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Journal of Geriatric Cardiology 2016年第9期13卷 733-739页

作者： Evan Kurniawan Feng-Hua DING Qi ZHANG zhen-kun yang Jian HU Wei-Feng SHEN Rui-Yan ZHANG Department of Cardiology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China

Objective To evaluate the predictive value of SYNTAX Score II （SS-II） for percutaneous coronary intervention （PCI） in octogenarian （≥ 80 years old） undergoing PCI. Methods ＆ Results Data from three consecutive years of octogenarian undergoing PCI from Ruijin Hospital （Shanghai, China） was retrospectively collected （n = 308）. Follow up clinical data at one year including all cause mortality, cardiac mortality and main adverse cardiovascular and cerebrovascular events （MACCE） were collected. Patients were stratified according to tertiles of SS-II for PCI： SS-II 〈 26 （n = 104）, SS-II： 27-31 （n = 102）, SS-II 〉 31 （n = 102）. After adjustment for confounding factors, SS-II for PCI was an independent risk factors for all cause mortality （odds ratio： 2.77, 95% CI： 1.13-8.06; P = 0.04）. Kaplan-Meier curves showed higher event rates for all cause mortality and cardiac mortality in higher tertile of SS-II for PCI （Log-Rank test P = 0.002 and P = 0.001, respectively）. SSdl for PCI predicted one year mortality in octogenarian population undergoing PCI. Conclusions In octogenarian, SS-II which incorporated clinical variables with angiographic anatomy variable was suitable in risk stratifying and predicting clinical outcomes at one year.

关键词： Clinical research Elderly Risk stratification

Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第5期16卷 362-369页

作者： zhen-kun yang Chen YING Hong-yan ZHAO Yue-hua FANG Ying CHEN Wei-feng SHEN Department of Cardiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Endocrinology and Metabolism Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired renal function. Methods：We measured serum levels of calcium, phosphate, alkaline phosphatase （AKP）, intact parathyroid hormone （iPTH）, 25-hydroxyvitamin D （25-OHD）, and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis （AVSc）（n=164） or stenosis （AVS）（n=96） and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results：Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels （al P〈0.001）. Similarly, osteocalcin, procol agen I N-terminal peptide, andβ-isomerized type I col agen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS （al P〈0.001）. In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding varia-bles, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were in-dependently associated with the presence and severity of CAVD. Conclusions： This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.

关键词： Valve heart disease Aortic stenosis Mineral metabolism Calcium Phosphate

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基于室内试验的页岩脆性特征评价方法

东北大学学报（自然科学版） 2016年第10期37卷 1496-1500,1506页

作者：侯振坤杨春和王磊徐峰重庆大学煤矿灾害动力学与控制国家重点实验室重庆400044 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071

基于全应力应变曲线,提出了包含多参数的综合脆性指标Bd1和Bd2.从扩容拐点(峰前曲线)、残余强度(峰后曲线)、能量分析(全过程曲线)等多角度对脆性指标进行了诠释,通过页岩单三轴实验并结合破坏模式对其适用性进行了验证.结果表明,该指... 详细信息

基于全应力应变曲线,提出了包含多参数的综合脆性指标Bd1和Bd2.从扩容拐点(峰前曲线)、残余强度(峰后曲线)、能量分析(全过程曲线)等多角度对脆性指标进行了诠释,通过页岩单三轴实验并结合破坏模式对其适用性进行了验证.结果表明,该指标较好地反应了页岩的脆性,Bd1可根据不同的目的需求选择不同的参数,对脆性评价具有侧重性,且Bd1与围压具有较好的拟合关系,拟合曲线为指数函数;Bd2综合性强,可作为脆性的综合评价指标,但围压较高时对围压不够敏感;90°取芯角度下,随着围压的增加,脆性指数降低,岩石有脆性向延性转化的趋势;低围压下脆性指数对围压比较敏感,降低速度较快,高围压下则相反.

关键词：页岩脆性指标扩容拐点残余强度能量分析破坏模式

Impact of successful staged revascularization of a chronic total occlusion in the non-infarct-related artery on long-term outcome in patients with acute ST-segment elevation myocardial infarction

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Impact of successful staged revascularization of a chronic t...

One-year clinical outcome of interventionalist-versus patient-transfer strategies for primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: results from the REVERSE-STEMI study

中华医学会第十五次全国心血管病学大会

作者： zhen kun yang Rui Yan Zhang Qi Zhang Feng Hua Ding Jian Hu Wei Feng Shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Background Recently, a chronic total occlusion (CTO) in the non-infarct-related artery (non-IRA) was reported as an independent predictor of clinical outcome in patients with acute ST-segment elevation myocardial infa...

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One-year clinical outcome of interventionalist-versus patien...

中华医学会第十五次全国心血管病学大会

作者： Qi Zhang Rui Yan Zhang Jian Sheng Zhang Jian Hu zhen kun yang Wei Feng Shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Background Traditional reperfusion options for patients with acute ST-segment elevation myocardial infarction (STEMI) presenting to non-primary percutaneous coronary intervention (PPCI)-capable hospitals generally include onsite fibrinolytics or emergency transfer for PPCI. A third option, involving interventionalist transfer, was examined in the REVERSE-STEMI study.

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基于预见控制的甲板运动跟踪控制研究

电光与控制 2017年第11期24卷 74-77,99页

作者：马坤甄子洋覃海群南京航空航天大学自动化学院南京211106

甲板运动是舰载机完成海上作战任务的关键影响因素之一。针对无人舰载机着舰过程中甲板运动干扰问题,设计了基于最优预见控制的甲板运动补偿器,并与基于卡尔曼滤波算法的甲板运动预估器相结合,组成甲板运动跟踪控制系统。该系统利用了... 详细信息

甲板运动是舰载机完成海上作战任务的关键影响因素之一。针对无人舰载机着舰过程中甲板运动干扰问题,设计了基于最优预见控制的甲板运动补偿器,并与基于卡尔曼滤波算法的甲板运动预估器相结合,组成甲板运动跟踪控制系统。该系统利用了甲板运动预估信息以及预见控制提前操作的特点,可有效避免传统甲板补偿系统的相位延迟。最后,以非线性小型固定翼无人机模型为研究对象进行数值仿真,仿真结果表明,该系统能够有效跟踪甲板运动,从而提高无人机着舰成功率。

关键词：无人机着舰最优预见控制甲板运动补偿甲板运动跟踪

Predictive value of SYNTAX score Ⅱ for clinical outcomes in octogenarian undergoing percutaneous coronary intervention

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Journal of Geriatric Cardiology 2016年第9期 733-739页

作者： Evan Kurniawan Feng-Hua DING Qi ZHANG zhen-kun yang Jian HU Wei-Feng SHEN Rui-Yan ZHANG Department of Cardiology Rui Jin HospitalSchool of MedicineShanghai Jiao Tong University

Objective To evaluate the predictive value of SYNTAX Score Ⅱ(SS-Ⅱ) for percutaneous coronary intervention(PCI) in octogenarian(≥ 80 years old) undergoing *** & Results Data from three consecutive years of octogenarian undergoing PCI from Ruijin Hospital(Shanghai,China) was retrospectively collected(n = 308).Follow up clinical data at one year including all cause mortality,cardiac mortality and main adverse cardiovascular and cerebrovascular events(MACCE) were *** were stratified according to tertiles of SS-Ⅱ for PCI:SS-Ⅱ ≤26(n = 104),SS-Ⅱ:27-31(n = 102).SS-Ⅱ > 31(n = 102).After adjustment for confounding factors,SS-Ⅱ for PCI was an independent risk factors for all cause mortality(odds ratio:2.77,95%CI:1.13-8.06;P = 0.04).Kaplan-Meier curves showed higher event rates for all cause mortality and cardiac mortality in higher fertile of SS-Ⅱ for PCI(Log-Rank test P = 0.002 and P = 0.001,respectively).SS-Ⅱ for PCI predicted one year mortality in octogenarian population undergoing *** In octogenarian,SS-Ⅱ which incorporated clinical variables with angiographic anatomy variable was suitable in risk stratifying and predicting clinical outcomes at one year.

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小肠推进动力学实验结合正交实验优选加味血肿解的提取工艺

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中医药导报 2017年第19期23卷 47-49页

作者：王秀真黄坤央杜天信谢文河南省洛阳正骨医院/河南省骨科医院河南洛阳471002 平顶山市第二人民医院河南平顶山467000

目的:优选加味血肿解复方的提取工艺。方法:采用小肠推进动力学试验比较水煎煮法和水蒸气蒸馏法对加味血肿解复方药效的影响;以大黄酸、大黄酚及浸膏得率的综合评分为指标,采用正交实验考察溶剂用量、提取时间、提取次数对提取工艺的影... 详细信息

目的:优选加味血肿解复方的提取工艺。方法:采用小肠推进动力学试验比较水煎煮法和水蒸气蒸馏法对加味血肿解复方药效的影响;以大黄酸、大黄酚及浸膏得率的综合评分为指标,采用正交实验考察溶剂用量、提取时间、提取次数对提取工艺的影响,确定最佳提取工艺。结果:采用煎煮法提取,最佳提取工艺为加8倍量水提取2次,每次2 h。结论:该试验优选的提取工艺稳定可靠、简便易行、经济适用,适用于加味血肿解的工业生产。

关键词：加味血肿解小肠推进动力学试验大黄酸大黄酚

The Role of Consumer Privacy Concerns in Shaping Platform Strategy for Online Markets

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Journal of the Operations Research Society of China 2024年第2期12卷 363-386页

作者： Jin-kun yang Yong-Rui Duan Jia-zhen Huo School Economics and Management Tongji UniversityShanghai 200092China

We investigate the effects of consumer privacy concerns on the pricing and personal data collection strategy of an online *** online platform derives revenues from disclosing consumer information to *** compete for the information in order to enable them to price discriminate and thus derive revenues from consumer purchases.A novel aspect of our research is that we allow the online platform to sell only a subset of consumer *** develop analytical models where consumers can/cannot protect their *** analysis yields three main ***,in the monopoly case,we find that when the consumer privacy disclosure aversion cost is relatively low,it is optimal for the platform to sell all consumer information to the ***,in the duopoly case,we illustrate that when the consumer privacy disclosure aversion cost is relatively low,the platform will sell all consumer information to only one firm;when the cost is moderate,the platform will choose to sell the information of only some consumers and to only one firm;when the cost is relatively high,the platform will select only some of the consumers and sell their information to both ***,it will be better for the platform to provide the information protection service for free when the privacy cost is low.

关键词： Price discrimination User privacy Consumer information Two-sided market Privacy disclosure aversion cost

Controls on geomorphic characteristics of the Xiaohei River basin in the upper Lancang-Mekong, China

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Journal of Mountain Science 2020年第5期17卷 1032-1044页

作者： GU zhen-kui FAN Hui LOU Jun-peng yang kun Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Institute of International Rivers and Eco-SecurityYunnan UniversityKunming 650091China Department of Hydraulic Engineering Tsinghua UniversityBeijing 10084China

Understanding the evolution of the fluvial geomorphology in an orogenic belt provides valuable insight into the relationship between upper crustal deformation and surface *** upper Lancang-Mekong River is in an area experiencing both uplift and *** related processes provide a steady sediment supply to the lower reaches of the river and play an important role in the regional environmental *** Xiaohei(Weiyuan)River Basin is an important sub-basin in this area,which is characterized by large-scale topographic fluctuations,active tectonics and erosion,and anthropogenic *** different factors introduce numerous complexities to the local surface *** this study,we investigate and quantify the controls of geomorphic evolution of the Xiaohei River *** located and mapped the main knick-zones within the channels and examined the main genetic factors,such as faults and stratigraphic *** results show that the areas with the lowest uplift rates are characterized by a low steepness index and are located in the southeastern part of the *** stream power of the mainstream increases downstream,with an average value of^122 W/*** erosional activity of the various stream channels is ***,the basin tends to expansion,with only local instances of inward *** analysis confirms that a number of the geomorphic evolutionary characteristics of the Xiaohei River Basin are *** addition,the future potential for the increasing the number of dams and the hydropower development in the basin may weaken the expansion trend of the basin over a long period of time.

关键词： Longitudinal profile Steepness Divide migration Stream power Hydropower development Lancang