检索结果-南通市图书馆

Human iP SC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells

引用

Science China Life Sciences 2024年

作者： Zhen Zhang Weijun Huang Xiaoran Zhang zhecun wang Manting Xie Bingbing Xie Yiling wang Xiaoyong Chen Andy Peng Xiang Qiuling Xiang Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education Sun Yat-sen University Department of Physiology Zhongshan School of Medicine Sun Yat-sen University Department of Vascular Surgery the First Affiliated Hospital Sun Yat-sen University

Despite substantial advancements in modern medicine, the management of hypertension remains a major challenge. Stem cell-based therapies have recently demonstrated remarkable efficacy in treating cardiovascular diseases, including hypertension. However, the antihypertensive mechanism of mesenchymal stem cells（MSCs） has not been extensively explored. This study aimed to investigate the role of injected MSCs in regulating blood pressure homeostasis. Our previous study demonstrated that human induced pluripotent stem cellderived mesenchymal stem cells（hiPSC-MSCs） are functional and homogeneous sources for MSC-based therapy. After the injection of hiPSCMSCs, a significant reduction in blood pressure and end target organ inflammation were observed in spontaneously hypertensive rats（SHRs）. Cell tracking assays demonstrated that the injected hiPSC-MSCs accumulated in the spleens of the SHRs. The injected hiPSC-MSCs accumulated adjacent to the splenic nerve, potentially contributing to the antihypertensive effects. Furthermore, the hiPSC-MSCs released abundant glutamate, which acts as a neuromodulator to activate the splenic sympathetic nerve. After inhibition of glutamate synthesis by siRNA, the ability of hiPSC-MSCs to activate sympathetic nerves was significantly diminished. In addition, the antihypertensive effects of hiPSC-MSCs were eliminated after splenic nerve denervation（SND）, underscoring the critical role of the splenic nerve. Moreover, activation of the splenic nerve resulted in increased release of norepinephrine（NE）, which increased the number of choline acetyltransferase-positive（ChAT+） cells in the spleen and peripheral blood. Consequently, the acetylcholine（ACh） produced by elevated ChAT+cells could act as a vasodilator, lowering blood pressure and mitigating inflammation in end target organs. In summary, our findings indicate that hiPSC-MSCs effectively lower blood pressure in hypertension by influencing the splenic nerves and regulating ChAT+cells. The co

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Molecular and nanostructure designed superhydrophilic material with unprecedented antioil-fouling property for diverse oil/water separation

引用

Science China(Technological Sciences) 2022年第6期65卷 1273-1282页

作者： wang zhecun GUAN Min YANG Xin LI HanZhen wang LaiGui College of Materials Science and Engineering Liaoning Technical UniversityFuxin 123000China School of Mechanics and Engineering Liaoning Technical UniversityFuxin 123000China

The design and development of new advanced superwetting porous membranes with antioil-fouling performance are still rare and highly desirable because of their potential widespread applications.A metallic phosphate nanoflower-covered mesh membrane with superhydrophilic and unprecedented antioil-fouling properties is prepared by an exceptionally simple and effective in-situ solution corrosion *** demonstrated,the outstanding antioil-fouling property of the resulting mesh membrane is connected with the special phosphate group and the three-dimensional(3 D) nanoflower *** to the antioil-fouling property,upon to water,the oil-fouled mesh membrane can keep the surface free of various kinds of oils,including viscous crude oil to light *** to its unprecedented self-cleaning property,the superhydrophilic mesh membrane can effectively separate different oil/water mixtures without prior wetted by water,exhibiting great potential for practical spilled oil remediation.

关键词： crude oil/water separation inorganic membrane antioil-fouling property metallic phosphate nanoflowers oil spill remediation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

外周动脉疾病的血管体检与早期治疗进展

引用

中华实验外科杂志 2020年第5期37卷 795-799页

作者：王深明王折存中山大学附属第一医院血管外科广州510080

外周动脉疾病( PAD)最常见的病因为动脉粥样硬化,终末期患者出现肢体缺血乃至组织坏死,常因截肢而致残。外科及血管腔内治疗等方式开通血管、改善局部组织血供,可以缓解患者的临床症状,改善生活质量。但是依然有部分患者的血管解剖条件... 详细信息

外周动脉疾病( PAD)最常见的病因为动脉粥样硬化,终末期患者出现肢体缺血乃至组织坏死,常因截肢而致残。外科及血管腔内治疗等方式开通血管、改善局部组织血供,可以缓解患者的临床症状,改善生活质量。但是依然有部分患者的血管解剖条件较差不适合手术,即使是血管腔内手术后有短期立竿见影的疗效,但远期有高达30%~50%的血管再狭窄率,严重影响患者的预后甚至截肢。因此,早期诊断、早期治疗是达到理想治愈的最佳手段。近年来,关于 PAD早期诊断、早期治疗的研究取得了显著的进步,相信随着这些研究的不断深入,一定能大大降低 PAD发病率,提高 PAD的治愈率,减轻家庭及社会的经济负担。

关键词：外周动脉疾病下肢动脉粥样硬化闭塞血管体检早期治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stanford B型主动脉夹层腔内隔绝术后主动脉重塑特点

引用

中华临床医师杂志（电子版） 2015年第6期9卷 111-116页

作者：王折存师天雄广东省中山市人民医院普外二科 518403

主动脉夹层是最常见的主动脉急症,TEVAR(Thoracic Endovascular Aortic Repair)治疗开创了腔内微创治疗Stanford B型主动脉夹层的新纪元,已渐渐取代手术治疗成为B型主动脉夹层的主要治疗方式。本文就目前国内外B型主动脉夹层行TEVAR术... 详细信息

主动脉夹层是最常见的主动脉急症,TEVAR(Thoracic Endovascular Aortic Repair)治疗开创了腔内微创治疗Stanford B型主动脉夹层的新纪元,已渐渐取代手术治疗成为B型主动脉夹层的主要治疗方式。本文就目前国内外B型主动脉夹层行TEVAR术后的主动脉重塑过程、形态学变化及特点进行综述。

关键词： Stanford B型主动脉夹层主动脉重塑

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

微波消融闭合治疗原发性下肢静脉曲张效果分析

引用

中华医学杂志 2021年第39期101卷 3232-3237页

作者：李梓伦王冕武日东王折存严杰姚陈常光其王深明中山大学附属第一医院血管外科广州510080 赣州市南康区第一人民医院普外科赣州341400

目的探讨微波消融闭合治疗原发性下肢静脉曲张的效果。方法纳入2017年1月至2019年11月中山大学附属第一医院接受微波消融闭合术的214例原发性下肢静脉曲张患者,依据术式分为:大隐静脉主干微波消融组(n=128)和大隐静脉主干高位结扎+微波... 详细信息

目的探讨微波消融闭合治疗原发性下肢静脉曲张的效果。方法纳入2017年1月至2019年11月中山大学附属第一医院接受微波消融闭合术的214例原发性下肢静脉曲张患者,依据术式分为:大隐静脉主干微波消融组(n=128)和大隐静脉主干高位结扎+微波消融组(n=86);根据大隐静脉主干直径,上述两组患者进一步分别被分为两个亚组:0.05);两组患者的皮肤活动性溃疡发生率分别为6.4%和15.6%,差异有统计学意义(P=0.020)。两组患者的局部皮肤麻木感在最长2年随访期内均恢复,皮肤局部瘀斑均在术后1个月内恢复,活动性溃疡在最长1年随访期内均愈合。结论微波消融闭合手术安全有效,尤其是结合大隐静脉主干高位结扎;单纯微波消融闭合手术对于直径10 mm的大隐静脉曲张手术成功率降低。

关键词：静脉曲张隐静脉微波消融腔内手术随访研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Swarm intention identification via dynamic distribution probability image

引用

Chinese Journal of Aeronautics 2024年第10期37卷 380-392页

作者： Yinhan wang Jiang wang Shaoming HE Fei wang Qi wang School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

In the realm of decision-making for defense and security applications,it is paramount to swiftly and accurately identify the intentions of incoming *** identification methods predominantly focus on single-target applications and overlook the perturbations introduced by measurement *** this study,we propose a novel concept:the Dynamic Distribution Probability(DDP)image,which is constructed using the estimated state and its covariance *** grayscale pixel value within the image signifies the probability of the presence of the agent within the *** proposed identification scheme integrates the use of Extended Kalman Filter(EKF),Convolutional Neural Network(CNN),Back Propagation(BP)network,and Gated Recurrent Unit(GRU)***,the DDP image is processed through a CNN to distill the formation characteristics,and the estimated swarm state from EKF is inputted into a BP network to deduce the kinematic *** outputs from both networks are summed and subsequently channeled into a GRU network to capture temporal *** numerical simulations and flight experiments are presented to demonstrate the robust anti-noise capability of the proposed scheme compared with conventional methods,as well as its superior training efficiency.

关键词： Intention Identification Kalman filters Convolutional neural networks Swarm intelligence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The reformation of catalyst:From a trial-and-error synthesis to rational design

引用

Nano Research 2024年第4期17卷 3261-3301页

作者： Ligang wang Jiabin Wu Shunwu wang Huan Liu Yao wang Dingsheng wang Department of Chemistry Tsinghua UniversityBeijing 100084China

The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules,which is of great importance in the study of chemistry,chemical industry,energy,materials and environmental ***,efficient,environmentally friendly,and easy to operate synthesis methods have been used to prepare various types of *** previous studies have reported the synthesis and characterization of the aforementioned catalysts,more still remain in trial and error methods,without in-depth consideration and improvement of traditional synthesis ***,we comprehensively summarize and compare the preparation methods of the trial-and-error synthesis strategy,structure–activity relationships and density functional theory(DFT)guided catalysts rational design for nanomaterials and atomically dispersed *** also discuss in detail the utilization of the nanomaterials and single atom catalysts for converting small molecules(H_(2)O,O_(2),CO_(2),N_(2),etc.)into value-added products driven by electrocatalysis,photocatalysis,and ***,the challenges and outlooks of mass preparation and production of efficient and green catalysts through conventional trial and error synthesis and DFT theory are featured in accordance with its current development.

关键词： trial-and-error synthesis structure–activity relationships density functional theory(DFT)guidance nanomaterials atomically dispersed catalysts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical Analysis of PRISM-PY Calculations for Hard-and Soft-Core Generic Polymer Models

引用

Chinese Journal of Polymer Science 2024年第4期42卷 532-543页

作者： Qiang wang Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Generic polymer models capturing the chain connectivity and excluded-volume interactions between polymer segments can be classified, according to whether or not the 3D integral of the latter diverges, into hard- and soft-core models. Taking homogeneous systems of compressible homopolymer melts (or equivalently homopolymer solutions in an implicit, good solvent) in the continuum as an example, we recently compared the correlation effects on the structural and thermodynamic properties of the hard- and soft-core models given by the polymer reference interaction site model (PRISM) theory with the Percus-Yevick (PY) closure (Polymers 2023, 15, 1180). Here we analyzed in detail the numerical errors and behavior of the interchain pair correlation functions (PCFs) given by the PRISM-PY calculations of these models using an efficient numerical approach that we proposed. Our numerical approach has the least number of independent variables to be iteratively solved, analytically treats the discontinuities caused by the non-bonded pair potential (such as that of the hard spheres) and takes only the inverse Fourier transform of the interchain indirect PCF between polymer segments (which is continuous and decays towards 0 with increasing wavenumber much faster than both the interchain direct and total PCFs), and is essential for us to accurately solve the PRISM-PY theory for chain length N as large as 106. To capture the correlation-hole effect, the real-space cut-off in the PRISM calculations should be proportional to the square root of N.

关键词： Generic polymer models Soft potentials Polymer reference interaction site model theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

引用

Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： wang Yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A multi-source information fusion layer counting method for penetration fuze based on TCN-LSTM

引用

Defence Technology（防务技术） 2024年第3期33卷 463-474页

作者： Yili wang Changsheng Li Xiaofeng wang Nanjing University of Science and Technology Nanjing 210094JiangsuChina State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of *** address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent *** leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration *** analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,*** model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target *** maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed ***,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.

关键词： Penetration fuze Temporal convolutional network(TCN) Long short-term memory(LSTM) Layer counting Multi-source fusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：