检索结果-南通市图书馆

Comparison of toxicity between lanthanum oxide nanoparticles and lanthanum chloride

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第2期42卷 424-430,I0007页

作者： Kun Huang Songchang Lai Miao Guo Xingwu Zhu Jiashuangwei Yuan zhehao Liu Gonghua Hu Yanfang Gao School of Public Health and Health Management Gannan Medical UniversityGanzhou341000China

Due to the wide application of rare earth elements,lanthanum(La) is gradually accumulated in our living *** can enter the body through a variety of routes,which has a series of effects on various *** a consequence,the safety of lanthanum deserves our *** study aims to compare the toxicity of lanthanum oxide nanoparticles(La_(2.O_(3) NPs) and lanthanum chloride(LaCl_(3)) and enrich the toxicity evaluation of ***,a 30 d intragastal experiment was conducted.C57BL/6j mice were given by La_(2.O_(3) NPs solution and LaCl_(3) solution respectively at doses of 0,30,60 and12. mg/kg BW(lanthanum content).The results show that,compared with the control group,both La_(2.O_(3)NPs and LaCl_(3) can reduce the body weight of female mice in the high-dose group,but for male mice,the high-dose La_(2.O_(3) NPs solution can increase the body weight,while LaCl_(3) has the opposite *** coefficients of liver,kidney,heart,lung,uterine and ovaries increase first and then decrease with the exposure dose,but testes and epididymides coefficient keep increasing with the exposure of LaCl_(3) and La_(2.O_(3) ***_(2.O_(3) NPs and LaCl_(3) can reduce the concentration of triglycerides(TG) and increase the level of low density lipoprotein(LDL),but the effect of La_(2.O_(3) NPs is more ***_(2.O_(3) NPs and LaCl_(3) can reduce the concentration of malondialdehyde(MDA),increase the total antioxidant capacity(T-AOC)and enhance the activity of catalase(CAT),but LaCl_(3) has more obvious protective effects on oxidative ***_(2.O_(3) NPs and LaCl_(3) have potential risks to liver,and the toxicity of La_(2.O_(3) NPs might be higher than that of LaCl_(3).

关键词： Rare earth elements Lanthanum oxide nanoparticles Lanthanum chloride Lipid metabolism Oxidative stress

Unlocking epigenetics for precision treatment of Ewing’s sarcoma

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第3期36卷 322-340页

作者： zhehao Fan Shuangshuang Dong Ning Wang Muhammad Babar Khawar Jingcheng Wang Haibo Sun Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Jiangsu Key Laboratory of Experimental&Translational Non-Coding RNA Research Yangzhou 225001China Department of Pathology Northern Jiangsu People’s Hospital Affiliated to Yangzhou University/Clinical Medical CollegeYangzhou UniversityYangzhou 225001China Department of Orthopedics Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhou 225001China

Ewing’s sarcoma(EWS)is a highly aggressive malignant bone tumor primarily affecting adolescents and young *** the efficacy of chemoradiotherapy in some cases,the cure rate for patients with metastatic and recurrent disease remains ***,there is an urgent need for innovative therapeutic approaches to address the challenges associated with EWS *** regulation,a crucial factor in physiological processes,plays a significant role in controlling cell proliferation,maintaining gene integrity,and regulating *** studies highlight the importance of abnormal epigenetic regulation in the initiation and progression of EWS.A comprehensive understanding of the intricate interactions between EWS and aberrant epigenetic regulation is essential for advancing clinical drug *** review aims to provide a comprehensive overview of both epigenetic targets implicated in EWS,integrating various therapeutic modalities to offer innovative perspectives for the clinical diagnosis and treatment of EWS.

关键词： Ewing’s sarcoma epigenetic targets drug resistance drug development

Hourly land surface temperature retrieval over the Tibetan Plateau using Geo-LightGBM framework: Fusion of Himawari-8 satellite, ERA5 and site observations

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第4期15卷 623-635页

作者： Zhao-Hua LIU Shan-Shan WENG Zhao-Liang ZENG Ming-Hu DING Ya-Qiang WANG zhehao LIANG Civil and Surveying&Mapping Engineering Jiangxi University of Science and TechnologyGanzhou 341000China State Key Laboratory of Severe Weather Chinese Academy of Meteoroogical Sciences Beijing 100081China Space Geodesy and Geoinformation Technical Unviersity of BerlinBerlin 10623Germany

The Tibetan Plateau(TP)is highly sensitive to even minor fluctuations in land surface temperature(LST),which can result in permafrost melting and degradation of alpine grasslands,leading to serious ecological ***,it is crucial to have high-temporal-resolution and seamless hourly estimating and monitoring of LST for a better understanding of climate change on the ***,we employed Himawari-8 satellite,Digital Elevation Model(DEM),ERA5 reanalysis and meteorological station observations data to develop a new LightGBM framework(called Geo-LightGBM)for estimating LST on the TP,and then analyzed the spatiotemporal variations of those ***-LightGBM demonstrated excellent LST estimation accuracy,with an R2.coefficient of determination)of 0.971,RMSE(root-mean-square error)of 2.479℃,and MAE(mean absolute error)of 1.510℃.The estimated LST values for the year 2.2. agreed well with observed values,with remarkable differences in hourly LST ***,the estimated LST was more accurate than that from ***,there were two high LST centers,located in the Yarlung Zangbo River Basin and the Qaidam Basin,and a low LST center located in the central *** SHAP(SHapley Additive exPlanations)and correlation analyses revealed DSCS(the mean ground downward shortwave radiation under clear-sky conditions)to be the most importantly input variable for estimating *** dummy variables(e.g.,longitude,latitude,DEM)were also found to be crucial for model accuracy *** findings indicate the potential for constructing a high-precision and seamless 2.-h LST real-time retrieval and monitoring platform for the TP by combining satellite and China's independently developed CLDAS(China Land Data Assimilation System)data in future.

关键词： Tibetan Plateau Himawari-8 ERA5 Land surface temperature Geo-LightGBM

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金属钽表面处理工艺进展

金属热处理 2024年第2期49卷 259-264页

作者：王哲昊核工业理化工程研究院天津300180 粒子输运与富集技术全国重点实验室天津300180

总结归纳了利用渗层、微弧氧化、化学气相沉积、热喷涂等表面处理技术提高金属钽综合性能、减少钽材料失效行为、提升钽设备服役寿命等方面的研究成果和应用实例,最后对钽材料表面增强处理的发展方向进行了展望。

关键词：钽稀有金属表面处理综合性能提升服役寿命

等离子喷涂技术在工程陶瓷涂层制备中的应用现状及展望

在线全文

学校读者我要写书评

暂无评论

材料导报 2024年第11期38卷 48-57页

作者：王哲昊吕绪明核工业理化工程研究院天津300180 粒子输运与富集技术全国重点实验室天津300180

等离子喷涂作为一种成熟的表面处理技术,具有适用范围广、生产效率高、涂层质量好的优点,在基体材料表面增强过程中扮演了愈发重要的角色。与此同时,越来越多的实例也证明:陶瓷涂层对提高基体材料的整体性能和服役寿命起到了关键作用。... 详细信息

等离子喷涂作为一种成熟的表面处理技术,具有适用范围广、生产效率高、涂层质量好的优点,在基体材料表面增强过程中扮演了愈发重要的角色。与此同时,越来越多的实例也证明:陶瓷涂层对提高基体材料的整体性能和服役寿命起到了关键作用。本文综述了大气等离子喷涂、超音速等离子喷涂、悬浮液等离子喷涂、真空等离子喷涂、低压等离子喷涂等常规等离子喷涂技术在制备陶瓷涂层方面的研究进展,总结了各种制备方法的优势与不足,并在此基础上对该领域的后续发展提出展望。

关键词：等离子喷涂陶瓷涂层表面增强整体性能服役寿命

在线全文

学校读者我要写书评

暂无评论

多措并举标本兼治有力有效做好基督教工作

中国宗教 2024年第5期 33-34页

作者： 1.中共山东省委统战部 2.山东省民宗委中共山东省委统战部山东省民宗委

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责... 详细信息

近年来,山东省结合实际,采取有力举措,扎实做好基督教工作,有效推进基督教中国化山东实践,全省基督教领域呈现出和谐稳定的良好局面。一、严格落实宗教工作责任制,着力构建齐抓共管的宗教事务管理格局山东严格落实各级各部门宗教工作责任制,通过强化组织保障“小切口”,推动基层宗教事务管理“大文章”。一是压实主体责任。将宗教工作纳入各级党委重要议事日程,构建起各级党委齐抓共管的工作体制。

关键词：基督教中国化齐抓共管宗教事务管理主体责任工作责任制和谐稳定严格落实标本兼治

Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 2327-2345页

作者： Chenghao Fu zhehao Liang Zemiao Niu Ning Chen Yuemin Li Zhenhua Liang Yanwei Huo Hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang Yun Huang Yan Zhang Mingming Gao Pin Lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Laboratory of Lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or ***,it is still uncertain how to select immunotherapy drugs to combine with intermittent *** we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast *** this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(IL)7R^(+)and granzyme B^(+)T cells in the tumor ***,we observed that Ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic *** investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and IL-6,which both contributed to the accumulation of *** the other hand,glucose metabolism restriction can directly induce the apoptosis of Ly6G^(low)G-MDSC,but not Ly6G^(high)*** summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)T cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： Intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction

永恒的丰碑：“大陈岛垦荒红色档案”建设侧记

在线全文

学校读者我要写书评

暂无评论

浙江档案 2024年第5期 10-11+16页

作者： 1.台州市档案馆 2.台州市椒江区档案馆台州市档案馆台州市椒江区档案馆

在台州市椒江区档案馆的特藏馆内，挂着一幅由团中央在1956年赠给温州青年志愿垦荒队的旗帜“建设伟大祖国的大陈岛”，这面旗帜承载着一件件珍贵的档案史料和一个个生动的历史场景，大陈岛激情燃烧的垦荒史、波澜壮阔的发展史，宛如画...

在台州市椒江区档案馆的特藏馆内，挂着一幅由团中央在1956年赠给温州青年志愿垦荒队的旗帜“建设伟大祖国的大陈岛”，这面旗帜承载着一件件珍贵的档案史料和一个个生动的历史场景，大陈岛激情燃烧的垦荒史、波澜壮阔的发展史，宛如画卷般展现在眼前。“大陈岛垦荒精神”是台州的城市精神，是这座城市发展生生不息的力量源泉。1956年到1960年，温州、台州两地467名青年陆续上岛支援建设，他们卷起裤管，咬紧牙关，用血和汗锻炼成了一个个生产能手，在荒岛上发展出种植业、畜牧业和海洋养殖业。一代垦荒人用青春和汗水孕育了“艰苦创业、奋发图强、无私奉献、开拓创新”

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

要闻

上海国资 2024年第4期 9-10页

作者： 1.新华社 2.国家数据局新华社国家数据局

国务院国资委全面深化改革领导小组召开2.2.年第一次全体会议2.2.年3月2.日，国务院国资委全面深化改革领导小组召开2.2.年第一次全体会议。会议指出，今年是深入实施国有企业改革深化提升行动承上启下的关键一年，要聚焦重点难点任务...

国务院国资委全面深化改革领导小组召开2.2.年第一次全体会议2.2.年3月2.日，国务院国资委全面深化改革领导小组召开2.2.年第一次全体会议。会议指出，今年是深入实施国有企业改革深化提升行动承上启下的关键一年，要聚焦重点难点任务全力攻坚，紧盯重点任务和关键时点，全力以赴抓好各项任务落实。

关键词：

来源：博看期刊