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Axl Alleviates Neuroinflammation and Delays Japanese Encephalitis Progression in Mice

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Virologica Sinica 2021年第4期36卷 667-677页

作者： Zhao-Yang Wang Zi-da zhen Dong-Ying Fan Pei-Gang Wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100093China

Japanese encephalitis virus(JEV)is a mosquito-borne flavivirus,which causes the most commonly diagnosed viral encephalitis named Japanese encephalitis(JE)in the world with an unclear ***,a receptor tyrosine kinase from TAM family,plays crucial role in many inflammatory *** have previously discovered that Axl deficiency resulted in more severe body weight loss in mice during JEV infection,which we speculate is due to the anti-inflammatory effect of Axl during ***,the role of Axl in regulating the neuroinflammation and brain damage during JE has not been investigated *** this study,by using Axl deficient and heterozygous control mice,we discovered that Axl deficient mice displayed accelerated JE progression and exacerbated brain damage characterized by increased neural cell death,extended infiltration of inflammatory cells,and enhanced production of pro-inflammatory cytokines,in comparison to control ***,consistent with our previous report,Axl deficiency had no impact on the infection and target cell tropism of JEV in *** together,our results suggest that Axl plays an anti-inflammatory and neuroprotective role during the pathogenesis of JE.

关键词： Axl Japanese encephalitis virus(JEV) Inflammation Cytokine

Copper Promoted Au/ZnO-CuO Catalysts for Low Temperature Water-gas Shift Reaction

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Chemical Research in Chinese Universities 2006年第1期22卷 99-102页

作者： LIAN Hong-lei JIA Ming-jun PAN Wei-cheng ZHANG Wen-xiang JIANG da-zhen College of Chemistry Jilin University Changchun 130023 P. R. China School of Chemical Engineering Zhengzhou University Zhengzhou 450002 P. R. China

Various copper promoted Au/ZnO-CuO catalysts with different atomic ratios of Cu to Zn prepared by means of co-precipitation were tested for the low temperature water-gas shift（WGS） reaction. The catalytic activity of the catalyst depends largely on the ratio of Cu to Zn. The addition of an appropriate amount of copper can considerably improve both the catalytic activity and the stability of the catalyst in comparison with those of copper-free Au/ZnO cata- lysts. The enhanced reducibility of copper oxide in the Au/ZnO-CuO ternary-component catalysts, which was confirmed by H2-TPR, may be related to the high activity and stability of the catalyst for the low temperature WGS reaction.

关键词： Water-gas shift reaction ZnO CuO Gold

Pilaring of Zn_2Al Layered Double Hydroxide by dawson Polyoxometalate Anions

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Chemical Research in Chinese Universities 1998年第2期14卷 68-70页

作者： GUO Jun LI Yun-lun JIAO Qing-ze JIANG da-zhen MIN En-ze Department of Chemistry Jilin UniversityChangchun130023 Research Institute of Petroleum Processing Beijing100083

Zn2Al layered double hydroxide pillared with dawson polyoxometalates,P2W17ZO8-61(Z=Mn2+,Co2+,Ni2+,Cu2+,Zn2+)was prepared.A basal space ofca.16 nm indicates the intercalated dawson ions to be oriented with their C2 axis perpendicular to the double hydroxide layers(with the exception of P2W17ZnLDH).The IR and^(13)P MASNMR spectral reveal that the dawson ions retain their integrity in the interlayer space of LDH.A preliminary study shows that these compounds are highly active catalysts for the oxidation of cyclohexene with molecular oxygen.

关键词： Pillaring dawson structure Polyoxometalate anions

Development of land desertification in Bashang area in the past 20 years

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Journal of Geographical Sciences 2001年第4期11卷 53-57页

作者： Chen Zhi-qing Zhu zhen-da Institute of Geographic Sciences and Natural Resources Research CAS Beijing China Institute of Cold and Arid Regions and Environmental Engineering CAS Lanzhou China

Natural conditions in Bashang area are characterized by zonal transitions which are liable to be impacted by natural disasters and intensified human activities. The extremely fragile eco-environment is also liable to have desertification formed and developed. In the 18 years from 1978 to 1996, the desertified land area of Bashang within the scope of the map nearly doubled, a total increase of 2199.11 km2, averaging an increase of 122.17 km2 per year. Moreover, the seriously desertified area increases rapidly. Land desertification in Bashang is the combined result of natural factors and irrational human economic activities. Cultivated land expansion, population growth, and overgrazing aggrevate desertification development.

关键词： Bashang area desertification impact of human activities

Alkylation　of　Benzene　with　Propene　over　Hβ　Zeolite──The　Effect　of　Reaction　Conditions　on　the　Distribution　of　Products

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Chemical Research in Chinese Universities 1995年第1期11卷 39-44页

作者： MA Jun SHEN Jian-ping SUN Tie and JIANG da-zhen(Department of Chernistry , Jilin University , Changchun , 130023 ) JILIN UNIV DEPT CHEMCHANGCHUN 130023PEOPLES R CHINA

he effects of reaction temperature , flow rate of carrier gas , space velocity andbenzene to propene ratio on the alkylation of benzene with propene over Hβ zeolitewere investigated. At lower flow rate of carrier gas and space velocity, higher ben-zene to propene ratio the formation of cumene is favoured due to the difference be-tween rates of reactions of the alkylation of benzene (or cumene) with propene andthe alkyltranslation of diisopropylbenzene with benzene. The propylbenzene is pro-duced directly by the alkylation of benzene with propene.

关键词： Benzene Propene Alkylation Hβ zeolite

Catalytic Oxidation of Cyclohexene with Molecular Oxygen on Hydrotalcite－like Compounds

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Chemical Research in Chinese Universities 1995年第3期11卷 256-258页

作者： Guo, Jun Wang, Ning Jiao, Qing-ze Jiang, da-zhen Yang, Guang-hui Min, En-ze JILIN UNIV DEPT CHEMCHANGCHUN 130023PEOPLES R CHINA EDUC INST JILIN PROV DEPT CHEMCHANGCHUN 130021PEOPLES R CHINA RES INST PETR PROC BEIJING 100083PEOPLES R CHINA

ＣａｔａｌｙｔｉｃＯｘｉｄａｔｉｏｎｏｆＣｙｃｌｏｈｅｘｅｎｅｗｉｔｈＭｏｌｅｃｕｌａｒＯｘｙｇｅｎｏｎＨｙｄｒｏｔａｌｃｉｔｅ－ＩｉｋｅＣｏｍｐｏｕｎｄｓＧＵＯＪｕｎ，ＷＡＮＧＮｉｎｇ，ＪＩＡＯＱｉｎｇ－ｚｅａｎｄ... 详细信息

ＣａｔａｌｙｔｉｃＯｘｉｄａｔｉｏｎｏｆＣｙｃｌｏｈｅｘｅｎｅｗｉｔｈＭｏｌｅｃｕｌａｒＯｘｙｇｅｎｏｎＨｙｄｒｏｔａｌｃｉｔｅ－ＩｉｋｅＣｏｍｐｏｕｎｄｓＧＵＯＪｕｎ，ＷＡＮＧＮｉｎｇ，ＪＩＡＯＱｉｎｇ－ｚｅａｎｄＪＩＡＮＧＤａ－ｚｈｅｎ（Ｄｅｐａ...

关键词： Catalytic Oxidation Cyclohexene Molecular oxygen

Characteristics and control mechanisms of coalbed permeability change in various gas production stages

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Petroleum Science 2015年第4期12卷 684-691页

作者： da-zhen Tang Chun-Miao Deng Yan-Jun Meng Zhi-Ping Li Hao Xu Shu Tao Song Li School of Energy Resources China University of Geosciences Coal Reservoir Laboratory of National Engineering Research Center of Coalbed Methane Development & Utilization

According to dimensionless analysis of the coalbed methane （CBM） production data of Fanzhuang block in southern Qinshui basin, the dimensionless gas production rate is calculated to quantitatively divide the CBM well production process into four stages, i.e., drai- nage stage, unstable gas production stage, stable gas pro- duction stage, and gas production decline stage. By the material balance method, the coal reservoir permeability change in different stages is quantitatively characterized. The characteristics and control mechanisms of change in coalbed permeability （CICP） during different production stages are concluded on five aspects, i.e., permeability trend variation, controlling mechanism, system energy, phase state compositions, and production performance. The study reveals that CICP is characterized by first decline, then recovery, and finally by increase and is controlled directly by effective stress and matrix shrinkage effects. Further, the duration and intensity of the matrix shrinkage effect are inherently controlled by adsorption and desorp- tion features.

关键词： Production stage - Coalbed methane Permeability Dynamic change - Control mechanism

Characterization and Catalytic Activity of Titanium-containing Aluminum Phosphate Prepared by Sol-gel and Nonuniform Precipitation for O-Alkylation of Catechol with Ethanol

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Chemical Research in Chinese Universities 2003年第3期19卷 330-334页

作者： PAN Chun-liu ZHANG Wen-xiang LI Xue-mei JIANG da-zhen WU Tong-hao College of Chemistry Jilin UniversityChangchun 130023P.R.China

Three titanium-containing aluminum phosphate catalysts with a general formula Al 0.77 Ti 0.23 PO 4 were prepared by the sol-gel method at room temperature(APTS), and a nonuniform precipitation procedure at room temperature(APTR) and under reflux(APTF), respectively. The structural features and the surface properties of the three catalysts were determined by means of the physical adsorption of nitrogen at liquid N 2 temperature, XRD, UV-Vis, NH 3-TPD and IR of adsorbed pyridine. The vapor phase O-alkylation of catechol with ethanol over the prepared catalysts was studied. It was found that the activity and the selectivity of these catalysts are greatly dependent on the preparation method, and catalyst APTF shows the highest activity and selectivity. The characterization evidence indicates that the weak Brnsted acid sites were more effective for the reaction.

关键词： Catechol Alkylation Ethanol Aluminum phosphate

The synthesis of pillared nickel-substituted saponite and its hydroisomerization activity

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Chinese Journal of Chemistry 1993年第6期11卷 509-516页

作者： da-zhen Jiang Tie Sun Zi-Yang Liu En-Ze Min Ming-Yuan He Department of Chemistry Jilin University Changchun 130023 Research Institute of Petroleum Processing Beijing 100083

Nickel-substituted saponite clays (NiS) were synthesized. The pillared clays noted PNiS were prepared from the NiS intercalated with large inorganic cations such as [Al_(13)O_4(OH)_(24). (H_2O)_(12)]^(7+). It is found that the pillar density is correlative with aluminium content in the tetra- hedral sheet of NiS. The results from TPR indicate that the palladium loaded on samples promotes the reduction of the nickel ion in the octahedral sheet. The pillared clays impregnated with Pd^(2+) noted PdPNiS show excellent hydroisomerization property which is much better than that of nickel substituted mica-montmorillonite pillared with silicon oxide oligomer noted PdPSMM. The hexane conversion increases with the content of aluminium ion in the tetrahedral sheet, whereas the change of the selectivity of isomerization is not obvious.

关键词： NIS The synthesis of pillared nickel-substituted saponite and its hydroisomerization activity