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Nano Research 2024年第7期17卷 6203-6211页

作者： Yan Zhang Huandi Zhang Xiaoxiao Wang Cheng Tang Xiaowei Shi Zehua Zhao Jiamei Liu Guolong Wang Jianfeng Shen lei Li State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong University28 Xianning West RoadXi’an 710049China Center for Materials Chemistry Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Instrument Analysis Center of Xi'an Jiaotong university Xi’an Jiaotong University28 Xianning West RoadXi’an 710049China Institute of special materials and technology Fudan UniversityShanghai 200433China

The graphene-based microsupercapacitors(MSCs)suffer from graphene aggregation issue in *** reduces the electrolyte ions transportation in the electrodes to degrade the charge storage ability of MSCs,hampering their practical *** the electrolyte ions transportation in the electrodes can boost the charge storage ability of ***,we design and experimentally realize pillar array structure of graphene electrodes for MSCs by direct ink writing *** graphene electrodes with pillar array structure increase the contact area with electrolyte and short the electrolyte ions transport path,facilitating electrolyte ions transport in *** MSCs exhibit high areal capacitance of 25.67 mF·cm^(−2),high areal energy density of 20.54μWh·cm^(−2),and high power density of 1.45 mW·cm^(−2).One single MSCs can power timer for 10 min and pressure sensor more than 160 min,showing high practical application *** work provides a new avenue for developing high performance MSCs.

关键词： microsupercapacitors pillar array structure direct ink writing areal energy density ion transport

A mutation in TBXT causes congenital vertebral malformations in humans and mice

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Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： Shuxia Chen Yunping lei Yajun Yang Chennan Liu Lele Kuang Li Jin Richard HFinnell Xueyan Yang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s Hospital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(CVMs)involving T are not well ***,we report a family with 15 CVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members,indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its DNA-binding affinity,but reduces its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes CVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human CVM.

关键词： Congenital vertebral malformation TBXT T gene Loss-of-function mutation

A Small Heat Shock Protein for Rosa chinesis Confers Resistance to a Variety of Stresses in Both Prokaryotic and Eurkaryotic Cells

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A Small Heat Shock Protein for Rosa chinesis Confers Resista...

梯度洗脱高效液相色谱法测定萘丁美酮的含量及其有关物质检查

中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者： Chang-Hua Jiang Jin-lei Shi Jian-Yao Xu,Feng Ming~* (Institute of Genetics,State Key Laboratory of Genetic Engineering,school of Life Science,fudan university,shanghai 200433,china)

The Chinese rose(Rosa chinesis)is an important horticultural plant throughout the *** have identify two different varieties(MD and KP)that exhibit differing responses to high *** this study,we have used comparative pr... 详细信息

关键词： Rosa chinesis L. thermotolerance smHSP resistence expression

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中国新药与临床杂志 2004年第10期23卷 677-679页

作者：蔡磊段更利复旦大学药学院药物分析教研室上海200032

目的 :建立测定萘丁美酮的HPLC方法 ,并进行萘丁美酮含量测定和有关物质检查。方法 :Agilent 110 0型高效液相色谱仪 ,色谱柱为AgilentZorbaxC 18(15 0mm× 4 .6mm ,5 μm ) ,流动相采用梯度洗脱。UV检测波长为 2 5 4nm。结果 :本法测... 详细信息

目的 :建立测定萘丁美酮的HPLC方法 ,并进行萘丁美酮含量测定和有关物质检查。方法 :Agilent 110 0型高效液相色谱仪 ,色谱柱为AgilentZorbaxC 18(15 0mm× 4 .6mm ,5 μm ) ,流动相采用梯度洗脱。UV检测波长为 2 5 4nm。结果 :本法测定萘丁美酮的线性相关系数为 0 .9999;日内、日间精密度均小于 1% ,方法回收率高、中、低 3点分别为 99.4 0 % ,10 1.6 0 %和 97.11%。结论 :本方法测定萘丁美酮 ,专属性强 ,灵敏度高。

关键词：色谱法高压液相消炎药非甾类关节炎梯度洗脱萘丁美酮

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中国股票市场的三因子模型

系统工程学报 2002年第6期17卷 537-546页

作者：范龙振余世典复旦大学管理学院上海200433

通过对中国股票市场从 1995年 7月到 2 0 0 0年 6月所有A股股票月收益率的研究 ,发现股票市场具有显著的市值效应、账面市值比效应、市盈率效应和价格效应 .这些效应不能用市场 β值来解释 ,但再加上两个因子 :市值因子和账面市值比因... 详细信息

通过对中国股票市场从 1995年 7月到 2 0 0 0年 6月所有A股股票月收益率的研究 ,发现股票市场具有显著的市值效应、账面市值比效应、市盈率效应和价格效应 .这些效应不能用市场 β值来解释 ,但再加上两个因子 :市值因子和账面市值比因子 ,可以很好地解释这些效应 .

关键词：中国股票市场三因子模型 Fama-Macheth回归收益率因子效应证券交易金融理论

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溴化锂吸收式制冷系统开机方式的探讨

上海交通大学学报 2004年第2期38卷 276-280页

作者：王磊陆震上海交通大学机械与动力工程学院上海200030

通过实验探讨了不同季节、不同规模及不同的开机方式对溴化锂吸收式制冷系统动态性能的影响,有助于实现良好的开机控制和减少能源耗费.结果表明,系统冷量的产生时间与冷剂水泵的运行控制有关,燃烧器点火和溶液循环泵的开启顺序及开启时... 详细信息

通过实验探讨了不同季节、不同规模及不同的开机方式对溴化锂吸收式制冷系统动态性能的影响,有助于实现良好的开机控制和减少能源耗费.结果表明,系统冷量的产生时间与冷剂水泵的运行控制有关,燃烧器点火和溶液循环泵的开启顺序及开启时间对系统开机工况下的动态特性有较大影响.不同高、低压发生器筒体尺寸及溶液量的吸收式制冷机可采用不同的开机方式.

关键词：溴化锂吸收式制冷机开机方式动态特性

Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei SHI Xia MA Xin YU Jun lei XU Jin Chuan QIAN Cheng Cheng HU Zhi Dong ZHANG Hui shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China school of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples

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高强度间歇训练在心脏康复中的应用与探讨

中华心血管病杂志 2024年第5期52卷 571-576页

作者：范瑀轩李真范志清王磊杨新春同济大学医学院、同济大学附属同济医院心脏康复科上海200092 大连医科大学附属第一医院心内科大连116021 大庆油田总医院心脏康复科大庆163001 南京市鼓楼医院心脏康复科南京210008 首都医科大学附属朝阳医院心内科北京100020

近年来,高强度间歇性训练(HIIT)广泛应用于冠心病和慢性心力衰竭等心血管疾病患者的心脏康复之中。该文从HIIT的优势、方案类型选择、方案制订与优化等方面,对HIIT在心脏康复中的应用现状进行了深入探讨,认为HIIT可以在传统运动训练模... 详细信息

近年来,高强度间歇性训练(HIIT)广泛应用于冠心病和慢性心力衰竭等心血管疾病患者的心脏康复之中。该文从HIIT的优势、方案类型选择、方案制订与优化等方面,对HIIT在心脏康复中的应用现状进行了深入探讨,认为HIIT可以在传统运动训练模式基础上进一步提高心血管疾病患者心肺耐力,在心脏做功参数和骨骼肌功能改善方面也可能优于中等强度持续运动训练,同时还具有良好的安全性。HIIT方案的多样性可以增加运动兴趣,也增加了HIIT方案制订的复杂性,如何优化HIIT方案以获得最大获益仍需更多研究探索和验证。

关键词：心血管疾病高强度间歇性训练心脏康复中等强度持续训练心肺耐力运动强度恢复类型冠心病心力衰竭

A repertoire of intronic lariat RNAs reveals tissue-specific regulation and target mimicry potential in plants

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Science china(Life sciences) 2024年第6期67卷 1280-1291页

作者： Yong Zhang Xiaotuo Zhang Qi Tang lei Li Ting Jiang Yixiao Fang Hong Zhang Jixian Zhai Guodong Ren Binglian zheng State Key Laboratory of Genetic Engineering Institute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China

Lariat RNA is concomitantly produced by excised intron during RNA splicing,which is usually debranched by DBR1,an RNA debranching ***,increasing evidence showed that some lariat RNA could escape *** is known about how and why these lariat RNAs could be *** comparing the atlas of lariat RNAs between the non-dividing cell(mature pollen)and three actively dividing tissues(young shoot apex,young seeds,and young roots),we identified hundreds to thousands of lariat RNA naturally retained in each tissue,and the incidence of lariat RNA retention is much less in shoot apex while much more in *** lariat RNAs derived from the same intron or different lariat RNAs from the same pre-m RNA could be retained in one tissue while degraded in the other *** deciphering lariat RNA sequences,we identified an AG-rich(RAAAAVAAAR)motif and a UC-rich(UCUCUYUCUC)motif for pollen-specific and the other three tissues-retained lariat RNAs,*** of the pollen-specific AG-rich motif indeed enhanced lariat RNA retention in ***,hundreds of lariat RNAs harbored mi RNA binding sites,and dual-luciferase reporter assay showed that these natural lariat RNAs had the potential to protect expression of mi RNA target ***,our results uncover that selective retention of lariat RNA is an actively regulatory process,and provide new insights into understanding how lariat RNA metabolism may impact mi RNA activity.

关键词： intron turnover lariat RNA miRNA RNA splicing DBR1

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长期隐性互惠合约下的超稳定社会结构研究

上海财经大学学报 2004年第4期6卷 7-15页

作者：石磊钱勇复旦大学经济学院上海200433

　本文分析了中国传统社会结构的超稳定性特征。利用中国传统社会长期隐性互惠合约,说明了对于声誉偏离的冲击和整个社会结构具有趋向于超稳定状态的趋势。在经济发展较为缓慢的情况下,如果社会结构的设计者过于强调收益流的变化,就会... 详细信息

　本文分析了中国传统社会结构的超稳定性特征。利用中国传统社会长期隐性互惠合约,说明了对于声誉偏离的冲击和整个社会结构具有趋向于超稳定状态的趋势。在经济发展较为缓慢的情况下,如果社会结构的设计者过于强调收益流的变化,就会导致社会基准声誉的调整,同时,我们指出了影响声誉收敛速度的约束因素。

关键词：长期隐性互惠合约超稳定社会结构中国声誉-收益模型社会契约社会制约个人