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Acta Pharmacologica Sinica 2004年第10期 45-51页

作者： cai-zhen YAN, Yan-ning HOU Bathune International Peace Hospital, Hebei Medical University,Shijiazhuang 050082, China

AIM: To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain. METHODS: A method of simultaneous quantification of neurosteroids by gas chromatography-mass spectrometry (GC-MS) had been established. RESULTS: The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG), progesterone (PROG), and pregenenolone sulfate (PREGS) in rats killed 6 h after the last treatment. In contrast, there were no significant effects of morphine dependence on the brain concentrations of allopregnanolone (AP), dihydroepiandrosterone (DHEA), and dihydroepiandrosterone sulfate (DHEAS). Naloxone-induced withdrawal produced a significant increase in the concentrations of PREG, PROG, AP, DHEA, PREGS, and DHEAS as compared with the control group. CONCLUSION: Morphine dependence and withdrawal affected the concentrations of neurosteroids in rat brain, which suggests that endogenous neurosteroids in brain might be

关键词： morphine dependence withdrawal steroids mass fragmentography

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酸洗搪瓷钢密着性能影响关键因素研究

材料保护 2024年第5期57卷 178-183页

作者：蔡珍刘永前刘洋胡俊韩荣东陈昊王辉肖厚念宝山钢铁股份有限公司中央研究院上海201900 武汉钢铁有限公司技术中心湖北武汉430080 武汉钢铁有限公司热轧厂湖北武汉430080 武汉钢铁有限公司制造管理部湖北武汉430080 武汉钢铁有限公司冷轧厂湖北武汉430080

为提高酸洗搪瓷钢的密着性能,研究了酸洗搪瓷钢密着性能的影响因素,包括烧搪时间、脱脂效能、表面色差和表面粗糙度,对不同脱脂程度、表面状态及粗糙度的试样进行涂搪和烧搪,并采用落球冲击法对密着性能评级。结果表明:在850℃进行烧搪... 详细信息

为提高酸洗搪瓷钢的密着性能,研究了酸洗搪瓷钢密着性能的影响因素,包括烧搪时间、脱脂效能、表面色差和表面粗糙度,对不同脱脂程度、表面状态及粗糙度的试样进行涂搪和烧搪,并采用落球冲击法对密着性能评级。结果表明:在850℃进行烧搪时,烧搪时间从5 min延长至10 min,密着等级从2.0级提高至1.0级。同时,烧搪5 min时,脱脂不充分、保护渣增碳所致色差和降低粗糙度都会降低钢板和瓷釉之间的密着性能,其中脱脂不充分和色差的影响可通过延长烧搪时间至10 min进行改善,但延长烧搪时间后,粗糙度对密着性能仍存在显著影响。

关键词：酸洗搪瓷钢搪瓷密着性能烧搪时间脱脂效能保护渣增碳粗糙度

Safety and immunogenicity of COVID-19 vaccination among liver transplant recipients in China

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 605-608页

作者： Qiu-Ju Tian Man Xie Ji-Tao Wang Yi Wang Bei Zhang Jin-zhen cai Xiao-Long Qi Wei Rao Division of Hepatology Liver Disease CenterThe Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Organ Transplantation The Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000China CHESS-COVID-19 Group Xingtai People’s HospitalXingtai 054000China Department of Clinical Laboratory The Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Immunology Qingdao University Medical CollegeQingdao 266000China CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhou 730000China

To the Editor:During the ongoing coronavirus disease 2019(COVID-19)pan-demic globally,patients with chronic liver diseases(CLD),par-ticularly cirrhosis,hepatobiliary malignancies,candidates for liver transplantation(LT),and immunosuppressed LT recipients appear to be at increased risk of infections,which leads to an increase in mortality[1-6].Apart from physical distancing,quarantine and isolation,vaccination is crucial for the restraining of the epidemic and the protection from severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2)infection and aggravation of COVID-19[7,8].A recent prospective,multicenter,open-label study in China has demonstrated the safety of inactivated whole-virion SARS-CoV-2 vaccines in patients with CLD.

关键词： vaccination liver mortality

Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-Xiu Yuan Qi-Gui cai zhen-Yang Zhang Jian-Zhong Zhou cai-Yun Lan Jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of *** To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database *** up to December 2022 comparing nCRT and nCT in patients with EC were *** The analysis revealed significant differences between nCRT and nCT in terms of disease-free *** results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than ***,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for ***,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

CUDC-101 as a dual-target inhibitor of EGFR and HDAC enhances the anti-myeloma effects of bortezomib by regulating G2/M cell cycle arrest

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 442-454页

作者： Wen CAO Shunnan YAO Anqi LI Haoguang CHEN Enfan ZHANG Liqin CAO Jinna ZHANG Yifan HOU zhenfeng DAI Jing CHEN Xi HUANG Li YANG zhen cai Bone Marrow Transplantation Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Institute of Hematology Zhejiang UniversityHangzhou 310058China School of Medicine Zhejiang UniversityHangzhou 310058China

CUDC-101,an effective and multi-target inhibitor of epidermal growth factor receptor(EGFR),histone deacetylase(HDAC),and human epidermal growth factor receptor 2(HER2),has been reported to inhibit many kinds of cancers,such as acute promyelocytic leukemia and non-Hodgkin's ***,no studies have yet investigated whether CUDC-101 is effective against ***,we proved that CUDC-101 effectively inhibits the proliferation of multiple myeloma(MM)cell lines and induces cell apoptosis in a time-and dose-dependent ***,CUDC-101 markedly blocked the signaling pathway of EGFR/phosphoinositide-3-kinase(PI3K)and HDAC,and regulated the cell cycle G2/M ***,we revealed through in vivo experiment that CUDC-101 is a potent anti-myeloma *** is one of the important drugs in MM treatment,and we investigated whether CUDC-101 has a synergistic or additive effect with *** results showed that this drug combination had a synergistic anti-myeloma effect by inducing G2/M phase ***,our findings revealed that CUDC-101 could act on its own or in conjunction with bortezomib,which provides insights into exploring new strategies for MM treatment.

关键词： CUDC-101 Multiple myeloma Bortezomib Epidermal growth factor receptor(EGFR) Cell cycle

Comparison between laparoscopic and open surgery for large gastrointestinal stromal tumors:A meta-analysis

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 48-55页

作者： Jian-Xin Cui Yun-He Gao Hong-Qing Xi Ai-zhen cai Ke-Cheng Zhang Ji-Yang Li Bo Wei Lin Chen Department of General Surgery Chinese PLA General Hospital

AIM To investigate whether laparoscopic surgery is as safe and feasible as open resection for patients with larger gastrointestinal stromal tumors(GISTs)(≥ 5 cm).METHODS A systematic search of Pub Med, EMBASE, Web of Science and the Cochrane Library database was performed. Relevant studies of laparoscopic and open surgery for GISTs of > 5 cm published before December 2016 were identified from these databases. The quality of the studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. The tumor size, operation time, blood loss, postoperative hospital stay, complication rate, and disease-free survival rate were assessed. The software Stata(version 12.0) was used for the *** Five clinical trials comprising 209 patients with GISTs of similar larger sizes were evaluated. The pooled analysis of 100 patients in the laparoscopic resection group and 109 patients in the open resection group demonstrated that laparoscopic surgery was significantly associated with a shorter postoperative hospital stay(P < 0.001)and less blood loss(P = 0.002). Moreover, there were no statistically significant differences in the operation time(P = 0.38), postoperative complication rate(P = 0.88), or disease-free survival rate(P = 0.20) between two groups. CONCLUSION Our findings revealed that for patients with large GISTs of comparable sizes, laparoscopic surgery did not significantly influence the operation factors or clinical outcomes compared with open surgery. This suggests that laparoscopic resection is as acceptable as open surgery for treatment of large gastric GISTs.

关键词： Laparoscopic resection Open resection Gastrointestinal stromal tumor Meta-analysis Clinical outcome

数字PCR在人巨细胞病毒核酸定量检测中的应用

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分子诊断与治疗杂志 2024年第9期16卷 1618-1621页

作者：罗景燕许少飞于海洋向春艳王保平蔡贞广东永诺医疗科技有限公司广东佛山528051 深圳市龙华妇幼保健院不孕不育与生殖健康科广东深圳518102 南方医科大学南方医院检验科广东广州510515

目的分析微滴式数字PCR(ddPCR)和实时荧光定量PCR(qPCR)检测人巨细胞病毒(HCMV)核酸的结果,比较两种方法的差异性,并评估ddPCR技术的临床有效性和实用性。方法收集306例疑似HCMV感染相关疾病患者血浆标本,采用ddPCR和qPCR两种方法测定... 详细信息

目的分析微滴式数字PCR(ddPCR)和实时荧光定量PCR(qPCR)检测人巨细胞病毒(HCMV)核酸的结果,比较两种方法的差异性,并评估ddPCR技术的临床有效性和实用性。方法收集306例疑似HCMV感染相关疾病患者血浆标本,采用ddPCR和qPCR两种方法测定同一份标本的HCMVDNA载量。结果疑似HCMV感染人群中,基于ddPCR的检测结果,男性和女性的阳性率差异无统计学意义(χ^(2)=1.07,P>0.05);不同年龄段的病例阳性率差异无统计学意义(χ^(2)=0.03,P>0.05);不同疾病类型的样本阳性率差异有统计学意义(χ^(2)=10.38,P<0.05)。采用ddPCR方法检测的阳性率为46.41%(120/306),采用qPCR方法检测的阳性率为22.86%(70/306),阳性率差异有统计学意义(χ^(2)=103.80,P<0.05)。受试者工作特征曲线(ROC)分析显示,ddPCR检测的灵敏度为0.96,特异性为0.97,ROC曲线下面积(Area Under Curve,AUC)为0.98。结论采用ddPCR检测HCMVDNA比qPCR具有更好的可定量性,尤其是在低浓度样本检测中更具优势,可以进一步作为临床诊断的直接方法,对现有qPCR检测体系做出有益补充和升级。

关键词：微滴式数字PCR 实时荧光定量PCR HCMV病毒核酸定量

Characterization of Pozzolanic Reaction and Its Effect on the C-S-H Gel in Fly Ash-cement Paste

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Journal of Wuhan University of Technology(Materials Science) 2011年第2期26卷 320-325页

作者：王磊何真 State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

High resolution solid-state 29Si MAS NMR,combined with XRD,SEM and FTIR were used to characterize the pozzolanic activity of FA,type of main pozzolanic reaction products,and the effect of pozzolanic reaction on the C-S-H microstructure in fly ash-cement （FC） *** experimental results indicate that in the hydrated FC paste with 30% dosage of FA at 3 d,FA partially participated in the pozzolanic reaction,while,at 120 d,FA largely *** the hydration of FC paste at laboratory temperature,the pozzolanic reaction products are C-S-H gel rather than zeolitic ***,after the covalent bonds of Si-O-Si,Si-O-Al and Al-O-Al in the structure of FA are broken,monosilicates Si-OH and Al-OH groups form,these chemical species can connect C-S-H dimers,thus producing more Al-free C-S-H and aluminous C-S-H than in the plain cement *** increased content of Al for Si substitution in the bridging tetrahedra of C-S-H may decrease the stability of C-S-H,which results in a rather obvious loss in the mechanical strength of hardened FC paste.

关键词： NMR C-S-H microstructure dimer polymerization

Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

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Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： Xiao-Yu Li Chun-Ru Xu Xing Ji zhen-Peng Zhu zhen-Ke Guo Tian-Yu cai Jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the *** are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely *** reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding