检索结果-南通市图书馆

大黄黄连泻心汤对幽门螺旋杆菌感染的系统药理学研究

在线全文

学校读者我要写书评

暂无评论

世界中医药 2020年第12期15卷 1699-1704页

作者：鲁春花赵凯萨震王华兴覃彩孟高雪刘岩松卢涛北京中医药大学生命科学学院北京100029 北京中医药大学中医学院北京100029

目的:运用系统药理学探讨大黄黄连泻心汤对治疗幽门螺旋杆菌感染的分子作用机制,挖掘潜在的作用靶点和信号通路。方法:首先利用中医药整合数据库(SymMap)筛选大黄黄连泻心汤的潜在作用靶点;从比较毒理基因组学数据库(CTD)发现幽门螺旋... 详细信息

目的:运用系统药理学探讨大黄黄连泻心汤对治疗幽门螺旋杆菌感染的分子作用机制,挖掘潜在的作用靶点和信号通路。方法:首先利用中医药整合数据库(SymMap)筛选大黄黄连泻心汤的潜在作用靶点;从比较毒理基因组学数据库(CTD)发现幽门螺旋杆菌感染的相关疾病靶点;将筛选后的靶点输入到String中构建“大黄黄连泻心汤-幽门螺旋杆菌”的蛋白质相互作用网络(PPI);采用在线分析工具WebGestalt对筛选出的靶点进行GO功能注释和KEGG通路富集分析。结果:获得大黄黄连泻心汤和幽门螺旋杆菌感染重合的靶点共有222个,通过PPI网络发现71个相互作用靶点,其中主要以IL6、MYC、VEGFA、CASP3、EP300、IL10、ERBB2、CDKN1A、MPO、NFE2L2为关键靶点;发现10个关键生物过程和10条关键信号通路。结论:大黄黄连泻心汤可能通过调节机体免疫炎性反应,发挥对幽门螺旋杆菌感染的治疗作用,同时可能通过抗肿瘤机制起到防止幽门螺旋杆菌感染进一步向更严重胃肠道疾病转化的作用。本研究为中医药治疗幽门螺旋杆菌提供了理论依据。

关键词：大黄黄连泻心汤幽门螺旋杆菌系统药理学胃癌网络分析

Estrogen Receptor-A in Medial Preoptic Area Contributes to Sex Difference of Mice in Response to Sevoflurane Anesthesia

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第7期38卷 703-719页

作者： Yunyun Zhang Huiming Li Xinxin Zhang sa Wang Dan Wang Jiajia Wang Tingting Tong zhen Zhang Qianzi Yang Hailong Dong Department of Anesthesiology and Perioperative Medicine Xijing HospitalThe Fourth Military Medical UniversityXi'an 710032China

A growing number of studies have identified sex differences in response to general anesthesia;however,the underlying neural mechanisms are *** medial preoptic area(MPA),an important sexually dimorphic structure and a critical hub for regulating consciousness transition,is enriched with estrogen receptor alpha(ERa),particularly in neuronal clusters that participate in regulating *** found that male mice were more sensitive to *** inhibition of ERαin the MPA abolished the sex differences in sevoflurane anesthesia,in particular by extending the induction time and facilitating emergence in males but not in *** of ERαin vitro inhibited GABAergic and glutamatergic neurons of the MPA in males but not in ***,ERα.knockdown in GABAergic neurons of the male MPA was sufficient to eliminate sex differences during sevoflurane ***,MPA ERαpositively regulates the activity of MPA GABAergic neurons in males but not in females,which contributes to the sexdifference of mice in sevoflurane anesthesia.

关键词： Sex difference Anesthesia Estrogen receptor alpha Medial preoptic area Sevoflurane

军人心理应激对军队士气的影响:疲劳的中介效应

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

空军军医大学学报 2023年第10期44卷 982-986页

作者：吾超颜佳冉撒真杜娟林亚玮陈娜娜梁莹杨克俭郎红娟空军军医大学护理系临床护理学教研室陕西西安710032 解放军第69245部队新疆乌鲁木齐830000 空军军医大学护理系基础护理学教研室陕西西安710032 解放军第32280部队四川夹江614100 解放军第69243部队新疆昌吉831100 解放军联勤保障部队第九六○医院山东济南250031

目的探讨军人心理应激、疲劳、军队士气三者之间的关系。方法采用一般情况调查表、军人心理应激自评问卷、疲劳量表、军队士气量表,于2021年6月至9月对某战区700名驻训战士展开问卷调查,并采用结构方程模型进行数据分析。结果共回收有... 详细信息

目的探讨军人心理应激、疲劳、军队士气三者之间的关系。方法采用一般情况调查表、军人心理应激自评问卷、疲劳量表、军队士气量表,于2021年6月至9月对某战区700名驻训战士展开问卷调查,并采用结构方程模型进行数据分析。结果共回收有效问卷666份,研究结果显示,军队士气与军人心理应激和疲劳呈负相关(均P<0.01);军人心理应激对军队士气有显著的直接影响(P<0.05),并通过疲劳的中介作用对信息素养起间接影响(P<0.01)。结论驻训战士存在心理应激问题,这会导致疲劳从而影响军队士气。部队主官要充分关注驻训期间军人的心理状况,尤其是心理应激与疲劳状况,积极进行干预,以提高部队整体士气水平。

关键词：战士军人心理应激疲劳军队士气结构方程模型

Deformation treatment and microstructure of graphene-reinforced metal matrix nanocomposites: A review of graphene post-dispersion

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 888-899页

作者： Yong Mei Pu-zhen Shao Ming Sun Guo-qin Chen Murid Hussain Feng-lei Huang Qiang Zhang Xiao-sa Gao Yin-yin Pei Su-juan Zhong Gao-hui Wu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Institute of Defense Engineering AMSPLABeijing 100036China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemical Engineering COMSATS University IslamabadLahore CampusLahore 54000Pakistan State Key Laboratory of Advanced Brazing Filler Materials&Technology Zhengzhou Research Institute of Mechanical Engineering Co.Ltd.Zhengzhou 450001China

Graphene/aluminum(Gr/Al)composites have attracted the attention of researchers all over the world due to their excellent ***,graphene agglomerates easily because of the van der Waals force between graphite sheets,thereby affecting the performance of the *** the agglomeration of graphene and dispersing it uniformly in the Al matrix is a key *** the preparation process,predispersion treatment and deformation treatment can play important roles in graphene *** have conducted a series of research and literature reviews of the graphene predispersion and consolidation of ***,they paid less attention to post-deformation *** review summarizes different deformation treatments involved in the preparation process of Gr/Al composites and the evolution of the microstructure during the *** on deformation parameters is expected to further improve the properties of Gr/Al composites and would provide a deep understanding of the strengthening effect of graphene.

关键词： graphene/aluminum composites deformation treatment dispersion microstructure

Smart superabsorbent alginate/carboxymethyl chitosan composite hydrogel beads as efficient biosorbents for methylene blue dye removal

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第28期159卷 81-90页

作者： zhen Zhang Noureddine Abidi Lucian Lucia Department of Forest Biomaterials NC State UniversityRaleighNCUSA Fiber and Biopolymer Research Institute Department of Plant and Soil ScienceTexas Tech UniversityLubbockTXUSA Department of Chemistry NC State UniversityRaleighNCUSA

The presence of toxic dyes in the aqueous medium has threatened environmental safety, and thereby re- moving them from wastewater in an efficient way is highly desired. Herein, the efficient biosorbents were successfully fabricated via a facile physical gelation process of sodium alginate (sa) and carboxymethyl chitosan (CMCTS) in an acidic aqueous solution. The as-prepared hydrogel beads not only displayed water superabsorbent properties and pH-responsive swelling characters but also exhibited excellent methylene blue (MB) adsorption capacity removal efficiency with experimental maximum MB adsorption capacity of 2518 and 1005 mg g -1 , which are comparable with most reported lignocellulosic and alginate-based hydrogels. The MB adsorption process fitted well in different kinetic and isotherm models and became more heterogeneous in concentrated MB solutions as verified by principal component analysis results. The adsorption mechanism was proposed, and the high dye absorbency was attributed to the strong electro- static forces between adsorbents and adsorbates. Our current study provides a promising and sustainable composite hydrogels platform targeted to dye decontamination.

关键词： Hydrogel Dye adsorption Composites Superabsorbent Sodium alginate Carboxymethyl chitosan

A comparison of sensitivity indices for tolerance design of a transmission mechanism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第7期23卷 527-542页

作者： zhen-yu LIU Han-chao XU Guo-dong sa Yu-feng LYU Jian-rong TAN State Key Laboratory of CAD&CG Zhejiang UniversityHangzhou310027China Ningbo Research Institute Zhejiang UniversityNingbo315100China School of Mechanical Engineering Zhejiang UniversityHangzhou310027China Polytechnic Institute Zhejiang UniversityHangzhou310027China

Sensitivity analysis is used to quantify the contribution of the uncertainty of input variables to the uncertainty of systematic output *** tolerance design in manufacturing and assembly,sensitivity analysis is applied to help designers allocate tolerances ***,different sensitivity indices derived from different sensitivity analysis methods will always lead to conflicting *** is necessary to find a sensitivity index suitable for tolerance allocation to transmission mechanisms so that the sensitivity results can truly reflect the effects of tolerances on kinematic and dynamic *** this paper,a variety of sensitivity indices are investigated and compared based on hybrid ***,the hybrid simulation model of the crank-slider mechanism is ***,samples of the kinematic and dynamic responses of the mechanism with joint clearances and link length errors are obtained,and the surrogate model established using polynomial chaos expansion(PCE).Then,different sensitivity indices are calculated based on the PCE model and are further used to evaluate the effect of joint clearances and link length errors on the output *** with the tolerance-cost function,the corresponding tolerance allocation schemes are obtained based on different sensitivity analysis ***,the kinematic and dynamic responses of the mechanism adopting different tolerance allocation schemes are simulated,and the sensitivity index corresponding to the optimal response is determined as the most appropriate index.

关键词： Transmission mechanism Sensitivity analysis Tolerance allocation Hybrid simulation Polynomial chaos expansion(PCE)

基于多距离声阵实测回归传播损失的浅水域水下辐射噪声源级测量方法

在线全文

学校读者我要写书评

暂无评论

船舶力学 2023年第4期27卷 598-606页

作者：庞业珍俞孟萨中国船舶科学研究中心船舶振动噪声重点实验室江苏无锡214082

浅水域水下辐射噪声传播会受到海面与海底反射的影响。基于传统单水听器方法进行浅水域船舶水下辐射噪声源级测量相比深水域测量面临三个问题:(1)浅水域声场中复杂的声场分布特征会增加单水听器测量结果的不确定度;(2)浅水域传播损失系... 详细信息

浅水域水下辐射噪声传播会受到海面与海底反射的影响。基于传统单水听器方法进行浅水域船舶水下辐射噪声源级测量相比深水域测量面临三个问题:(1)浅水域声场中复杂的声场分布特征会增加单水听器测量结果的不确定度;(2)浅水域传播损失系数小于深水域,采用球面波衰减系数进行源级修正会带来较大偏差;(3)水听器近水面布放会导致测量结果受到水面镜像反射的影响比深水域更大。本文提出一种工程化的基于多距离声阵实测传播损失的浅水域船舶水下辐射噪声源级推算方法,在浅水域测量船舶水下辐射噪声源级时剥离界面反射的影响,得到自由场环境下船舶水下辐射噪声源特性。利用不少于3个正横距离分析该海域的传播损失系数,并提出剥离水面劳埃德镜像效应的修正公式。为了验证该方法的有效性,使用UW350声源模拟船舶噪声源在千岛湖开展验证试验,试验结果表明,在20 Hz~1 kHz频段内,推算得到的声源级频谱与1m处参考水听器测量声压级频谱平均偏差小于3 dB。

关键词：船舶噪声浅水域传播损失水听器声阵

在线全文

学校读者我要写书评

暂无评论

舰船辐射声场及声源特性测量方法研究综述

船舶力学 2017年第1期21卷 107-126页

作者：俞孟萨庞业珍中国船舶科学研究中心江苏无锡214082

舰船辐射声场及声源特性测量是船舶声学研究的主要方向。文章梳理了舰船模型和实船声学测量的基本问题,重点综述了频响逆矩阵法、无限与有限空间波束形成、无界近场声全息、有界空间近场声全息和远场声全息、声强和声矢量及时反声聚焦... 详细信息

舰船辐射声场及声源特性测量是船舶声学研究的主要方向。文章梳理了舰船模型和实船声学测量的基本问题,重点综述了频响逆矩阵法、无限与有限空间波束形成、无界近场声全息、有界空间近场声全息和远场声全息、声强和声矢量及时反声聚焦等测量方法的发展脉络和取得的进展。

关键词：舰船声场声源近场声全息波束形成声强矢量

在线全文

学校读者我要写书评

暂无评论

非均衡湍流边界层脉动压力测试研究

船舶力学 2016年第5期20卷 515-522页

作者：庞业珍俞孟萨中国船舶科学研究中心船舶振动噪声重点实验室江苏无锡214082

通过建立非均衡湍流边界层脉动压力测试技术及可提供较高测试信噪比的低噪声风洞试验装置,采用表面贴装式硅微传声器线列阵,测量获得了不同压力梯度模型的湍流边界层脉动压力特性,压力梯度模型表面湍流边界层脉动压力低频平台区幅值增加... 详细信息

通过建立非均衡湍流边界层脉动压力测试技术及可提供较高测试信噪比的低噪声风洞试验装置,采用表面贴装式硅微传声器线列阵,测量获得了不同压力梯度模型的湍流边界层脉动压力特性,压力梯度模型表面湍流边界层脉动压力低频平台区幅值增加3-5 dB;回归得到了非均衡湍流边界层流脉动压力频谱与Strauhal数及Re数和压力梯度相关的拟合模型,具有一定的适用性;压力梯度对湍流边界层脉动压力频率—波数谱的影响主要集中在300 Hz以下的低频段,传输波数附近峰脊区谱级增加3-5 dB。

关键词：非均衡湍流边界层脉动压力波数—频率谱