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Emission and optical characteristics of brown carbon in size-segregated particles from three types of Chinese ships

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Journal of Environmental sciences 2024年第8期142卷 248-258页

作者： Fengqin Yang Fan Zhang Zeyu Liu Yingjun Chen Yan Zhang Can Wu Yali lei Shijie Liu Binyu Xiao Xinyi Wan Yubao Chen Yong Han Min Cui Cheng Huang Gehui Wang Key Lab of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China Institute of Eco-Chongming 20 Cuiniao Rd.ChongmingShanghai 202150China State Environmental Protection Key Laboratory of Formation and Prevention of the Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Department of Civil and Environmental Engineering and State Key Laboratory of Marine Pollution The Hong Kong Polytechnic UniversityKowloon 100872Hong KongChina College of Environmental Science and Engineering Yangzhou UniversityYangzhou 225009China

Brown carbon(BrC)is one of the important light absorption substances that have high light absorption ability under short wavelength ***,limit studies have focused on the BrC emission from *** this study,size-segregated particulate matters(PM)were collected from three different types of ships,light absorption characteristics and size distribution of methanol-soluble BrC and water-soluble BrC in PM from ship exhausts were *** showed that four-stroke low-power diesel fishing boat(4-LDF)had the highest mass concentrations of methanol-soluble organic carbon(MSOC)and water-soluble organic carbon(WSOC),followed by 2-stroke high-power heavy-fuel-oil vessel(2-HHV),and fourstroke high-power marine-diesel vessel(4-HMV).While 2-HHV had obviously higher light absorption coefficients of methanol-soluble BrC(Abs365,M)and water-soluble BrC(Abs365,W)in unit weight of PM than the other two types of *** tested ships presented comparable or higher absorption efficiency of BrC in water extracts(MAE365,W)compared with other BrC emission *** of BrC was concentrated in fine particles,and the particle size distributions of both Abs365,Mand Abs365,Wshowed bimodal patterns,peaking at0.43–0.65μm and 4.7–5.8μm,***,different particle size distributions were found for MAE365,Mbetween diesel and heavy fuel oil ***,different wavelength dependence in particles with different size were also *** exhaust could be confirmed as a non-ignorable BrC emission source,and complex influencing factor could affect the light absorption characteristics of ship *** size should also be considered when light absorption ability of BrC was evaluated.

关键词： Ship emission Brown carbon Light absorption Size distribution

On the Synchronizable System

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Chinese Annals of Mathematics,Series B 2020年第6期41卷 821-828页

作者： zhen lei Tatsien LI Bopeng RAO school of mathematical sciences Fudan UniversityShanghai 200433China shanghai Key Laboratory for Contemporary Applied Mathematics Nonlinear mathematical Modeling and Methods Laboratory Institut de Recherche Mathematique Avancee Universite de Strasbourg67084 StrasbourgFrance

In this paper,the synchronizable system is defined and studied for a coupled system of wave equations with the same wave speed or with different wave speeds.

关键词： Synchronizable system Synchronization solution Coupled system of wave equations Exact boundary synchronization

Angiotensin 1-7 reverses angiotensinⅡinduced cell proliferation and extracellular matrix synthesis effects on renal mesangial cells via activation of Mas receptor

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Angiotensin 1-7 reverses angiotensinⅡinduced cell prolifera...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Hong XUE~1,Li ZHOU~1,Jun NI~1,zhen WANG~1,Yu HUANG~2,Tai YAO~1,Li-Min LU~1 1 Department of Physiology and Pathophysiology,shanghai Medical College,fudan university,shanghai 200032,china 2 Institute of Vascular Medicine,Li Ka Shing Institute of Health sciences and school of Biomedical sciences,Chinese university of Hong Kong, Hong Kong,china

＜正＞The classic renin-angiotensin system（RAS） concept has recently undergone important *** updated RAS,it contains the angiotensin converting enzyme（ACE） -angiotensin（Ang）Ⅱ-Angtiogensin type 1 receptor（AT1） axis and the angiotensin-converting enzyme-related carboxypeptidase（ACE2） -Ang1-7- Mas axis. The former axis performs the vasoconstrictive,proliferative and pro-inflammatory functions mainly by activation of AT1 receptors,while the later new identified axis is considered counterbalancing the effects of the *** present study aimed to explore the mechanisms that Ang1-7 counterbalances the effect of AngⅡon cultured rat renal mesangial *** staining and Confocal microscopy observation were used to identify the co-localization of AT1 and Mas receptors on cultured rat renal mesangial *** proliferation was assessed by bromodeoxyuridine（BrdU） incorporation *** extracellular signal-regulated kinase（ERK） 1/2 was analyzed by western ***,collagenⅣand transforming growth factor（TGF）-β1 mRNA levels were determined by real-time *** results showed that both AT1 receptor and Mas receptor were co-distributed in rat renal mesangial *** stimulated ERK 1/2 phosphorylation and TGF-β1 synthesis,and increased cell proliferation and extracellular matrix ***1-7 specifically reversed the AngⅡ-induced effects in a dose dependent manner,but failed to alter the changes induced by *** effect of Ang1-7 was blocked by Mas receptor antagonist A779,but not AT1 receptor antagonist losartan nor AT2 receptor antagonist PD123319. These results suggest Ang1-7 specifically counterbalance the AngⅡinduced cell proliferation and extracellular matrix synthesis effects on renal mesangial cell via acting on Mas receptor.

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历史建筑价值认识的发展及其保护的经济学因素

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同济大学学报（社会科学版） 2009年第5期20卷 44-51页

作者：李浈雷冬霞同济大学建筑与城市规划学院上海200092 上海建科结构新技术工程有限公司上海200023

本文在前人研究的基础上,梳理了国内外对历史建筑价值的认识过程,分析了价值构成中的经济学因素,以及历史建筑经济价值的特色和影响,介绍了国外关于经济价值实现的一些经验、方式和相关的经济政策导向,强调了遗产保护经济学研究的迫切... 详细信息

本文在前人研究的基础上,梳理了国内外对历史建筑价值的认识过程,分析了价值构成中的经济学因素,以及历史建筑经济价值的特色和影响,介绍了国外关于经济价值实现的一些经验、方式和相关的经济政策导向,强调了遗产保护经济学研究的迫切性和重要性。

关键词：保护遗产价值经济学

Strategies and progress on metabolic engineering of medicinal plants

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Strategies and progress on metabolic engineering of medicina...

中国植物学会七十五周年年会

作者： Kexuan Tang~(1,2) Ling Zhang~1 Fuyuan Jing~1 Yifu Gong~1 lei Zhang~2 Xiaofen Sun~2 Yuliang Wang~1 Quan Wang~1 Guofeng Wang~1 (1.Plant Biotechnology Research Center,school of Agriculture and Biology,fudan-SJTU-Nottingham Plant Biotechnology R&D Center,shanghai Jiaotong university,shanghai 200240,china 2.State Key Laboratory of Genetic Engineering,school of Life sciences,fudan-SJTU-Nottingham Plant Biotechnology R&D Center,fudan university,shanghai 200433,P.R.china)

china is rich in plant resources,and many native plant species produce pharmaceutically important secondary metabolites which have been widely used in clinical treatments of various diseases or used in traditional Chinese *** example,artemisinin,an endoperoxide-containing sesquiterpene isolated from Artemisia annua L.,an annual herb native

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超高性能混凝土中热处理钢纤维在氯离子环境下的腐蚀试验

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科学技术与工程 2024年第6期24卷 2512-2520页

作者：雷真杨洋张翔陈敬男李林锐云南大学建筑与规划学院昆明650500 上海城建城市运营(集团)有限公司上海200000 东方电气集团东方汽轮机有限公司成都618000

钢纤维是超高性能混凝土(ultra-high performance concrete, UHPC)的主要增强材料,为进一步提高钢纤维的耐腐蚀性,推进UHPC在腐蚀环境中的使用,从增强钢纤维的耐腐蚀性出发,对钢纤维在150、300、450和600℃4种不同温度下进行热处理,并... 详细信息

钢纤维是超高性能混凝土(ultra-high performance concrete, UHPC)的主要增强材料,为进一步提高钢纤维的耐腐蚀性,推进UHPC在腐蚀环境中的使用,从增强钢纤维的耐腐蚀性出发,对钢纤维在150、300、450和600℃4种不同温度下进行热处理,并用作原材料制作超高性能混凝土。将UHPC、钢纤维(含对照组)置于3.5%氯离子溶液中浸泡100 d,采用电化学方法和微观形貌分析法对钢纤维的耐腐蚀性进行分析。结果表明,随着热处理温度的升高,改性钢纤维的耐腐蚀性逐渐增强,钢纤维经过600℃热处理后氧化皮最耐腐蚀,表面形貌最致密,但耐腐蚀性能下降程度在所有热处理温度中最大;改性钢纤维浸泡后,原材料钢纤维表面锈层未出现明显腐蚀产物FeOOH的标准形态;在150、300、450℃热处理温度下具有双相结构,随着热处理温度的升高,α-FeOOH减少,γ-FeOOH增多;在600℃热处理温度下,钢纤维的锈层除了生成α-FeOOH和γ-FeOOH之外,还生成了促进腐蚀的β-FeOOH。

关键词：热处理钢纤维电化学耐蚀性微观表征

A novel inhibition of martentoxin on neuronal BK channel subtype(α +β4)and functional modulation of neural excitability

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A novel inhibition of martentoxin on neuronal BK channel sub...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jian SHI~1,Hui-Qiong HE~1,Rong ZHAO~1,Jin CHEN~1,Ying CHEN~2,Yan-Hong DUAN~2,Juan YANG~2,lei ZHONG~2,Jian-Wei ZHANG~2,Xue-Qin SHU~2,Ping zhenG~3,Yong-Hua JI~(2,*) 1 Graduate school of the Chinese Academy of sciences,Institute of Physiology,shanghai Institutes for Biological sciences,Chinese Academy of sciences,shanghai,200031,china 2 school of Life sciences,shanghai university,Shang-Da Road 99,shanghai,200444,china 3 State Key Laboratory of Medical Neurobiology,fudan university shanghai Medical College,shanghai,200032,china

Martentoxin as a 37 residues peptidyl toxin was capable of blocking large-conductance Ca-activated K(BK) channels in adrenal medulla chromaffin *** present study investigated the pharmacological discrimination of martentoxin on BK channels subtypes and implicated the physiological function of neuronal BK channels(α+β4) through the pharmacological *** results showed that the iberiotoxin-insensitive BK channels composed ofαandβ4 subunits could be potently blocked by martentoxin(IC50 =～80 nM).In contrast,the iberiotoxin-sensitive BK channel consisting of only a subunits showed a low sensitivity to *** inhibitory effect of martentoxin on BK channels(α+β4) appears with a novel interaction mode,including Ca dependence and two possible interaction sites:one for trapping and the other for ***,in vivo experiments also suggested that this subtype of BK channels was the target of ***,EEG recordings showed that the inhibition of BK channels(α+β4) by martentoxin would induce exacerbated abnormal discharges,which indicated a braking role of BK channels(α+β4) in spontaneous bursting ***,this research not only sheds light on a unique ligand for BK channels(α+β4),but also highlights a novel model for the interaction between BK channel and neurotoxin.

关键词： BK channel martentoxin iberiotoxin insensitivity allosteric effects excitability

Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu zhen zheng Xiaobing Lan Yi Wang Yan zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

Large circuit models: opportunities and challenges

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Science china(Information sciences) 2024年第10期67卷 25-66页

作者： lei CHEN Yiqi CHEN Zhufei CHU Wenji FANG Tsung-Yi HO Ru HUANG Yu HUANG Sadaf KHAN Min LI Xingquan LI Yu LI Yun LIANG Jinwei LIU Yi LIU Yibo LIN Guojie LUO Hongyang PAN zhengyuan SHI Guangyu SUN Dimitrios TSARAS Runsheng WANG Ziyi WANG Xinming WEI Zhiyao XIE Qiang XU Chenhao XUE Junchi YAN Jun YANG Bei YU Mingxuan YUAN Evangeline F.Y.YOUNG Xuan ZENG Haoyi ZHANG Zuodong ZHANG Yuxiang ZHAO Hui-Ling zhen Ziyang zhenG Binwu ZHU Keren ZHU Sunan ZOU Huawei Noah’s Ark Lab school of Integrated Circuits Peking University Faculty of Electrical Engineering and Computer Science Ningbo University Department of Electronic and Computer Engineering Hong Kong University of Science and Technology Department of Computer Science and Engineering The Chinese University of Hong Kong school of Integrated Circuits Southeast University Huawei HiSilicon Peng Cheng Laboratory school of Computer Science Peking University school of Microelectronics State Key Laboratory of Integrated Chips and System Fudan University school of Artificial Intelligence Shanghai Jiao Tong University

Within the electronic design automation(EDA) domain, artificial intelligence(AI)-driven solutions have emerged as formidable tools, yet they typically augment rather than redefine existing methodologies. These solutions often repurpose deep learning models from other domains, such as vision, text, and graph analytics, applying them to circuit design without tailoring to the unique complexities of electronic circuits. Such an “AI4EDA” approach falls short of achieving a holistic design synthesis and understanding,overlooking the intricate interplay of electrical, logical, and physical facets of circuit data. This study argues for a paradigm shift from AI4EDA towards AI-rooted EDA from the ground up, integrating AI at the core of the design process. Pivotal to this vision is the development of a multimodal circuit representation learning technique, poised to provide a comprehensive understanding by harmonizing and extracting insights from varied data sources, such as functional specifications, register-transfer level(RTL) designs, circuit netlists,and physical layouts. We champion the creation of large circuit models(LCMs) that are inherently multimodal, crafted to decode and express the rich semantics and structures of circuit data, thus fostering more resilient, efficient, and inventive design methodologies. Embracing this AI-rooted philosophy, we foresee a trajectory that transcends the current innovation plateau in EDA, igniting a profound “shift-left” in electronic design methodology. The envisioned advancements herald not just an evolution of existing EDA tools but a revolution, giving rise to novel instruments of design-tools that promise to radically enhance design productivity and inaugurate a new epoch where the optimization of circuit performance, power, and area(PPA) is achieved not incrementally, but through leaps that redefine the benchmarks of electronic systems' capabilities.

关键词： AI-rooted EDA large circuit models (LCMs) multimodal circuit representation learning circuit optimization