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A prospective microbiome analysis of the impact of physical exercise and blueberry supplementation on the gut microbiome of obesity-induced hypertensive in college students

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Food Science and Human Wellness 2024年

作者： zhen cheng Rendong Li Tie Ma Aihua Xu Yuanyuan Bian Bin Li College of Food Science Shenyang Agricultural University Physical Education Department Shenyang University of Chemical Technology Shenyang Economic and Technological Development Zone The College of Kinesiology Shenyang Sport University Department of Rehabilitation Medicine The First Hospital of China Medical University

The prevalence of high blood pressure is on the rise among younger individuals， and recent findings have linked exercise to changes in the diversity and configuration of gut microbiota. However， specific modifications to one's diet， such as incorporating blueberries while engaging in physical activity， can also influence this association. To explore the effects of exercise and blueberry consumption on gut bacteria， we conducted an eight-week study involving healthy and hypertensive college students. Our microbiome analysis revealed slight shifts in gut bacteria composition in response to increased physical activity， with significant changes in the diversity of the g＿[Eubacterium]＿eligens＿group observed in hypertensive college students who regularly consumed blueberries. Although exercise and blueberry supplementation had a negligible impact on the gut microbiota diversity of healthy college students， it significantly boosted the production of butyric acid bacteria in hypertensive young adults. These results suggest that the changes in gut bacteria variety and abundance brought about by blueberries may be tied to alterations in the body composition of patients with hypertension. This study aims to reveal the impact of blueberry on the hypertensive students from a unique perspective， suggesting the impact of taking blueberry while taking exercises.

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Mucosal immune responses to Ichthyophthirius multifiliis in the ocular mucosa of rainbow trout(Oncorhynchus mykiss,Walbaum),an ancient teleost fish

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Marine Life Science & Technology 2024年第2期6卷 266-279页

作者： Weiguang Kong Guangyi Ding Gaofeng cheng Peng Yang zhen Xu Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Department of Aquatic Animal Medicine College of FisheriesHuazhong Agricultural UniversityWuhan 430070China

The eye,as a specialized visual organ,is directly exposed to the external environment,and,therefore,it faces constant chal-lenges from external pathogenic organisms and toxins.In the ocular mucosa(OM)of mammals,mucosal-associated lymphoid tissues(MALTs)constitute the primary line of defense.However,the immune defense role of the OM remains unknown in aquatic vertebrates.To gain insights into the immune processes within the OM of teleost fish,we developed an infection model of rainbow trout(Oncorhynchus mykiss)OM using a parasite,Ichthyophthirius multifiliis(Ich).Immunofluorescence,qPCR,and H&E staining revealed that Ich successfully infiltrates the OM of rainbow trout,leading to pathological struc-tural changes,as evidenced by A&B staining.Importantly,the qPCR results indicate an up-regulation of immune-related genes following Ich infection in the OM.Moreover,transcriptome analyses were conducted to detect immune responses and impairments in eye function within the OM of rainbow trout with Ich infection.The results of the transcriptome analysis that Ich infection can cause an extensive immune response in the OM,ultimately affecting ocular function.To the best of our knowledge,our findings represent for the first time that the teleost OM could act as an invasion site for parasites and trigger a strong mucosal immune response to parasitic infection.

关键词： Ocular mucosa Mucosal immunity Transcriptome analysis Oncorhynchus mykiss Ichthyophthirius multifiliis

Safety and effectiveness of butorphanol in epidural labor analgesia:A protocol for a systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第8期12卷 1416-1421页

作者： Guan-cheng Tang Man He zhen-Zhao Huang Yan cheng Department of Anesthesiology Yongkang Hospital of Traditional Chinese MedicineJinhua 321301Zhejiang ProvinceChina Department of Gynecology and Obstetrics Yongkang Hospital of Traditional Chinese MedicineJinhua 321301Zhejiang ProvinceChina Department of Anesthesiology Hangzhou United Liger Sixth Medical Beauty HospitalHangzhou 311215Zhejiang ProvinceChina Department of Ultrasound Hangzhou Women’s HospitalHangzhou 310008Zhejiang ProvinceChina

BACKGROUND Epidural analgesia is the most effective analgesic method during labor.Butorphanol administered epidurally has been shown to be a successful analgesic method during labor.However,no comprehensive study has examined the safety and efficacy of using butorphanol as an epidural analgesic during labor.AIM To assess butorphanol's safety and efficacy for epidural labor analgesia.METHODS The PubMed,Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure,and Google Scholar databases will be searched from inception.Other types of literature,such as conference abstracts and references to pertinent reviews,will also be reviewed.We will include randomized controlled trials comparing butorphanol with other opioids combined with local anesthetics for epidural analgesia during labor.There will be no language restrictions.The primary outcomes will include the visual analog scale score for the first stage of labor,fetal effects,and Apgar score.Two independent reviewers will evaluate the full texts,extract data,and assess the risk of bias.Publication bias will be evaluated using Egger's or Begg's tests as well as visual analysis of a funnel plot,and heterogeneity will be evaluated using the Cochran Q test,P values,and I2 values.Meta-analysis,subgroup analysis,and sensitivity analysis will be performed using RevMan software version 5.4.This protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)Protocols statement,and the PRISMA statement will be used for the systematic review.RESULTS This study provides reliable information regarding the safety and efficacy of using butorphanol as an epidural analgesic during labor.CONCLUSION To support clinical practice and development,this study provides evidence-based findings regarding the safety and efficacy of using butorphanol as an epidural analgesic during labor.

关键词： Epidural analgesia during labor Butorphanol Safety Protocol Meta-analysis

A systematic COSMO-RS study on mutual solubility of ionic liquids and C6-hydrocarbons

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Green Chemical Engineering 2024年第1期5卷 97-107页

作者： Chuxin Qi zhen Song Hongye cheng Lifang Chen Zhiwen Qi State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and Technology130 Meilong RoadShanghai200237China

When considering the usage of ionic liquids(ILs)for reactions and separations involving non-polar or weak-polar hydrocarbons,the knowledge of the mutual solubility behaviors of ILs and hydrocarbons is of the utmost importance.In this work,taking four typical C6-hydrocarbons namely benzene,cyclohexene,cyclohexane,and hexane as representatives,the mutual solubility of ILs and non-polar or weak-polar hydrocarbons are systematically studied based on the COSMO-RS model.The reliability of COSMO-RS for these systems is first evaluated by comparing experimental and predicted hydrocarbon-in-IL activity coefficient at infinite dilution and binary/ternary liquid-liquid equilibria of related systems.Then,the mutual solubility of the four hydrocarbons and13,650 ILs(composed by 210 cations and 65 anions)are predicted.The effect of different IL structural characteristics including alkyl chain length,cation family/symmetry/functional group,and anion on the IL-hydrocarbon mutual solubility behaviors are further analyzed by the analyses of interaction energy and screen charge distribution.The mutual solubility databases and the structural effects identified thereon could provide useful guidance for IL selection in related applications.

关键词： C6-hydrocarbons Ionic liquids Mutual solubility COSMO-RS Structural effect analysis

Conceptual design of a 714-MHz RFQ for compact proton injectors and development of a new tuning algorithm on its aluminium prototype

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Nuclear Science and Techniques 2024年第1期35卷 45-58页

作者： Yi-Xing Lu Wen-cheng Fang Yu-Sen Guo zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800China University of Chinese Academy of Sciences Beijing 101408China Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201204China Shanghai Key Laboratory of Cryogenics&Superconducting RF Technology Shanghai 201800China ShanghaiTech University Shanghai 201210China

Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator facilities.An RFQ with a high frequency of 714 MHz dedicated to compact proton injectors for medi-cal applications is designed in this study.The RFQ is designed to accelerate proton beams from 50 keV to 4 MeV within a short length of 2 m and can be matched closely with the downstream drift tube linac to capture more particles through a preliminary optimization.To develop an advanced RFQ,challenging techniques,including fabrication and tuning method,must be evaluated and verified using a prototype.An aluminium prototype is derived from the conceptual design of the RFQ and then redesigned to confirm the radio frequency performance,fabrication procedure,and feasibility of the tuning algorithm.Eventually,a new tuning algorithm based on the response matrix and least-squares method is developed,which yields favorable results based on the prototype,i.e.,the errors of the dipole and quadrupole components reduced to a low level after several tuning iterations.Benefiting from the conceptual design and techniques obtained from the prototype,the formal mechanical design of the 2-m RFQ is ready for the next manufacturing step.

关键词： Compact proton injector RFQ IH-DTL High gradient Tuning

Evidence-Based Dampness-Heat zhenG(Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor

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Chinese Journal of Integrative Medicine 2024年第1期30卷 85-95页

作者： JIAO Ju-ying cheng Chien-shan CAO Zhang-qi CHEN Lian-yu CHEN zhen Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghai(200032)China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai(200032)China

Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and zhenG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat zhenG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized zhenG-based cancer animal model.

关键词： cancer Chinese medicine syndrome zhenG dampness-heat syndrome animal model pancreatic tumor evaluation methods

Mixing states and secondary formation processes of organic nitrogen-containing single particles in Guangzhou,China

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Journal of Environmental Sciences 2024年第4期138卷 62-73页

作者： Lijun Yun Chunlei cheng Suxia Yang Zaihua Wang Mei Li Qi En Zhong LiyuanMao Sulin Liu Xiaoya cheng Duanying Chen Fan Yang zhen Zhou Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for on-line source apportionment system of air pollutionJinan UniversityGuangzhou 510632China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 510632China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy ScienceXi’an 710061China Institute for Environment and Climate Research Jinan UniversityGuangzhou 510632China Guangdong Academy of Sciences Institute of Resources Utilization and Rare Earth DevelopmentGuangzhou 510650China Environmental Monitoring Station of Pudong New District Shanghai 201200China

Organic nitrogen(ON)compounds play a significant role in the light absorption of brown carbon and the formation of organic aerosols,however,the mixing state,secondary formation processes,and influencing factors of ON compounds are still unclear.This paper reports on the mixing state of ON-containing particles based on measurements obtained using a highperformance single particle aerosol mass spectrometer in January 2020 in Guangzhou.The ON-containing particles accounted for 21% of the total detected single particles,and the particle count and number fraction of the ON-containing particles were two times higher at night than during the day.The prominent increase in the content of ON-containing particles with the enhancement of NO_xmainly occurred at night,and accompanied by high relative humidity and nitrate,which were associated with heterogeneous reactions between organics and gaseous NO_(x)and/or NO_(3)radical.The synchronous decreases in ON-containing particles and the mass absorption coefficient of water-soluble extracts at 365 nm in the afternoon may be associated with photo-bleaching of the ON species in the particles.In addition,the positive matrix factorization analysis found five factors dominated the formation processes of ON particles,and the nitrate factor(33%)mainly contributed to the production of ON particles at night.The results of this study provide unique insights into the mixing states and secondary formation processes of the ON-containing particles.

关键词： Organic nitrogen compounds Single particles Mixing state Secondary formation Nighttime chemistry

Time evolutions of scalar field perturbation in Schwarzschild de-Sitter black hole from Einstein-scalar–Gauss–Bonnet theory

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Communications in Theoretical Physics 2024年第1期76卷 76-81页

作者： cheng Xu zhen-Hao Yang Xiao-Mei Kuang Rui-Hong Yue Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou225009China

The scalar-free black hole could be unstable against the scalar field perturbation when it is coupled to a Gauss–Bonnet(GB)invariant in a special form.It is known that the tachyonic instability in this scenario is triggered by the sufficiently strong GB coupling.In this paper,we focus on the time domain analysis of massive scalar field perturbation around the Schwarzschild de-Sitter black hole in Einstein-scalar–Gauss–Bonnet gravity.By analyzing the scalar field propagation,we find that the scalar field will finally grow when the GB coupling is large enough.This could lead to the instability of the background black hole.Furthermore,we demonstrate how the mass of the scalar field and the GB coupling strength affect the onset of tachyonic instability.

关键词： black hole perturbation scalar-Einstein-Gauss-Bonnet gravity time domain evolution me

Manipulating the Phase Transition Behavior of Dual Temperature-Responsive Block Copolymers by Adjusting Composition and Sequence

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Chinese Journal of Polymer Science 2024年第2期42卷 176-187,I0006页

作者： Zhi Zou Xiang Xu Hai-Tao Zhao Jian-Nan cheng Wei-Wei He Li-Fen Zhang zhen-Ping cheng Suzhou key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of JiangsuSoochow UniversitySuzhou215123China

Temperature-responsive polymers have garnered significant attention due to their ability to respond to external stimuli.In this work,dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization(RAFT)polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine(SBMA) and N-isopropyl acrylamide(NIPAAm) as monomers.The thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate(BN) or hydrophilic monomer acrylic acid(AA),adjusting concentration or pH,or varying the degree of polymerization of the block chain segments.The cloud points of the copolymers are determined by UV-Vis spectrophotometry,and these copolymers exhibit both controlled upper and lower critical solu bility temperatures(LCST and UCST) in aqueous solution.This study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation laws.It is very interesting that the introduction of poly-acrylic acid(PAA) segments in the middle of di-block copolymer PSBMA_(55)-b-PNIPAAm_(80) to form PSBMA_(55)-b-PAA_(x)-b-PNIPAAm_(80) results in a reversal of temperature-responsive behaviors from 'U'(LCST UCST) type,while the copolymer PSBMA_(55)-b-P(NIPAAm_(80)-co-AA_(x)) not.This work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.

关键词： Temperature responsive polymers High critical solubility temperature(UCST) Low critical solubility temperature(LCST) Block copolymers