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Association between the-1562 C/T polymorphism in the MMP-9 promoter and phenotype of esophageal squamous cell carcinoma in northern Chinese population

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Journal of Pharmaceutical Analysis 2010年第1期22卷 39-43页

作者： Peng Xia1,Dong-Min Chang1,Cheng-Xue Dang1,lei Meng1,Hua Xue1,Yang Liu2 1.Department of Surgical Oncology,the First Affiliated Hospital,Medical school of Xi’an Jiaotong university,Xi’an 710061 2.Institute of Proteomics and Systems Biology,Zhongshan Hospital of fudan university,shanghai 200032,china. Department of Surgical Oncology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 China Institute of Proteomics and Systems Biology Zhongshan Hospital Fudan University Shanghai 200032 China

Objective To conduct a case-control study on the association of the nucleotide polymorphisms in the promoter region of the matrix metalloproteinase-9(MMP-9)gene with phenotype of esophageal *** All subjects were unrelated residents in northern regions of *** chain reaction-restriction fragment length polymorphism(PCR-RFLP)analysis was used to determine the MMP-9 *** The overall distribution of genotypes in the patients was not different from that in the controls(OR=0.77,95% CI=0.45-1.34;P=0.36).There were no significant differences between the patients and the control subjects in terms of the distributions of sex and age,smoking status,alcohol dependence,pickled diet status,or history of environmental *** patients were further examined with stratifications by age,sex,grade,depth of tumor invasion,lymphatic invasion,venous invasion and TNM *** results showed no pronounced association among the *** There is no significant association between the MMP-9 single nucleotide polymorphism genotypes and phenotype of esophageal cancer.

关键词： matrix metalloproteinase-9(MMP-9) single nucleotide polymorphism phenotype esophageal cancer polymorphism

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光子晶体的原理与应用

物理实验 2004年第6期24卷 3-7页

作者：宋清海徐雷复旦大学信息科学与工程学院光科学与工程系上海200433

光子晶体是一种在微米、亚微米等光波长量级上折射率呈现周期性变化的介质材料 ,它使某些频率范围内的光子态密度大大降低 ,甚至完全形成光子禁带 .本文介绍了光子晶体的原理、制备及应用 .

关键词：光子晶体光子禁带折射率

小型直燃型吸收式机组部分负荷特性的实验研究

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上海交通大学学报 2002年第2期36卷 202-205页

作者：王磊陆震上海交通大学动力与能源工程学院上海200030

部分负荷工况是制冷系统常见的运行工况 .对于只带有一个燃烧器的小型直燃型机组 ,采用燃烧器间歇运行的方式 ,实现了小型直燃型吸收式机组的部分负荷运行 ;研究了过渡过程中发生器等部件的性能参数的变化 ;分析了压力。

关键词：小型直燃型吸收式机组部分负荷特性实验研究燃烧器制冷系统

Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 51-64页

作者： Mingming XU Zhaoliang LIU Wenhua HU Ying HAN zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG Center for Clinical Mass Spectrometry College of Pharmaceutical SciencesSoochow UniversitySuzhou215123China school of Life Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of Genetic Engineering Department of BiochemistrySchool of Life SciencesFudan UniversityShanghai200438China Department of Clinical Laboratory Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou310014China

Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival ***,no methods have been derived that can reliably identify early precursors of development into ***,it is urgent to discover early molecular changes during pancreatic *** aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further ***,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient *** profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific *** results indicated the potential role for tumor-specific glycosylation as disease *** also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510.

关键词： Pancreatic cancer Glycosylation Biomarker Glycoproteomics Mass spectrometry

Prompt learning in computer vision: a survey

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 42-63页

作者： Yiming lei Jingqi LI Zilong LI Yuan CAO Hongming SHAN shanghai Key Laboratory of Intelligent Information Processing School of Computer ScienceFudan UniversityShanghai 200438China Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghai 200433China MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 201210China

Prompt learning has attracted broad attention in computer vision since the large pre-trained visionlanguagemodels (VLMs) exploded. Based on the close relationship between vision and language information builtby VLM, prompt learning becomes a crucial technique in many important applications such as artificial intelligencegenerated content (AIGC). In this survey, we provide a progressive and comprehensive review of visual promptlearning as related to AIGC. We begin by introducing VLM, the foundation of visual prompt learning. Then, wereview the vision prompt learning methods and prompt-guided generative models, and discuss how to improve theefficiency of adapting AIGC models to specific downstream tasks. Finally, we provide some promising researchdirections concerning prompt learning.

关键词： Prompt learning Visual prompt tuning(VPT) Image generation Image classification Artificial intelligence generated content(AIGC)

An increased Vitamin C content accompanied by an enhanced recycling pathway

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An increased Vitamin C content accompanied by an enhanced re...

TSCompiler: efficient compilation framework for dynamic-shape models

中华中医药学会第九届中药鉴定学术会议

作者： lei Zhang,Zinan Wang,Yang Xia,Wansheng Chen,Kexuan Tang 1 Department of Pharmacognosy,school of Pharmacy,Second Military Medical university, shanghai,200433,P.R.china 2 State Key Laboratory of Genetic Engineering,school of Life Science, fudan-SJTU-Nottingham Plant Biotechnology R&D Center,fudan university,shanghai 200433,P.R.china 3 Department of pharmacy,Changzheng Hospital,Second Military Medical university, shanghai 200003,P.R.china

Vitamin C(L-ascorbic acid,AsA) has important antioxidant and metabolic functions in both plants and animals. Once used,ascorbic acid can be regenerated from its oxidized form in a reaction catalyzed by dehydroascorbate reductase (DHAR).A DHAR cDNA from Arabidopsis thaliana was isolated and expressed in *** to examine whether overexpression of DHAR in plants would increase the level of ascorbic acid through improved ascorbate *** transgenic seedlings,DHAR expression was increased up to 1.5 to 5.4 fold,which enhanced foliar ascorbic acid levels 2- to 4.25-fold and ratio of AsA/DHA about 3- to *** addition,the level of glutathione,the reductant used by DHAR,also increased as did its redox *** is suggested that the vitamin C content of plants can be increased through enhanced ascorbate recycling.

关键词： ascorbic acid dehydroascorbate reductase redox state glutathione metabolic engineering

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Science china(Information sciences) 2024年第10期67卷 67-84页

作者： Xiang LUO Chen ZHANG Chenbo GENG Yanzhi YI Jiahui HU Renwei ZHANG zhen ZHANG Gianpietro CONSOLARO Fan YANG Tun LU Ning GU Li SHANG school of Computer Science Fudan University school of Electronic Information and Electrical Engineering Shanghai Jiao Tong University school of Computer Science and Technology Harbin Institute of Technology Huawei Technologies Co. Ltd. Huawei Paris Research Center school of Microelectronics Fudan University

Today's deep learning models face an increasing demand to handle dynamic shape tensors and computation whose shape information remains unknown at compile time and varies in a nearly infinite range at runtime. This shape dynamism brings tremendous challenges for existing compilation pipelines designed for static models which optimize tensor programs relying on exact shape values. This paper presents TSCompiler, an end-to-end compilation framework for dynamic shape models. TSCompiler first proposes a symbolic shape propagation algorithm to recover symbolic shape information at compile time to enable subsequent optimizations. TSCompiler then partitions the shape-annotated computation graph into multiple subgraphs and fine-tunes the backbone operators from the subgraph within a hardware-aligned search space to find a collection of high-performance schedules. TSCompiler can propagate the explored backbone schedule to other fusion groups within the same subgraph to generate a set of parameterized tensor programs for fused cases based on dependence analysis. At runtime, TSCompiler utilizes an occupancy-targeted cost model to select from pre-compiled tensor programs for varied tensor shapes. Extensive evaluations show that TSCompiler can achieve state-of-the-art speedups for dynamic shape models. For example, we can improve kernel efficiency by up to 3.97× on NVIDIA RTX3090, and 10.30× on NVIDIA A100 and achieve up to five orders of magnitude speedups on end-to-end latency.

关键词： machine learning tensor compilers dynamic shape operator fusion code generation auto-tuning

Sigma-1 receptor mediates the effect of cyproheptadine on theⅠK in mouse cortical neurons

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Sigma-1 receptor mediates the effect of cyproheptadine on th...

Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2-Aminopyridines as an Expedient Route to lmidazo[1,2-a]pyridines

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yan-Lin HE,Chun-lei ZHANG,Xiao-Fei GAO,Jin-Jing YAO,Chang-Long HU,Yan-Ai MEI~* Institutes of Brain Science,school of Life sciences and State Key Laboratory of Medical Neurobiology,fudan university,shanghai 200433,china

Cyproheptadine is a histamine- and serotonin- receptor antagonist,and its effects are observed in the modulation of multiple intracellular signals in previous *** demonstrate here that intracellularly delivered cyproheptadine increased the delayed rectifier outward potassium current(I) by reducing the intracellular levels of phosphorylated PKA in mouse cortical ***-receptor binding assay indicated that cyproheptadine bound to sigma-1 receptor and mediate the cAMP/PKA *** to the sigma-1 receptor mimicked effects of CPH and knock down this receptor abolished the effects of CPH on *** of G eliminated the cyproheptadine-induced effect on I and PKA activity.K2.1α-subunit blocker reduced cyproheptadine-induced effect on I in mouse cortical ***,CPH also enhance the K current when expressed the K2.1α-subunit on HEK293 *** reveal for the first time that CPH enhances I by a sigma-1 receptor-dependent mechanism and selective targeting of the K2.1α-subunit. This result may help to explain some of the uncharacterized effects of CPH on neuron excitability and contribute to the understanding of CPH as more than just a competitive inhibitor of the histamine H and serotonin receptors.

关键词： sigma-1 receptor cyprohetadine IK Kγ2.1α-subunit cAMP/PKA pathway cortical neurons

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Tandem Amination/Cycloisomerization of Aryl Propargylic Alco...