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Fecal microbiota transplantation for irritable bowel syndrome:Current evidence and perspectives

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World Journal of Gastroenterology 2024年第16期30卷 2179-2183页

作者： Cong dai yu-Hong Huang Min Jiang Department of Gastroenterology First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

In this editorial we comment on the article published in the recent issue of the World journal of *** focus specifically on the mechanisms underlying the effects of fecal microbiota transplantation(FMT)for irritable bowel syndrome(IBS),the factors which affect the outcomes of FMT in IBS patients,and *** has emerged as a efficacious intervention for clostridium difficile infection and holds promise as a therapeutic modality for *** utilization of FMT in the treatment of IBS has undergone scrutiny in numerous randomized controlled trials,yielding divergent *** current frontier in this field seeks to elucidate these variations,underscore the existing knowledge gaps that necessitate exploration,and provide a guideline for successful FMT implementation in IBS *** the same time,the application of FMT as a treatment for IBS confronts several challenges.

关键词： Fecal microbiota transplantation Irritable bowel syndrome Microbiota Randomized controlled trial Meta-analysis

Outer-surface Covering of Nanochannels with Hydrogel for Highly Sensitive and Specific Cr(VI)Detection Through Analyte-caused Charge Change in Hydrogel

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Chemical Research in Chinese Universities 2024年第2期40卷 326-332页

作者： LIU Huan SUN Xueting dai yu ZHANG Xiaojin XIA Fan Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074P.R.China

Nanochannels have made great progress and are a promising platform for detecting a series of ***,most nanochannels are modified on the inner wall,while ignoring the outer ***,we modified the outer surface of nanochannels with *** from other reported outer-surface modification methods,we directly cover nanochannels with hydrogel to form heterogeneous *** selected hydrogel hardly adsorbs other ions and shows specific adsorption for Cr(VI).The adsorption sites in hydrogel are homogeneous,and Cr(VI)adsorption onto hydrogel is endothermic and *** charge in hydrogel changes after Cr(VI)adsorption,and the resulting current changes can be used for the detection of Cr(VI)with the detection limit of 10−11 mol/*** platform is expected to be used for Cr(VI)detection in living organisms,especially within *** work provides a new approach for outer-surface modification of nanochannels and offers a new choice for nanochannel detection platforms.

关键词： Nanochannel Hydrogel Heterogeneous membrane Cr(VI)detection

RL and AHP-Based Multi-Timescale Multi-Clock Source Time Synchronization for Distribution Power Internet of Things

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Computers, Materials & Continua 2024年第3期78卷 4453-4469页

作者： Jiangang Lu Ruifeng Zhao Zhiwen yu yue dai Kaiwen Zeng Electric Power Dispatching and Control Center Guangdong Power Grid Co.Ltd.Guangzhou510600China

Time synchronization(TS)is crucial for ensuring the secure and reliable functioning of the distribution power Internet of Things(IoT).Multi-clock source time synchronization(MTS)has significant advantages of high reliability and accuracy but still faces challenges such as optimization of the multi-clock source selection and the clock source weight calculation at different timescales,and the coupling of synchronization latency jitter and pulse phase *** this paper,the multi-timescale MTS model is conducted,and the reinforcement learning(RL)and analytic hierarchy process(AHP)-based multi-timescale MTS algorithm is designed to improve the weighted summation of synchronization latency jitter standard deviation and average pulse phase ***,the multi-clock source selection is optimized based on Softmax in the large timescale,and the clock source weight calculation is optimized based on lower confidence bound-assisted AHP in the small *** shows that the proposed algorithm can effectively reduce time synchronization delay standard deviation and average pulse phase difference.

关键词： Multi-clock source time synchronization(TS) power Internet of Things reinforcement learning analytic hierarchy process

Automatic diagnosis of diabetic retinopathy using vision transformer based on wide-field optical coherence tomography angiography

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 35-44页

作者： Zenan Zhou Huanhuan yu Jiaqing Zhao Xiangning Wang Qiang Wu Cuixia dai Shanghai Institute of Technology Shanghai P.R.China Shanghai Sixth People'sHospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai P.R.China

Diabetic retinopathy(DR)is one of the major causes of visual impairment in adults with *** coherence tomography angiography(OCTA)is nowadays widely used as the golden criterion for diagnosing ***,wide-field OCTA(WF-OCTA)provided more abundant information including that of the peripheral retinal degenerative changes and it can contribute in accurately diagnosing *** need for an automatic DR diagnostic system based on WF-OCTA pictures attracts more and more attention due to the large diabetic population and the prevalence of retinopathy *** this study,automatic diagnosis of DR using vision transformer was performed using WF-OCTA images(12 mm×12 mm single-scan)centered on the fovea as the ***-OCTA images were automatically classified into four classes:No DR,mild nonproliferative diabetic retinopathy(NPDR),moderate to severe NPDR,and proliferative diabetic retinopathy(PDR).The proposed method for detecting DR on the test set achieves accuracy of 99.55%,sensitivity of 99.49%,and specificity of 99.57%.The accuracy of the method for DR staging reaches up to 99.20%,which has been proven to be higher than that attained by classical convolutional neural network *** show that the automatic diagnosis of DR based on vision transformer and WF-OCTA pictures is more effective for detecting and staging DR.

关键词： Wide field optical coherence tomography angiography diabetic retinopathy vision transformer image classification

Manipulating Nb-doped SrFeO_(3−δ)with excellent performance for proton-conducting solid oxide fuel cells

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Journal of Advanced Ceramics 2024年第5期13卷 579-589页

作者： Hailu dai Hongzhe Du Samir Boulfrad Shoufu yu Lei Bi Qinfang Zhang School of Materials Science and Engineering Yancheng Institute of TechnologyYancheng 224051China College of Science&Engineering Hamad Bin Khalifa UniversityDoha 34110Qatar School of Resource Environment and Safety Engineering University of South ChinaHengyang 421001China

Nb-doped SrFeO_(3−δ)(SFO)is used as a cathode in proton-conducting solid oxide fuel cells(H-SOFCs).First-principles calculations show that the SrFe0.9Nb0.1O_(3−δ)(SFNO)cathode has a lower energy barrier in the cathode reaction for H-SOFCs than the Nb-free SrFeO_(3−δ)*** experimental studies show that Nb doping substantially enhances the performance of the SrFeO_(3−δ)***,oxygen vacancies(VO)were introduced into SFNO using the microwave sintering method,further improving the performance of the SFNO *** mechanism behind the performance improvement owing to VO was revealed using first-principles calculations,with further optimization of the SFNO cathode achieved by developing a suitable wet chemical synthesis route to prepare nanosized SFNO *** method significantly reduces the grain size of SFNO compared with the conventional solid-state reaction method,although the solid-state reaction method is generally used for preparing Nb-containing *** a result of defect engineering and synthesis approaches,the SFNO cathode achieved an attractive fuel cell performance,attaining an output of 1764 mW·cm−2 at 700℃ and operating for more than 200 *** manipulation of Nb-doped SrFeO_(3−δ)can be seen as a“one stone,two birds”strategy,enhancing cathode performance while retaining good stability,thus providing an interesting approach for constructing high-performance cathodes for H-SOFCs.

关键词： SrFeO_(3−δ)-(SFO) cathode proton conductor solid oxide fuel cells(SOFCs)

In-situ measurement via the flow-through method and numerical simulations for radon exhalation during measurements of the radon exhalation rate

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Nuclear Science and Techniques 2024年第7期35卷 192-207页

作者： Ming Xia Yong-Jun Ye Shan-Wei Shang Ting yu dai-Jia Chen School of Resources Environment and Safety Engineering University of South ChinaHengyang421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang421001China

Small-scale measurements of the radon exhalation rate using the flow-through and closed-loop methods were conducted on the surface of a uranium tailing pond to better understand the differences between the two *** abnormal radon exhalation behavior was observed,leading to computational fluid dynamics(CFD)-based simulations in which dynamic radon migration in a porous medium and accumulation chamber was *** on the in-situ experimental and numerical simulation results,variations in the radon exhalation rate subject to permeability,flow rate,and insertion depth were quantified and *** in-situ radon exhalation rates measured using the flow-through method were higher than those measured using the closed-loop method,which could be explained by the negative pressure difference between the inside and outside of the chamber during the *** consistency of the variations in the radon exhalation rate between the experiments and simulations suggests the reliability of CFD-based techniques in obtaining the dynamic evolution of transient radon exhalation rates for diffusion and convection at the porous medium-air *** synergistic effects of the three factors(insertion depth,flow rate,and permeability)on the negative pressure difference and measured exhalation rate were quantified,and multivariate regression models were established,with positive correlations in most cases;the exhalation rate decreased with increasing insertion depth at a permeability of 1×10^(−11) m^(2).CFD-based simulations can provide theoretical guidance for improving the flow-through method and thus achieve accurate measurements.

关键词： Radon exhalation Flow-through Numerical simulation Accumulation chamber Multivariate regression

Air-Ground Collaborative Mobile Edge Computing:Architecture,Challenges,and Opportunities

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China Communications 2024年第5期21卷 1-16页

作者： Qin zhen He Shoushuai Wang Hai Qu yuben dai Haipeng Xiong Fei Wei zhenhua Li Hailong College of Communications Engineering Army Engineering University of PLANanjing 210000China Department of Information and Communication Noncommissioned Officer Academy of PAPHangzhou 310000China Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space Ministry of Industry and Information TechnologyNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China CMC Political and Law Commission Beijing100120China Xi’an Research Institute of High Technology Xi’an 710025China

By pushing computation,cache,and network control to the edge,mobile edge computing(MEC)is expected to play a leading role in fifth generation(5G)and future sixth generation(6G).Nevertheless,facing ubiquitous fast-growing computational demands,it is impossible for a single MEC paradigm to effectively support high-quality intelligent services at end user equipments(UEs).To address this issue,we propose an air-ground collaborative MEC(AGCMEC)architecture in this *** proposed AGCMEC integrates all potentially available MEC servers within air and ground in the envisioned 6G,by a variety of collaborative ways to provide computation services at their best for ***,we introduce the AGC-MEC architecture and elaborate three typical use ***,we discuss four main challenges in the AGC-MEC as well as their potential ***,we conduct a case study of collaborative service placement for AGC-MEC to validate the effectiveness of the proposed collaborative service placement ***,we highlight several potential research directions of the AGC-MEC.

关键词： air-ground architecture collaborative mobile edge computing

An Efficient Optimization Design Framework for Low-Resistance Shape of Bionic Amphibious Robot

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China Ocean Engineering 2024年第1期38卷 117-128页

作者： ZHANG dai-yu ZHANG Man-yu WANG Zhi-dong zhenG Wen-sheng LING Hong-jie HU Jun-ming School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

To realize the low-resistance shape optimization design of amphibious robots,an efficient optimization design framework is proposed to improve the geometric deformation flexibility and optimization *** the proposed framework,the free-form deformation parametric model of the flat slender body is established and an analytical calculation method for the height constraints is *** method is introduced to carry out the high-precision resistance calculation and a constrained Kriging-based optimization method is built to improve the optimization efficiency by circularly infilling the new sample points which satisfying the ***,the shape of an amphibious robot example is optimized to get the low-resistance shape and the results demonstrate that the presented optimization design framework has the advantages of simplicity,flexibility and high efficiency.

关键词： amphibious robot optimization method free-form deformation CFD-based hydrodynamic calculation

Biomimetic design of highly flexible metal oxide nanofibrous membranes with exceptional mechanical performance for superior phosphopeptide enrichment

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Nano Research 2024年第5期17卷 4270-4278页

作者： Xue Mao zhen-zhen Li Dong-Lian Hao Wei-Dong Han Gao-Peng Li Yao-yu Wang Kun Zhang School of Textile Science and Engineering Key Laboratory of Functional Textile Material and Product(Ministry of Education)Xi’an Polytechnic UniversityXi’an 710048China Key Laboratory of Magnetic Molecules&Magnetic Information Materials of the Ministry of Education School of Chemistry&Material ScienceShanxi Normal UniversityTaiyuan 030031China Department of Clinical Laboratory The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Shanghai iProteome Biotechnology Co. LtdShanghai 201210China College of Chemistry&Materials Science Northwest UniversityXi'an 710127China

Developing free-standing and mechanical robust membrane materials capable of superior enrichment of phosphopeptides for analyzing and identifying the specific phosphoproteome of cancer cells is significant in understanding the molecular mechanisms of cancer development and exploring new therapeutic approaches,but still a significant challenge in materials *** this end,we firstly constructed highly flexible ZrTiO_(4) nanofibrous membranes(NFMs)with excellent mechanical stability through a cost-effective and scalable electrospinning and subsequent calcination ***,to further increase the enrichment capacity of the phosphopeptide,the biomimetic TiO_(2)@ZrTiO_(4) NFMs with root hair or leaf like branch microstructure are developed by the hydrothermal post-synthetic modification of ZrTiO_(4) NFMs through growing unfurling TiO_(2) nanosheets onto the ZrTiO_(4) ***,remarkable flexibility and mechanical stability enable the resulting TiO_(2)@ZrTiO_(4) NFMs excellent practicability,while the biomimetic microstructure allows it outstanding enrichment ability of the phosphopeptide and identification ability of the specific phosphoproteins in the digest of cervical cancer ***,6770 phosphopeptides can be enriched by TiO_(2)@ZrTiO_(4) NFMs(2205 corresponding phosphoproteins can be identified),and the value is much higher than that of ZrTiO_(4) NFMs(6399 phosphopeptides and 2132 identified phosphoproteins)and commercial high-performance TiO_(2) particles(4525 phosphopeptides and 1811 identified phosphoproteins).These results demonstrate the super ability of TiO_(2)@ZrTiO_(4) NFMs in phosphopeptide enrichment and great potential for exploring the pathogenesis of cancer.

关键词： inorganic nanofibers flexible ceramic nanofibrous membranes biomimetic materials exceptional mechanical performance flexibility