 详细信息

中国博古图与西方静物画的兴盛都始于16世纪前后,都以静物为表现对象,但又有所不同。从物的属性来看,博古图中的物与人们的精神需求紧密相关,其主要功能经历了从宋代的正经补史到明代的雅文化象征再到清代的吉祥文化寓意的变迁;在西方静物画发展史上具有节点意义的罗马静物画、荷兰静物画、夏尔丹静物画的繁荣都与特定时期物质生活的变化紧密相关。从物的审美来看,博古图因物喻志,以志为本,体现了中国传统诗学的比兴理论;静物画观物绘形,以物为本,使被忽视或熟视无睹的事物变得陌生、反常,体现了陌生化的审美追求。从物的感知来看,两者体现了中西文化中感物与观物两种不同的美学传统及其背后的感官倚重的不同。但由于艺术有其自身的特征和发展规律,所以两者的这些不同只是相对的。

关键词：博古图静物画感物观物

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Hydrometallurgical recovery of lithium carbonate and iron phosphate from blended cathode materials of spent lithium-ion battery

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Rare Metals 2024年第3期43卷 1275-1287页

作者： Shao-Le Song Run-Qing Liu Miao-Miao Sun Ai-Gang zhen Fan-zhen Kong Yue Yang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083China Zhejiang Tianneng New Materials Co. Ltd.Huzhou313103China

The recycling of cathode materials from spent lithium-ion battery has attracted extensive attention,but few research have focused on spent blended cathode materials.In reality,the blended materials of lithium iron phosphate and ternary are widely used in electric vehicles,so it is critical to design an effective recycling technique.In this study,an efficient method for recovering Li and Fe from the blended cathode materials of spent LiFePO_(4)and Lini_(x)Co_(y)Mn_(1-x-y)O_(2)batteries is proposed.First,87%A1 was removed by alkali leaching.Then,91.65%Li,72.08%ni,64.6%Co and 71.66%Mn were further separated by selective leaching with H_(2)SO_(4)and H_(2)O_(2).Li,ni,Co and Mn in solution were recovered in the form of Li_(2)CO_(3)and hydroxide respectively.Subsequently,98.38%Fe was leached from the residue by two stage process,and it is recovered as FePO_(4)·2H_(2)O with a purity of 99.5%by precipitation.Fe and P were present in FePO_(4)·2H_(2)O in amounts of 28.34%and 15.98%,respectively.Additionally,the drift and control of various components were discussed,and cost-benefit analysis was used to assess the feasibility of potential application.

关键词： Spent lithium-ion battery Blended cathode materials Recovery Lithium carbonate Iron phosphate

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