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Yinyanghuo(Herba Epimedii Brevicornus) and its components for chronic obstructive pulmonary disease:preclinical evidence and possible mechanisms

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Journal of Traditional Chinese Medicine 2023年第2期43卷 386-396页

作者： WANG Yide gao zhen Department of Respiration Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830000China Department of Integrative Medicine Huashan hospital of Fudan UniversityShanghai 200040China

OBJECTIVE:To integrate Meta-analysis and bioinformatics strategies in the preliminary exploration of the potential mechanism of Yinyanghuo(Herba Epimedii Brevicornus) and its extract in treating chronic obstructive pulmonary disease(COPD).METHODS:First,Meta-analysis was carried *** Chinese and English literature of Yinyanghuo(Herba Epimedii Brevicornus) in treating COPD was searched using the systematic strategy of combining subject words with free *** included studies were evaluated by the SYRCLE risk bias assessment tool,after which the review manager software was used to combine the effect quantities for statistical ***,based on bioinformatics technology,the active ingredients and their targets of Yinyanghuo(Herba Epimedii Brevicornus) were screened,and the intersection genes were obtained by mapping and comparing with the targets of *** "medicinal materials-compounds-targets model" was constructed,and the key pathways were ***,the core target was docked with important ***:A total of 8 studies were included in the *** results showed that the Yinyanghuo(Herba Epimedii Brevicornus) group could significantly downregulate pro-inflammatory factors such as tumor necrosis factor-α(TNF-α) and interleukin(IL)-8 and increase the expression of anti-inflammatory factors and antioxidant factors such as IL-10 and phospho-protein kinase B(pAKT) in the COPD model(all P < 0.05).A total of 23 active components and 102 corresponding target genes of Yinyanghuo(Herba Epimedii Brevicornus) were obtained by bioinformatics technology,among which 17 compounds and 63 targets were closely related to *** results of enrichment analysis mainly included TNF signaling pathway,phosphoinositide 3-kinase(PI3K)/Akt signaling pathway,cancer signaling pathway,and other inflammatory reactions,oxidative stress,and tumorrelated *** molecular docking results showed that the binding energy fractions of the top five components

关键词： Yinyanghuo(Herba Epimedii Brevicornus) pulmonary disease chronic obstructive Meta-analysis computational biology

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Feasibility of LTE-Based GEO Satellite Mobile Communication Systems to Support VoIP for Handheld Terminals

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Chinese Journal of Electronics 2019年第4期28卷 829-834页

作者： DING Dan gao zhen CHENG Naiping Department of Electronic and Optical Engineering Space Engineering University School of Electrical and Information Engineering Tianjin University

To facilitate the integration of terrestrial and satellite mobile communication systems in the future,the new generation of satellite mobile communication system should be Long-term evolution(LTE)-*** LTE, voice is carried by Internet protocol(IP)packets(voice over IP, VoIP). The feasibility of LTEbased Geosynchronous earth orbit(GEO) satellite mobile communication systems for Vo IP is discussed. Detailed link budgets are created for typical handheld *** effectiveness of Physical resource block(PRB)bundling and Transmission time interval(TTI) bundling for the capacity improvement of downlink and uplink are evaluated, and further uplink improvement for low level terminals by Narrowband resource block(NRB)scheme is also studied. The analysis results show that the downlink VoIP transmission is mainly power limited, and optimization of PRB or TTI bundling can maximize the capacity. For uplink, only highlevel terminals can support VoIP under the normal LTE frame structure, and TTI bundling and Resource block(RB) block techniques can help the low-level terminals support VoIP transmission.

关键词： Satellite mobile communications Geosynchronous earth orbit(GEO) Long-term evolution(LTE) Voice over internet protocol(VoIP) Handheld terminals

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On the Choice of Design Points for Least Square Polynomial Approximations with Application to Uncertainty Quantification

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Communications in Computational Physics 2014年第7期16卷 365-381页

作者： zhen gao Tao Zhou School of Mathematical Sciences Ocean University of ChinaQingdaoChina Institute of Computational Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China.

In this work,we concern with the numerical comparison between different kinds of design points in least square(LS)approach on polynomial *** a topic is motivated by uncertainty quantification(UQ).Three kinds of design points are considered,which are the Sparse Grid(SG)points,the Monte Carlo(MC)points and the Quasi Monte Carlo(QMC)*** focus on three aspects during the comparison:(i)the convergence properties;(ii)the stability,*** properties of the resulting condition number of the design matrix;(iii)the robustness when numerical noises are present in function *** classical high dimensional functions together with a random ODE model are *** is shown numerically that(i)neither the MC sampling nor the QMC sampling introduce the low convergence rate,namely,the approach achieves high order convergence rate for all cases provided that the underlying functions admit certain regularity and enough design points are used;(ii)The use of SG points admits better convergence properties only for very low dimensional problems(say d≤2);(iii)The QMC points,being deterministic,seem to be a good choice for higher dimensional problems not only for better convergence properties but also in the stability point of view.

关键词： Least square polynomial approximations uncertainty quantification condition number.

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HIGH ORDER WEIGHTED ESSENTIALLY NON-OSCILLATION SCHEMES FOR ONE-DIMENSIONAL DETONATION WAVE SIMULATIONS

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Journal of Computational Mathematics 2011年第6期29卷 623-638页

作者： zhen gao Wai Sun Don Zhiqiu Li School of Mathematical Sciences Ocean University of China Qingdao 266100 China Department of Mathematics Hong Kong Baptist University Hong Kong China

In this paper, three versions of WENO schemes WENO-JS, WENO-M and WENO-Z are used for one-dimensional detonation wave simulations with fifth order characteristic based spatial flux reconstruction. Numerical schemes for solving the system of hyperbolic conversation laws using the ZND analytical solution as initial condition are presented. Numerical simulations of one-dimensional detonation wave for both stable and unstable cases are performed. In the stable case with overdrive factor f = 1.8, the temporal histories of peak pressure of the detonation front computed by WENO-JS and WENO-Z reach the theoretical steady state. In comparison, the temporal history of peak pressure computed by the WENO-M scheme fails to reach and oscillates around the theoretical steady state. In the unstable cases with overdrive factors f = 1.6 and f = 1.3, the results of all WENO schemes agree well with each other as the resolution, defined as the number of grid points per half-length of reaction zone, increases. Furthermore, for overdrive factor f = 1.6, the grid convergence study demonstrates that the high order WENO schemes converge faster than other existing lower order schemes such as unsplit scheme, Roe＇s solver with minmod limiter and Roe＇s solver with superbee limiter in reaching the predicted peak pressure. For overdrive factor f = 1.3, the temporal history of peak pressure shows an increasingly chaotic behavior even at high resolution. In the case of overdrive factor f = 1.1, in accordance with theoretical studies, an explosion occurs and different WENO schemes leading to this explosion appear at slightly different times.

关键词： Weighted Essentially Non-Oscillatory Detonation ZND.

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Tonifying kidney therapy for stable chronic obstructive pulmonary disease: a systematic review

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Journal of Traditional Chinese Medicine 2020年第2期40卷 188-196页

作者： gao zhen Liu Yingying Xu Yizhe Dong Jingcheng Department of Integrative Medicine Huashan HospitalFudan UniversityShanghai 200040China National Clinical Research Base of Traditional Chinese Medicine Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830000China

OBJECTIVE: To evaluate the efficacy and safety of tonifying kidney therapy(Bushen, TK) for stable chronic obstructive pulmonary disease(COPD).METHODS: Randomized controlled trials(RCTs) of TK use for treatment of stable COPD were searched in four databases including Pub Med, the Cochrane Library, Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database from inception to December 2017. Two reviewers independently screened the literature, extracted the data, and assessed the risk of bias in the included studies. Rev Man 5.3 software was used for the ***: Eight RCTs involving 809 patients with stable COPD were included. Compared with the conventional Western Medicine(CWM) group, the TK group(TK combined with CWM) showed significant improvements in the effectiveness rates(RR =1.37, 95% CI 1.22 to 1.53, P < 0.000 01) and 6-min walk distance in meters(MD 11.92, 95% CI 3.52 to20.32, P = 0.005), this study also showed that the TK group can decrease The Traditional Chinese Medicine Syndrome Score(MD-8.01, 95% CI-12.89 to-3.13, P = 0.001). The lung function [forced expiratory volume in one second%(FEV1%), FEV1/forced vital capacity] showed no difference between the TK and control ***: For patients with stable COPD, TK can improve the clinical effectiveness and exercise capacity but fail to improve the patient's symptoms. Because of the low methodological quality of the included trials, additional high-quality and large-scale RCTs are required.

关键词： Pulmonary disease,chronic obstructive Reinforcing kidney Review Randomized controlled trial

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EFFECT OF SURFACTANT ON TWO-PHASE FLOW PATTERNS OF WATER-GAS IN CAPILLARY TUBES

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Journal of Hydrodynamics 2007年第5期19卷 630-634页

作者： LIU zhen-hua gao Yi-pu School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200240 China

Flow patterns of liquid-gas two-phase flow were experimentally investigated. The experiments were carried out in both vertical and horizontal capillary tubes having inner diameters of 1,60 mm, The working liquid was the mixture of water and Sodium Dodecyl Benzoyl Sulfate （SDBS）. The working gas was Nitrogen. For the water/SDBS mixture-gas flow in the vertical capillary tube, flow-pattern transitions occurred at lower flow velocities than those for the water-gas flow in the same tube. For the water/SDBS mixture-gas flow in the horizontal capillary tube, surface tension had little effect on the bubbly-intermittent transition and had only slight effect on the plug-slug and slug-annular transitions. However, surface tension had significant effect on the wavy stratified flow regime. The wavy stratified flow regime of water/SDBS mixture-gas flow expanded compared with that of water-gas.

关键词： two-phase flow flow pattern map capillarytube surfactant

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Efficient Solution of Ordinary Differential Equations with High-Dimensional Parametrized Uncertainty

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Communications in Computational Physics 2011年第7期10卷 253-278页

作者： zhen gao Jan S.Hesthaven Research Center for Applied Mathematics Ocean University of ChinaQingdao 266071ShandongChina Division of Applied Mathematics Brown University182 George StreetProvidenceRI 02912USA

The important task of evaluating the impact of random parameters on the output of stochastic ordinary differential equations(SODE)can be computationally very demanding,in particular for problems with a high-dimensional parameter *** this work we consider this problem in some detail and demonstrate that by combining several techniques one can dramatically reduce the overall cost without impacting the predictive accuracy of the output of *** discuss how the combination of ANOVA expansions,different sparse grid techniques,and the total sensitivity index(TSI)as a pre-selective mechanism enables the modeling of problems with hundred of *** demonstrate the accuracy and efficiency of this approach on a number of challenging test cases drawn from engineering and science.

关键词： Sparse grids stochastic collocation method ANOVA expansion total sensitivity index

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Borderline form of empty follicle syndrome treated with a novel dual trigger method combined with delayed oocyte retrieval: A case report

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World Journal of Clinical Cases 2020年第4期8卷 825-830页

作者： Xian-Ling Cao zhen-gao Sun College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250011Shandong ProvinceChina Integrative Medicine Research Centre of Reproduction and Heredity the Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011Shandong ProvinceChina

BACKGROUND Borderline form of empty follicle syndrome is a condition in which only a few mature or immature oocytes are recovered after meticulous follicular aspiration,despite adequate ovarian response to *** is a rare phenomenon with an unclear ***,the condition still lacks effective *** SUMMARY A patient with secondary infertility who had undergone three cycles of assisted reproductive technique(ART)is *** regard to good follicular response,two oocytes were obtained in the first two ART cycles,but no embryo was *** the third ART cycle,which is the subject of this study,ovulation was induced by dual trigger of a supernormal dose of human chorionic gonadotropin(HCG)combined with a delayed oocyte retrieval *** method involved administration of gonadotropin-releasing hormone agonist,recombinant HCG,and urinary HCG 39 h before ovum *** oocytes were recovered,two out of three mature eggs were fertilized after intracytoplasmic sperm injection,resulting in two embryos that were subsequently *** case report guidelines have been used herein to present the first case of this novel dual trigger *** This approach provides a new treatment option for patients with a similar condition in the *** study can also inspire further investigation on the effects of variousβ-HCG serum levels 36 h after intramuscular HCG administration.

关键词： Empty follicle syndrome Dual trigger Delayed oocyte retrieval β-HCG threshold Case report

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Partial Iterative Decode of Turbo Codes for On-Board Processing Satellite Platform

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China Communications 2015年第11期12卷 104-111页

作者： LI Hang gao zhen ZHAO Ming WANG Jing Department of Electronic Engineering Tsinghua University School of Electronic Information Engineering Tianjin University

There is a contradiction between high processing complexity and limited processing resources when turbo codes are used on the on-board processing(OBP)satellite *** solve this problem,this paper proposes a partial iterative decode method for on-board application,in which satellite only carries out limited number of iteration according to the on-board processing resource limitation and the throughput capacity *** this method,the soft information of parity bits,which is not obtained individually in conventional turbo decoder,is encoded and forwarded along with those of information *** save downlink transmit power,the soft information is limited and normalized before *** iteration number and limiter parameters are optimized with the help of EXIT chart and numerical analysis,*** results show that the proposed method can effectively decrease the complexity of onboard processing while achieve most of the decoding gain..

关键词： satellite communication on-board processing partial iterative decoding

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Laser Double Ablation Reactions of Chromium(Iron)and Sulfur Clusters

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Chemical Research in Chinese Universities 2001年第4期17卷 473-476页

作者： LIU Peng ZHANG Xia gao zhen ZHU Qi-he State Key Laboratory of Molecular Reaction Dynamics Center of Molecular ScienceInstitute of ChemistryChinese Academy of SciencesBeijing 100080P.R.China

The sulfides of transitional metals chromium[1-3] and iron[4] are of great importance inmaterial and biology sciences due to their characteristic structures and *** the studyon the properties of Cr－S and Fe－S cluste... 详细信息

关键词： Cluster Laser double ablation reaction Formation mechanism Stable configuration

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