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Attenuation of the Activation of NLRP3 Inflammasome in Fibroblast Like Synoviocytes of Rheumatoid Arthritis by Baicalin through Regulating the Let-7i-3p/PI3K/Akt/NF-κB Signaling Axis

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Medicinal Plant 2024年第2期15卷 69-73,76页

作者： Wei ZHANG Li WANG Yuxin YANG Rui MA Li WANG Ling huang Qiaofeng WAN Department of Pathogenic Biology and Immunology School of Basic MedicineNingxia Medical UniversityYinchuan 750004China Department of Rheumatology Ningxia Medical University General HospitalYinchuan 750003China School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004China

[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-RA).[Methods]To confirm that baicalin alleviated the activation of NLRP3 inflammasome in HFLS-RA,the expression of NLRP3 before and after baicalin treatment was observed by *** blot was used to detect the protein expression of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1 after baicalin treatment for 48 h,and the contents of IL-1 and IL-18 in the supernatents were detected by *** order to explore the mechanism of baicalin alleviating the activation of NLRP3 inflammasome,the corresponding relationship between let-7i-3p and PIK3CA was verified by double luciferin and Westen blot *** expression of let-7i-3p and PI3K before and after baicalin intervention was detected by ***-7i-3p interference was used to verify whether baicalin mitigated the activation of enhanced NLRP3 inflammasome.[Results]Baicalin(50 and 100 mg/L)significantly reduced the activation of NLRP3 inflammasome,inhibited the protein expressions of p-PI3K,p-Akt,NF-κB p65,NLRP3,ASC and caspase-1,and the secretion of IL-1 and ***-7i-3p and PIK3CA had a targeted correspondence,and baicalin up-regulated the expression of let-7i-3p and down-regulated the expression of *** attenuated the activation of NLRP3 inflammasome enhanced by let-7i-3p interference.[Conclusions]Baicalin can up-regulate let-7i-3p expression,inhibit PI3K/Akt/NF-κB signal transduction,and thus reduce the activation of NLRP3 inflammasome in HFLS-RA.

关键词： Baicalin Rheumatoid arthritis Human fibroblast like synoviocytes of rheumatoid arthritis NLRP3 inflammasome miRNA Dual-luciferase

External blast load factors for dome structures based on reliability

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Defence Technology（防务技术） 2022年第2期18卷 170-182页

作者： Shao-bo Qi Guang-yan huang Xu-dong Zhi feng Fan Richard GJFlay State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China Key Lab of Structure Dynamic Behaviour and Control of the Ministry of Education Harbin Institute of TechnologyHarbin150090China Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin150090China Department of Mechanical Engineering University of AucklandPrivate Bag 92019Auckland1142New Zealand

Dome structures have been used extensively for industrial,residential,and military ***,it is necessary to understand the damage risk potential for such structures for blast-resistant design *** paper investigates the effect of blast load variability on the design value and the structural dynamic ***,the sources of uncertainty in the external blast load on dome structures were discussed *** based on the probabilistic blast load model for the dome,the rationality of a deterministic mass-increase safety method was *** was found that previous deterministic design method cannot provide a consistent and sound assurance factor or reliability index on the entire dome *** addition,it was also proved that the assurance-based load method fails to ensure compliance with structural safety design standards on the dome roof when compared with the reliability-based blast method.A sensitivity analysis on the probabilistic blast load was conducted,and the results indicate that stand-off distance and explosive mass both act as dominant sources to influence the mean and variability of blast ***,based on the Latin hypercube sampling method,a reliability-based external blast load factor technique was *** technique was further used to estimate structural damage levels of a single-layer reticulated dome under different reliability requirements,associated with a low,medium,and high level of protection grades for a specific explosion scenario,and it indicated that this technique can be useful in the building design to achieve a higher structural anti-explosion *** study herein can serve as a reference for the calculation method of designed blast load.

关键词： Dome structure Airblast variability Deterministic design Assurance factor Reliability-based blast load factor Structural damage levels

Extraction mechanism and separation behaviors of low-concentration Nd^(3+) and Al^(3+) in P507-H_(2)SO_(4) system

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Journal of Rare Earths 2022年第6期40卷 952-957,I0004页

作者： Hongyuan Zhang Longsheng Zhao Xudong zheng Depeng Liu Zongyu feng Yongqi Zhang Xiaowei huang National Engineering Research Center for Rare Earth Materials GRINM Group Co.Ltd.Beijing 100088China General Research Institute for Nonferrous Metals Beijing 100088China Grirem Advanced Materials Co. Ltd.Beijing 100088China Rare Earth Functional Materials(Xiong’an)Innovation Center Co. Ltd.Baoding 071700China

In order to clarify the solvent extraction and separation behaviors of rare earths and impurity of Al during the extraction and enrichment of low-concentration leach solution of ion-adsorption rare earth ore,the extraction mechanism and separation behaviors of Nd^(3+)and Al^(3+)in the Nd_(2)(SO_(4))_(3)-AI_(2)(SO_(4))_(3) mixed solution using P507 were studied in this *** extraction of Nd^(3+)and Al^(3+)follows the cation exchange *** the increase of the equilibrium pH,β_(Nd/Al) in the extraction of the Nd_(2)(SO_(4))_(3)-Al_(2)(SO_(4))_(3) mixed solution using P507 is always higher than that in the extraction of single Nd_(2)(SO_(4))_(3) and Al_(2)(SO_(4))_(3) *** can be attributed to the fact that the extraction of Nd^(3+)using P507 is much faster than that of Al^(3+),and Al^(3+)is more prone to be hydrolyzed at lower pH.β_(Nd/Al) in the extraction of the Nd_(2)(SO_(4))_(3)-Al_(2)(SO_(4))_(3) mixed solution decreases gradually with the increase of mixing time within the equilibrium pH range of *** extraction of Nd^(3+)using P507 is much faster than that of Al^(3+),but the stability of Al^(3+)-Ioaded organic phase is better than that of Nd^(3+)-loaded organic phase,thus Nd^(3+)in the Nd^(3+)-loaded organic phase is gradually replaced by Al^(3+)in the aqueous phase with the increase of mixing time.

关键词： Ion-adsorption rare earth ore Low-concentration rare earth Aluminum Extraction mechanism Separation factor

Carbon dots and polyurethane composite for photo-induced elimination of uranium under air atmosphere

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中国化学快报:英文版 2023年第9期34卷 340-343页

作者： Zhe Wang Lingyu Zhang zhen Lei Liyuan zheng Liqin huang Shuang Liu Yuexiang Lu The MOE Key Laboratory of Resources and Environmental System Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Nuclear Research Institute for Future Technology and Policy Seoul National UniversitySeoul 08826Republic of Korea

Uranium is the main fuel of nuclear power and elimination uranium from nuclear wastewater is significant both in environmental protection and fuel *** we report for the first time the synthesis of carbon dots/polyurethane(CDs/PU)composite materials for the photoinduced elimination of uranium from *** with visible light,CDs/PU could eliminate uranium efficiently with the generation of(UO_(2))O_(2)·_(2)H_(2)O as solid products in *** further investigated mechanism showed that the addition of CDs/PU could produce more H_(2)O_(2)under visible light,which reacted with uranyl ions to form(UO_(2))O_(2)·_(2)H_(2)***,the sponge-like CDs/PU could be easily removed from water with high reusability as the elimination efficiency remained above 95%after 5 ***/PU also displayed good selectivity in the presence of other metal *** work affords exciting strategies for developing photocatalysts and eliminating uranium from water.

关键词： Carbon dots Polyurethane Uranium Photocatalyst Air atmosphere

共沉淀法和浸渍法制备的HoCeMn/TiO_(2)催化剂的脱硝性能

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无机化学学报 2024年第3期40卷 629-645页

作者：黄利华华坚西南科技大学环境与资源学院绵阳621010 国家烟气脱硫工程技术中心成都610065

采用浸渍法和共沉淀法制备了HoCeMn/TiO_(2)脱硝催化剂并对其结构和性能进行了表征。结果表明共沉淀法增强了活性组分和载体的相互作用,从而增加了HoCeMnTi-C催化剂表面Ce^(3+)、Mn^(4+)以及吸附氧的含量,使其表现出优异的低温氧化还原... 详细信息

采用浸渍法和共沉淀法制备了HoCeMn/TiO_(2)脱硝催化剂并对其结构和性能进行了表征。结果表明共沉淀法增强了活性组分和载体的相互作用,从而增加了HoCeMnTi-C催化剂表面Ce^(3+)、Mn^(4+)以及吸附氧的含量,使其表现出优异的低温氧化还原性能。此外,共沉淀法制备的HoCeMnTi-C具有更多的表面酸性位点及更强的表面酸性。催化剂表面酸性和氧化还原性能的提高有助于氨的吸附和活化,从而显著提高其活性。表面酸性位点的增多还抑制了H_(2)O和SO_(2)在催化剂表面的吸附,提升了催化剂的抗水抗硫性能。催化剂上的选择性催化还原(SCR)反应遵循Eley-Rideal(E-R)机制,催化剂硫中毒是源于形成的硫酸盐覆盖或破坏了催化剂活性位。

关键词： HoCeMn/TiO_(2)催化剂活性抗水抗硫性能

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颗粒土中剪切带临界状态数学描述及其完全解

应用数学和力学 2024年第3期45卷 287-294页

作者：黄文雄崔贤河海大学力学与材料学院南京210098

为正确模拟土体涉及剪切带演化的后失效力学响应,需采用包含细观特征长度的高阶连续介质力学模型.笔者利用前期所建立的微极亚塑性模型,对颗粒土中剪切带的发展过程进行了分析推导,得到了剪切带临界状态条件下关键变量所满足的非线性微... 详细信息

为正确模拟土体涉及剪切带演化的后失效力学响应,需采用包含细观特征长度的高阶连续介质力学模型.笔者利用前期所建立的微极亚塑性模型,对颗粒土中剪切带的发展过程进行了分析推导,得到了剪切带临界状态条件下关键变量所满足的非线性微分方程.该文展示了上述非线性微分方程的简要推导,重点讨论了该非线性微分方程的主要性质、主要参数变化范围和求解途径;通过对剪切带进一步的力学分析补充建立了一个能量方程,使问题具有确定解.在此基础上,应用数值积分求出了剪切带厚度因子和剪切内应力、变形率分布及剪切速度分布的完全解.其中剪切带厚度因子对于微极亚塑性模型细观参数的确定具有重要作用.

关键词：剪切带微极亚塑性模型临界状态非线性常微分方程完全解

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结合实体边界线索的中文命名实体识别方法

计算机工程与应用 2024年第6期60卷 199-206页

作者：黄蓉陈艳平扈应黄瑞章秦永彬贵州大学公共大数据国家重点实验室贵阳550025 贵州大学计算机科学与技术学院贵阳550025

命名实体识别作为信息抽取领域的一个基础任务,能为机器翻译、关系抽取等下游任务提供有效支撑,具有重要的研究意义。针对中文命名实体识别方法中存在的实体边界模糊的问题,提出了一种结合实体边界线索的命名实体识别模型,模型由边界检... 详细信息

命名实体识别作为信息抽取领域的一个基础任务,能为机器翻译、关系抽取等下游任务提供有效支撑,具有重要的研究意义。针对中文命名实体识别方法中存在的实体边界模糊的问题,提出了一种结合实体边界线索的命名实体识别模型,模型由边界检测、线索生成、实体分类三个模块组成。利用边界检测模块识别实体边界。在线索生成模块中依据边界信息生成实体跨度,得到带边界线索标签的文本序列,使模型通过边界线索标签感知句子中的实体边界,学习实体边界和上下文的语义依赖特征。将带有边界线索标签的文本序列作为实体分类模块的输入,使用双仿射机制增强标签之间的语义交互,并结合双仿射机制与多层感知机的共同预测作为实体识别的结果。该模型在ACE2005中文数据集和Weibo数据集上的F1值分别达到了90.47%和73.54%,验证了模型对中文命名实体识别的有效性。

关键词：命名实体识别嵌套命名实体识别线索标签边界检测

晋西黄土区不同密度刺槐人工林叶片-枯落物-土壤化学计量特征

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林业科学研究 2024年第2期37卷 156-164页

作者：巩大鹏毕华兴王劲峰赵丹阳黄靖涵宋艺琳北京林业大学北京100083 林木资源高效生产全国重点实验室北京100083 山西吉县森林生态系统国家野外科学观测研究站北京100083 水土保持国家林业和草原局重点实验室北京100083 北京市水土保持工程技术研究中心北京100083 林业生态工程教育部工程研究中心北京100083 北京市丰台区水文和水土保持工作站北京100165

[目的]研究不同林分密度对刺槐人工林叶片、枯落物、土壤C、N、P化学计量特征的影响,为晋西黄土区刺槐人工林的经营管理提供科学参考。[方法]通过野外调查,选择晋西黄土区5种不同密度(500、1000、1500、2000、2500株·hm^(-2))刺槐人工... 详细信息

[目的]研究不同林分密度对刺槐人工林叶片、枯落物、土壤C、N、P化学计量特征的影响,为晋西黄土区刺槐人工林的经营管理提供科学参考。[方法]通过野外调查,选择晋西黄土区5种不同密度(500、1000、1500、2000、2500株·hm^(-2))刺槐人工林,测定和分析叶片、枯落物、土壤的养分。用单因素分析法分析密度对三者养分的影响,采用Pearson相关系数,分析刺槐人工林叶片、枯落物、土壤C、N、P及其化学计量比之间的相关性。[结果]随着密度增加,刺槐人工林叶片C、N、P含量先增加后减小,叶片C∶P、N∶P先降低后增加;枯落物的C、C∶N、C∶P、N∶P随着密度先减少后增大,N、P则先增大后减少;土壤C、P、N含量及C∶P、N∶P随密度的增大而降低;C∶N随密度呈先降低后增加的趋势。不同林分密度下,叶片N∶P均大于14,叶片-枯落物-土壤C、N、P及其化学计量比中除了叶片N、C∶N以外,均存在不同的显著差异性(p<0.05)。[结论]不同林分密度下,叶片N∶P均大于14,说明研究区刺槐人工林主要受到P限制;密度在一定程度上影响着刺槐人工林的养分循环及其分配和化学计量特征;在密度为1000~1500株·hm-2的刺槐人工林叶片、枯落物、土壤C、N、P含量最高,养分限制最弱,枯落物分解速率相对较快,为适宜经营密度。

关键词：林分密度刺槐养分循环化学计量特征

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2A12高强铝合金变断面挤压工艺仿真研究

重型机械 2024年第1期 38-44页

作者：牛勇成少峰张宗元葛鹏黄胜郭晓锋太原科技大学山西太原030024 中国重型机械研究院股份公司陕西西安710018 西安沐程重工科技有限公司陕西西安710086

挤压成形是变断面结构一种重要的成形工艺,采用有限元软件对2A12铝合金变断面管材挤压过程进行了数值模拟。研究了挤压过程中温度场和应变场在整个挤压过程中的变化特征,坯料温度、挤压速度、工作带长度和挤压模具锥角对模具口处温度场... 详细信息

挤压成形是变断面结构一种重要的成形工艺,采用有限元软件对2A12铝合金变断面管材挤压过程进行了数值模拟。研究了挤压过程中温度场和应变场在整个挤压过程中的变化特征,坯料温度、挤压速度、工作带长度和挤压模具锥角对模具口处温度场和应变场的影响规律。结果表明:随着挤压模具锥角、挤压速度的增加和坯料温度的降低,出口处温度场和应变场均匀性降低;工作带长度的变化对出口温度场和应变场的影响较小。

关键词： 2A12铝合金变断面挤压

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